2,692
Views
107
CrossRef citations to date
0
Altmetric
Review Article

Aqueous solubility of crystalline and amorphous drugs: Challenges in measurement

, , &
Pages 187-200 | Received 12 Aug 2009, Accepted 12 Mar 2010, Published online: 30 Apr 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Dipak Kumar Gupta, Mohd Humair Ali, Asad Ali, Pooja Jain, Md. Khalid Anwer, Zeenat Iqbal & Mohd. Aamir Mirza. (2022) 3D printing technology in healthcare: applications, regulatory understanding, IP repository and clinical trial status. Journal of Drug Targeting 30:2, pages 131-150.
Read now
Jyotsana R. Madan, Kajal Patil, Rajendra Awasthi & Kamal Dua. (2021) Formulation and evaluation of solid self-microemulsifying drug delivery system for azilsartan medoxomil. International Journal of Polymeric Materials and Polymeric Biomaterials 70:2, pages 100-116.
Read now
Melissa Wallis, Zaisam Al-Dulimi, Deck Khong Tan, Mohammed Maniruzzaman & Ali Nokhodchi. (2020) 3D printing for enhanced drug delivery: current state-of-the-art and challenges. Drug Development and Industrial Pharmacy 46:9, pages 1385-1401.
Read now
Seyed Mohammad Mousavi, Alireza Milajerdi, Hamed Kord Varkaneh, Mohammad Mohsen Gorjipour & Ahmad Esmaillzadeh. (2020) The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition 60:1, pages 171-180.
Read now
Ardita Veseli, Simon Žakelj & Albin Kristl. (2019) A review of methods for solubility determination in biopharmaceutical drug characterization. Drug Development and Industrial Pharmacy 45:11, pages 1717-1724.
Read now
Mitra Hariri & Fahimeh Haghighatdoost. (2018) Effect of Curcumin on Anthropometric Measures: A Systematic Review on Randomized Clinical Trials. Journal of the American College of Nutrition 37:3, pages 215-222.
Read now
Ying-Yuan Lu, Wen-Bing Dai, Xin Wang, Xiao-Wei Wang, Jun-Yi Liu, Pu Li, Ya-Qing Lou, Chuang Lu, Qiang Zhang & Guo-Liang Zhang. (2018) Effects of crystalline state and self-nanoemulsifying drug delivery system (SNEDDS) on oral bioavailability of the novel anti-HIV compound 6-benzyl-1-benzyloxymethyl-5-iodouracil in rats. Drug Development and Industrial Pharmacy 44:2, pages 329-337.
Read now
Andrea Salis, Elena P. Porcu, Elisabetta Gavini, Giulia R. Fois, Antonia Icaro Cornaglia, Giovanna Rassu, Marco Diana, Marcello Maestri, Paolo Giunchedi & Ioannis Nikolakakis. (2017) In situ forming biodegradable poly(ε-caprolactone) microsphere systems: a challenge for transarterial embolization therapy. In vitro and preliminary ex vivo studies. Expert Opinion on Drug Delivery 14:4, pages 453-465.
Read now
Shashank Jain, Niketkumar Patel & Senshang Lin. (2015) Solubility and dissolution enhancement strategies: current understanding and recent trends. Drug Development and Industrial Pharmacy 41:6, pages 875-887.
Read now
A. Gianfrancesco, C. Smarrito-Menozzi, G. Niederreiter & S. Palzer. (2012) Developing Supra-Molecular Structures During Freeze-Drying of Food. Drying Technology 30:11-12, pages 1160-1166.
Read now

Articles from other publishers (97)

Paola A. Mura, Marzia Cirri, Alan Rossetti, Daniel A. Allemandi, Alejandro J. Paredes & Santiago D. Palma. (2023) Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods. Journal of Drug Delivery Science and Technology, pages 105222.
Crossref
Julia L. Shamshina & Robin D. Rogers. (2023) Ionic Liquids: New Forms of Active Pharmaceutical Ingredients with Unique, Tunable Properties. Chemical Reviews 123:20, pages 11894-11953.
