6,033
Views
60
CrossRef citations to date
0
Altmetric
Review Article

Sigma receptors [σRs]: biology in normal and diseased states

&
Pages 327-388 | Received 27 Nov 2014, Accepted 25 Jan 2015, Published online: 09 Jun 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

An-Sofie Schoonjans & Berten Ceulemans. (2022) A critical evaluation of fenfluramine hydrochloride for the treatment of Dravet syndrome. Expert Review of Neurotherapeutics 22:5, pages 351-364.
Read now
Limei Wang, Jin Pei, Zhongcheng Cong, Yifang Zou, Tianmeng Sun, Fionán Davitt, Adrià Garcia-Gil, Justin D Holmes, Caitriona M O’Driscoll, Kamil Rahme & Jianfeng Guo. (2019) Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumor-bearing mice. International Journal of Nanomedicine 14, pages 1817-1833.
Read now
Alexandra VSL Rodrigues, Francisco Jcg Almeida & Maria A Vieira-Coelho. (2019) Dimethyltryptamine: Endogenous Role and Therapeutic Potential. Journal of Psychoactive Drugs 51:4, pages 299-310.
Read now

Articles from other publishers (56)

Santosh Reddy Alluri, MingQiang Zheng, Daniel Holden, Ying Zhang, Li Zhang, Zachary Felchner, Songye Li, Jim Ropchan, Richard Carson, Hongmei Jia & Yiyun Huang. (2023) Evaluation of a First PET Tracer Suitable for Imaging the Sigma-2 Receptor in the Brain of Nonhuman Primates. Molecular Pharmaceutics.
Crossref
Talha Siddiqui & Lokesh Kumar Bhatt. (2023) Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson’s Disease. Neurochemical Research.
Crossref
Dicson S. Malar, Premrutai Thitilertdecha, Kanokphorn S. Ruckvongacheep, Sirikalaya Brimson, Tewin Tencomnao & James M. Brimson. (2023) Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders. CNS Drugs 37:5, pages 399-440.
Crossref
I. G. Kapitsa, A. A. Alymov, E. V. Savinkova, T. A. Voronina & S. B. Seredenin. (2023) Experimental Study of Antidepressant Properties of Afobazole. Bulletin of Experimental Biology and Medicine 175:1, pages 59-62.
Crossref
Joseph Pergolizzi, Giustino Varrassi, Mark Coleman, Frank Breve, Dana K Christo, Paul J Christo & Charbel Moussa. (2023) The Sigma Enigma: A Narrative Review of Sigma Receptors. Cureus.
Crossref
Masoud Sadeghzadeh, Barbara Wenzel, Julia Nikodemus, Alexandru Florea, Fabian Hertel, Klaus Kopka, Andreas T. J. Vogg, Fabian Kiessling & Felix M. Mottaghy. (2023) Improved protocol for the radiosynthesis of [ 18 F]FTC‐146: A potent and selective sigma‐1 receptor radioligand . Journal of Labelled Compounds and Radiopharmaceuticals 66:3, pages 116-125.
Crossref
Joyeeta Roy, Armita Kyani, Maha Hanafi, Yibin Xu, John Takyi-Williams, Duxin Sun, Essam Eldin A. Osman & Nouri Neamati. (2023) Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer. Journal of Medicinal Chemistry 66:3, pages 1990-2019.
Crossref
Agnieszka Piechal, Alicja Jakimiuk, Justyna Pyrzanowska, Kamilla Blecharz-Klin, Ilona Joniec-Maciejak, Alicja Wiercińska-Drapało, Dagmara Mirowska-Guzel & Ewa Widy-Tyszkiewicz. (2023) Long-term Administration of 3-Di-O-Tolylguanidine Modulates Spatial Learning and Memory in Rats and Causes Transition in the Concentration of Neurotransmitters in the Hippocampus, Prefrontal Cortex and Striatum. Neuroscience 510, pages 129-146.
Crossref
Lanqing Li, Xiaoqiang Wang, Haiying Xu, Xianqiong Liu & Kang Xu. (2022) Perspectives and mechanisms for targeting ferroptosis in the treatment of hepatocellular carcinoma. Frontiers in Molecular Biosciences 9.
Crossref
Peng Ren, Jingya Wang, Nanxi Li, Guangxiang Li, Hui Ma, Yongqi Zhao & Yunfeng Li. (2022) Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development. Frontiers in Pharmacology 13.
