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Prehospital Emergency Care Volume 17, 2013 - Issue 1
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Research Article

Impact of Delayed and Infrequent Administration of Vasopressors on Return of Spontaneous Circulation during Out-of-Hospital Cardiac Arrest

Clyde L. Cantrell Jr.From the Emergency Medical Care Program, Western Carolina University (CLC, MWH), Cullowhee, North Carolina; and the Department of Emergency Medicine, University of New Mexico (MER), Albuquerque, New Mexico.
, MHS, NREMT-P,
Michael W. HubbleFrom the Emergency Medical Care Program, Western Carolina University (CLC, MWH), Cullowhee, North Carolina; and the Department of Emergency Medicine, University of New Mexico (MER), Albuquerque, New Mexico.Correspondence[email protected]
, PhD, MBA, NREMT-P &
Michael E. RichardsFrom the Emergency Medical Care Program, Western Carolina University (CLC, MWH), Cullowhee, North Carolina; and the Department of Emergency Medicine, University of New Mexico (MER), Albuquerque, New Mexico.Correspondence[email protected]
, MD, MPA
Pages 15-22 | Received 07 May 2012, Accepted 03 Jun 2012, Published online: 23 Jul 2012

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Tae Han Kim, Eui Jung Lee, Sang Do Shin, Young Sun Ro, Yu Jin Kim, Ki Ok Ahn, Kyoung Jun Song, Ki Jeong Hong & Kyung won Lee. (2018) Neurological Favorable Outcomes Associated with EMS Compliance and On-Scene Resuscitation Time Protocol. Prehospital Emergency Care 22:2, pages 214-221.
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Michael W. Hubble, Christopher Johnson, Jamie Blackwelder, Kevin Collopy, Sara Houston, Melisa Martin, Delbert Wilkes & Jonina Wiser. (2015) Probability of Return of Spontaneous Circulation as a Function of Timing of Vasopressor Administration in Out-of-Hospital Cardiac Arrest. Prehospital Emergency Care 19:4, pages 457-463.
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Articles from other publishers (21)

Mohamad Hakam Tiba, Takahiro Nakashima, Brendan M. McCracken, Cindy H. Hsu, Adam L. Gottula, Nicholas L. Greer, Traci A. Cramer, Nadia R. Sutton, Kevin R. Ward & Robert W. Neumar. (2023) Haemodynamic impact of aortic balloon occlusion combined with percutaneous left ventricular assist device during cardiopulmonary resuscitation in a swine model of cardiac arrest. Resuscitation 189, pages 109885.
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Liyu Ran, Jinglun Liu, Hideharu Tanaka, Michael W. Hubble, Takyu Hiroshi & Wei Huang. (2020) Early Administration of Adrenaline for Out‐of‐Hospital Cardiac Arrest: A Systematic Review and Meta‐Analysis. Journal of the American Heart Association 9:11.
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Ashish R. Panchal, Katherine M. Berg, Karen G. Hirsch, Peter J. Kudenchuk, Marina Del Rios, José G. Cabañas, Mark S. Link, Michael C. Kurz, Paul S. Chan, Peter T. Morley, Mary Fran Hazinski & Michael W. Donnino. (2019) 2019 American Heart Association Focused Update on Advanced Cardiovascular Life Support: Use of Advanced Airways, Vasopressors, and Extracorporeal Cardiopulmonary Resuscitation During Cardiac Arrest: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 140:24.
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Brian Grunau, Takahisa Kawano, Frank X. Scheuermeyer, Ian Drennan, Christopher B. Fordyce, Sean van Diepen, Joshua Reynolds, Steve Lin & Jim Christenson. (2019) The Association of the Average Epinephrine Dosing Interval and Survival With Favorable Neurologic Status at Hospital Discharge in Out-of-Hospital Cardiac Arrest. Annals of Emergency Medicine 74:6, pages 797-806.
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Mohammed A. Al-Mulhim, Mohammed S. Alshahrani, Laila Perlas Asonto, Ahmad Abdulhady, Talal M. Almutairi, Mariam Hajji, Mohammed A. Alrubaish, Khalid N. Almulhim, Mariam H. Al-Sulaiman & Layla B. Al-Qahtani. (2019) Impact of epinephrine administration frequency in out-of-hospital cardiac arrest patients: a retrospective analysis in a tertiary hospital setting. Journal of International Medical Research 47:9, pages 4272-4283.
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Mohamad Hakam Tiba, Brendan M. McCracken, Brandon C. Cummings, Carmen I. Colmenero, Chandler J. Rygalski, Cindy H. Hsu, Thomas H. Sanderson, Brahmajee K. Nallamothu, Robert W. Neumar & Kevin R. Ward. (2019) Use of resuscitative balloon occlusion of the aorta in a swine model of prolonged cardiac arrest. Resuscitation 140, pages 106-112.