Crossref
Ackmez Mudhoo & Charles U. PittmanJr.Jr.. (2023) The Dubinin-Radushkevich models: Dissecting the p/p to c/c replacement in solid-aqueous interfacial adsorption and tracking the validity of E = 8 kJ mol–1 for assigning sorption type. Chemical Engineering Research and Design 198, pages 370-402.
Crossref
Arushi Manchanda, Mustafa Bookwala, Peter L. D. Wildfong & Robin H. Bogner. (2023) Effect of Structurally Related Compounds on Desupersaturation Kinetics of Indomethacin. Pharmaceutical Research.
Crossref
Daiki Nagamatsu, Shigeru Ando, Yuko Fujimura, Tetsuya Miyano, Katsuji Sugita & Hiroshi Ueda. (2023) Formation of Hemihydrate Crystal form Overcomes Milling Issue Induced by Exposed Functional Groups on Cleavage Plane for a Y5 Receptor Antagonist of Neuropeptide Y. Journal of Pharmaceutical Sciences 112:9, pages 2516-2523.
Crossref
Matthew N. O'Brien Laramy, Padmavani Bezawada, Reto Horst, Rohit Jaini, Jonathan Lillis, Yizhou Liu, Suman Luthra, Bao Nguyen, Nandini Patel, Smita Soni, Bradley P. Sullivan, Andrew Thiel & Martyn D. Ticehurst. (2023) Self-Assembly Properties of an Amphiphilic Phosphate Ester Prodrug Designed for the Treatment of COVID-19. Journal of Pharmaceutical Sciences.
Crossref
Anand Kumar Meka, Akshatha Gopalakrishna, Claudia Iriarte-Mesa, Prarthana Rewatkar, Zhi Qu, Xiaoxin Wu, Yuxue Cao, Indira Prasadam, Taskeen Iqbal Janjua, Freddy Kleitz, Tushar Kumeria & Amirali Popat. (2023) Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the Solubility and Antioxidant Activity of Confined Coenzyme Q10. Molecular Pharmaceutics 20:6, pages 2966-2977.
Crossref
Chenglong Deng, Li Liang, Guomeng Xing, Yi Hua, Tao Lu, Yanmin Zhang, Yadong Chen & Haichun Liu. (2022) Multi-channel GCN ensembled machine learning model for molecular aqueous solubility prediction on a clean dataset. Molecular Diversity 27:3, pages 1023-1035.
Crossref
Xiangwei Zhu, Valery R. Polyakov, Krishna Bajjuri, Huiyong Hu, Andreas Maderna, Clare A. ToveeSuzanna C. Ward. (2023) Building Machine Learning Small Molecule Melting Points and Solubility Models Using CCDC Melting Points Dataset. Journal of Chemical Information and Modeling 63:10, pages 2948-2959.
Crossref
Prakash Khadka, Ian G. Tucker & Shyamal C. Das. (2022) In vitro Dissolution Testing of Rifampicin Powder Formulations For Prediction of Plasma Concentration–Time Profiles After Inhaled Delivery. Pharmaceutical Research 40:5, pages 1153-1163.
Crossref
Yi Zhang, Himali Balasooriya, Sameera Sirisena & Ken Ng. (2023) The effectiveness of dietary polyphenols in obesity management: A systematic review and meta-analysis of human clinical trials. Food Chemistry 404, pages 134668.
Crossref
Roman Svoboda, Nicola Koutná, Daniela Košťálová, Miloš Krbal & Alena Komersová. (2023) Indomethacin: Effect of Diffusionless Crystal Growth on Thermal Stability during Long-Term Storage. Molecules 28:4, pages 1568.
Crossref
Andrew M. Davis & Paul D. Leeson. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry 1 39 .
Jared S. Wood, Guilherme Dal Poggetto, Xiao Wang, Mikhail Reibarkh, R. Thomas Williamson & Ryan D. Cohen. (2022) Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach. Magnetic Resonance in Chemistry 61:1, pages 22-31.
