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Free Radical Research Volume 48, 2014 - Issue 9: Oxidative stress and mitochondrial alterations in ageing and disease
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ORIGINAL ARTICLE

Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model

T. MukaideDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Y. HattoriDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan;Department of Obstetrics /and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
N. MisawaDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
S. FunahashiDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
L. JiangDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
T. HirayamaLaboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Gifu, Japan
,
H. NagasawaLaboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Gifu, Japan
&
S. ToyokuniDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, JapanCorrespondence[email protected]
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Pages 990-995 | Received 21 Jan 2014, Accepted 23 Feb 2014, Published online: 21 Jul 2014

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Daniel Tsun-Yee Chiu & Yau-Huei Wei. (2014) Special issue on “Oxidative stress and mitochondrial alterations in aging and disease”. Free Radical Research 48:9, pages 967-969.
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Kazuhisa Yamada, Akira Tazaki, Nanako Ushio-Watanabe, Yoshihiko Usui, Atsunobu Takeda, Masaaki Matsunaga, Ayana Suzumura, Hideyuki Shimizu, Hao Zheng, Nanang R. Ariefta, Masahiro Yamamoto, Hideaki Hara, Hiroshi Goto, Koh-Hei Sonoda, Koji M. Nishiguchi, Masashi Kato, Yoshifumi Nishikawa, Shinya Toyokuni & Hiroki Kaneko. (2023) Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis. Redox Biology 67, pages 102890.
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Shinya Toyokuni, Yingyi KongHao ZhengYuki MaedaMisako KatabuchiYashiro Motooka. (2023) Three-Dimensional Regulation of Ferroptosis at the Intersection of Iron, Sulfur, and Oxygen Executing Scrap and Build Toward Evolution. Antioxidants & Redox Signaling 39:10-12, pages 807-815.
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T. Hirayama. 2023. Fluorescent Chemosensors. Fluorescent Chemosensors 326 344 .
Hao Zheng & Shinya Toyokuni. 2023. Ferroptosis in Health and Disease. Ferroptosis in Health and Disease 23 40 .
Teruyuki Kawabata. (2022) Iron-Induced Oxidative Stress in Human Diseases. Cells 11:14, pages 2152.
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Ximeng Duan, Zhiyu Xie, Liying Ma, Xueyang Jin, Ming Zhang, Yuliang Xu, Yue Liu, Hongxiang Lou & Wenqiang Chang. (2022) Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans. Microbiology Spectrum 10:3.
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Takujiro Homma, Sho Kobayashi & Junichi Fujii. (2022) Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in Ferroptosis That Is Induced by Cysteine Starvation. Cells 11:10, pages 1603.
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Tianming Wang, Min Gong, Yuting Cao, Chengcheng Zhao, Yingfei Lu, Yu Zhou, Shasha Yao, Jianquan Chen, Chun Zhao & Rong Ju. (2022) Persistent ferroptosis promotes cervical squamous intraepithelial lesion development and oncogenesis by regulating KRAS expression in patients with high risk-HPV infection. Cell Death Discovery 8:1.
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Lin Yue, Yaguang Luo, Li Jiang, Yoshitaka Sekido & Shinya Toyokuni. (2022) PCBP2 knockdown promotes ferroptosis in malignant mesothelioma. Pathology International 72:4, pages 242-251.
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Peter W. Halcrow, Nirmal Kumar, Zahra Afghah, Jalyn P. Fischer, Nabab Khan, Xuesong Chen, Olimpia Meucci & Jonathan D. Geiger. (2022) Heterogeneity of ferrous iron‐containing endolysosomes and effects of endolysosome iron on endolysosome numbers, sizes, and localization patterns. Journal of Neurochemistry 161:1, pages 69-83.
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Ying Cheng, Wenhao Qu, Jing Li, Bowen Jia, Yiting Song, Liyu Wang, Tongyu Rui, Qianqian Li & Chengliang Luo. (2022) Ferristatin II, an Iron Uptake Inhibitor, Exerts Neuroprotection against Traumatic Brain Injury via Suppressing Ferroptosis. ACS Chemical Neuroscience 13:5, pages 664-675.
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Lu Zhou, Peng Yu, Ting-ting Wang, Yi-wei Du, Yang Chen, Zhen Li, Man-lin He, Lan Feng, Hui-rong Li, Xiao Han, Heng Ma & Hong-bao Liu. (2022) Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis. Oxidative Medicine and Cellular Longevity 2022, pages 1-14.
