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Original Article

Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?

Pages 439-454 | Received 13 Nov 1995, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (34)

Muhammad Khalid, Saeed ur Rahman, Xinxin Liu & Nan Hui. (2023) Exogenous application of glycine and nitrate on antioxidant and polyphenol metabolism in Brassica campestris spp. Chinensis. Journal of Plant Nutrition 46:9, pages 2089-2103.
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Shraddha Rastogi, Sameer Gupta, Chandana Haldar & Dinesh Chandra. (2020) Nephroprotective effect of melatonin and L-Ascorbic acid (Vitamin-C) against ampicillin- induced toxicity in Funambulus pennanti. Egyptian Journal of Basic and Applied Sciences 7:1, pages 8-19.
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Sabrine Kasmi, Intithar Bkhairia, Bahira Harrabi, Hela Mnif, Rim Marrakchi, Hanen Ghozzi, Choumous Kallel, Moncef Nasri, Khaled Zeghal, Kamel Jamoussi & Ahmed Hakim. (2018) Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. Toxicology Mechanisms and Methods 28:1, pages 12-22.
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Yanita McLeay, Stephen Stannard, Stuart Houltham & Carlene Starck. (2017) Dietary thiols in exercise: oxidative stress defence, exercise performance, and adaptation. Journal of the International Society of Sports Nutrition 14:1.
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Oshra Saphier, Tali Silberstein, Guy Yardeni, Jeanine Blumenfeld, Israel Zilbermann & Ariela Burg. (2016) Role of lycopene in preventing lipid peroxidation products, in commercial infant milk formula. The Journal of Maternal-Fetal & Neonatal Medicine 29:17, pages 2865-2869.
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Neha Babbar, Harinder Singh Oberoi & Simranjeet Kaur Sandhu. (2015) Therapeutic and Nutraceutical Potential of Bioactive Compounds Extracted from Fruit Residues. Critical Reviews in Food Science and Nutrition 55:3, pages 319-337.
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Alaa A. Bekhit, DavidL. Hopkins, Geert Geesink, AdnanA. Bekhit & Philip Franks. (2014) Exogenous Proteases for Meat Tenderization. Critical Reviews in Food Science and Nutrition 54:8, pages 1012-1031.
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J.-B. Chang, C.-C. Lin, J.-F. Chiou, S.-Y. Mau, T.-Z. Liu & C.-H. Chen. (2013) Treatment of acute paraquat intoxication using recommended megadose of vitamin C: A reappraisal. Free Radical Research 47:12, pages 991-1001.
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Saloua Kouass Sahbani, Klaus Klarskov, Amine Aloui, Salah Kouass & Ahmed Landoulsi. (2013) Protective role of ascorbic acid in the decontamination of cow milk casein by gamma-irradiation. International Journal of Radiation Biology 89:6, pages 411-415.
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Balz Frei, Ines Birlouez-Aragon & Jens Lykkesfeldt. (2012) Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?. Critical Reviews in Food Science and Nutrition 52:9, pages 815-829.
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Yoshihiro Matsumoto, Makoto Mukai, Kazuo Arihara, Takao Saito & Hiromichi Kumagai. (2011) Ethylene-Vinyl Alcohol Copolymer Dialyzer Membrane Reduces Protein Oxidation in Hemodialysis Patients. Renal Failure 33:4, pages 382-387.
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Nehad Nasef, Rosetta Belcastro, Andrea Nash, Rosine Bishara, Dolores Iaboni, Crystal Kantores, A. Keith Tanswell & Robert P. Jankov. (2011) Role of ascorbate in lung cellular toxicity mediated by light-exposed parenteral nutrition solution. Free Radical Research 45:3, pages 359-365.
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R. J. Dinis-Oliveira, J. A. Duarte, A. Sánchez-Navarro, F. Remião, M. L. Bastos & F. Carvalho. (2008) Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment. Critical Reviews in Toxicology 38:1, pages 13-71.