Crossref
Jie Chang, Liufang Mo, Jinfeng Song, Xiaochen Wang, Hanhan Liu, Chenchen Meng & Yijun Wu. (2022) A pH-responsive mesoporous silica nanoparticle-based drug delivery system for targeted breast cancer therapy. Journal of Materials Chemistry B 10:17, pages 3375-3385.
Crossref
Anna Szilágyi, Barbara Takács, Réka Szekeres, Vera Tarjányi, Mariann Bombicz, Dániel Priksz, Attila Kovács, Béla Juhász, Ede Frecska, Zoltán Szilvássy & Balázs Varga. (2022) Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye. Biomedicines 10:5, pages 997.
Crossref
Jacob P. Sorrentino & Ryan A. Altman. (2022) Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability. ACS Medicinal Chemistry Letters 13:4, pages 707-713.
Crossref
Barinderjit KaurMuthuraman A.Surya P Gautam. (2021) Sigma Receptors Ligands: New insights into the Cardioprotective Potential. Research Journal of Pharmacy and Technology, pages 6753-6760.
Crossref
José Alexandre Salerno, Thayana Torquato, Jairo R. Temerozo, Livia Goto-Silva, Karina Karmirian, Mayara A. Mendes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Letícia R Q. Souza, Isis M. Ornelas, Carla P. Veríssimo, Luiz Guilherme H S. Aragão, Gabriela Vitória, Carolina S G. Pedrosa, Suelen da Silva Gomes Dias, Vinicius Cardoso Soares, Teresa Puig-Pijuan, Vinícius Salazar, Rafael Dariolli, Diogo Biagi, Daniel R. Furtado, Luciana Barreto Chiarini, Helena L. Borges, Patrícia T. Bozza, Marilia Zaluar P. Guimarães, Thiago M.L. Souza & Stevens K. Rehen. (2021) Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating. PeerJ 9, pages e12595.
Crossref
Lixia Lou, Chunhong Li, Jie Wang, Aiming Wu, Ting Zhang, Zhe Ma, Limin Chai, Dongmei Zhang, Yizhou Zhao, Bo Nie, Qiushuo Jin, Huiyang Chen & Wei Liu. (2021) Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction. Experimental and Therapeutic Medicine 22:5.
Crossref
Giuseppe Romeo, Valeria Ciaffaglione, Emanuele Amata, Maria Dichiara, Loredana Calabrese, Luca Vanella, Valeria Sorrenti, Salvo Grosso, Agata Grazia D’Amico, Velia D’Agata, Sebastiano Intagliata & Loredana Salerno. (2021) Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity. Molecules 26:13, pages 3860.
Crossref
Giuseppe Romeo, Federica Bonanno, Lisa L. Wilson, Emanuela Arena, Maria N. Modica, Valeria Pittalà, Loredana Salerno, Orazio Prezzavento, Jay P. McLaughlin & Sebastiano Intagliata. (2021) Development of New Benzylpiperazine Derivatives as σ 1 Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects . ACS Chemical Neuroscience 12:11, pages 2003-2012.
Crossref
Deborah Guery & Sylvain Rheims. (2020) Is the mechanism of action of antiseizure drugs a key element in the choice of treatment?. Fundamental & Clinical Pharmacology 35:3, pages 552-563.
Crossref
Rui Huang, David C. Luther, Xianzhi Zhang, Aarohi Gupta, Samantha A. Tufts & Vincent M. Rotello. (2021) Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design. Nanomaterials 11:4, pages 1001.
Crossref
Alisa Pavel, Giusy del Giudice, Antonio Federico, Antonio Di Lieto, Pia A S Kinaret, Angela Serra & Dario Greco. (2021) Integrated network analysis reveals new genes suggesting COVID-19 chronic effects and treatment. Briefings in Bioinformatics 22:2, pages 1430-1441.
Crossref
Wojciech Danysz, Andrzej Dekundy, Astrid Scheschonka & Peter Riederer. (2021) Amantadine: reappraisal of the timeless diamond—target updates and novel therapeutic potentials. Journal of Neural Transmission 128:2, pages 127-169.
Crossref
Nikoletta Almási, Szilvia Török, Zsuzsanna Valkusz, Máté Tajti, Ákos Csonka, Zsolt Murlasits, Anikó Pósa, Csaba Varga & Krisztina Kupai. (2020) Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis. Antioxidants 9:11, pages 1081.
Crossref
Mikhail V. Voronin, Yulia V. Vakhitova & Sergei B. Seredenin. (2020) Chaperone Sigma1R and Antidepressant Effect. International Journal of Molecular Sciences 21:19, pages 7088.
