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Original Article

Angiotensin Converting Enzyme Inhibitors as Oxygen Free Radical Scavengers

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Pages 173-181 | Received 06 Dec 1992, Published online: 07 Jul 2009

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Vidosava B. Djordjevic, Vidosava Djordjevic, Vladan Cosic, Dušica Pavlovic, Predrag Vlahovic, Tatjana Jevtovic, Gordana Kocic & Vojin Savic. (2000) DOES CAPTOPRIL CHANGE OXIDATIVE STRESS IN PUROMYCIN AMINONUCLEOSIDE NEPHROPATHY?. Renal Failure 22:5, pages 535-544.
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Masashi Suzuki, Shinji Teramoto, Hirofumi Katayama, Eijiro Ohga, Takeshi Matsuse & Yasuyoshi Ouchi. (1999) Effects of Angiotensin-Converting Enzyme (ACE) Inhibitors on Oxygen Radical Production and Generation by Murine Lung Alveolar Macrophages. Journal of Asthma 36:8, pages 665-670.
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Simon RJ Maxwell. (1997) Anti-oxidant therapy: does it have a role in the treatment of human disease?. Expert Opinion on Investigational Drugs 6:3, pages 211-236.
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Articles from other publishers (37)

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Nan Hu & Hongyan Ji. (2022) Medications on hypertension, hyperlipidemia, diabetes, and risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis. Neurological Sciences 43:9, pages 5189-5199.
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Carmine Izzo, Paolo Vitillo, Paola Di Pietro, Valeria Visco, Andrea Strianese, Nicola Virtuoso, Michele Ciccarelli, Gennaro Galasso, Albino Carrizzo & Carmine Vecchione. (2021) The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases. Life 11:1, pages 60.
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Ganiyu Oboh, Ayokunle Olubode Ademosun, Oyewumi John Oyetomi & Taiwo Mary Adewuni. (2018) Influence of Moringa (Moringa oleifera) leaf extracts on the antioxidant and angiotensin-1 converting enzyme inhibitory properties of lisinopril. Oriental Pharmacy and Experimental Medicine 18:4, pages 317-324.
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Michael J. Giese & Robert C. Speth. (2014) The ocular renin–angiotensin system: A therapeutic target for the treatment of ocular disease. Pharmacology & Therapeutics 142:1, pages 11-32.
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Ahmad Ghanizadeh. (2011) Captopril as a novel possible treatment for children with ADHD and elevated lead level, a hypothesis. Environmental Research 111:8, pages 1330-1331.
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Naglaa M El-Lakkany, Walaa El-Maadawy, Afaf Ain-Shoka, Afkar Badawy, Olfat Hammam & Fatma Ebeid. (2011) Potential antifibrotic effects of AT1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by Schistosoma mansoni. Clinical and Experimental Pharmacology and Physiology 38:10, pages 695-704.
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Jalal Pourahmad, Mir-Jamal Hosseini, Soudeh Bakan & Mahmoud Ghazi-Khansari. (2011) Hepatoprotective activity of angiotensin-converting enzyme (ACE) inhibitors, captopril and enalapril, against paraquat toxicity. Pesticide Biochemistry and Physiology 99:1, pages 105-110.
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Birgit Mertens, Patrick Vanderheyden, Yvette Michotte & Sophie Sarre. (2009) The role of the central renin-angiotensin system in Parkinson’s disease. Journal of the Renin-Angiotensin-Aldosterone System 11:1, pages 49-56.
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F. Roy, J.I. Boye & B.K. Simpson. (2010) Bioactive proteins and peptides in pulse crops: Pea, chickpea and lentil. Food Research International 43:2, pages 432-442.
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Deepak Kejariwal, Karolina M Stepien, Tracy Smith, Hugh Kennedy, David A Hughes & Mike J Sampson. (2008) Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control. BMC Endocrine Disorders 8:1.
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Afshin Mohammadi-Bardbori & Mahmoud Ghazi-Khansari. (2007) Nonthiol ACE inhibitors, enalapril and lisinopril are unable to protect mitochondrial toxicity due to paraquat. Pesticide Biochemistry and Physiology 89:2, pages 163-167.
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Ebtehal El-Demerdash, Omar M Abdel Salam, Seham A El-Batran, Heba MI Abdallah & Nermeen M Shaffie. (2007) INHIBITION OF THE RENIN?ANGIOTENSIN SYSTEM ATTENUATES THE DEVELOPMENT OF LIVER FIBROSIS AND OXIDATIVE STRESS IN RATS. Clinical and Experimental Pharmacology and Physiology 0:0, pages 070928213402001-???.
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Iliyana Ilieva, Kazuhiro Ohgami, Xue-Hai Jin, Yukari Suzuki, Kenji Shiratori, Kazuhiko Yoshida, Satoru Kase & Shigeaki Ohno. (2006) Captopril suppresses inflammation in endotoxin-induced uveitis in rats. Experimental Eye Research 83:3, pages 651-657.
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Ana Muñoz, Pablo Rey, Maria J. Guerra, Estefania Mendez-Alvarez, Ramon Soto-Otero & Jose L. Labandeira-Garcia. (2006) Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology 51:1, pages 112-120.
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A. Lopez-Real, P. Rey, R. Soto-Otero, E. Mendez-Alvarez & J.L. Labandeira-Garcia. (2005) Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism. Journal of Neuroscience Research 81:6, pages 865-873.
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Nermina Jahovic, Feriha Ercan, Nursal Gedik, Meral Yüksel, Göksel Şener & İnci Alican. (2005) The effect of angiotensin-converting enzyme inhibitors on experimental colitis in rats. Regulatory Peptides 130:1-2, pages 67-74.
