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Free Radical Research Communications Volume 3, 1987 - Issue 1-5
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Original Article

Desferrioxamine as an Electron Donor. Inhibition of Membranal Lipid Peroxidation Initiated by H202 –Activated Metmyoglobin and Other Peroxidizing Systems

Joseph Kanner Dept. of Food Science, Agricultural Research Organization, The Volcani, Center, P.O. Box 6. Bet Dagan, Israel
&
Stella Harel Dept. of Food Science, Agricultural Research Organization, The Volcani, Center, P.O. Box 6. Bet Dagan, Israel
Pages 309-317 | Received 21 Jul 1986, Published online: 07 Jul 2009

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Abdu I Alayash, Felice D’Agnillo & Paul W Buehler. (2007) First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives. Expert Opinion on Biological Therapy 7:5, pages 665-675.
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Graham S. Timmins, Michael J. Da Vies, De-Xiu Song & Ursula Muller-Eberhard. (1995) Epr Studies on the Effects of Complexation of Heme by Hemopexin upon its Reactions with Organic Peroxides. Free Radical Research 23:6, pages 559-569.
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Chris E. Cooper, Emma S.R. Green, Catherine A. Rice-evans, Michael J. Davies & John M. Wriggleswort. (1994) A Hydrogen-Donating Monohydroxamate Scavenges Ferryl Myoglobin Radicals. Free Radical Research 20:4, pages 219-227.
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Barry Halliwell. (1990) How to Characterize a Biological Antioxidant. Free Radical Research Communications 9:1, pages 1-32.
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C. Rice-Evans, G. Okunade & R. Khan. (1989) The Suppression of Iron Release from Activated Myoglobin by Physiological Electron Donors and by Desferrioxamine. Free Radical Research Communications 7:1, pages 45-54.
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Stella Harel & Joseph Kanner. (1989) Haemoglobin and Myoglobin as Inhibitors of Hydroxyl Radical Generation in a Model System of “Iron Redox” Cycle. Free Radical Research Communications 6:1, pages 1-10.
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Alain Puppo & Barry Halliwell. (1988) Formation of Hydroxyl Radicals in Biological Systems. Does Myoglobin Stimulate Hydroxyl Radical Formation from Hydrogen Peroxide?. Free Radical Research Communications 4:6, pages 415-422.
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Chen Zhu, Xinyao Zeng, Lihang Chen, Meihong Liu, Mingzhu Zheng, Jingsheng Liu & Huimin Liu. (2024) Changes in quality characteristics based on protein oxidation and microbial action of ultra-high pressure-treated grass carp (Ctenopharyngodon idella) fillets during magnetic field storage. Food Chemistry 434, pages 137464.
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Ben-Zhan Zhu, Dan Xu, Li Qin, Chun-Hua Huang, Lin-Na Xie, Li Mao, Jie Shao & Balaraman Kalyanaraman. (2020) An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids. Free Radical Biology and Medicine 146, pages 150-159.
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Se Hoon Hong, Dae-Hee Lee, Young-Sun Lee, Min Jee Jo, Yoon A Jeong, William T. Kwon, Haroon A. Choudry, David L. Bartlett & Yong J. Lee. (2017) Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression. Oncotarget 8:70, pages 115164-115178.
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Mark P. Richards. (2013) Redox Reactions of Myoglobin. Antioxidants & Redox Signaling 18:17, pages 2342-2351.
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Naihao Lu, Lian Yi, Qinqin Deng, Jinyang Li, Zhonghong Gao & Hailing Li. (2012) The interaction between desferrioxamine and hemin: A potential toxicological implication. Toxicology in Vitro 26:5, pages 732-735.
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Margaret A. Adgent, Giuseppe L. Squadrito, Carol A. Ballinger, David M. Krzywanski, Jack R. Lancaster & Edward M. Postlethwait. (2012) Desferrioxamine inhibits protein tyrosine nitration: Mechanisms and implications. Free Radical Biology and Medicine 53:4, pages 951-961.
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JoséÁngel Pérez‐Alvarez & Juana Fernández‐López. 2012. Handbook of Meat, Poultry and Seafood Quality. Handbook of Meat, Poultry and Seafood Quality 1 24 .
