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Journal of Receptors and Signal Transduction Volume 31, 2011 - Issue 5
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Review Article

Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms

Luigi Francesco AgnatiIRCCS San Camillo, Lido VE, ItalyCorrespondence[email protected]
,
Diego GuidolinDepartment of Human Anatomy and Physiology, University of Padova, Padova, Italy
,
Giuseppina LeoDepartment of BioMedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
,
Michele GuesciniDepartment of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino, Italy
,
Marina Pizzi
,
Vilberto StocchiDepartment of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino, Italy
,
Pier Francesco Spano
,
Roberta GhidoniProteomics Unit, IRCCS “Centro S. Giovanni di Dio-Fatebenefratelli”, Brescia, Italy
,
Francisco CiruelaUnitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Universitat de Barcelona, Barcelona, Spain
,
Susanna GenedaniDepartment of BioMedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
&
Kjell FuxeDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden
 show all
Pages 315-331 | Received 26 May 2011, Accepted 20 Jun 2011, Published online: 19 Sep 2011

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Diego Guidolin, Luigi F Agnati, Manuela Marcoli, Dasiel O Borroto-Escuela & Kjell Fuxe. (2015) G-protein-coupled receptor type A heteromers as an emerging therapeutic target. Expert Opinion on Therapeutic Targets 19:2, pages 265-283.
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Bryan D. Spiegelberg. (2013) G protein coupled-receptor signaling and reversible lysine acetylation. Journal of Receptors and Signal Transduction 33:5, pages 261-266.
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L. F. Agnati, D. Guidolin, M. Guescini, L. Battistin, V. Stocchi, R. De Caro, S. Genedani & K. Fuxe. (2012) Aspects on the integrative actions of the brain from neural networks to “brain-body medicine”. Journal of Receptors and Signal Transduction 32:4, pages 163-180.
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Articles from other publishers (16)

Guendalina Olivero, Massimo Grilli, Mario Marchi & Anna Pittaluga. (2023) Metamodulation of presynaptic NMDA receptors: New perspectives for pharmacological interventions. Neuropharmacology 234, pages 109570.
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Luigi F. Agnati, Diego Guidolin, Chiara Cervetto, Guido Maura & Manuela Marcoli. (2023) Brain Structure and Function: Insights from Chemical Neuroanatomy. Life 13:4, pages 940.
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Federica Bono, Veronica Mutti, Zaira Tomasoni, Giulia Sbrini, Cristina Missale & Chiara Fiorentini. 2023. Therapeutic Applications of Dopamine D3 Receptor Function. Therapeutic Applications of Dopamine D3 Receptor Function 47 72 .
Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. 2020. Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors. Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors 247 277 .
Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. (2018) G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication. Reviews in the Neurosciences 29:7, pages 703-726.
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Luigi F. Agnati, Diego Guidolin, Guido Maura & Manuela Marcoli. (2018) Functional roles of three cues that provide nonsynaptic modes of communication in the brain: electromagnetic field, oxygen, and carbon dioxide. Journal of Neurophysiology 119:1, pages 356-368.
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Diego Guidolin, Manuela Marcoli, Guido Maura & Luigi F. Agnati. (2017) New dimensions of connectomics and network plasticity in the central nervous system. Reviews in the Neurosciences 28:2, pages 113-132.
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Kshitiz Kshitiz, Junaid Afzal, Yasir Suhail, Eun Hyun Ahn, Ruchi Goyal, Maimon E. Hubbi, Qasim Hussaini, David D. Ellison, Jatinder Goyal, Benjamin Nacev, Deok-Ho Kim, Justin Ho Lee, Sam Frankel, Kevin Gray, Rashmi Bankoti, Andy J. Chien & Andre Levchenko. (2015) Control of the interface between heterotypic cell populations reveals the mechanism of intercellular transfer of signaling proteins. Integrative Biology 7:3, pages 364-372.
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Luigi F. Agnati, Diego Guidolin, Guido Maura, Manuela Marcoli, Giuseppina Leo, Chiara Carone, Raffaele De Caro, Susanna Genedani, Dasiel O. Borroto-Escuela & Kjell Fuxe. (2014) Information handling by the brain: proposal of a new “paradigm” involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission. Journal of Neural Transmission 121:12, pages 1431-1449.
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Jonathan C. Andrews, María Paz Fernández, Qin Yu, Greg P. Leary, Adelaine K. W. Leung, Michael P. Kavanaugh, Edward A. Kravitz & Sarah J. Certel. (2014) Octopamine Neuromodulation Regulates Gr32a-Linked Aggression and Courtship Pathways in Drosophila Males. PLoS Genetics 10:5, pages e1004356.
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Luigi Francesco Agnati, Susanna Genedani, PierFranco Spano, Diego Guidolin & Kjell Fuxe. 2014. Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics. Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics 103 119 .
Yasir Suhail, Kshitiz, Justin Lee, Mark Walker, Deok-Ho Kim, Matthew D. Brennan, Joel S. Bader & Andre Levchenko. (2013) Modeling Intercellular Transfer of Biomolecules Through Tunneling Nanotubes. Bulletin of Mathematical Biology 75:8, pages 1400-1416.
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David D. Gonda, Johnny C. Akers, Ryan Kim, Steven N. Kalkanis, Fred H. Hochberg, Clark C. Chen & Bob S. Carter. (2013) Neuro-oncologic Applications of Exosomes, Microvesicles, and Other Nano-Sized Extracellular Particles. Neurosurgery 72:4, pages 501-510.
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Noelle C. Anastasio, Scott R. Gilbertson, Marcy J. Bubar, Anton Agarkov, Sonja J. Stutz, Yowjiun Jeng, Nicole M. Bremer, Thressa D. Smith, Robert G. Fox, Sarah E. Swinford, Patricia K. Seitz, Marc N. Charendoff, John W. CraftJrJr, Fernanda M. Laezza, Cheryl S. Watson, James M. Briggs & Kathryn A. Cunningham. (2013) Peptide Inhibitors Disrupt the Serotonin 5-HT 2C Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior . The Journal of Neuroscience 33:4, pages 1615-1630.
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Alexander O. Tarakanov, Kjell G. Fuxe & Dasiel O. Borroto-Escuela. (2011) On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors. Journal of Neural Transmission 119:5, pages 517-523.
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M. Guescini, G. Leo, S. Genedani, C. Carone, F. Pederzoli, F. Ciruela, D. Guidolin, V. Stocchi, M. Mantuano, D.O. Borroto-Escuela, K. Fuxe & L.F. Agnati. (2012) Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures. Experimental Cell Research 318:5, pages 603-613.
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