Crossref
Sina Majidi, Jebrail Movaffagh, Hossein Kamali, Azadeh Shahroodi, Mohsen Tafaghodi & Davoud Salarbashi. (2022) Development and characterization of sumatriptan-loaded soy bean polysaccharide nanofiber using electrospinning technique. Journal of Drug Delivery Science and Technology 78, pages 103940.
Crossref
Marina Chachorovska, Gjorgji Petrushevski, Monika Stojanovska Pecova, Sonja Ugarkovic & Petre Makreski. (2022) Thermal analysis assisted by spectra-structure studies of BCS class II active pharmaceutical ingredients: ezetimibe and lercanidipine hydrochloride. The concept of preformulation. Journal of Thermal Analysis and Calorimetry 147:16, pages 8779-8790.
Crossref
Mori Dhaval, Poonam Vaghela, Kajal Patel, Keshvi Sojitra, Mohini Patel, Sushma Patel, Kiran Dudhat, Sunny Shah, Ravi Manek & Ramesh Parmar. (2021) Lipid-based emulsion drug delivery systems — a comprehensive review. Drug Delivery and Translational Research 12:7, pages 1616-1639.
Crossref
Inês C. B. Martins, Andreia Forte, Hermínio P. Diogo, Luís R. Raposo, Pedro V. Baptista, Alexandra R. Fernandes, Luís C. Branco & M. Teresa Duarte. (2022) A Solvent‐free Strategy to Prepare Amorphous Salts of Folic Acid with Enhanced Solubility and Cell Permeability. Chemistry–Methods 2:6.
Crossref
Meshal Alshamrani, Muhammad Khalid Khan, Barkat Ali Khan, Ahmad Salawi & Yosif Almoshari. (2022) Technologies for Solubility, Dissolution and Permeation Enhancement of Natural Compounds. Pharmaceuticals 15:6, pages 653.
Crossref
Monica R. P. Rao, Sharwari Sapate & Ashwini Sonawane. (2022) Pharmacotechnical Evaluation by SeDeM Expert System to Develop Orodispersible Tablets. AAPS PharmSciTech 23:5.
Crossref
Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh & Amit S. Kalgutkar. (2022) Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans. Drug Metabolism and Disposition 50:5, pages 576-590.
Crossref
Md Sajjadur Rahman, Jennifer Kyeremateng, Mousumi Saha, Sampson Asare, Nizam Uddin, Mohammad A. Halim & Douglas E. Raynie. (2022) Evaluation of the experimental and computed properties of choline chloride-water formulated deep eutectic solvents. Journal of Molecular Liquids 350, pages 118520.
Crossref
M Vertzoni, J Alsenz, P Augustijns, A Bauer-Brandl, CAS Bergström, J Brouwers, A Müllerz, G Perlovich, C Saal, K Sugano & C Reppas. (2022) UNGAP best practice for improving solubility data quality of orally administered drugs. European Journal of Pharmaceutical Sciences 168, pages 106043.
Crossref
Sofia Valenti, Luis del Valle, Omid Yousefzade, Roberto Macovez, Lourdes Franco & Jordi Puiggalí. (2021) Chloramphenicol loaded polylactide melt electrospun scaffolds for biomedical applications. International Journal of Pharmaceutics 606, pages 120897.
Crossref
Xiomara López-Legarda, Magdalena Rostro-Alanis, Roberto Parra-Saldivar, Janny A. Villa-Pulgarín & Freimar Segura-Sánchez. (2021) Submerged cultivation, characterization and in vitro antitumor activity of polysaccharides from Schizophyllum radiatum. International Journal of Biological Macromolecules 186, pages 919-932.
Crossref
Shridhar H. ThoratChristy P. GeorgeParth S. Shaligram, Suresha P. R. & Rajesh G. Gonnade. (2021) Polymorphs and hydrates of the anticancer drug erlotinib: X-ray crystallography, phase transition and biopharmaceutical studies. CrystEngComm 23:22, pages 3961-3974.