Gheorghe DucaGheorghe Duca. 2012. Homogeneous Catalysis with Metal Complexes. Homogeneous Catalysis with Metal Complexes 261 317 .
Gheorghe DucaGheorghe Duca. 2012. Homogeneous Catalysis with Metal Complexes. Homogeneous Catalysis with Metal Complexes 123 260 .
Olivier Boutaud & L. Jackson RobertsIIII. (2011) Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radical Biology and Medicine 51:5, pages 1062-1067.
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Byungrok Min, Joseph C. Cordray & Dong Uk Ahn. (2011) Antioxidant effect of fractions from chicken breast and beef loin homogenates in phospholipid liposome systems. Food Chemistry 128:2, pages 299-307.
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B. Min, K.C. Nam & D.U. Ahn. (2010) Catalytic mechanisms of metmyoglobin on the oxidation of lipids in phospholipid liposome model system. Food Chemistry 123:2, pages 231-236.
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J. Kanner. 2010. Oxidation in Foods and Beverages and Antioxidant Applications. Oxidation in Foods and Beverages and Antioxidant Applications 36 56 .
Naihao Lu, Mingyi Zhang, Hailing Li & Zhonghong Gao. (2008) Completely Different Effects of Desferrioxamine on Hemin/Nitrite/H 2 O 2 -Induced Bovine Serum Albumin Nitration and Oxidation . Chemical Research in Toxicology 21:6, pages 1229-1234.
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Lixin LiBalz Frei. (2006) Iron Chelation Inhibits NF-κB–Mediated Adhesion Molecule Expression by Inhibiting p22 phox Protein Expression and NADPH Oxidase Activity . Arteriosclerosis, Thrombosis, and Vascular Biology 26:12, pages 2638-2643.
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Niels B.J. Vollaard, Brandon J. Reeder, Jerry P. Shearman, Patrick Menu, Michael T. Wilson & Chris E. Cooper. (2005) A new sensitive assay reveals that hemoglobin is oxidatively modified in vivo. Free Radical Biology and Medicine 39:9, pages 1216-1228.
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Mark P. Richards & Rong Li. (2004) Effects of Released Iron, Lipid Peroxides, and Ascorbate in Trout Hemoglobin-Mediated Lipid Oxidation of Washed Cod Muscle. Journal of Agricultural and Food Chemistry 52:13, pages 4323-4329.
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Freya Q Schafer & Garry R Buettner. (2000) Acidic pH amplifies iron-mediated lipid peroxidation in cells. Free Radical Biology and Medicine 28:8, pages 1175-1181.
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Ben-Zhan Zhu, Ronit Har-El, Nahum Kitrossky & Mordechai Chevion. (1998) New Modes of Action of Desferrioxamine. Free Radical Biology and Medicine 24:2, pages 360-369.
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Ben-Zhan Zhu, Ronit Har-El, Nahum Kitrossky & Mordechai Chevion. 1998. Free Radicals, Oxidative Stress, and Antioxidants. Free Radicals, Oxidative Stress, and Antioxidants 15 24 .
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Klaus Stolze, Yang Liu & Hans Nohl. (2008) INVESTIGATIONS ON THE LIGHT‐EMITTING SPECIES IN THE REACTION OF METMYOGLOBIN AND METHEMOGLOBIN WITH HYDROGEN PEROXIDE. Photochemistry and Photobiology 60:2, pages 91-95.
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B.J. Juven, J. Kanner, F. Schved & H. Weisslowicz. (2008) Factors that interact with the antibacterial action of thyme essential oil and its active constituents. Journal of Applied Bacteriology 76:6, pages 626-631.
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E. Shimoni, R. Armon & I. Neeman. (1994) Antioxidant properties of deferoxamine. Journal of the American Oil Chemists’ Society 71:6, pages 641-644.
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Jean Nève, Alain Favier & Patrice FaureCatherine Rice-Evans. 1994. Trace Elements and Free Radicals in Oxidative Diseases. Trace Elements and Free Radicals in Oxidative Diseases 92 99 .