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Mathias J. Holmberg, Mahmoud S. Issa, Ari Moskowitz, Peter Morley, Michelle Welsford, Robert W. Neumar, Edison F. Paiva, Amin Coker, Christopher K. Hansen, Lars W. Andersen, Michael W. Donnino, Katherine M. Berg, Bernd W. Böttiger, Clifton W. Callaway, Charles D. Deakin, Ian R. Drennan, Tonia C. Nicholson, Jerry P. Nolan, Brian J. O’Neil, Michael J. Parr, Joshua C. Reynolds, Claudio Sandroni, Jasmeet Soar & Tzong-Luen Wang. (2019) Vasopressors during adult cardiac arrest: A systematic review and meta-analysis. Resuscitation 139, pages 106-121.
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Asger Granfeldt, Suzanne R. Avis, Tonia C. Nicholson, Mathias J. Holmberg, Ari Moskowitz, Amin Coker, Katherine M. Berg, Michael J. Parr, Michael W. Donnino, Jasmeet Soar, Kevin Nation, Lars W. Andersen, Clifton W. Callaway, Bernd W. Böttiger, Edison F. Paiva, Tzong-Luen Wang, Brian J. O’Neil, Peter T. Morley, Michelle Welsford, Ian R. Drennan, Joshua C. Reynolds, Robert W. Neumar, Claudio Sandroni, Charles D. Deakin, Jerry P. Nolan, Clifton W. Callaway, Bernd W. Böttiger, Edison F. Paiva, Tzong-Luen Wang, Brian J. O’Neil, Peter T. Mo rley, Michelle Welsford, Ian R. Drennan, Joshua C. Reynolds, Robert W. Neumar, Claudio Sandroni, Charles D. Deakin & Jerry P. Nolan. (2019) Advanced airway management during adult cardiac arrest: A systematic review. Resuscitation 139, pages 133-143.
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Yosuke Homma, Takashi Shiga, Hiraku Funakoshi, Dai Miyazaki, Atsushi Sakurai, Yoshio Tahara, Ken Nagao, Naohiro Yonemoto, Arino Yaguchi & Naoto Morimura. (2019) Association of the time to first epinephrine administration and outcomes in out-of-hospital cardiac arrest: SOS-KANTO 2012 study. The American Journal of Emergency Medicine 37:2, pages 241-248.
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Nicholas Asselin, Bryan Choi, Catherine C. Pettit, Max Dannecker, Jason T. Machan, Derek L. Merck, Lisa H. Merck, Selim Suner, Kenneth A. Williams, Janette Baird, Gregory D. Jay & Leo Kobayashi. (2018) Comparative Analysis of Emergency Medical Service Provider Workload During Simulated Out-of-Hospital Cardiac Arrest Resuscitation Using Standard Versus Experimental Protocols and Equipment. Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare 13:6, pages 376-386.
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Bram J. Geller & Benjamin S. Abella. (2018) Evolving Strategies in Cardiac Arrest Management. Cardiology Clinics 36:1, pages 73-84.
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Michael W. Hubble & Clark Tyson. (2017) Impact of Early Vasopressor Administration on Neurological Outcomes after Prolonged Out-of-Hospital Cardiac Arrest. Prehospital and Disaster Medicine 32:3, pages 297-304.
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H. Ueta, H. Tanaka, S. Tanaka, R. Sagisaka & H. Takyu. (2017) Quick epinephrine administration induces favorable neurological outcomes in out-of-hospital cardiac arrest patients. The American Journal of Emergency Medicine 35:5, pages 676-680.
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H. Tanaka, H. Takyu, R. Sagisaka, H. Ueta, Toru Shirakawa, Tomoya Kinoshi, Hiroyuki Takahashi, Takashi Nakagawa, Syuji Shimazaki & M. Ong Eng Hock. (2016) Favorable neurological outcomes by early epinephrine administration within 19 minutes after EMS call for out-of-hospital cardiac arrest patients. The American Journal of Emergency Medicine 34:12, pages 2284-2290.
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Mari Amino, Sadaki Inokuchi, Koichiro Yoshioka, Yoshihide Nakagawa, Yuji Ikari, Hiraku Funakoshi, Katsura Hayakawa, Masakazu Matsuzaki, Atsushi Sakurai, Yoshio Tahara, Naohiro Yonemoto, Ken Nagao, Arino Yaguchi & Naoto Morimura. (2016) Does Antiarrhythmic Drug During Cardiopulmonary Resuscitation Improve the One-month Survival: The SOS-KANTO 2012 Study. Journal of Cardiovascular Pharmacology 68:1, pages 58-66.