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Zhen Cheng, Shinya Akatsuka, Guang Hua Li, Kiyoshi Mori, Takashi Takahashi & Shinya Toyokuni. (2021) Ferroptosis resistance determines high susceptibility of murine A/J strain to iron‐induced renal carcinogenesis . Cancer Science 113:1, pages 65-78.
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Shinya Toyokuni, Yingyi Kong, Hao Zheng, Danyang Mi, Misako Katabuchi, Yashiro Motooka & Fumiya Ito. (2021) Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles. Journal of Cancer Prevention 26:4, pages 244-249.
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Anuj Saini, Zachary Gatland, Jack Begley & Lydia Kisley. (2021) Investigation of fluorophores for single-molecule detection of anodic corrosion redox reactions. MRS Communications 11:6, pages 804-810.
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Sipeng Zuo, Jie Yu, Hui Pan & Linna Lu. (2020) Novel insights on targeting ferroptosis in cancer therapy. Biomarker Research 8:1.
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Gabriela Warpsinski, Matthew J. Smith, Salil Srivastava, Thomas P. Keeley, Richard C.M. Siow, Paul A. Fraser & Giovanni E. Mann. (2020) Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation. Redox Biology 37, pages 101708.
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Shinya Toyokuni, Izumi Yanatori, Yingyi Kong, Hao Zheng, Yashiro Motooka & Li Jiang. (2020) Ferroptosis at the crossroads of infection, aging and cancer. Cancer Science 111:8, pages 2665-2671.
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Sabina Khatun, Shayeri Biswas, Anupama Binoy, Arup Podder, Nandita Mishra & Sankarprasad Bhuniya. (2020) Highly chemoselective turn-on fluorescent probe for ferrous (Fe2+) ion detection in cosmetics and live cells. Journal of Photochemistry and Photobiology B: Biology 209, pages 111943.
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Matthew J. Smith, Mark Fowler, Richard J. Naftalin & Richard C.M. Siow. (2020) UVA irradiation increases ferrous iron release from human skin fibroblast and endothelial cell ferritin: Consequences for cell senescence and aging. Free Radical Biology and Medicine 155, pages 49-57.
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Chen Liang, Xinglin Zhang, Mengsu Yang & Xiaochen Dong. (2019) Recent Progress in Ferroptosis Inducers for Cancer Therapy. Advanced Materials 31:51, pages 1904197.
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Takujiro Homma, Sho Kobayashi, Hideyo Sato & Junichi Fujii. (2019) Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro. Experimental Cell Research 384:1, pages 111592.
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Takujiro Homma, Sho Kobayashi & Junichi Fujii. (2019) Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide. Biochemical and Biophysical Research Communications 518:3, pages 519-525.
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Zan Li, Li Jiang, Shan Hwu Chew, Tasuku Hirayama, Yoshitaka Sekido & Shinya Toyokuni. (2019) Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia. Redox Biology 26, pages 101297.
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Bradley Nash, Kevin Tarn, Elena Irollo, Jared Luchetta, Lindsay Festa, Peter Halcrow, Gaurav Datta, Jonathan D. Geiger & Olimpia Meucci. (2019) Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons. eneuro 6:4, pages ENEURO.0237-19.2019.
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Christopher J. Greene, Nitika J. Sharma, Peter N. Fiorica, Emily Forrester, Gary J. Smith, Kenneth W. Gross & Eric C. Kauffman. (2019) Suppressive effects of iron chelation in clear cell renal cell carcinoma and their dependency on VHL inactivation. Free Radical Biology and Medicine 133, pages 295-309.
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Tasuku Hirayama. (2019) Fluorescent probes for the detection of catalytic Fe(II) ion. Free Radical Biology and Medicine 133, pages 38-45.
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Tasuku Hirayama, Ayaji Miki & Hideko Nagasawa. (2019) Organelle-specific analysis of labile Fe( ii ) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes . Metallomics 11:1, pages 111-117.
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Tasuku Hirayama. (2019) Development and applications of Fe(II)-selective fluorescent probes二価鉄イオンの選択的蛍光プローブ開発とその応用. Folia Pharmacologica Japonica 154:6, pages 322-326.
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Shinya Toyokuni & Izumi Yanatori. 2019. Ferroptosis in Health and Disease. Ferroptosis in Health and Disease 27 41 .
