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Research Article

Use of soft sensors to monitor a pharmaceuticals freeze-drying process in vials

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Pages 148-159 | Received 03 Oct 2012, Accepted 03 Dec 2012, Published online: 22 Jan 2013

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Read on this site (7)

A. Arsiccio, A. C. Sparavigna, R. Pisano & A. A. Barresi. (2019) Measuring and predicting pore size distribution of freeze-dried solutions. Drying Technology 37:4, pages 435-447.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2017) On the robustness of the soft sensors used to monitor a vial freeze-drying process. Drying Technology 35:9, pages 1085-1097.
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Serena Bosca, Antonello Barresi & Davide Fissore. (2016) On the use of model-based tools to optimize in-line a pharmaceuticals freeze-drying process. Drying Technology 34:15, pages 1831-1842.
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Irene Oddone, Daniele Fulginiti, Antonello A. Barresi, Sabrina Grassini & Roberto Pisano. (2015) Non-Invasive Temperature Monitoring in Freeze Drying: Control of Freezing as a Case Study. Drying Technology 33:13, pages 1621-1630.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2015) Design of a Robust Soft-Sensor to Monitor In-Line a Freeze-Drying Process. Drying Technology 33:9, pages 1039-1050.
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Serena Bosca, Simone Corbellini, AntonelloA. Barresi & Davide Fissore. (2013) Freeze-Drying Monitoring Using a New Process Analytical Technology: Toward a “Zero Defect” Process. Drying Technology 31:15, pages 1744-1755.
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Articles from other publishers (15)

Marco Carfagna, Monica Rosa, Andrea Hawe & Wolfgang Frieß. (2023) Lyophilization cycle design for highly concentrated protein formulations supported by micro freeze-dryer and heat flux sensor. International Journal of Pharmaceutics 643, pages 123285.
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Xiaofan Jiang, Petr Kazarin, Michael D. Sinanis, Ahmad Darwish, Nithin Raghunathan, Alina Alexeenko & Dimitrios Peroulis. (2022) A non-invasive multipoint product temperature measurement for pharmaceutical lyophilization. Scientific Reports 12:1.
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Ahmed Abdelraheem, Rishabh Tukra, Petr Kazarin, Michael D Sinanis, Elizabeth M Topp, Alina Alexeenko & Dimitrios Peroulis. (2022) Statistical electromagnetics for industrial pharmaceutical lyophilization. PNAS Nexus 1:3.
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Bhaskar Pandya, Geoff Smith, Irina Ermolina & Evgeny Polygalov. (2021) Observations on the Changing Shape of the Ice Mass and the Determination of the Sublimation End Point in Freeze-Drying: An Application for Through-Vial Impedance Spectroscopy (TVIS). Pharmaceutics 13:11, pages 1835.
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Davide Fissore, Roberto Pisano & Antonello A. Barresi. (2017) On the use of temperature measurement to monitor a freeze-drying process for pharmaceuticals. On the use of temperature measurement to monitor a freeze-drying process for pharmaceuticals.
Ilona Vollrath, Victoria Pauli, Wolfgang Friess, Angelika Freitag, Andrea Hawe & Gerhard Winter. (2017) Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying. Journal of Pharmaceutical Sciences 106:5, pages 1249-1257.
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Geoff Smith, Muhammad Sohail Arshad, Eugene Polygalov, Irina Ermolina, Timothy R McCoy & Paul Matejtschuk. (2016) Process Understanding in Freeze-Drying Cycle Development: Applications for Through-Vial Impedance Spectroscopy (TVIS) in Mini-pilot Studies. Journal of Pharmaceutical Innovation 12:1, pages 26-40.
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Davide Fissore. (2017) Model-Based PAT for Quality Management in Pharmaceuticals Freeze-Drying: State of the Art. Frontiers in Bioengineering and Biotechnology 5.
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Davide Fissore. (2016) On the Design of a Fuzzy Logic–Based Control System for Freeze-Drying Processes. Journal of Pharmaceutical Sciences 105:12, pages 3562-3572.
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Serena Bosca, Davide Fissore & Micaela Demichela. (2015) Risk-Based Design of a Freeze-Drying Cycle for Pharmaceuticals. Industrial & Engineering Chemistry Research 54:51, pages 12928-12936.
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. 2015. Advances in Probiotic Technology. Advances in Probiotic Technology 264 271 .
Davide Fissore & Roberto Pisano. (2015) Computer-Aided Framework for the Design of Freeze-Drying Cycles: Optimization of the Operating Conditions of the Primary Drying Stage. Processes 3:2, pages 406-421.
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Serena Bosca & Davide Fissore. (2014) Monitoring of a Pharmaceuticals Freeze-Drying Process by Model-Based Process Analytical Technology Tools. Chemical Engineering & Technology 37:2, pages 240-248.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2013) Fast freeze-drying cycle design and optimization using a PAT based on the measurement of product temperature. European Journal of Pharmaceutics and Biopharmaceutics 85:2, pages 253-262.
Crossref
Serena Bosca, Antonello A. Barresi & Davide Fissore. (2013) Use of a soft sensor for the fast estimation of dried cake resistance during a freeze-drying cycle. International Journal of Pharmaceutics 451:1-2, pages 23-33.
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