Crossref
Cecilie Maria Madsen, Jakob Plum, Bart Hens, Patrick Augustijns, Anette Müllertz & Thomas Rades. (2021) Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol. Journal of Pharmaceutical Sciences 110:6, pages 2479-2488.
Crossref
Roni Sverdlov Arzi, Asaf Kay, Yulia Raychman & Alejandro Sosnik. (2021) Excipient-Free Pure Drug Nanoparticles Fabricated by Microfluidic Hydrodynamic Focusing. Pharmaceutics 13:4, pages 529.
Crossref
Richard S. Hong, Alessandra Mattei, Ahmad Y. Sheikh, Rajni Miglani Bhardwaj, Michael A. Bellucci, Keith F. McDaniel, M. Olivia Pierce, Guangxu Sun, Sizhu Li, Lingle Wang, Sayan Mondal, Jianguo Ji & Thomas B. Borchardt. (2021) Novel Physics-Based Ensemble Modeling Approach That Utilizes 3D Molecular Conformation and Packing to Access Aqueous Thermodynamic Solubility: A Case Study of Orally Available Bromodomain and Extraterminal Domain Inhibitor Lead Optimization Series. Journal of Chemical Information and Modeling 61:3, pages 1412-1426.
Crossref
Farah J. Alsharif & Yara A. Almuhtadi. (2021) The Effect of Curcumin Supplementation on Anthropometric Measures among Overweight or Obese Adults. Nutrients 13:2, pages 680.
Crossref
Harsha Jain & Naveen Chella. (2020) Methods to improve the solubility of therapeutical natural products: a review. Environmental Chemistry Letters 19:1, pages 111-121.
Crossref
Murat Cihan Sorkun, J.M. Vianney A. Koelman & Süleyman Er. (2021) Pushing the limits of solubility prediction via quality-oriented data selection. iScience 24:1, pages 101961.
Crossref
Hanlu Gao, Wei Wang, Jie Dong, Zhuyifan Ye & Defang Ouyang. (2021) An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design. European Journal of Pharmaceutics and Biopharmaceutics 158, pages 336-346.
Crossref
Raj Schneider, Jana Kerkhoff, Andreas Danzer, Amelie Mattusch, Andrijan Ohmann, Markus Thommes & Gabriele Sadowski. (2020) The interplay of dissolution, solution crystallization and solid-state transformation of amorphous indomethacin in aqueous solution. International Journal of Pharmaceutics: X 2, pages 100063.
Crossref
Xiomara López-Legarda, Carolina Arboleda-Echavarría, Roberto Parra-Saldívar, Magdalena Rostro-Alanis, Juan F. Alzate, Janny A. Villa-Pulgarín & Freimar Segura-Sánchez. (2020) Biotechnological production, characterization and in vitro antitumor activity of polysaccharides from a native strain of Lentinus crinitus. International Journal of Biological Macromolecules 164, pages 3133-3144.
Crossref
Zahra Al-Sahaf, Bahijja Raimi-Abraham, Mariano Licciardi & Laura Modica de Mohac. (2020) Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA) Microcrystalline Solid Dispersion Films. AAPS PharmSciTech 21:7.
Crossref
Kuthuru Suresh, Vilmalí López-Mejías, Saikat Roy, Daniel F. Camacho & Adam J. Matzger. (2020) Leveraging Framework Instability: A Journey from Energy Storage to Drug Delivery. Synlett 31:16, pages 1573-1580.
Crossref
Giovana Carolina Bazzo, Bianca Ramos Pezzini & Hellen Karine Stulzer. (2020) Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs. International Journal of Pharmaceutics 588, pages 119741.
Crossref
Hiroshi Ueda, Johan Peter Bøtker, Magnus Edinger, Korbinian Löbmann, Holger Grohganz, Anette Müllertz, Thomas Rades & Jesper Østergaard. (2020) Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy. International Journal of Pharmaceutics 587, pages 119662.