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Sedat Ustundag, Omer Yalcın, Saniye Sen, Ziya Cukur, Senturk Ciftci & Bora Demirkan. (2008) Experimental Myoglobinuric Acute Renal Failure: The Effect of Vitamin C. Renal Failure 30:7, pages 727-735.
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Yeter Topcu Tarladacalisir, Mehmet Kanter & Muberra Uygun. (2008) Protective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic Study. Renal Failure 30:1, pages 1-8.
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Dimitrios Stagos, Todd M. Umstead, David S. Phelps, Leandros Skaltsounis, Serko Haroutounian, Joanna Floros, Dimitrios Stagos, Todd M. Umstead, David S. Phelps, Leandros Skaltsounis, Serko Haroutounian, Joanna Floros & Demetrios Kouretas. (2007) Inhibition of ozone-induced SP-A oxidation by plant polyphenols. Free Radical Research 41:3, pages 357-366.
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Minyi Shi, Baohui Xu, Kazuko Azakami, Tomohiro Morikawa, Kunitomo Watanabe, Kanehisa Morimoto, Masaharu Komatsu, Kohji Aoyama & Toru Takeuchi. (2005) Dual role of vitamin C in an oxygen-sensitive system: Discrepancy between DNA damage and dell death. Free Radical Research 39:2, pages 213-220.
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Patric J. Jansson, Christer Lindqvist & Tommy Nordström. (2005) Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radical Research 39:11, pages 1233-1239.
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Patric J. Jansson, Hye R. Jung, Christer Lindqvist & Tommy Nordström. (2004) Oxidative Decomposition of Vitamin C in Drinking Water. Free Radical Research 38:8, pages 855-860.
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Narisa Futrakul, Piyaratana Tosukhowong, Yuvadee Valyapongpichit, Numdee Tipprukmas, Prasit Futrakul & Suthiluk Patumraj. (2002) OXIDATIVE STRESS AND HEMODYNAMIC MALADJUSTMENT IN CHRONIC RENAL DISEASE: A THERAPEUTIC IMPLICATION. Renal Failure 24:4, pages 433-445.
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Gunther Guetens, Gert De Boeck, Martin Highley, Allan T. van Oosterom & Ernst A. de Bruijn. (2002) Oxidative DNA Damage: Biological Significance and Methods of Analysis. Critical Reviews in Clinical Laboratory Sciences 39:4-5, pages 331-457.
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A.H. Chalmers, J.S. Blake-Mortimer & A.H. Winefield. (2000) Lymphocyte 5′-ectonucleotidase: an indicator of oxidative stress in humans?. Redox Report 5:2-3, pages 89-91.
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M. Suter & C. Richter. (2000) Anti- and pro-oxidative properties of PADMA 28, a Tibetan herbal formulation. Redox Report 5:1, pages 17-22.
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Hyun-Jeong Lee & Dai-Eun Sok. (2000) Cu2+-catalyzed oxidative degradation of thyroglobulin. Free Radical Research 33:4, pages 359-368.
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Barry Halliwell. (1999) Antioxidant defence mechanisms: From the beginning to the end (of the beginning). Free Radical Research 31:4, pages 261-272.
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Soon Ahkang, Yeon Jin Jang & Hyoungsuf' Park. (1998) In Vivo Dual Effects of Vitamin C on Paraquat-Induced Lung Damage: Dependence on Released Metals from the Damaged Tissue. Free Radical Research 28:1, pages 93-107.
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Louise C. Bourne & Catherine A. Rice-Evans. (1998) Urinary Detection of Hydroxycinnamates and Flavonoids in Humans after High Dietary Intake of Fruit. Free Radical Research 28:4, pages 429-438.
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Lennart Möller, Tim Hofer & Magnus Zeisig. (1998) Methodological considerations and factors affecting 8-hydroxy-2′-deoxyguanosine analysis. Free Radical Research 29:6, pages 511-524.
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J. Gutierrez-Correa & A. O. M. Stoppani. (1997) Inactivation of Yeast Glutathione Reductase by Fenton Systems: Effect of Metal Chelators, Catecholamines and Thiol Compounds. Free Radical Research 27:6, pages 543-555.
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