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Prehospital Emergency Care Volume 16, 2012 - Issue 2
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Preliminary Reports

Can Nebulized Naloxone Be Used Safely and Effectively by Emergency Medical Services for Suspected Opioid Overdose?

Joseph M. WeberFrom the Department of Emergency Medicine, Cook County Hospital (JMW, KLT, SEA, MBM), Chicago, Illinois; and the Chicago Fire Department, Emergency Medical Services (JDH), Chicago, Illinois.Correspondence[email protected]
, MD,
Katie L. TatarisFrom the Department of Emergency Medicine, Cook County Hospital (JMW, KLT, SEA, MBM), Chicago, Illinois; and the Chicago Fire Department, Emergency Medical Services (JDH), Chicago, Illinois.
, MD,
Joyce D. HoffmanFrom the Department of Emergency Medicine, Cook County Hospital (JMW, KLT, SEA, MBM), Chicago, Illinois; and the Chicago Fire Department, Emergency Medical Services (JDH), Chicago, Illinois.
, EMT-P,
Steven E. AksFrom the Department of Emergency Medicine, Cook County Hospital (JMW, KLT, SEA, MBM), Chicago, Illinois; and the Chicago Fire Department, Emergency Medical Services (JDH), Chicago, Illinois.
, DO &
Mark B. MycykFrom the Department of Emergency Medicine, Cook County Hospital (JMW, KLT, SEA, MBM), Chicago, Illinois; and the Chicago Fire Department, Emergency Medical Services (JDH), Chicago, Illinois.
, MD
Pages 289-292 | Received 29 Aug 2011, Accepted 30 Aug 2011, Published online: 22 Dec 2011

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Muhammad Sameed & Heidi Teague. (2019) Use of nebulized naloxone to reverse methadone overdose – A case report and review of literature. Journal of Community Hospital Internal Medicine Perspectives 9:5, pages 422-424.
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Nazey Gulec, Joseph Lahey, James C. Suozzi, Matthew Sholl, Charles D. MacLean & Daniel L. Wolfson. (2018) Basic and Advanced EMS Providers Are Equally Effective in Naloxone Administration for Opioid Overdose in Northern New England. Prehospital Emergency Care 22:2, pages 163-169.
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Christa R Lewis, Hoa T Vo & Marc Fishman. (2017) Intranasal naloxone and related strategies for opioid overdose intervention by nonmedical personnel: a review. Substance Abuse and Rehabilitation 8, pages 79-95.
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Elizabeth Tiffany, Christine M. Wilder, Shannon C. Miller & Theresa Winhusen. (2016) Knowledge of and interest in opioid overdose education and naloxone distribution among US veterans on chronic opioids for addiction or pain. Drugs: Education, Prevention and Policy 23:4, pages 322-327.
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Articles from other publishers (28)