Crossref
Alain Murhimalika Bapolisi, Christian Isalomboto Nkanga, Roderick Bryan Walker & Rui Werner Maçedo Krause. (2020) Simultaneous liposomal encapsulation of antibiotics and proteins: Co-loading and characterization of rifampicin and Human Serum Albumin in soy-liposomes. Journal of Drug Delivery Science and Technology 58, pages 101751.
Crossref
D. Gobbo, P. Ballone, S. Decherchi & A. Cavalli. (2020) Solubility Advantage of Amorphous Ketoprofen. Thermodynamic and Kinetic Aspects by Molecular Dynamics and Free Energy Approaches. Journal of Chemical Theory and Computation 16:7, pages 4126-4140.
Crossref
Lesego L. Tshweu, Mohamed A. Shemis, Aya Abdelghany, Abdullah Gouda, Lynne A. Pilcher, Nicole R. S. Sibuyi, Mervin Meyer, Admire Dube & Mohammed O. Balogun. (2020) Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin. RSC Advances 10:34, pages 19770-19780.
Crossref
Xiaojun Feng, Lei Zhang, Suowen Xu & Ai-zong Shen. (2020) ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review. Progress in Lipid Research 77, pages 101006.
Crossref
Priyanka Shit & Haider Banka. 2020. Big Data, Machine Learning, and Applications. Big Data, Machine Learning, and Applications 14 24 .
Arushi Manchanda, Mary S. Kleppe & Robin H. Bogner. (2019) Nuances in the Calculation of Amorphous Solubility Enhancement Ratio. Journal of Pharmaceutical Sciences 108:11, pages 3560-3574.
Crossref
Michael Gruss. 2019. Innovative Dosage Forms. Innovative Dosage Forms 155 207 .
Sofia Valenti, Angelica Diaz, Michela Romanini, Luis Javier del Valle, Jordi Puiggalí, Josep Lluis Tamarit & Roberto Macovez. (2019) Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: Morphology, molecular relaxations, and controlled drug release. International Journal of Pharmaceutics 568, pages 118565.
Crossref
B.L.A. Costa, M. Sauceau, S. Del Confetto, R. Sescousse & M.I. Ré. (2019) Determination of drug-polymer solubility from supersaturated spray-dried amorphous solid dispersions: A case study with Efavirenz and Soluplus®. European Journal of Pharmaceutics and Biopharmaceutics 142, pages 300-306.
Crossref
David Hespeler, Sanaa El Nomeiri, Jonas Kaltenbach & Rainer H Müller. (2019) Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products. Beilstein Journal of Nanotechnology 10, pages 1666-1678.
Crossref
Sheida Khajir, Ali Shayanfar, William E. AcreeJr.Jr. & Abolghasem Jouyban. (2019) Effects of N-methylpyrrolidone and temperature on phenytoin solubility. Journal of Molecular Liquids 285, pages 58-61.
Crossref
Siamak Javanbakht & Ahmad Shaabani. (2019) Carboxymethyl cellulose-based oral delivery systems. International Journal of Biological Macromolecules 133, pages 21-29.
Crossref
Jernej Štukelj, Sami Svanbäck, Mikael Agopov, Korbinian Löbmann, Clare J. Strachan, Thomas Rades & Jouko Yliruusi. (2019) Direct Measurement of Amorphous Solubility. Analytical Chemistry 91:11, pages 7411-7417.
Crossref
Nandkishor K. Nere, Manish S. Kelkar, Ann M. Czyzewski, Kushal Sinha & Evelina B. Kim. 2019. Chemical Engineering in the Pharmaceutical Industry. Chemical Engineering in the Pharmaceutical Industry 591 616 .
Joaquim J. Moura Ramos, M. Fátima M. Piedade, Hermínio P. Diogo & M. Teresa Viciosa. (2019) Thermal Behavior and Slow Relaxation Dynamics in Amorphous Efavirenz: A Study by DSC, XRPD, TSDC, and DRS. Journal of Pharmaceutical Sciences 108:3, pages 1254-1263.
