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Original Article

Nitroxide Sod-Mimics: Modes of Action

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Pages 187-194 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Tareq Taha Jubeh, Mirela Nadler-Milbauer, Yechezkel Barenholz & Abraham Rubinstein. (2006) Local treatment of experimental colitis in the rat by negatively charged liposomes of catalase, TMN and SOD. Journal of Drug Targeting 14:3, pages 155-163.
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Reiner F. Haseloff, Stefan Zöllner, Igor a. Kirilylik, Igor a. Grigorev, Regina Reszka, Rita Bernhardt, Katharina Mertsch, Birgit Roloff & Ingolf e. Blasig. (1997) Superoxide-Mediated Reduction of the Nitroxide Group Can Prevent Detection of Nitric Oxide by Nitronyl Nitroxides. Free Radical Research 26:1, pages 7-17.
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Rolf J. Mehlhorn & Christopher E. Swanson. (1992) Nitroxide-Stimulated H2O2 Decomposition by Peroxidases and Pseudoperoxidases. Free Radical Research Communications 17:3, pages 157-175.
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Articles from other publishers (79)

Grzegorz Bartosz, Natalia Pieńkowska, Kacper Kut, Bogumił Cieniek, Ireneusz Stefaniuk & Izabela Sadowska-Bartosz. (2023) Effect of Low Concentration of Nitroxides on SH-SY5Y Cells Transfected with the Tau Protein. International Journal of Molecular Sciences 24:23, pages 16675.
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Lawrence Huang, Feng Cheng, Xuetao ZhangJacek Zielonka, Matthew A. Nystoriak, Weiwei Xiang, Kunal Raygor, Shaoxun WangAditya Lakshmanan, Weiya JiangSai Yuan, Kevin S. HouJiayi ZhangXitao WangArsalan U. SyedMatea Juric, Takamune Takahashi, Manuel F. Navedo & Rong A. Wang. (2023) Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation. Science Advances 9:21.
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Astrid C. R. Larin, Michael C. Pfrunder, Kathleen M. Mullen, Sandra Wiedbrauk, Nathan R. Boase & Kathryn E. Fairfull-Smith. (2023) Synergistic or antagonistic antioxidant combinations – a case study exploring flavonoid-nitroxide hybrids. Organic & Biomolecular Chemistry 21:8, pages 1780-1792.
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Danielba Almeida da Silva, Thiago Macêdo Lopes Correia, Rafael Pereira, Robson Amaro Augusto da Silva, Ohara Augusto & Raphael Ferreira Queiroz. (2020) Tempol reduces inflammation and oxidative damage in cigarette smoke-exposed mice by decreasing neutrophil infiltration and activating the Nrf2 pathway. Chemico-Biological Interactions 329, pages 109210.
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Hirotada Fujii, Miho Emoto & Hideo Sato-Akaba. (2019) Brain Redox Imaging Using In Vivo Electron Paramagnetic Resonance Imaging and Nitroxide Imaging Probes. Magnetochemistry 5:1, pages 11.
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Minako Nyui, Ikuo Nakanishi, Kazunori Anzai, Toshihiko Ozawa & Ken-ichiro Matsumoto. (2019) Reactivity of redox sensitive paramagnetic nitroxyl contrast agents with reactive oxygen species. Journal of Clinical Biochemistry and Nutrition 64:1, pages 13-19.
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Carleton J. C. Hsia & W. Keith Miskimins. (2018) Can Macromolecular Nitroxide Work as Extracellular Superoxide Dismutase Mimetic in Cancer and Stroke Therapy?. Cell Biochemistry and Biophysics 76:4, pages 443-444.
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Rosalin Bonetta. (2018) Potential Therapeutic Applications of MnSODs and SOD-Mimetics. Chemistry - A European Journal 24:20, pages 5032-5041.
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Feng Wang, Peng Gao, Ling Guo, Ping Meng, Yuexing Fan, Yongbin Chen, Yanyun Lin, Guozhen Guo, Guirong Ding & Haibo Wang. (2017) Radio-protective effect and mechanism of 4-Acetamido-2,2,6,6- tetramethylpiperidin-1-oxyl in HUVEC cells. Environmental Health and Preventive Medicine 22:1.
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Marcin Lewandowski & Krzysztof Gwozdzinski. (2017) Nitroxides as Antioxidants and Anticancer Drugs. International Journal of Molecular Sciences 18:11, pages 2490.
