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Journal of Receptors and Signal Transduction Volume 30, 2010 - Issue 5: Special Issue: The changing world of G protein-coupled receptors
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Research Article

An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A2A, dopamine D2, cannabinoid CB1, and metabotropic glutamate mGlu5 receptors

Luigi F. AgnatiIRCCS San Camillo, Lido Venezia, ItalyCorrespondence[email protected]
,
Diego GuidolinDepartment of Human Anatomy and Physiology, University of Padova, Padova, Italy
,
Giovanna AlbertinDepartment of Human Anatomy and Physiology, University of Padova, Padova, Italy
,
Elena TrivelloDepartment of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
,
Francisco CiruelaUnitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL-Universitat de Barcelona, Barcelona, Spain
,
Susanna GenedaniDepartment of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
,
Alexander TarakanovSaint Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russian Federation
&
Kjell FuxeDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden
 show all
Pages 355-369 | Received 24 Feb 2010, Accepted 27 Mar 2010, Published online: 04 Jun 2010

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Diego Guidolin, Luigi F Agnati, Manuela Marcoli, Dasiel O Borroto-Escuela & Kjell Fuxe. (2015) G-protein-coupled receptor type A heteromers as an emerging therapeutic target. Expert Opinion on Therapeutic Targets 19:2, pages 265-283.
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Alexander O. Tarakanov, Kjell G. Fuxe & Dasiel O. Borroto-Escuela. (2012) Integrin triplets of marine sponges in human D2 receptor heteromers. Journal of Receptors and Signal Transduction 32:4, pages 202-208.
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Fabio Blandini & Marie-Therese Armentero. (2012) New pharmacological avenues for the treatment of l-DOPA-induced dyskinesias in Parkinson's disease: targeting glutamate and adenosine receptors. Expert Opinion on Investigational Drugs 21:2, pages 153-168.
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Articles from other publishers (25)

Luigi F. Agnati, Diego Guidolin, Chiara Cervetto, Guido Maura & Manuela Marcoli. (2023) Brain Structure and Function: Insights from Chemical Neuroanatomy. Life 13:4, pages 940.
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Ana B. Caniceiro, Beatriz Bueschbell, Anke C. Schiedel & Irina S. Moreira. (2022) Class A and C GPCR Dimers in Neurodegenerative Diseases. Current Neuropharmacology 20:11, pages 2081-2141.
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G. Martella, P. Bonsi, P. Imbriani, G. Sciamanna, H. Nguyen, L. Yu-Taeger, M. Schneider, S.M. Poli, R. Lütjens & A. Pisani. (2021) Rescue of striatal long-term depression by chronic mGlu5 receptor negative allosteric modulation in distinct dystonia models. Neuropharmacology 192, pages 108608.
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Rory Sleno & Terence E. Hébert. (2019) Shaky ground - The nature of metastable GPCR signalling complexes. Neuropharmacology 152, pages 4-14.
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Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. (2019) Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?. Frontiers in Endocrinology 10.
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Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. (2018) G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication. Reviews in the Neurosciences 29:7, pages 703-726.
Crossref
Rory Sleno & Terence E. Hébert. 2018. G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A. G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A 141 171 .
Batoul Farran. (2017) An update on the physiological and therapeutic relevance of GPCR oligomers. Pharmacological Research 117, pages 303-327.
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Nadhir Litim, Marc Morissette & Thérèse Di Paolo. (2017) Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease: An update from the last 5 years of research. Neuropharmacology 115, pages 166-179.
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Michael D. Nguyen, Ying Wang, Mallikarjunarao Ganesana & B. Jill Venton. (2017) Transient Adenosine Release Is Modulated by NMDA and GABA B Receptors . ACS Chemical Neuroscience 8:2, pages 376-385.
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Rory Sleno, Dominic Devost & Terence E. Hébert. 2017. G-Protein-Coupled Receptor Dimers. G-Protein-Coupled Receptor Dimers 451 465 .
Rodrigo A. Cunha. (2016) How does adenosine control neuronal dysfunction and neurodegeneration?. Journal of Neurochemistry 139:6, pages 1019-1055.
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Luigi F. Agnati, Diego Guidolin, Chiara Cervetto, Dasiel O. Borroto-Escuela & Kjell Fuxe. (2016) Role of iso-receptors in receptor-receptor interactions with a focus on dopamine iso-receptor complexes. Reviews in the Neurosciences 27:1, pages 1-25.
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G. Sciamanna, G. Ponterio, A. Tassone, M. Maltese, G. Madeo, G. Martella, S. Poli, T. Schirinzi, P. Bonsi & A. Pisani. (2014) Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia. Neuropharmacology 85, pages 440-450.
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Morgan Le Naour, Mary M. Lunzer, Michael D. Powers, Alexander E. Kalyuzhny, Michael A. Benneyworth, Mark J. Thomas & Philip S. Portoghese. (2014) Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects. Journal of Medicinal Chemistry 57:15, pages 6383-6392.
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Dasiel Borroto-Escuela, Ismel Brito, Wilber Romero-Fernandez, Michael Di Palma, Julia Oflijan, Kamila Skieterska, Jolien Duchou, Kathleen Van Craenenbroeck, Diana Suárez-Boomgaard, Alicia Rivera, Diego Guidolin, Luigi Agnati & Kjell Fuxe. (2014) The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components. International Journal of Molecular Sciences 15:5, pages 8570-8590.
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Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Gian Filippo Antoninetti, Rafael Franco, Jos? Luis Lanciego, Younis Baqi, Christa E. M?ller, Annalisa Pinna, Fabio Blandini & Marie Therese Armentero. (2014) Neuroprotective Potential of Adenosine A 2A and Cannabinoid CB 1 Receptor Antagonists in an Animal Model of Parkinson Disease . Journal of Neuropathology & Experimental Neurology 73:5, pages 414-424.
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Kelly A Newell. (2013) Metabotropic glutamate receptor 5 in schizophrenia: emerging evidence for the development of antipsychotic drugs. Future Medicinal Chemistry 5:13, pages 1471-1474.
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Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang & Kelly A. Newell. (2013) Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment. Schizophrenia Research 146:1-3, pages 170-176.
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Natalie Matosin & Kelly A. Newell. (2013) Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia. Neuroscience & Biobehavioral Reviews 37:3, pages 256-268.
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Darlaine Pétrin & Terence E. Hébert. 2012. GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity. GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity 67 81 .
Alexander O. Tarakanov & Kjell G. Fuxe. (2011) The Triplet Puzzle of Homologies in Receptor Heteromers Exists Also in Other Types of Protein?Protein Interactions. Journal of Molecular Neuroscience 44:3, pages 173-177.
Crossref
Dasiel O. Borroto-Escuela, Alexander O. Tarakanov, Diego Guidolin, Francisco Ciruela, Luigi F. Agnati & Kjell Fuxe. (2011) Moonlighting characteristics of G protein-coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration. IUBMB Life 63:7, pages 463-472.
Crossref
Diego Guidolin, Francisco Ciruela, Susanna Genedani, Michele Guescini, Cinzia Tortorella, Giovanna Albertin, Kjell Fuxe & Luigi Francesco Agnati. (2011) Bioinformatics and mathematical modelling in the study of receptor?receptor interactions and receptor oligomerization. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808:5, pages 1267-1283.
Crossref
Irina Glazkova, Katrin Altosaar & Terence E. Hébert. 2011. 19 49 .

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