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Mahmoud Ghazi-Khansari, Ghodratolla Nasiri & Marzyieh Honarjoo. (2005) Decreasing the oxidant stress from paraquat in isolated perfused rat lung using captopril and niacin. Archives of Toxicology 79:6, pages 341-345.
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Christiane P. Tiefenbacher, Stefanie Friedrich, Tina Bleeke, Christian Vahl, Xiaobo Chen & Feraydoon Niroomand. (2004) ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles. American Journal of Physiology-Heart and Circulatory Physiology 286:4, pages H1425-H1432.
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Andreas Schäfer, Daniela Fraccarollo, Piet Tas, Isabel Schmidt, Georg Ertl & Johann Bauersachs. (2004) Endothelial dysfunction in congestive heart failure: ACE inhibition vs. angiotensin II antagonism. European Journal of Heart Failure 6:2, pages 151-159.
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Elena M.V. de Cavanagh, Barbara Piotrkowski & Cesar G. Fraga. (2004) Concerted action of the renin–angiotensin system, mitochondria, and antioxidant defenses in aging. Molecular Aspects of Medicine 25:1-2, pages 27-36.
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Peter Johnson. (2002) Antioxidant enzyme expression in health and disease: effects of exercise and hypertension. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 133:4, pages 493-505.
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Maria A Oliveira, Maria Helena C Carvalho, Dorothy Nigro, Rita de Cássia A.T Passaglia & Zuleica B Fortes. (2002) Angiotensin-(1–7) and bradykinin interaction in diabetes mellitus: in vivo study. Peptides 23:8, pages 1449-1455.
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Olivier Vosters & Jean Nève. (2002) Inhibitory effects of thiol-containing drugs on erythrocyte oxidative damages investigated with an improved assay system. Talanta 57:3, pages 595-600.
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Hiroyuki Tsutsui, Tomomi Ide, Shunji Hayashidani, Shintaro Kinugawa, Nobuhiro Suematsu, Hideo Utsumi & Akira Takeshita. (2001) Effects of ACE Inhibition on Left Ventricular Failure and Oxidative Stress in Dahl Salt-Sensitive Rats. Journal of Cardiovascular Pharmacology 37:6, pages 725-733.
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Kerryn Simpson & Blair Jarvis. (2000) Lisinopril. Drugs 59:5, pages 1149-1167.
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Heinz Theres, Kay-Dietrich Wagner, Sabine Schulz, Steffen Strube, Kate P. Leiterer, Dietrich Romberg, Joachim Günther, Holger Scholz, Gert Baumann & Ingolf Schimke. (2000) Oxygen Radical System in Chronic Infarcted Rat Heart: The Effect of Combined Beta Blockade and ACE Inhibition. Journal of Cardiovascular Pharmacology 35:5, pages 708-715.
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S. Teramoto, M. Suzuki, T. Matsuse, E. Ohga, T. Ishii & Y. Ouchi. (2014) Inhibitory effects of angiotensin-converting enzyme (ACE) inhibitors on oxygen radicals produced by bronchoalveolar lavage cells in young and aged guinea pigs. Aging Clinical and Experimental Research 12:1, pages 22-28.
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Wen-Chuan Lin, Tung-Yuan Lai & Yuen-Wern Wu. (2012) Scavenging of Reactive Oxygen Species by a Urinary Preparation. The American Journal of Chinese Medicine 28:02, pages 251-258.
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Shinji Teramoto, Masashi Suzuki, Takeshi Matsuse, Takeo Ishii, Yoshinosuke Fukuchi & Yasuyoshi Ouchi. (2000) Effects of Angiotensin-Converting Enzyme Inhibitors on Spontaneous or Stimulated Generation of Reactive Oxygen Species by Bronchoalveolar Lavage Cells Harvested From Patients With or Without Chronic Obstructive Pulmonary Disease. Japanese Journal of Pharmacology 83:1, pages 56-62.
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Alexander Ravati, Vera Junker, Maria Kouklei, Barbara Ahlemeyer, Carsten Culmsee & Josef Krieglstein. (1999) Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. European Journal of Pharmacology 373:1, pages 21-33.
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M. Tereza Fernandez, M. Manuela Silva, Lurdes Mira, M. Helena Florêncio, Andrew Gill & Keith R. Jennings. (1998) Iron and copper complexation by angiotensin-converting enzyme inhibitors. A study by ultraviolet spectroscopy and electrospray mass spectrometry. Journal of Inorganic Biochemistry 71:1-2, pages 93-98.
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Karen S. Cabell, Lin Ma & Peter Johnson. (1997) Effects of antihypertensive drugs on rat tissue antioxidant enzyme activities and lipid peroxidation levels. Biochemical Pharmacology 54:1, pages 133-141.
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Okezie I. Aruoma. (1996) Characterization of drugs as antioxidant prophylactics. Free Radical Biology and Medicine 20:5, pages 675-705.
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Afonso C Fernandes, Paulo M Filipe, JoÃo P Freitas & Carlos F Manso. (1996) Different effects of thiol and nonthiol ace inhibitors on copper-induced lipid and protein oxidative modification. Free Radical Biology and Medicine 20:4, pages 507-514.
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Elena M.V. de Cavanagh, Felipe Inserra, León Ferder, Luis Romano, Liliana Ercole & César G. Fraga. (1995) Superoxide dismutase and glutathione peroxidase activities are increased by enalapril and captopril in mouse liver. FEBS Letters 361:1, pages 22-24.
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Lurdes Mira, Manuela Silva & C.F. Manso. (1994) Scavenging of reactive oxygen species by silibinin dihemisuccinate. Biochemical Pharmacology 48:4, pages 753-759.
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