Kyle A Weant, Regan A Baum, Garrett B Hile, Roger L Humphries, Elise L Metts, Amy R Miller, Jordan A Woolum & Abby M Bailey. (2023) Nebulized medications in the emergency department: A narrative review of nontraditional agents. American Journal of Health-System Pharmacy.
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Joseph V. PergolizziJrJr, Albert Dahan, Jo Ann LeQuang & Robert B. Raffa. (2021) Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit. Journal of Clinical Pharmacy and Therapeutics 46:6, pages 1501-1504.
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John F. Peppin, Joseph V. PergolizziJr.Jr., Albert Dahan & Robert B. Raffa. (2021) Are opioid receptor antagonists adequate for “Opioid” overdose in a changing reality?. Journal of Clinical Pharmacy and Therapeutics 46:4, pages 861-866.
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Farrokh Sharifi, Yazan J. Meqbil, Andrew Otte, Anna M. Gutridge, Arryn T. Blaine, Richard M. van Rijn & Kinam Park. (2021) Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose. Pharmaceutical Research 38:7, pages 1221-1234.
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Katja Troberg, Pernilla Isendahl, Marianne Alanko Blomé, Disa Dahlman & Anders Håkansson. (2020) Protocol for a multi-site study of the effects of overdose prevention education with naloxone distribution program in Skåne County, Sweden. BMC Psychiatry 20:1.
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Ryan Huebinger, Hashim Zaidi, Katie Tataris, Joseph Weber, Kenneth Pearlman, Eddie Markul, Leslee Stein-Spencer & Christopher Richards. (2020) Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies. Western Journal of Emergency Medicine 21:3.
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Ravikaran Patti, Vignesh Ponnusamy, Navjot Somal, Ankur Sinha, Shaurya Sharma, Taek Sang Yoon & Yizhak Kupfer. (2020) Naloxone-Induced Noncardiogenic Pulmonary Edema. American Journal of Therapeutics 27:6, pages e672-e673.
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James Gilham & Gavin Lloyd. (2019) Naloxone prescribing: room for finesse. British Journal of Hospital Medicine 80:3, pages C46-C48.
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Shawn A Ryan & Robert B Dunne. (2018) Pharmacokinetic properties of intranasal and injectable formulations of naloxone for community use: a systematic review. Pain Management 8:3, pages 231-245.
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Faisal S. Minhaj, Rachel F. Schult, Aaron Fields & Timothy J. Wiegand. (2018) A Case of Nebulized Naloxone Use With Confirmatory Serum Naloxone Concentrations. Annals of Pharmacotherapy 52:5, pages 495-496.
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Ashley Sanello, Marianne Gausche-Hill, William Mulkerin, Karl Sporer, John Brown, Kristi Koenig, Eric Rudnick, Angelo Salvucci & Gregory Gilbert. (2018) Altered Mental Status: Current Evidence-based Recommendations for Prehospital Care. Western Journal of Emergency Medicine 19:3, pages 527-541.
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Rachael Rzasa Lynn & JL Galinkin. (2017) Naloxone dosage for opioid reversal: current evidence and clinical implications. Therapeutic Advances in Drug Safety 9:1, pages 63-88.
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Neeraj Chhabra & Steven E. Aks. (2017) Current Opiate and Opioid Hazards in Children and Adolescents. Clinical Pediatric Emergency Medicine 18:3, pages 173-180.
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John Strang, Rebecca McDonald, Abdulmalik Alqurshi, Paul Royall, David Taylor & Ben Forbes. (2016) Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal. Drug and Alcohol Dependence 163, pages 16-23.
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Abdulmalik Alqurshi, Zahrae Kumar, Rebecca McDonald, John Strang, Asma Buanz, Shagufta Ahmed, Elizabeth Allen, Peter Cameron, James A. Rickard, Verity Sandhu, Chris Holt, Rebecca Stansfield, David Taylor, Ben Forbes & Paul G. Royall. (2016) Amorphous Formulation and in Vitro Performance Testing of Instantly Disintegrating Buccal Tablets for the Emergency Delivery of Naloxone . Molecular Pharmaceutics 13:5, pages 1688-1698.
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John Strang, Rebecca McDonald, Basak Tas & Ed Day. (2016) Clinical provision of improvised nasal naloxone without experimental testing and without regulatory approval: imaginative shortcut or dangerous bypass of essential safety procedures?. Addiction 111:4, pages 574-582.
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Marco L.A. Sivilotti. (2016) Flumazenil, naloxone and the ‘coma cocktail’. British Journal of Clinical Pharmacology 81:3, pages 428-436.
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Eric J. Lavonas, Ian R. Drennan, Andrea Gabrielli, Alan C. Heffner, Christopher O. Hoyte, Aaron M. Orkin, Kelly N. Sawyer & Michael W. Donnino. (2015) Part 10: Special Circumstances of Resuscitation. Circulation 132:18_suppl_2.
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Mark FaulMichael W. DaileyDavid E. SugermanScott M. SasserBenjamin LevyLen J. Paulozzi. (2015) Disparity in Naloxone Administration by Emergency Medical Service Providers and the Burden of Drug Overdose in US Rural Communities. American Journal of Public Health 105:S3, pages e26-e32.
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Thomas F. Kresina, Robert Lubran & H. Westley Clark. (2014) Technology-Assisted Addiction Treatment for Key Populations. Psychology 05:09, pages 1044-1054.
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Hollynn Larrabee & Leslie A. Willard. 2014. Prehospital Care of Neurologic Emergencies. Prehospital Care of Neurologic Emergencies 165 188 .
Jeffrey K. Aronson. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 171 195 .
Richard J. Bodnar. (2013) Endogenous opiates and behavior: 2012. Peptides 50, pages 55-95.
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Michael Wasson & O. Ross Beirne. (2013) Buprenorphine therapy: an increasing challenge in oral and maxillofacial surgery. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 116:2, pages 142-146.
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Katie L. Tataris, Joseph M. Weber, Leslee Stein-Spencer & Steven E. Aks. (2013) The effect of prehospital nebulized naloxone on suspected heroin-induced bronchospasm. The American Journal of Emergency Medicine 31:4, pages 717-718.
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Brigitte M. Baumann, Rachel A. Patterson, Dominic A. Parone, Molly K. Jones, Lindsey J. Glaspey, Nicole M. Thompson, Mary P. Stauss & Rachel Haroz. (2013) Use and efficacy of nebulized naloxone in patients with suspected opioid intoxication. The American Journal of Emergency Medicine 31:3, pages 585-588.
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Cian McDermott & Niamh C. Collins. (2012) Prehospital Medication Administration: A Randomised Study Comparing Intranasal and Intravenous Routes. Emergency Medicine International 2012, pages 1-5.
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