Crossref
Oleg A. Raevsky, Veniamin Y. Grigorev, Daniel E. Polianczyk, Olga E. Raevskaja & John C. Dearden. (2019) Aqueous Drug Solubility: What Do We Measure, Calculate and QSPR Predict?. Mini-Reviews in Medicinal Chemistry 19:5, pages 362-372.
Crossref
Sofia Valenti, Michela Romanini, Lourdes Franco, Jordi Puiggalí, Josep Lluis Tamarit & Roberto Macovez. (2018) Tuning the Kinetic Stability of the Amorphous Phase of the Chloramphenicol Antibiotic. Molecular Pharmaceutics 15:12, pages 5615-5624.
Crossref
Sama Ghalei, Hamid Asadi & Behnam Ghalei. (2018) Zein nanoparticle-embedded electrospun PVA nanofibers as wound dressing for topical delivery of anti-inflammatory diclofenac. Journal of Applied Polymer Science 135:33, pages 46643.
Crossref
Atheer Awad, Sarah J. Trenfield, Simon Gaisford & Abdul W. Basit. (2018) 3D printed medicines: A new branch of digital healthcare. International Journal of Pharmaceutics 548:1, pages 586-596.
Crossref
Hale Cigdem Arca, Laura I. Mosquera-Giraldo, Vivian Bi, Daiqiang Xu, Lynne S. Taylor & Kevin J. Edgar. (2018) Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters. Biomacromolecules 19:7, pages 2351-2376.
Crossref
Alamelu Banda, Arushi Manchanda, Wei Zhang, Grace May Alba & Karthik Nagapudi. (2018) Comparative Assessment of Miniaturized Screening Approaches for Selection of Polymers for Amorphous Drug Stabilization. Journal of Pharmaceutical Sciences 107:3, pages 897-908.
Crossref
Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz & Marian PaluchMarzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz & Marian Paluch. 2018. Amorphous Drugs. Amorphous Drugs 1 7 .
Si Qin, Lifan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Hong Ren & Huaidong Hu. (2017) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutrition Journal 16:1.
Crossref
Arjun Kalra, Patrick Tishmack, Joseph W. Lubach, Eric J. Munson, Lynne S. Taylor, Stephen R. Byrn & Tonglei Li. (2017) Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State. Molecular Pharmaceutics 14:6, pages 2126-2137.
Crossref
Sawani G. Khare, Sunil K. Jena, Abhay T. Sangamwar, Sadhika Khullar & Sanjay K. Mandal. (2017) Multicomponent Pharmaceutical Adducts of α-Eprosartan: Physicochemical Properties and Pharmacokinetic Study. Crystal Growth & Design 17:4, pages 1589-1599.
Crossref
Mei Wong & Mark McAllister. 2017. Oral Formulation Roadmap from Early Drug Discovery to Development. Oral Formulation Roadmap from Early Drug Discovery to Development 9 37 .
Yue Xu, Shu-Ping Wu, Xi-Jian Liu, Li-Juan Zhang & Jie Lu. (2017) Crystal characterization and transformation of the forms I and II of anticoagulant drug rivaroxaban. Crystal Research and Technology 52:3, pages 1600379.
Crossref
Xiaolong Tao, Baohong Hou, Xiaoxue Hu, Fuli Zhou, Haijiao Lu, Ting Wang, Jiangfeng Zhao & Hongxun Hao. (2016) Measurement and Correlation of Solubility of Amorphous Cefmetazole Sodium in Pure Solvents and Binary Solvent Mixtures. Journal of Chemical & Engineering Data 62:1, pages 398-406.
