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Research Article

Development and optimization of lyophilized orally disintegrating tablets using factorial design

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Pages 935-943 | Received 16 Jun 2011, Accepted 24 Aug 2011, Published online: 22 Nov 2011

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Mahmoud H Teaima, Khaled M Abdel-Haleem, Rewan Osama, Mohamed A El-Nabarawi & Osama S Elnahas. (2021) A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam Using Co-Processed Excipients: Formulation, Characterization and Pharmacokinetic Study. Drug Design, Development and Therapy 15, pages 4229-4242.
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Ahmed H. Ibrahim, Hany M. Ibrahim, Hatem R. Ismael & Ahmed M. Samy. (2018) Optimization and evaluation of lyophilized fenofibrate nanoparticles with enhanced oral bioavailability and efficacy. Pharmaceutical Development and Technology 23:4, pages 358-369.
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Aurica P. Chiriac, Alina Diaconu, Loredana E. Nita, Nita Tudorachi, Liliana Mititelu-Tartau, Andreea Creteanu, Oana Dragostin, Daniela Rusu & Gratiela Popa. (2017) The influence of excipients on physical and pharmaceutical properties of oral lyophilisates containing a pregabalin-acetaminophen combination. Expert Opinion on Drug Delivery 14:5, pages 589-599.
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Doaa Ahmed El-Setouhy, Alaa Abdel-Rahman Gamiel, Alia Abd El-Latif Badawi, Afaf Sayed Osman & Dina Ahmed Labib. (2017) Comparative study on the in vitro performance of blister molded and conventional lornoxicam immediate release liquitablets: accelerated stability study and anti-inflammatory and ulcerogenic effects. Pharmaceutical Development and Technology 22:2, pages 256-265.
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Martina Manyikana, Yahya E. Choonara, Lomas K. Tomar, Charu Tyagi, Pradeep Kumar, Lisa C. du Toit & Viness Pillay. (2016) A review of formulation techniques that impact the disintegration and mechanical properties of oradispersible drug delivery technologies. Pharmaceutical Development and Technology 21:3, pages 354-366.
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Veeran Gowda, Ritesh M. Pabari, John G. Kelly & Zebunnissa Ramtoola. (2015) Influence of Prosolv and Prosolv:Mannitol 200 direct compression fillers on the physicomechanical properties of atorvastatin oral dispersible tablets. Pharmaceutical Development and Technology 20:4, pages 394-400.
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Kishan S. Italiya, Arihant K. Singh, Deepak Chitkara & Anupama Mittal. (2021) Nanoparticulate tablet dosage form of lisofylline-linoleic acid conjugate for type 1 diabetes: in situ single-pass intestinal perfusion (SPIP) studies and pharmacokinetics in rat. AAPS PharmSciTech 22:3.
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Samia M. Omar, Fathy I. AbdAlla & Noha M. Abdelgawad. (2018) Preparation and Optimization of Fast-Disintegrating Tablet Containing Naratriptan Hydrochloride Using D-Optimal Mixture Design. AAPS PharmSciTech 19:6, pages 2472-2487.
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Haifei Zhang. 2018. Ice Templating and Freeze-Drying for Porous Materials and Their Applications. Ice Templating and Freeze-Drying for Porous Materials and Their Applications 63 102 .
Iman S. Ahmed, Rania El Hosary, Mariame A. Hassan, Mohamed Haider & Marwa M. Abd-Rabo. (2017) Efficacy and Safety Profiles of Oral Atorvastatin-Loaded Nanoparticles: Effect of Size Modulation on Biodistribution. Molecular Pharmaceutics 15:1, pages 247-255.
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Alaa H. Salama, Mona Basha & Sally El Awdan. (2018) Experimentally designed lyophilized dry emulsion tablets for enhancing the antihyperlipidemic activity of atorvastatin calcium: Preparation, in-vitro evaluation and in-vivo assessment. European Journal of Pharmaceutical Sciences 112, pages 52-62.
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Amr Hefnawy, Islam A Khalil & Ibrahim M El-Sherbiny. (2017) Facile development of nanocomplex-in-nanoparticles for enhanced loading and selective delivery of doxorubicin to brain. Nanomedicine 12:24, pages 2737-2761.
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Hitendra S. Mahajan & Yashaswi V. Kelkar. (2017) Pregelatinized hydroxypropyl pea starch as matrix forming material for lyophilized orodispersible tablets of tadalafil. Journal of Drug Delivery Science and Technology 41, pages 310-316.
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Shahinaze A. Fouad, Rehab N. Shamma, Emad B. Basalious, Mohamed A. El-Nabarawi & Saadia A. Tayel. (2016) Novel instantly-soluble transmucosal matrix (ISTM) using dual mechanism solubilizer for sublingual and nasal delivery of dapoxetine hydrochloride: In-vitro / in-vivo evaluation. International Journal of Pharmaceutics 505:1-2, pages 212-222.
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