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Drug Delivery Volume 23, 2016 - Issue 4: Liposome- and lipid-based drug delivery
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Research Article

Pharmacokinetics and tissue distribution study in mice of triptolide-loaded lipid emulsion and accumulation effect on pancreas

Xue LiSchool of Chinese Medicines, Shenyang Pharmaceutical University, Shenyang, China,
,
Yuling MaoSchool of Chinese Medicines, Shenyang Pharmaceutical University, Shenyang, China,
,
Kai LiDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China,
,
Tianyu ShiDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China,
,
Huimin YaoDepartment of Pharmaceutical and Food Science, Tonghua Normal University, Tonghua, China, and
,
Jianhua YaoDepartment of Foreign Language, School of Social Sciences and Literary, Shenyang Pharmaceutical University, Shenyang, China
&
Shujun WangDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China, Correspondence[email protected]
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Pages 1344-1354 | Received 01 Feb 2015, Accepted 09 Mar 2015, Published online: 08 Apr 2015

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Lijuan Wang, Keke Che & Yan Liu. (2021) Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model. Xenobiotica 51:6, pages 703-715.
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Xin-Yi Liu, Wen-Jun Pei, Ye-Zhen Wu, Fang-Li Ren, Si-Yu Yang & Xiu Wang. (2021) Transdermal delivery of triptolide–phospholipid complex to treat rheumatoid arthritis. Drug Delivery 28:1, pages 2127-2136.
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Huahui Zeng, Xin Zhu, Qikang Tian, Yinyin Yan, Lan Zhang, Min Yan, Ruiqin Li, Xiaofang Li, Guoqiang Wang, Jinlian Ma, Yufang Su, Xiangbo Zhang, Linyu Ma, Zhenqiang Zhang & Xiangxiang Wu. (2020) In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration. Drug Delivery 27:1, pages 848-854.
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Qian-Qian Shan, Xiao-Jing Jiang, Fang-Yuan Wang, Zi-Xuan Shu & Shuang-Ying Gui. (2019) Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide. Drug Delivery 26:1, pages 490-498.
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Tao Yi, Dandan Tang, Fan Wang, Jiqiong Zhang, Jiao Zhang, Jirui Wang, Xiaoyu Xu & Jifen Zhang. (2017) Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. Drug Delivery 24:1, pages 422-429.
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Articles from other publishers (13)

Xiaoke Tan, Xin Zhu, Duanjie Xu, Yanmei Shi, Zhenzhen Wang, Mingzhuo Cao, Kai Hu, Lingzhou Zhao, Junwei Zhao, Mingsan Miao, Huahui Zeng & Xiangxiang Wu. (2022) A mitochondria-targeted nano-platform for pancreatic cancer therapy. Frontiers in Chemistry 10.
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Xinlong Wang, Huahui Zeng, Xin Zhu, Duanjie Xu, Qikang Tian, Can Wang, Lingzhou Zhao, Junwei Zhao, Mingsan Miao & Xiangxiang Wu. (2022) TP-CSO: A Triptolide Prodrug for Pancreatic Cancer Treatment. Molecules 27:12, pages 3686.
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Qing Ren, Meimei Li, Yun Deng, Aiping Lu & Jun Lu. (2021) Triptolide delivery: Nanotechnology-based carrier systems to enhance efficacy and limit toxicity. Pharmacological Research 165, pages 105377.
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Juliana Santos Rosa Viegas, Fabíola Garcia Praça, Marcelo Kravicz & Maria Vitoria Lopes Badra Bentley. (2020) Therapeutic applications and delivery systems for triptolide. Drug Delivery and Translational Research 10:6, pages 1584-1600.
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Belén P. Solans, María Jesús Garrido & Iñaki F. Trocóniz. (2019) Drug Exposure to Establish Pharmacokinetic–Response Relationships in Oncology. Clinical Pharmacokinetics 59:2, pages 123-135.
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Jie Wei, Yuanliang Yan, Xi Chen, Long Qian, Shuangshuang Zeng, Zhi Li, Shuang Dai, Zhicheng Gong & Zhijie Xu. (2019) The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27:7, pages 849-858.
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Wei Song, Meilin Liu, Junjun Wu, Hong Zhai, Yong Chen & Zhihong Peng. (2019) Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug. Current Drug Metabolism 20:2, pages 147-154.
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Ye Xu, Xiaoyan Chen & Dafang Zhong. (2018) A sensitive LC–MS/MS method for the determination of triptolide and its application to pharmacokinetic research in rats. Biomedical Chromatography 33:3, pages e4422.
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Zhen-yan Hou, Xiao-pei Tong, Yong-bo Peng, Bi-kui Zhang & Miao Yan. (2018) Broad targeting of triptolide to resistance and sensitization for cancer therapy. Biomedicine & Pharmacotherapy 104, pages 771-780.
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Chen Xi, Shaojun Peng, Zhengping Wu, Qingping Zhou & Jie Zhou. (2017) WITHDRAWN: Toxicity of triptolide and the molecular mechanisms involved. Environmental Toxicology and Pharmacology.
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Chen Xi, Shaojun Peng, Zhengping Wu, Qingping Zhou & Jie Zhou. (2017) Toxicity of triptolide and the molecular mechanisms involved. Biomedicine & Pharmacotherapy 90, pages 531-541.
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Diana Cláudia Gouveia Alves Pinto, Ana Maria Loureiro Seca & Artur Manuel Soares Silva. 2017. Anticancer Plants: Clinical Trials and Nanotechnology. Anticancer Plants: Clinical Trials and Nanotechnology 105 151 .
Yuling Mao, Xue Li, Ge Chen & Shujun Wang. (2016) Thermosensitive Hydrogel System With Paclitaxel Liposomes Used in Localized Drug Delivery System for In Situ Treatment of Tumor: Better Antitumor Efficacy and Lower Toxicity. Journal of Pharmaceutical Sciences 105:1, pages 194-204.
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