Crossref
A. Newman. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 497 518 .
Elsa Gorre & Kevin G. Owens. (2016) Microscale Solubility Measurements of Matrix-Assisted Laser Desorption–Ionization (MALDI) Matrices Using Attenuated Total Reflection (ATR) Fourier Transform Infrared Spectroscopy (FT-IR) Coupled with Partial Least Squares (PLS) Analysis. Applied Spectroscopy 70:11, pages 1831-1841.
Crossref
Sepideh Rahmani, Sedigheh Asgary, Gholamreza Askari, Mahtab Keshvari, Mahdi Hatamipour, Awat Feizi & Amirhossein Sahebkar. (2016) Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial. Phytotherapy Research 30:9, pages 1540-1548.
Crossref
Matthias Manne Knopp, Nabil Chourak, Fauzan Khan, Johan Wendelboe, Peter Langguth, Thomas Rades & René Holm. (2016) Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics 105, pages 106-114.
Crossref
Lynne S. Taylor & Geoff G.Z. Zhang. (2016) Physical chemistry of supersaturated solutions and implications for oral absorption. Advanced Drug Delivery Reviews 101, pages 122-142.
Crossref
Luis Almeida e Sousa, Susan M. Reutzel-Edens, Gregory A. Stephenson & Lynne S. Taylor. (2016) Supersaturation Potential of Salt, Co-Crystal, and Amorphous Forms of a Model Weak Base. Crystal Growth & Design 16:2, pages 737-748.
Crossref
Roberta Censi & Piera Di Martino. (2015) Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs. Molecules 20:10, pages 18759-18776.
Crossref
Andrew J. D. Magenau, Jeffrey A. Richards, Melissa A. Pasquinelli, Daniel A. Savin & Robert T. Mathers. (2015) Systematic Insights from Medicinal Chemistry To Discern the Nature of Polymer Hydrophobicity. Macromolecules 48:19, pages 7230-7236.
Crossref
Raphael Paus, Yuanhui Ji, Lisa Vahle & Gabriele Sadowski. (2015) Predicting the Solubility Advantage of Amorphous Pharmaceuticals: A Novel Thermodynamic Approach. Molecular Pharmaceutics 12:8, pages 2823-2833.
Crossref
M. Fátima Pina, João F. Pinto, João J. Sousa, Duncan Q.M. Craig & Min Zhao. (2015) Generation of hydrate forms of paroxetine HCl from the amorphous state: An evaluation of thermodynamic and experimental predictive approaches. International Journal of Pharmaceutics 481:1-2, pages 114-124.
Crossref
Grace A. Ilevbare, Wei Xu, Christopher T. John, James D. Ormes, Jesse L. Kuiper, Allen C. Templeton & Annette Bak. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 41 .
Harvey Lieberman & N. Murti Vemuri. 2015. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 767 791 .
Grace Ilevbare, Patrick Marsac & Amitava Mitra. 2015. Discovering and Developing Molecules with Optimal Drug-Like Properties. Discovering and Developing Molecules with Optimal Drug-Like Properties 287 343 .
D.N. Nguyen & G. Van den Mooter. (2014) The fate of ritonavir in the presence of darunavir. International Journal of Pharmaceutics 475:1-2, pages 214-226.
Crossref
Ursula Thormann, Maria De Mieri, Markus Neuburger, Sheela Verjee, Peter Altmann, Matthias Hamburger & Georgios Imanidis. (2014) Mechanism of Chemical Degradation and Determination of Solubility by Kinetic Modeling of the Highly Unstable Sesquiterpene Lactone Nobilin in Different Media. Journal of Pharmaceutical Sciences 103:10, pages 3139-3152.
Crossref
Hala M. Fadda, Xin Chen, Aktham Aburub, Dinesh Mishra & Rodolfo Pinal. (2014) A Novel Method for Determining the Solubility of Small Molecules in Aqueous Media and Polymer Solvent Systems Using Solution Calorimetry. Pharmaceutical Research 31:7, pages 1735-1743.
