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Drug Delivery Volume 23, 2016 - Issue 5: Topical and transdermal drug delivery & Targeted drug delivery
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Research Article

Liver-targeting self-assembled hyaluronic acid-glycyrrhetinic acid micelles enhance hepato-protective effect of silybin after oral administration

Xiaofeng HanBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and
,
Zhe WangBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and
,
Manyuan WangBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and
,
Jing LiBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and Correspondence[email protected] [email protected]
,
Yongsong XuBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and
,
Rui HeBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and
,
Hongyu GuanBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and
,
Zhujun YueBeijing YouAn Hospital, Capital Medical University, Beijing, P. R. China
&
Muxin GongBeijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China and Correspondence[email protected] [email protected]
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Pages 1818-1829 | Received 19 Aug 2015, Accepted 12 Oct 2015, Published online: 10 Nov 2015

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Hong Jiang, Zhi-Peng Li, Gui-Xiang Tian, Rui-Yan Pan, Chong-Mei Xu, Bo Zhang & Jing-liang Wu. (2019) Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects. International Journal of Nanomedicine 14, pages 1789-1804.
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Zhenhai Zhang, Changchang Cui, Fang Wei & Huixia Lv. (2017) Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. Drug Development and Industrial Pharmacy 43:8, pages 1276-1282.
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Articles from other publishers (26)