Crossref
Lydia Ramzy, Abdelkader A. Metwally, Maha Nasr & Gehanne A. S. Awad. (2020) Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors. Scientific Reports 10:1.
Crossref
Daniele Zampieri, Sara Fortuna, Antonella Calabretti, Maurizio Romano, Renzo Menegazzi, Dirk Schepmann, Bernhard Wünsch & Maria Grazia Mamolo. (2019) Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands. ACS Medicinal Chemistry Letters 11:5, pages 651-656.
Crossref
Mojtaba Keshavarz, Majid Reza Farrokhi, Elahe Amirinezhad Fard & Mohammad Mehdipour. (2020) Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells. Advanced Pharmaceutical Bulletin 10:3, pages 452-457.
Crossref
Zhuo Yu, Jianfeng Guo, Mengying Hu, Yueqiu Gao & Leaf Huang. (2020) Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma. ACS Nano 14:4, pages 4816-4828.
Crossref
Anna Schildt, Erik F.J. de Vries, Antoon T.M. Willemsen, Bruno Lima Giacobbo, Rodrigo Moraga-Amaro, Jürgen W.A. Sijbesma, Aren van Waarde, Vesna Sossi, Rudi A.J.O. Dierckx & Janine Doorduin. (2020) Effect of Dopamine D 2 Receptor Antagonists on [ 18 F]-FEOBV Binding . Molecular Pharmaceutics 17:3, pages 865-872.
Crossref
Tao Bai, Pengxu Lei, Hao Zhou, Ruopeng Liang, Rongtao Zhu, Weijie Wang, Lin Zhou & Yuling Sun. (2019) Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells. Journal of Cellular and Molecular Medicine 23:11, pages 7349-7359.
Crossref
D. Scott Wilbur & Michael J. Adam. (2019) Radiobromine and radioiodine for medical applications. Radiochimica Acta 107:9-11, pages 1033-1063.
Crossref
Fabio Del Bello, Maria Vittoria Micioni Di Bonaventura, Alessandro Bonifazi, Bernhard Wünsch, Dirk Schepmann, JoLynn B. Giancola, Emanuela Micioni Di Bonaventura, Giulio Vistoli, Gianfabio Giorgioni, Wilma Quaglia, Alessandro Piergentili & Carlo Cifani. (2019) Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ 1 Antagonist Analogue of Spipethiane . ACS Chemical Neuroscience 10:8, pages 3391-3397.
Crossref
Giuseppe Romeo, Orazio Prezzavento, Sebastiano Intagliata, Valeria Pittalà, Maria N. Modica, Agostino Marrazzo, Rita Turnaturi, Carmela Parenti, Santina Chiechio, Emanuela Arena, Agata Campisi, Giovanni Sposito & Loredana Salerno. (2019) Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands. European Journal of Medicinal Chemistry 174, pages 226-235.
Crossref
Friedrich-Alexander Ludwig, Steffen Fischer, Richard Houska, Alexander Hoepping, Winnie Deuther-Conrad, Dirk Schepmann, Marianne Patt, Philipp M. Meyer, Swen Hesse, Georg-Alexander Becker, Franziska Ruth Zientek, Jörg Steinbach, Bernhard Wünsch, Osama Sabri & Peter Brust. (2019) In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET). Frontiers in Pharmacology 10.
Crossref
Gladys Asong, Xue Y. Zhu, Barbara Bricker, Terrick Andey, Felix Amissah, Nazarius Lamango & Seth Y. Ablordeppey. (2019) New analogs of SYA013 as sigma-2 ligands with anticancer activity. Bioorganic & Medicinal Chemistry 27:12, pages 2629-2636.
Crossref
Kai Yang, Changcai Wang & Taolei Sun. (2019) The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson’s Disease (PD) and Major Depressive Disorder (MDD). Frontiers in Pharmacology 10.
Crossref
Xue Luan, Kamil Rahme, Zhongcheng Cong, Limei Wang, Yifang Zou, Yan He, Hao Yang, Justin D. Holmes, Caitriona M. O'Driscoll & Jianfeng Guo. (2019) Anisamide-targeted PEGylated gold nanoparticles designed to target prostate cancer mediate: Enhanced systemic exposure of siRNA, tumour growth suppression and a synergistic therapeutic response in combination with paclitaxel in mice. European Journal of Pharmaceutics and Biopharmaceutics 137, pages 56-67.
Crossref
Jacques Joubert, Natasha Strydom, Werner J. Geldenhuys, Yolande Greyling, Sandra V. Dyk & Sarel F. Malan. (2019) Hexacyclododecylamines with Sigma-1 Receptor Affinity and Calcium Channel Modulating Ability. The Open Medicinal Chemistry Journal 13:1, pages 29-39.