Crossref
Christel A.S. Bergström, René Holm, Søren Astrup Jørgensen, Sara B.E. Andersson, Per Artursson, Stefania Beato, Anders Borde, Karl Box, Marcus Brewster, Jennifer Dressman, Kung-I. Feng, Gavin Halbert, Edmund Kostewicz, Mark McAllister, Uwe Muenster, Julian Thinnes, Robert Taylor & Anette Mullertz. (2014) Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs. European Journal of Pharmaceutical Sciences 57, pages 173-199.
Crossref
Annika Sarnes, Miia Kovalainen, Merja R. Häkkinen, Timo Laaksonen, Johanna Laru, Juha Kiesvaara, Jukka Ilkka, Olli Oksala, Seppo Rönkkö, Kristiina Järvinen, Jouni Hirvonen & Leena Peltonen. (2014) Nanocrystal-based per-oral itraconazole delivery: Superior in vitro dissolution enhancement versus Sporanox® is not realized in in vivo drug absorption. Journal of Controlled Release 180, pages 109-116.
Crossref
Ali Shayanfar, Sitaram Velaga & Abolghasem Jouyban. (2014) Solubility of carbamazepine, nicotinamide and carbamazepine–nicotinamide cocrystal in ethanol–water mixtures. Fluid Phase Equilibria 363, pages 97-105.
Crossref
Dajun D. Sun & Ping I. Lee. (2013) Evolution of Supersaturation of Amorphous Pharmaceuticals: The Effect of Rate of Supersaturation Generation. Molecular Pharmaceutics 10:11, pages 4330-4346.
Crossref
David Elder & René Holm. (2013) Aqueous solubility: Simple predictive methods (in silico, in vitro and bio-relevant approaches). International Journal of Pharmaceutics 453:1, pages 3-11.
Crossref
E. Mikhailov, S. Vlasenko, D. Rose & U. Pöschl. (2013) Mass-based hygroscopicity parameter interaction model and measurement of atmospheric aerosol water uptake. Atmospheric Chemistry and Physics 13:2, pages 717-740.
Crossref
Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman, Ravi M. Shanker, William N. Charman, Colin W. Pouton & Christopher J. H. Porter. (2013) Strategies to Address Low Drug Solubility in Discovery and Development. Pharmacological Reviews 65:1, pages 315-499.
Crossref
H. Grohganz, K. Löbmann, P. Priemel, K. Tarp Jensen, K. Graeser, C. Strachan & T. Rades. (2013) Amorphous drugs and dosage forms. Journal of Drug Delivery Science and Technology 23:4, pages 403-408.
Crossref
Kristyn Greco & Robin Bogner. (2012) Solution-Mediated Phase Transformation: Significance During Dissolution and Implications for Bioavailability. Journal of Pharmaceutical Sciences 101:9, pages 2996-3018.
Crossref
Jie Wang & Edmund Matayoshi. (2012) Solubility at the Molecular Level: Development of a Critical Aggregation Concentration (CAC) Assay for Estimating Compound Monomer Solubility. Pharmaceutical Research 29:7, pages 1745-1754.
Crossref
Devendra Singh, M. S. M. Rawat, Ajay Semalty & Mona Semalty. (2011) Emodin–phospholipid complex. Journal of Thermal Analysis and Calorimetry 108:1, pages 289-298.
Crossref
Sharad B. Murdande, Michael J. Pikal, Ravi M. Shanker & Robin H. Bogner. (2012) ChemInform Abstract: Aqueous Solubility of Crystalline and Amorphous Drugs: Challenges in Measurement. ChemInform 43:10.
Crossref
David E. Alonzo, Yi Gao, Deliang Zhou, Huaping Mo, Geoff G.Z. Zhang & Lynne S. Taylor. (2011) Dissolution and Precipitation Behavior of Amorphous Solid Dispersions. Journal of Pharmaceutical Sciences 100:8, pages 3316-3331.
Crossref
Sharad B. Murdande, Michael J. Pikal, Ravi M. Shanker & Robin H. Bogner. (2010) Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals. Pharmaceutical Research 27:12, pages 2704-2714.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.