Han-Se Kim, Sehee Jo, Kwan-Sik Yun & Kyeong-Jun Lee. (2023) Effects of dietary micelle silymarin on the growth performance, feed utilization and health of olive flounder (Paralichthys olivaceus). Aquaculture International 31:6, pages 3419-3436.
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Xiaoyu Yang, Yang Yang, Haiyan Yu & Yi Zhou. (2023) Self-Assembled Polymers for Gastrointestinal Tract Targeted Delivery through the Oral Route: An Update. Polymers 15:17, pages 3538.
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Zijian Dai, Yiyun Zhang, Yantong Meng, Siqi Li, Zhuoma Suonan, Yuge Sun, Junfu Ji, Qun Shen, Hao Zheng & Yong Xue. (2023) Targeted delivery of nutraceuticals derived from food for the treatment of obesity and its related complications. Food Chemistry 418, pages 135980.
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Smriti R Deka, Reena Singh, Pratiksha Verma & Pradeep Kumar. (2022) Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications . Polymer International 72:2, pages 205-216.
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Linjun Zou, Qinglong Li, Yong Hou, Meiying Chen, Xudong Xu, Haifeng Wu, Zhaocui Sun & Guoxu Ma. (2022) Self-assembled glycyrrhetinic acid derivatives for functional applications: a review. Food & Function 13:24, pages 12487-12509.
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Hadel A. Abo El-Enin, Marwa F. Ahmed, Ibrahim A. Naguib, Shaymaa W. El-Far, Mohammed M. Ghoneim, Izzeddin Alsalahat & Hend Mohamed Abdel-Bar. (2022) Utilization of Polymeric Micelles as a Lucrative Platform for Efficient Brain Deposition of Olanzapine as an Antischizophrenic Drug via Intranasal Delivery. Pharmaceuticals 15:2, pages 249.
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Luciano A. Stecanella, Antonio P. R. Bitencourt, Gustavo Richter Vaz, Eride Quarta, José O. C. Silva Júnior & Alessandra Rossi. (2021) Glycyrrhizic Acid and Its Hydrolyzed Metabolite 18β-Glycyrrhetinic Acid as Specific Ligands for Targeting Nanosystems in the Treatment of Liver Cancer. Pharmaceutics 13:11, pages 1792.
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Mayuko Fujitsuka, Kouta Araki, Tatsuhiro Kodama, Tran Thi Dieu Hien, Mina Sakuragi, Sangeetha Srinivasa Shetty, Yasuhito Koyama & Keita Kuroiwa. (2021) Supramolecular Control of Spin Equilibrium and Oxidation State in Nanohybrids of Amphiphilic Glycyrrhetinic Acid Derivatives with [Fe(TACN) 2 ] 2+ . Chemistry Letters 50:6, pages 1142-1145.
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Hualu Lai, Xin Ding, Junxian Ye, Jie Deng & Shengmiao Cui. (2021) pH-responsive hyaluronic acid-based nanoparticles for targeted curcumin delivery and enhanced cancer therapy. Colloids and Surfaces B: Biointerfaces 198, pages 111455.
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Shou-yan Wu, Wen-jie Wang, Jin-hui Dou & Li-kun Gong. (2020) Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury. Acta Pharmacologica Sinica 42:1, pages 18-26.
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Tiantian Hao, Kai Wang, Shutong Zhang, Shuyan Yang, Pingxi Wang, Feng Gao, Yufan Zhao, Na Guo & Peng Yu. (2020) Preparation, characterization, antioxidant evaluation of new curcumin derivatives and effects of forming HSA-bound nanoparticles on the stability and activity. European Journal of Medicinal Chemistry 207, pages 112798.
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Alexandro Barbosa de Souza, Marco Vinícius Chaud, Thais Francine Alves, Juliana Ferreira de Souza & Maria Andrade Santana. (2020) Hyaluronic Acid in the Intestinal Tract: Influence of Structure, Rheology, and Mucoadhesion on the Intestinal Uptake in Rats. Biomolecules 10:10, pages 1422.
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Muneeb U. Rehman, Adil Farooq, Rayeesa Ali, Sana Bashir, Nazirah Bashir, Samia Majeed, Syed Taifa, Sheikh Bilal Ahmad, Azher Arafah, Aga Syed Sameer, Rehan Khan, Wajhul Qamar, Saiema Rasool & Anas Ahmad. (2020) Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review. Current Drug Metabolism 21:6, pages 436-465.
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Nan Zhang, Jing Zhang, Baocheng Tian, Keke Li, Baohuan Wu & Jingtian Han. (2020) Tumor-targeted and self-assembled mixed micelles as carriers for enhanced anticancer efficacy of gemcitabine. Journal of Drug Delivery Science and Technology 57, pages 101730.
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Congyong Sun, Wenjing Li, Ping Ma, Yang Li, Yuan Zhu, Huiyun Zhang, Michael Adu-Frimpong, Wenwen Deng, Jiangnan Yu & Ximing Xu. (2020) Development of TPGS/F127/F68 mixed polymeric micelles: Enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity. Food and Chemical Toxicology 137, pages 111126.
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Xingli Cun, Jiantao Chen, Mengmeng Li, Xuan He, Xian Tang, Rong Guo, Miao Deng, Man Li, Zhirong Zhang & Qin He. (2019) Tumor-Associated Fibroblast-Targeted Regulation and Deep Tumor Delivery of Chemotherapeutic Drugs with a Multifunctional Size-Switchable Nanoparticle. ACS Applied Materials & Interfaces 11:43, pages 39545-39559.
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Zhe Ma, Bing Zhang, Yuqi Fan, Meng Wang, Dereje Kebebe, Jiawei Li & Zhidong Liu. (2019) Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases. Biomedicine & Pharmacotherapy 117, pages 109128.
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Anthony J. Hayes & James Melrose. (2019) Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics. Advanced Therapeutics 2:8.
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Guixiang Tian, Xiue Sun, Jingkun Bai, Jinhua Dong, Bo Zhang, Zhiqin Gao & Jingliang Wu. (2018) Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in�vitro and in�vivo. Molecular Medicine Reports.
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Xiaodan Wang, Xiangqin Gu, Huimin Wang, Jingyu Yang & Shirui Mao. (2018) Enhanced delivery of doxorubicin to the liver through self-assembled nanoparticles formed via conjugation of glycyrrhetinic acid to the hydroxyl group of hyaluronic acid. Carbohydrate Polymers 195, pages 170-179.
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Xiaoye Yang, Xiaoqun Shi, Richard D'arcy, Nicola Tirelli & Guangxi Zhai. (2018) Amphiphilic polysaccharides as building blocks for self-assembled nanosystems: molecular design and application in cancer and inflammatory diseases. Journal of Controlled Release 272, pages 114-144.
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Tianhao Sun, Kelvin S. C. Cheung, Zhi-Li Liu, Frankie Leung & William W. Lu. (2018) Matrix metallopeptidase 9 targeted by hsa-miR-494 promotes silybin-inhibited osteosarcoma. Molecular Carcinogenesis 57:2, pages 262-271.
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Xiaofeng Han, Xuerong Dong, Jing Li, Manyuan Wang, Lei Luo, Zhaoxia Li, Xuran Lu, Rui He, Rongsong Xu & Muxin Gong. (2017) Free paclitaxel-loaded E-selectin binding peptide modified micelle self-assembled from hyaluronic acid-paclitaxel conjugate inhibit breast cancer metastasis in a murine model. International Journal of Pharmaceutics 528:1-2, pages 33-46.
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Shih-Cheng Chen, Ming-Hui Yang, Tze-Wen Chung, Ting-Syuan Jhuang, Jean-Dean Yang, Ko-Chin Chen, Wan-Jou Chen, Ying-Fong Huang, Shiang-Bin Jong, Wan-Chi Tsai, Po-Chiao Lin & Yu-Chang Tyan. (2017) Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol. BioMed Research International 2017, pages 1-8.
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Xiaodan Wang, Xiangqin Gu, Huimin Wang, Yujiao Sun, Haiyang Wu & Shirui Mao. (2017) Synthesis, characterization and liver targeting evaluation of self-assembled hyaluronic acid nanoparticles functionalized with glycyrrhetinic acid. European Journal of Pharmaceutical Sciences 96, pages 255-262.
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Jing-Liang Wu, Gui-Xiang Tian, Wen-Jing Yu, Guang-Tao Jia, Tong-Yi Sun & Zhi-Qin Gao. (2016) pH-Responsive Hyaluronic Acid-Based Mixed Micelles for the Hepatoma-Targeting Delivery of Doxorubicin. International Journal of Molecular Sciences 17:4, pages 364.
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