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Cecilia Giulivi & Enrique Cadenas. 1994. Oxygen Radicals in Biological Systems Part C. Oxygen Radicals in Biological Systems Part C 189 202 .
J. Kanner. (1994) Oxidative processes in meat and meat products: Quality implications. Meat Science 36:1-2, pages 169-189.
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Yoichi Osawa, John F. Darbyshire, Carl A. Meyer & Abdu I. Alayash. (1993) Differential susceptibilities of the prosthetic heme of hemoglobin-based red cell substitutes. Biochemical Pharmacology 46:12, pages 2299-2305.
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S SekiliP B McCayX Y LiM ZughaibJ Z SunL TangJ I ThornbyR Bolli. (1993) Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects.. Circulation Research 73:4, pages 705-723.
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Catherine A. Rice-Evans & Anthony T. Diplock. (1993) Current status of antioxidant therapy. Free Radical Biology and Medicine 15:1, pages 77-96.
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Catherine Rice-Evans, Emma Green, George Paganga, Christopher Cooper & John Wrigglesworth. (2001) Oxidised low density lipoproteins induce iron release from activated myoglobin. FEBS Letters 326:1-3, pages 177-182.
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Emma S.R. Green, Howard Evans, Peter Rice-Evans, Michael J. Davies, Nida Salah & Catherine Rice-Evans. (1993) The efficacy of monohydroxamates as free radical scavenging agents compared with di- and trihydroxamates. Biochemical Pharmacology 45:2, pages 357-366.
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Patricia J. Evans, Rubens Cecchini & Barry Halliwell. (1992) Oxidative damage to lipids and α1-antiproteinase by phenylbutazone in the presence of haem proteins: protection by ascorbic acid. Biochemical Pharmacology 44:5, pages 981-984.
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Dennis M. Miller, Nathan H. Spear & Steven D. Aust. (1992) Effects of deferrioxamine on iron-catalyzed lipid peroxidation. Archives of Biochemistry and Biophysics 295:2, pages 240-246.
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Daniel Ely, Gail Dunphy, Helmar Dollwet, Helen Richter, Frank Sellke & Masoud Azodi. (1992) Maintenance of left ventricular function (90%) after twenty-four-hour heart preservation with deferoxamine. Free Radical Biology and Medicine 12:6, pages 479-485.
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Arnold Stern, Allan J. Davison, Qizhuan Wu & Jim Moon. (1992) Desferrioxamine enhances the reactivity of vanadium (IV) and vanadium (V) toward ferri- and ferrocytochrome c. Free Radical Biology and Medicine 12:5, pages 373-380.
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P. Bilski, A.S.W. Li & C.F. Chignell. (2008) THE PHOTO‐OXIDATION OF N, N‐DIETHYLHYDROXYLAMINE BY ROSE BENGAL IN ACETONITRILE AND WATER. Photochemistry and Photobiology 54:3, pages 345-352.
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Alvaro Mordente, Elisabetta Meucci, Giacinto A.D. Miggiano & Giuseppe E. Martorana. (1990) Prooxidant action of desferrioxamine: Enhancement of alkaline phosphatase inactivation by interaction with ascorbate system. Archives of Biochemistry and Biophysics 277:2, pages 234-240.
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Catherine Rice-Evans, Erol Baysal, Surrinder Singh, Shelley-Anne Jones & J.Gareth Jones. (2002) The interactions of desferrioxamine and hydroxypyridone compounds with haemoglobin and erythrocytes. FEBS Letters 256:1-2, pages 17-20.
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O. HINOJOSA, T. J. JACKS, T. A. CALAMARI & D. P. THIBODEAUX. (2008) ELECTRON SPIN RESONANCE STUDY OF THE RELATIONSHIP OF UV IRRADIATION TO NITROXIDE RADICAL FORMATION IN DESFERRIOXAMINE (DESFERAL) AND RELATED HYDROXAMATE AND HYDROXYLAMINE DERIVATIVES. Photochemistry and Photobiology 49:1, pages 1-5.
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Barry Halliwell. (1989) Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?. Free Radical Biology and Medicine 7:6, pages 645-651.
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