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Pharmaceutical Development and Technology Volume 20, 2015 - Issue 8
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Review Article

Aerosol particle generation from solution-based pressurized metered dose inhalers: a technical overview of parameters that influence respiratory deposition

Bing ZhuRespiratory Technology, Woolcock Institute of Medical Research and ;Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
,
Daniela TrainiRespiratory Technology, Woolcock Institute of Medical Research and ;Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
&
Paul YoungRespiratory Technology, Woolcock Institute of Medical Research and ;Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, AustraliaCorrespondence[email protected]
Pages 897-910 | Received 19 Jun 2013, Accepted 18 Aug 2014, Published online: 22 Sep 2014

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Hanan M. El-Laithy, Amal Youssef, Shereen S. El-Husseney, Nesrine S. El Sayed & Ahmed Maher. (2021) Enhanced alveo pulmonary deposition of nebulized ciclesonide for attenuating airways inflammations: a strategy to overcome metered dose inhaler drawbacks. Drug Delivery 28:1, pages 826-843.
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Bing Zhu, Ningyi Xu, Daniela Traini, David Lewis & Paul M. Young. (2015) The Formation of Aerosol Particles from Solution-Based Pressurized Metered Dose Inhalers and Implications of Incomplete Droplet Drying: Theoretical and Experimental Comparison. Aerosol Science and Technology 49:11, pages 1090-1099.
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Articles from other publishers (9)

Michael Y.T. Chow, Harry W. Pan & Jenny K.W. Lam. 2023. Pulmonary Pharmacology. Pulmonary Pharmacology 273 311 .
Sayeed Mossadeq, Rajen Shah, Viraj Shah & Milind Bagul. (2022) Formulation, Device, and Clinical Factors Influencing the Targeted Delivery of COVID-19 Vaccines to the Lungs. AAPS PharmSciTech 24:1.
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Farnia Dastoorian, Leila Pakzad, Janusz Kozinski & Ehsan Behzadfar. (2022) A CFD Investigation on the Aerosol Drug Delivery in the Mouth–Throat Airway Using a Pressurized Metered-Dose Inhaler Device. Processes 10:7, pages 1230.
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Matthew S. Makowski, Christopher Sproul, Carol Swartz, Jeffrey I. Everitt, Darin A. Knaus, Jed C. Wilbur & Richard E. Moon. (2022) Safety evaluation of carbon tetrafluoride as an inert hyperbaric breathing gas in Sprague-Dawley rats. Toxicology and Applied Pharmacology 444, pages 116023.
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Paschalis Steiropoulos, Petros Bakakos, Elpis Hatziagorou, Paraskevi Katsaounou, Stelios Loukides, Andriana Papaioannou, Konstantinos Porpodis, Konstantinos Samaras, Argyrios Tzouvelekis, Konstantinos Kalafatakis & Konstantinos Kostikas. (2021) The present and future of inhalation therapy for the management of obstructive airway diseases: Emphasis on pressurized metered-dose inhalers. Pneumon, pages 1-13.
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Adam J. Plaunt, Sadikul Islam, Tony Macaluso, Helena Gauani, Thomas Baker, Donald Chun, Veronica Viramontes, Christina Chang, Michel R. Corboz, Richard W. Chapman, Zhili Li, David C. Cipolla, Walter R. Perkins & Vladimir S. Malinin. (2021) Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension. International Journal of Molecular Sciences 22:2, pages 548.
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Wenhua Wang, Zhengwei Huang, Ke Xue, Jiaye Li, Wenhao Wang, Jingyi Ma, Cheng Ma, Xuequn Bai, Ying Huang, Xin Pan & Chuanbin Wu. (2020) Development of Aggregation-Caused Quenching Probe-Loaded Pressurized Metered-Dose Inhalers with Fluorescence Tracking Potentials. AAPS PharmSciTech 21:8.
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Yuan He, Yingmin Liang, Run Han, Wan-Liang Lu, Judith Choi Wo Mak & Ying Zheng. (2019) Rational particle design to overcome pulmonary barriers for obstructive lung diseases therapy. Journal of Controlled Release 314, pages 48-61.
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Qian Zhong, Bruno V. Humia, Alisha R. Punjabi, Francine F. Padilha & Sandro R.P. da Rocha. (2017) The interaction of dendrimer-doxorubicin conjugates with a model pulmonary epithelium and their cosolvent-free, pseudo-solution formulations in pressurized metered-dose inhalers. European Journal of Pharmaceutical Sciences 109, pages 86-95.
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