Crossref
Инна Довжикова, Inna Dovzhikova, Ирина Андриевская, Irina Andrievskaya, Ксения Петрова & Kseniya Petrova. (2018) PROGESTERONE RECEPTORS: A REPRODUCTIVE ROLE. Bulletin physiology and pathology of respiration 1:70, pages 104-112.
Crossref
Danielle O. Sambo, Joseph J. Lebowitz & Habibeh Khoshbouei. (2018) The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. Pharmacology & Therapeutics 186, pages 152-167.
Crossref
Hideaki Yano, Alessandro Bonifazi, Min Xu, Daryl A. Guthrie, Stephanie N. Schneck, Ara M. Abramyan, Andrew D. Fant, W. Conrad Hong, Amy H. Newman & Lei Shi. (2018) Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays. Neuropharmacology 133, pages 264-275.
Crossref
Mateusz Kurciński, Małgorzata Jarończyk, Piotr Lipiński, Jan Dobrowolski & Joanna Sadlej. (2018) Structural Insights into σ1 Receptor Interactions with Opioid Ligands by Molecular Dynamics Simulations. Molecules 23:2, pages 456.
Crossref
Sean P. Sherman & Anne G. Bang. (2018) High-throughput screen for compounds that modulate neurite growth of human induced pluripotent stem cell-derived neurons. Disease Models & Mechanisms 11:2.
Crossref
Barbara J. Clark, Russell A. Prough & Carolyn M. Klinge. 2018. Dehydroepiandrosterone. Dehydroepiandrosterone 29 73 .
Colin G. Rousseaux. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 4951 4961 .
Inés Reynoso-Moreno, Israel Najar-Guerrero, Noé Escareño, Mario Eduardo Flores-Soto, Jürg Gertsch & Juan Manuel Viveros-Paredes. (2017) An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice. Journal of Agricultural and Food Chemistry 65:43, pages 9435-9442.
Crossref
Tao Bai, Shuai Wang, Yipu Zhao, Rongtao Zhu, Weijie Wang & Yuling Sun. (2017) Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications 491:4, pages 919-925.
Crossref
Jo Sourbron, Ilse Smolders, Peter de Witte & Lieven Lagae. (2017) Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish. Frontiers in Pharmacology 8.
Crossref
Ling Pan, David A. Pasternak, Jin Xu, Mingming Xu, Zhigang Lu, Gavril W. Pasternak & Ying-Xian Pan. (2017) Isolation and characterization of alternatively spliced variants of the mouse sigma1 receptor gene, Sigmar1. PLOS ONE 12:3, pages e0174694.
Crossref
O. Prezzavento, E. Arena, C. S?nchez-Fern?ndez, R. Turnaturi, C. Parenti, A. Marrazzo, R. Catalano, E. Amata, L. Pasquinucci & E.J. Cobos. (2017) (+)-and (?)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/?1 antagonist properties and antinociceptive effects. European Journal of Medicinal Chemistry 125, pages 603-610.
Crossref
J.R. Lever, D.K. Miller & S.Z. Lever. 2017. The Neuroscience of Cocaine. The Neuroscience of Cocaine 491 499 .
Gavril W. Pasternak. 2017.
Marta Valle, Ana Elda Maqueda, Mireia Rabella, Aina Rodr?guez-Pujadas, Rosa Maria Antonijoan, Sergio Romero, Joan Francesc Alonso, Miquel ?ngel Ma?anas, Steven Barker, Pablo Friedlander, Amanda Feilding & Jordi Riba. (2016) Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans. European Neuropsychopharmacology 26:7, pages 1161-1175.
Crossref
Emanuela Arena, Ivana Cacciatore, Laura S. Cerasa, Hasan Turkez, Valeria Pittalà, Lorella Pasquinucci, Agostino Marrazzo, Carmela Parenti, Antonio Di Stefano & Orazio Prezzavento. (2016) New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation. Bioorganic & Medicinal Chemistry 24:14, pages 3149-3156.
Crossref
John R. Lever, Emily A. Fergason-Cantrell, Lisa D. Watkinson, Terry L. Carmack, Sarah A. Lord, Rong Xu, Dennis K. Miller & Susan Z. Lever. (2016) Cocaine occupancy of sigma 1 receptors and dopamine transporters in mice . Synapse 70:3, pages 98-111.
Crossref
Colin G. Rousseaux. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 11 .