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Pharmaceutical Development and Technology Volume 1, 1996 - Issue 2
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Research Article

Water-Solid Interactions. III. Effect of Glass Transition Temperature, Tg, and Processing on Tensile Strength of Compacts of Lactose and Lactose/Polyvinyl Pyrrolidone

Lars Stubberud Pharmaceutical R&D, Astra Läkemedel AB, S-151 85, Södertälje, Sweden; Institute of Pharmacy, University of Oslo, N-0316, Oslo, Norway
,
Hans G. Arwidsson Pharmaceutical R&D, Astra Läkemedel AB, S-151 85, Södertälje, Sweden
,
Victoria Hjortsberg Department of Pharmaceutics, Uppsala Biomedical Center, Uppsala University, S-751 23, Uppsala, Sweden
&
Christina Graffner Pharmaceutical R&D, Astra Läkemedel AB, S-151 85, Södertälje, Sweden; Institute of Pharmacy, University of Oslo, N-0316, Oslo, Norway
Pages 195-204 | Received 13 Feb 1996, Accepted 24 Apr 1996, Published online: 27 Sep 2008

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John Rojas, Ira Buckner & Vijay Kumar. (2012) Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance. Drug Development and Industrial Pharmacy 38:10, pages 1159-1170.
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Paul M. Young, Herbert Chiou, Terrance Tee, Daniela Traini, Hak-Kim Chan, Frank Thielmann & Dan Burnett. (2007) The Use of Organic Vapor Sorption to Determine Low Levels of Amorphous Content in Processed Pharmaceutical Powders. Drug Development and Industrial Pharmacy 33:1, pages 91-97.
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Michael A. Repka & James W. McGinity. (2001) Influence of Chlorpheniramine Maleate on Topical Hydroxypropylcellulose Films Produced by Hot-Melt Extrusion. Pharmaceutical Development and Technology 6:3, pages 297-304.
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Hirofumi Takeuchi, Takehiko Yasuji, Hiromitsu Yamamoto & Yoshiaki Kawashima. (2000) Temperature- and Moisture-Induced Crystallization of Amorphous Lactose in Composite Particles with Sodium Alginate Prepared by Spray-Drying. Pharmaceutical Development and Technology 5:3, pages 355-363.
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Michael A. Repka, Thomas G. Gerding, Staci L. Repka & James W. McGinity. (1999) Influence of Plasticizers and Drugs on the Physical-Mechanical Properties of Hydroxypropylcellulose Films Prepared by Hot Melt Extrusion. Drug Development and Industrial Pharmacy 25:5, pages 625-633.
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Lars Stubberud, Maria Eriksson, Kamran Kordnejad & Christina Graffner. (1998) Water-Solid Interactions. IV. Influence of Moisture Sorption on the Compaction of Film-Coated Particles. Pharmaceutical Development and Technology 3:2, pages 141-151.
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Articles from other publishers (15)

Hirofumi Takeuchi. (2022) Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms. KONA Powder and Particle Journal 39:0, pages 150-175.
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Manjeet B. Pimparade, Anh Vo, Abhijeet S. Maurya, Jungeun Bae, Joseph T. Morott, Xin Feng, Dong Wuk Kim, Vijay I. Kulkarni, Roshan Tiwari, K. Vanaja, Reena Murthy, H.N. Shivakumar, D. Neupane, S.R. Mishra, S.N. Murthy & Michael A. Repka. (2017) Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology. European Journal of Pharmaceutics and Biopharmaceutics 119, pages 81-90.
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Siyuan Huang, Kevin P. O'Donnell, Sophie M. Delpon de Vaux, John O'Brien, John Stutzman & Robert O. WilliamsIIIIII. (2017) Processing thermally labile drugs by hot-melt extrusion: The lesson with gliclazide. European Journal of Pharmaceutics and Biopharmaceutics 119, pages 56-67.
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M. Sacchetti, R. Teerakapibal, K. Kim & E. J. ElderJr.Jr.. (2017) Role of Water Sorption in Tablet Crushing Strength, Disintegration, and Dissolution. AAPS PharmSciTech 18:6, pages 2214-2226.
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A. Jarray, V. Gerbaud & M. Hemati. (2016) Polymer-plasticizer compatibility during coating formulation: A multi-scale investigation. Progress in Organic Coatings 101, pages 195-206.
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Saad M. Alshahrani, Joseph T. Morott, Abdullah S. Alshetaili, Roshan V. Tiwari, Soumyajit Majumdar & Michael A. Repka. (2015) Influence of degassing on hot-melt extrusion process. European Journal of Pharmaceutical Sciences 80, pages 43-52.
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John Rojas. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 589 612 .
Ariana Qiao Jun Low, Johannes Parmentier, Yuet Mei Khong, Cherry Chang Er Chai, Thin Yu Tun, Jacqueline E. Berania, Xueming Liu, Rajeev Gokhale & Sui Yung Chan. (2013) Effect of type and ratio of solubilising polymer on characteristics of hot-melt extruded orodispersible films. International Journal of Pharmaceutics 455:1-2, pages 138-147.
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Y. Listiohadi, J.A. Hourigan, R.W. Sleigh & R.J. Steele. (2008) Moisture sorption, compressibility and caking of lactose polymorphs. International Journal of Pharmaceutics 359:1-2, pages 123-134.
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Ines Zurdo Schroeder, Patrick Franke, Ulrich F. Schaefer & Claus-Michael Lehr. (2007) Development and characterization of film forming polymeric solutions for skin drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 65:1, pages 111-121.
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E.I. Keleb, A. Vermeire, C. Vervaet & J.P. Remon. (2004) Single-step granulation/tabletting of different grades of lactose: a comparison with high shear granulation and compression. European Journal of Pharmaceutics and Biopharmaceutics 58:1, pages 77-82.
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M.E.C. Thomas, J. Scher & S. Desobry. (2004) Lactose/β-Lactoglobulin Interaction During Storage of Model Whey Powders. Journal of Dairy Science 87:5, pages 1158-1166.
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Shaun Fitzpatrick, James F McCabe, Catherine R Petts & Steven W Booth. (2002) Effect of moisture on polyvinylpyrrolidone in accelerated stability testing. International Journal of Pharmaceutics 246:1-2, pages 143-151.
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Michael A. Repka & James W. McGinity. (2000) Physical–mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films. Biomaterials 21:14, pages 1509-1517.
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Lars Stubberud & Robert T Forbes. (1998) The use of gravimetry for the study of the effect of additives on the moisture-induced recrystallisation of amorphous lactose. International Journal of Pharmaceutics 163:1-2, pages 145-156.
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