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Chih-Hung Wang, Chien-Hua Huang, Wei-Tien Chang, Min-Shan Tsai, Ping-Hsun Yu, Yen-Wen Wu, Kuan-Yu Hung & Wen-Jone Chen. (2016) The influences of adrenaline dosing frequency and dosage on outcomes of adult in-hospital cardiac arrest: A retrospective cohort study. Resuscitation 103, pages 125-130.
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Andreas Lundin, Therese Djärv, Johan Engdahl, Jacob Hollenberg, Per Nordberg, Annika Ravn-Fischer, Mattias Ringh, Susanne Rysz, Leif Svensson, Johan Herlitz & Peter Lundgren. (2016) Drug therapy in cardiac arrest: a review of the literature. European Heart Journal - Cardiovascular Pharmacotherapy 2:1, pages 54-75.
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Mark S. Link, Lauren C. Berkow, Peter J. Kudenchuk, Henry R. Halperin, Erik P. Hess, Vivek K. Moitra, Robert W. Neumar, Brian J. O’Neil, James H. Paxton, Scott M. Silvers, Roger D. White, Demetris Yannopoulos & Michael W. Donnino. (2015) Part 7: Adult Advanced Cardiovascular Life Support. Circulation 132:18_suppl_2.
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Clifton W. Callaway, Jasmeet Soar, Mayuki Aibiki, Bernd W. Böttiger, Steven C. Brooks, Charles D. Deakin, Michael W. Donnino, Saul Drajer, Walter Kloeck, Peter T. Morley, Laurie J. Morrison, Robert W. Neumar, Tonia C. Nicholson, Jerry P. Nolan, Kazuo Okada, Brian J. O’Neil, Edison F. Paiva, Michael J. Parr, Tzong-Luen Wang, Jonathan Witt, Lars W. Andersen, Katherine M. Berg, Claudio Sandroni, Steve Lin, Eric J. Lavonas, Eyal Golan, Mohammed A. Alhelail, Amit Chopra, Michael N. Cocchi, Tobias Cronberg, Katie N. Dainty, Ian R. Drennan, Michael Fries, Romergryko G. Geocadin, Jan-Thorsten Gräsner, Asger Granfeldt, Sarah Heikal, Peter J. Kudenchuk, Anthony T. LaginaIIIIII, Bo Løfgren, Jill Mhyre, Koenraad G. Monsieurs, Allan R. Mottram, Tommaso Pellis, Joshua C. Reynolds, Giuseppe Ristagno, Fred A. Severyn, Markus Skrifvars, William C. Stacey, Jonathon Sullivan, Sarah L. Todhunter, Gino Vissers, Stephen West, Wolfgang A. Wetsch, Natalie Wong, Theodoros Xanthos, Carolyn M. Zelop & Janice Zimmerman. (2015) Part 4: Advanced Life Support. Circulation 132:16_suppl_1.
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Jasmeet Soar, Clifton W. Callaway, Mayuki Aibiki, Bernd W. Böttiger, Steven C. Brooks, Charles D. Deakin, Michael W. Donnino, Saul Drajer, Walter Kloeck, Peter T. Morley, Laurie J. Morrison, Robert W. Neumar, Tonia C. Nicholson, Jerry P. Nolan, Kazuo Okada, Brian J. O’Neil, Edison F. Paiva, Michael J. Parr, Tzong-Luen Wang, Jonathan Witt, Lars W. Andersen, Katherine M. Berg, Claudio Sandroni, Steve Lin, Eric J. Lavonas, Eyal Golan, Mohammed A. Alhelail, Amit Chopra, Michael N. Cocchi, Tobias Cronberg, Katie N. Dainty, Ian R. Drennan, Michael Fries, Romergryko G. Geocadin, Jan-Thorsten Gräsner, Asger Granfeldt, Sarah Heikal, Peter J. Kudenchuk, Anthony T. LaginaIIIIII, Bo Løfgren, Jill Mhyre, Koenraad G. Monsieurs, Allan R. Mottram, Tommaso Pellis, Joshua C. Reynolds, Giuseppe Ristagno, Fred A. Severyn, Markus Skrifvars, William C. Stacey, Jonathon Sullivan, Sarah L. Todhunter, Gino Vissers, Stephen West, Wolfgang A. Wetsch, Natalie Wong, Theodoros Xanthos, Carolyn M. Zelop & Janice Zimmerman. (2015) Part 4: Advanced life support. Resuscitation 95, pages e71-e120.
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C. Koscik, A. Pinawin, H. McGovern, D. Allen, D.E. Media, T. Ferguson, W. Hopkins, K.N. Sawyer, J. Boura & R. Swor. (2013) Rapid epinephrine administration improves early outcomes in out-of-hospital cardiac arrest. Resuscitation 84:7, pages 915-920.
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