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Masato Niwa, Tasuku Hirayama, Ikumi Oomoto, Dan Ohtan Wang & Hideko Nagasawa. (2018) Fe(II) Ion Release during Endocytotic Uptake of Iron Visualized by a Membrane-Anchoring Fe(II) Fluorescent Probe. ACS Chemical Biology 13:7, pages 1853-1861.
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Kenji Sakamoto, Taishi Suzuki, Kosuke Takahashi, Takumi Koguchi, Tasuku Hirayama, Asami Mori, Tsutomu Nakahara, Hideko Nagasawa & Kunio Ishii. (2018) Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina. Experimental Eye Research 171, pages 30-36.
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Kapil Chaudhary, Wanwisa Promsote, Sudha Ananth, Rajalakshmi Veeranan-Karmegam, Amany Tawfik, Pachiappan Arjunan, Pamela Martin, Sylvia B. Smith, Muthusamy Thangaraju, Oleg Kisselev, Vadivel Ganapathy & Jaya P. Gnana-Prakasam. (2018) Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression. Scientific Reports 8:1.
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Shinya Toyokuni, Fumiya Ito, Kyoko Yamashita, Yasumasa Okazaki & Shinya Akatsuka. (2017) Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis. Free Radical Biology and Medicine 108, pages 610-626.
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Sebastian J. Sciegienka, Shane R. Solst, Kelly C. Falls, Joshua D. Schoenfeld, Adrienne R. Klinger, Natalie L. Ross, Samuel N. Rodman, Douglas R. Spitz & Melissa A. Fath. (2017) D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H 2 O 2 -mediated oxidative stress. Free Radical Biology and Medicine 108, pages 354-361.
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Pierre Danhier, Gladys Deumer, Nicolas Joudiou, Caroline Bouzin, Philippe Levêque, Vincent Haufroid, Bénédicte F. Jordan, Olivier Feron, Pierre Sonveaux & Bernard Gallez. (2017) Contribution of macrophages in the contrast loss in iron oxide-based MRI cancer cell tracking studies. Oncotarget 8:24, pages 38876-38885.
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Shima Hirako, Hiroyuki Tsuda, Fumiya Ito, Yasumasa Okazaki, Tasuku Hirayama, Hideko Nagasawa, Tomoko Nakano, Kenji Imai, Tomomi Kotani, Fumitaka Kikkawa & Shinya Toyokuni. (2017) Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114). Journal of Clinical Biochemistry and Nutrition 61:3, pages 176-182.
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Tasuku Hirayama & Hideko Nagasawa. (2017) Chemical tools for detecting Fe ions. Journal of Clinical Biochemistry and Nutrition 60:1, pages 39-48.
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Yusuke Kamihara, Kohichi Takada, Tsutomu Sato, Yutaka Kawano, Kazuyuki Murase, Yohei Arihara, Shohei Kikuchi, Naotaka Hayasaka, Makoto Usami, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune & Junji Kato. (2016) The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma. Oncotarget 7:39, pages 64330-64341.
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Fumiya Ito, Takahiro Nishiyama, Lei Shi, Masahiko Mori, Tasuku Hirayama, Hideko Nagasawa, Hiroyuki Yasui & Shinya Toyokuni. (2016) Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis. Biochemical and Biophysical Research Communications 476:4, pages 600-606.
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Shinya Toyokuni. (2016) The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy. Pathology International 66:5, pages 245-259.
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Yue Wang, Yasumasa Okazaki, Lei Shi, Hiro Kohda, Minoru Tanaka, Kentaro Taki, Tomoki Nishioka, Tasuku Hirayama, Hideko Nagasawa, Yoriko Yamashita & Shinya Toyokuni. (2016) Role of hemoglobin and transferrin in multi‐wall carbon nanotube‐induced mesothelial injury and carcinogenesis. Cancer Science 107:3, pages 250-257.
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V. F. Chekhun, Yu. V. Lozovska & A. P. Burlaka. (2016) Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents. The Ukrainian Biochemical Journal 88:1, pages 99-108.
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Masahiko Mori, Fumiya Ito, Lei Shi, Yue Wang, Chiharu Ishida, Yuka Hattori, Masato Niwa, Tasuku Hirayama, Hideko Nagasawa, Akira Iwase, Fumitaka Kikkawa & Shinya Toyokuni. (2015) Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron. Redox Biology 6, pages 578-586.
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