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Phetcharat Boonruamkaew, Pennapa Chonpathompikunlert, Long Binh Vong, Sho Sakaue, Yasushi Tomidokoro, Kazuhiro Ishii, Akira Tamaoka & Yukio Nagasaki. (2017) Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer’s disease. Scientific Reports 7:1.
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Sarah Neil, Jaebong Huh, Victoria Baronas, Xinhui Li, Henry F. McFarland, Murali Cherukuri, James B. Mitchell & Jacqueline A. Quandt. (2017) Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models. Brain, Behavior, and Immunity 62, pages 332-343.
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Christopher L. Bianco, Tyler A. Chavez, Victor Sosa, Simran, S. Saund, Q. Nhu N. Nguyen, Dean J. Tantillo, Andrew S. Ichimura, John P. Toscano & Jon M. Fukuto. (2016) The chemical biology of the persulfide (RSSH)/perthiyl (RSS·) redox couple and possible role in biological redox signaling. Free Radical Biology and Medicine 101, pages 20-31.
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Cassie L. Rayner, Steven E. Bottle, Glen A. Gole, Micheal S. Ward & Nigel L. Barnett. (2016) Real-time quantification of oxidative stress and the protective effect of nitroxide antioxidants. Neurochemistry International 92, pages 1-12.
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Karthikeyan Rajamani, V. C. Renju, S. Sethupathy & Somasundaram S. Thirugnanasambandan. (2015) Ameliorative effect of polyphenols from Padina boergesenii against ferric nitrilotriacetate induced renal oxidative damage: With inhibition of oxidative hemolysis and in vitro free radicals . Environmental Toxicology 30:8, pages 865-876.
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Christine H.J. Kim, James B. Mitchell, Christina A. Bursill, Anastasia L. Sowers, Angela Thetford, John A. Cook, David M. van Reyk & Michael J. Davies. (2015) The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE−/− mice. Atherosclerosis 240:1, pages 234-241.
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Aditya Sunkaria, Deep Raj Sharma, Willayat Yousuf Wani & Kiran Dip Gill. (2014) 4-Hydroxy TEMPO Attenuates Dichlorvos Induced Microglial Activation and Apoptosis. ACS Chemical Neuroscience 5:2, pages 115-127.
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Alexei Santiani Acosta, Shirley Evangelista Vargas, Martha Valdivia Cuya, Jennie Risopatrón González & Raúl Sánchez Gutiérrez. (2013) Effect of the addition of two superoxide dismutase analogues (Tempo and Tempol) to alpaca semen extender for cryopreservation. Theriogenology 79:5, pages 842-846.
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Wilmarie Flores‐Santana, Terry Moody, Weibin Chen, Michael J Gorczynski, Mai E Shoman, Carlos Velázquez, Angela Thetford, James B Mitchell, Murali K Cherukuri, S Bruce King & David A Wink. (2012) Nitroxide derivatives of non‐steroidal anti‐inflammatory drugs exert anti‐inflammatory and superoxide dismutase scavenging properties in A459 cells. British Journal of Pharmacology 165:4b, pages 1058-1067.
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Fredrik PalmLina Nordquist. (2011) Renal oxidative stress, oxygenation, and hypertension. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301:5, pages R1229-R1241.
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Pennapa Chonpathompikunlert, Toru Yoshitomi, Junkyu Han, Hiroko Isoda & Yukio Nagasaki. (2011) The use of nitroxide radical-containing nanoparticles coupled with piperine to protect neuroblastoma SH-SY5Y cells from Aβ-induced oxidative stress. Biomaterials 32:33, pages 8605-8612.
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Pennapa Chonpathompikunlert, Junkyu Han, Kazuko Toh, Hiroko Isoda & Yukio Nagasaki. (2011) TEMPOL protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell toxicity. European Journal of Pharmacology 650:2-3, pages 544-549.
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Zafer Teke, Burhan Kabay, Akin Ozden, Cigdem Yenisey, Ferda Bir, Nese Calli Demirkan, Tuncay Bicakci & Ergun Erdem. (2008) Effects of Tempol, a Membrane-Permeable Radical Scavenger, on Local and Remote Organ Injuries Caused by Intestinal Ischemia/Reperfusion in Rats. Journal of Surgical Research 149:2, pages 259-271.
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Yuma Yamada & Hideyoshi Harashima. (2008) Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Advanced Drug Delivery Reviews 60:13-14, pages 1439-1462.
