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Pharmaceutical Development and Technology Volume 18, 2013 - Issue 1
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Research Article

Comparison of spray congealing and melt emulsification methods for the incorporation of the water-soluble salbutamol sulphate in lipid microparticles

Santo ScaliaDepartment of Pharmaceutical Sciences, University of Ferrara, via Fossato di Mortara 17, 44121 Ferrara, ItalyCorrespondence[email protected]
,
Daniela TrainiAdvanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
,
Paul M. YoungAdvanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
,
Marcello Di SabatinoDepartment of Pharmaceutical Sciences, University of Bologna, via S. Donato 19, Bologna, Italy
,
Nadia PasseriniDepartment of Pharmaceutical Sciences, University of Bologna, via S. Donato 19, Bologna, Italy
&
Beatrice AlbertiniDepartment of Pharmaceutical Sciences, University of Bologna, via S. Donato 19, Bologna, Italy
Pages 266-273 | Received 16 Apr 2012, Accepted 26 Jul 2012, Published online: 24 Sep 2012

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Hongyi Ouyang, Soon Jun Ang, Zong Yang Lee, Tze Ning Hiew, Paul Wan Sia Heng & Lai Wah Chan. (2022) Effect of drug load and lipid–wax blends on drug release and stability from spray-congealed microparticles. Pharmaceutical Development and Technology 27:10, pages 1069-1082.
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Santo Scalia, Paul M Young & Daniela Traini. (2015) Solid lipid microparticles as an approach to drug delivery. Expert Opinion on Drug Delivery 12:4, pages 583-599.
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Ching Mien Oh, Qiyun Guo, Paul Wan Sia Heng & Lai Wah Chan. (2014) Spray-congealed microparticles for drug delivery – an overview of factors influencing their production and characteristics. Expert Opinion on Drug Delivery 11:7, pages 1047-1060.
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Articles from other publishers (10)

Alessandro Candiani, Andrea Milanesi, Andrea Foglio Bonda, Giada Diana, Elia Bari, Lorena Segale, Maria Luisa Torre & Lorella Giovannelli. (2022) Solid Lipid Microparticles by Spray Congealing of Water/Oil Emulsion: An Effective/Versatile Loading Strategy for a Highly Soluble Drug. Pharmaceutics 14:12, pages 2805.
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Hongyi Ouyang, Annabel Shi Yin Poh, Paul Wan Sia Heng & Lai Wah Chan. (2020) Effect of Surfactants on the Melt Viscosity and Extent of Drug Embedment of Paraffin Wax Blends in Spray Congealing. Journal of Pharmaceutical Innovation 17:2, pages 414-428.
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Khaled H. Al Zahabi, Hind Ben tkhayat, Ehab Abu-Basha, Al Sayed Sallam & Husam M. Younes. (2021) Formulation of Lipid-Based Tableted Spray-Congealed Microparticles for Sustained Release of Vildagliptin: In Vitro and In Vivo Studies. Pharmaceutics 13:12, pages 2158.
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Jelisaveta Ignjatović, Tijana Šušteršič, Aleksandar Bodić, Sandra Cvijić, Jelena Đuriš, Alessandra Rossi, Vladimir Dobričić, Svetlana Ibrić & Nenad Filipović. (2021) Comparative Assessment of In Vitro and In Silico Methods for Aerodynamic Characterization of Powders for Inhalation. Pharmaceutics 13:11, pages 1831.
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G.D Sorita, A Santamaria-Echart, A.M Gozzo, O.H Gonçalves, F.V Leimann, E Bona, Y Manrique, I.P.M Fernandes, I.C.F.R Ferreira & M.F Barreiro. (2021) Lipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticles. Advanced Powder Technology 32:5, pages 1710-1722.
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Jelisaveta Ignjatović, Jelena Đuriš, Sandra Cvijić, Vladimir Dobričić, Agnese Montepietra, Chiara Lombardi, Svetlana Ibrić & Alessandra Rossi. (2021) Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery. European Journal of Pharmaceutical Sciences 156, pages 105588.
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Kerstin Traub-Hoffmann, Katrin Gegenfurtner, Kay-Uwe Kraft & Wolfgang Friess. (2020) Spray congealed solid lipid microparticles as a sustained release delivery system for Gonadorelin [6-D-Phe]: Production, optimization and in vitro release behavior. European Journal of Pharmaceutics and Biopharmaceutics 154, pages 18-32.
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Serena Bertoni, Luisa S Dolci, Beatrice Albertini & Nadia Passerini. (2018) Spray congealing: a versatile technology for advanced drug-delivery systems. Therapeutic Delivery 9:11, pages 833-845.
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Ching Mien Oh, Paul Wan Sia Heng & Lai Wah Chan. (2015) Influence of Hydroxypropyl Methylcellulose on Metronidazole Crystallinity in Spray-Congealed Polyethylene Glycol Microparticles and Its Impact with Various Additives on Metronidazole Release. AAPS PharmSciTech 16:6, pages 1357-1367.
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Grace A. Ledet, Richard A. Graves, Levon A. Bostanian & Tarun K. Mandal. 2015. Lyophilized Biologics and Vaccines. Lyophilized Biologics and Vaccines 273 297 .

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