Advanced search
Publication Cover
Drug Delivery Volume 23, 2016 - Issue 5: Topical and transdermal drug delivery & Targeted drug delivery
Submit an article Journal homepage
3,817
Views
17
CrossRef citations to date
0
Altmetric
Research Article

A smart tumor targeting peptide–drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells

Qin SongState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
,
Xingxing ChuanState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
,
Binlong ChenState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
,
Bing HeState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
,
Hua ZhangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
,
Wenbing DaiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
,
Xueqing WangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, ChinaCorrespondence[email protected]
&
Qiang ZhangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
 show all
Pages 1734-1746 | Received 28 Jan 2015, Accepted 09 Mar 2015, Published online: 08 Apr 2015

Citations (17)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Ying Zan, Zhijun Dai, Liang Liang, Yujiao Deng & Lei Dong. (2019) Co-delivery of plantamajoside and sorafenib by a multi-functional nanoparticle to combat the drug resistance of hepatocellular carcinoma through reprograming the tumor hypoxic microenvironment. Drug Delivery 26:1, pages 1080-1091.
Read now
Junpeng Nie, Wei Cheng, Yunmei Peng, Gan Liu, Yuhan Chen, Xusheng Wang, Chaoyu Liang, Wei Tao, Yinping Wei, Xiaowei Zeng & Lin Mei. (2017) Co-delivery of docetaxel and bortezomib based on a targeting nanoplatform for enhancing cancer chemotherapy effects. Drug Delivery 24:1, pages 1124-1138.
Read now

Articles from other publishers (15)

Faith W. Wachira, Dancan C. Githirwa, Thomas McPartlon, Vladyslav Nazarenko, Jerel J. C. Gonzales, Makenzie M. Gazura, Caitlin Leen, Hannah R. Clary, Claire Alston, Lukas M. Klees, Lan Yao & Ming An. (2023) D-to-E and T19V Variants of the pH-Low Insertion Peptide and Their Doxorubicin Conjugates Interact with Membrane at Higher pH Ranges Than WT. Biochemistry 62:20, pages 2997-3011.
Crossref
Qingqing Zhang, Nanxin Liu, Jin Wang, Yuying Liu, Kai Wang, Jie Zhang & Xiaoyan Pan. (2023) The Recent Advance of Cell-Penetrating and Tumor-Targeting Peptides as Drug Delivery Systems Based on Tumor Microenvironment. Molecular Pharmaceutics 20:2, pages 789-809.
Crossref
Anna Moshnikova, Michael DuPont, Hannah Visca, Donald M. Engelman, Oleg A. Andreev & Yana K. Reshetnyak. (2022) Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP. Frontiers in Oncology 12.
Crossref
David Bauer, Hannah Visca, Anuradha Weerakkody, Lukas M. Carter, Zachary Samuels, Spencer Kaminsky, Oleg A. Andreev, Yana K. Reshetnyak & Jason S. Lewis. (2022) PET Imaging of Acidic Tumor Environment With 89Zr-labeled pHLIP Probes. Frontiers in Oncology 12.
Crossref
Sara Pereira, Guanglong Ma, Li Na, Samo Hudoklin, Mateja E. Kreft, Nina Kostevsek & Wafa T. Al-Jamal. (2022) Encapsulation of doxorubicin prodrug in heat-triggered liposomes overcomes off-target activation for advanced prostate cancer therapy. Acta Biomaterialia 140, pages 530-546.
Crossref
Lucy R. Hart, Charlotta G. Lebedenko, Saige M. Mitchell, Rachel E. Daso & Ipsita A. Banerjee. (2022) In Silico Studies of Tumor Targeted Peptide-Conjugated Natural Products for Targeting Over-Expressed Receptors in Breast Cancer Cells Using Molecular Docking, Molecular Dynamics and MMGBSA Calculations. Applied Sciences 12:1, pages 515.
Crossref
Félix Gayraud, Merlin Klußmann & Ines Neundorf. (2021) Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques. Molecules 26:6, pages 1591.
Crossref
Nayanthara U. Dharmaratne, Alanna R. Kaplan & Peter M. Glazer. (2021) Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides. Cells 10:3, pages 541.
Crossref
Mingming Yu, Yanqin Sun, Guangjie Yang & Zhenguang Wang. (2021) An Experimental Study on [125I]I-pHLIP (Var7) for SPECT/CT Imaging of an MDA-MB-231 Triple-Negative Breast Cancer Mouse Model by Targeting the Tumor Microenvironment. Molecular Imaging 2021, pages 1-9.
Crossref
Yana K. Reshetnyak, Anna Moshnikova, Oleg A. Andreev & Donald M. Engelman. (2020) Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Kebede K. Kefeni, Titus A.M. Msagati, Thabo TI. Nkambule & Bhekie B. Mamba. (2020) Spinel ferrite nanoparticles and nanocomposites for biomedical applications and their toxicity. Materials Science and Engineering: C 107, pages 110314.
Crossref
Rongjun He, Brian Finan, John P. Mayer & Richard D. DiMarchi. (2019) Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety. Molecules 24:10, pages 1855.
Crossref
Christos Tapeinos, Matteo Battaglini & Gianni Ciofani. (2017) Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. Journal of Controlled Release 264, pages 306-332.
Crossref
Qin Song, Xing Wang, Yaoqi Wang, Yanqin Liang, Yanxia Zhou, Xiaoning Song, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang & Qiang Zhang. (2015) Reduction Responsive Self-Assembled Nanoparticles Based on Disulfide-Linked Drug–Drug Conjugate with High Drug Loading and Antitumor Efficacy. Molecular Pharmaceutics 13:1, pages 190-201.
Crossref
Rainer Tietze, Jan Zaloga, Harald Unterweger, Stefan Lyer, Ralf P. Friedrich, Christina Janko, Marina Pöttler, Stephan Dürr & Christoph Alexiou. (2015) Magnetic nanoparticle-based drug delivery for cancer therapy. Biochemical and Biophysical Research Communications 468:3, pages 463-470.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.