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Darren S. HoffmannChristine J. WeydertEric LazartiguesWilliam J. KutschkeMartha F. KienzleJenny E. LeachJennifer A. SharmaRam V. SharmaRobin L. Davisson. (2008) Chronic Tempol Prevents Hypertension, Proteinuria, and Poor Feto-Placental Outcomes in BPH/5 Mouse Model of Preeclampsia. Hypertension 51:4, pages 1058-1065.
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Benjamin P. SouleFuminori HyodoKen-ichiro MatsumotoNicole L. SimoneJohn A. CookMurali C. KrishnaJames B. Mitchell. (2007) Therapeutic and Clinical Applications of Nitroxide Compounds. Antioxidants & Redox Signaling 9:10, pages 1731-1744.
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Mitchell P. Fink, Carlos A. Macias, Jingbo Xiao, Yulia Y. Tyurina, Jianfei Jiang, Natalia Belikova, Russell L. Delude, Joel S. Greenberger, Valerian E. Kagan & Peter Wipf. (2007) Hemigramicidin–TEMPO conjugates: Novel mitochondria-targeted anti-oxidants. Biochemical Pharmacology 74:6, pages 801-809.
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Aderville Cabassi, Simona Dancelli, Paolo Pattoneri, Giovanni Tirabassi, Fabio Quartieri, Luigi Moschini, Stefania Cavazzini, Roberta Maestri, Costanza Lagrasta, Gallia Graiani, Domenico Corradi, Elisabetta Parenti, Stefano Tedeschi, Elena Cremaschi, Pietro Coghi, Simonetta Vinci, Enrico Fiaccadori & Alberico Borghetti. (2007) Characterization of myocardial hypertrophy in prehypertensive spontaneously hypertensive rats: interaction between adrenergic and nitrosative pathways. Journal of Hypertension 25:8, pages 1719-1730.
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Carlos A. Macias, Jeffrey W. Chiao, Jingbo Xiao, Devinder S. Arora, Yulia Y. Tyurina, Russell L. Delude, Peter Wipf, Valerian E. Kagan & Mitchell P. Fink. (2007) Treatment With a Novel Hemigramicidin-TEMPO Conjugate Prolongs Survival in a Rat Model of Lethal Hemorrhagic Shock. Annals of Surgery 245:2, pages 305-314.
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Veronica Wasserman, Pablo Kizelsztein, Olga Garbuzenko, Ron Kohen, Haim Ovadia, Rinat Tabakman & Yechezkel Barenholz. (2007) The Antioxidant Tempamine:  In Vitro Antitumor and Neuroprotective Effects and Optimization of Liposomal Encapsulation and Release. Langmuir 23:4, pages 1937-1947.
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Haihong Li, Guanglong He, Yuanmu Deng, Periannan Kuppusamy & Jay L. Zweier. (2006) In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice. Magnetic Resonance in Medicine 55:3, pages 669-675.
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Qinghua Liang, Amanda D. Smith, Stephen Pan, Vladimir A. Tyurin, Valerian E. Kagan, Teresa G. Hastings & Nina Felice Schor. (2005) Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease. Biochemical Pharmacology 70:9, pages 1371-1381.
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Matthew E. Patterson, Cynthia R. Mouton, John J. Mullins & Kenneth D. Mitchell. (2005) Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension. American Journal of Physiology-Renal Physiology 289:4, pages F754-F759.
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Laura L. Howard, Matthew E. Patterson, John J. Mullins & Kenneth D. Mitchell. (2005) Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats. American Journal of Physiology-Renal Physiology 288:4, pages F810-F815.
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Tareq Taha Jubeh, Sivan Antler, Susan Haupt, Yechezkel Barenholz & Abraham Rubinstein. (2005) Local Prevention of Oxidative Stress in the Intestinal Epithelium of the Rat by Adhesive Liposomes of Superoxide Dismutase and Tempamine. Molecular Pharmaceutics 2:1, pages 2-11.
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Daniela Salvemini, Carolina Muscoli, Dennis P. Riley & Salvatore Cuzzocrea. (2002) Superoxide Dismutase Mimetics. Pulmonary Pharmacology & Therapeutics 15:5, pages 439-447.
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Stephen M Hahn, Murali C Krishna, Anne Marie DeLuca, Deborah Coffin & James B Mitchell. (2000) Evaluation of the hydroxylamine tempol-H as an in vivo radioprotector. Free Radical Biology and Medicine 28:6, pages 953-958.
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