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International EMS

A Comparison of Ketamine and Morphine Analgesia in Prehospital Trauma Care: A Cluster Randomized Clinical Trial in Rural Quang Tri Province, Vietnam

, MD, PhD, , MD, MPH, , MD, , MSci, , MD, , MD, MPH, , MD, PhD & , MD show all

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Read on this site (8)

Joseph Charles Watso, Mu Huang, Joseph Maxwell Hendrix, Luke Norman Belval, Gilbert Moralez, Matthew Nathaniel Cramer, Josh Foster, Carmen Hinojosa-Laborde & Craig Gerald Crandall. (2023) Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. Prehospital Emergency Care 27:5, pages 600-612.
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Madeline J. Foertsch, Jason T. McMullan, Nicole J. Harger, Dario Rodriquez$suffix/text()$suffix/text(), Ann Salvator, Eric W. Mueller PharmD & Christopher A. Droege. (2022) Ketamine Stability over Six Months of Exposure to Moderate and High Temperature Environments. Prehospital Emergency Care 26:3, pages 422-427.
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Emily J. Robinson, Brooke L. Watanabe & Lawrence H. Brown. (2021) Ketamine for Prehospital Pain Management Does Not Prolong Emergency Department Length of Stay. Prehospital Emergency Care 25:6, pages 753-760.
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Jason McMullan, Christopher Droege, Richard Strilka, Kimberly Hart & Christopher Lindsell. (2021) Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain: Design and Rationale of a Randomized Controlled Trial. Prehospital Emergency Care 25:4, pages 519-529.
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Jason McMullan, Christopher Droege, Col. Richard Strilka, Christopher Lindsell & Michael J. Linke. (2021) Food and Drug Administration and Institutional Review Board Approval of a Novel Prehospital Informed Consent Process for Emergency Research. Prehospital Emergency Care 25:4, pages 512-518.
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Diana M. Sobieraj, Brandon K. Martinez, Benjamin Miao, Mark X. Cicero, Richard A. Kamin, Adrian V. Hernandez, Craig I. Coleman & William L. Baker. (2020) Comparative Effectiveness of Analgesics to Reduce Acute Pain in the Prehospital Setting. Prehospital Emergency Care 24:2, pages 163-174.
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E. Stein Bronsky, Catherine Koola, Alessandro Orlando, Diane Redmond, Cecile D'Huyvetter, Heather Sieracki, Allen Tanner$suffix/text()$suffix/text(), Ray Fowler, Charles Mains & David Bar-Or. (2019) Intravenous Low-Dose Ketamine Provides Greater Pain Control Compared to Fentanyl in a Civilian Prehospital Trauma System: A Propensity Matched Analysis. Prehospital Emergency Care 23:1, pages 1-8.
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John Gale, Andrew Coburn, Karen Pearson, Zachariah Croll & George Shaler. (2017) Developing Program Performance Measures for Rural Emergency Medical Services. Prehospital Emergency Care 21:2, pages 157-165.
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Articles from other publishers (41)

F. Michelet, M. Smyth, R. Lall, H. Noordali, K. Starr, L. Berridge, J. Yeung, G. Fuller, S. Petrou, A. Walker, J. Mark, A. Canaway, K. Khan & G. D. Perkins. (2023) Randomised controlled trial of analgesia for the management of acute severe pain from traumatic injury: study protocol for the paramedic analgesia comparing ketamine and morphine in trauma (PACKMaN). Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 31:1.
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Andrea Fabbri, Antonio Voza, Alessandro Riccardi, Sossio Serra & Fabio Iaco. (2023) The Pain Management of Trauma Patients in the Emergency Department. Journal of Clinical Medicine 12:9, pages 3289.
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Alessandro Riccardi, Mario Guarino, Sossio Serra, Michele Spampinato, Simone Vanni, Dana Shiffer, Antonio Voza, Andrea Fabbri & Fabio De Iaco. (2023) Narrative Review: Low-Dose Ketamine for Pain Management. Journal of Clinical Medicine 12:9, pages 3256.
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Christian Zanza, Tatsiana Romenskaya, Marta Zuliani, Fabio Piccolella, Maria Bottinelli, Giorgia Caputo, Eduardo Rocca, Antonio Maconi, Gabriele Savioli & Yaroslava Longhitano. (2023) Acute Traumatic Pain in the Emergency Department. Diseases 11:1, pages 45.
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Sally L Westcott, A Wojahn, T C Morrison & E Leslie. (2023) Ketamine decreased opiate use in US military combat operations from 2010 to 2019. BMJ Military Health, pages e002291.
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Mihai Octavian Botea & Erika Bimbo-Szuhai. 2022. Ketamine Revisited - New Insights into NMDA Inhibitors. Ketamine Revisited - New Insights into NMDA Inhibitors.
Melanie M Randall, Jennifer Raae-Nielsen, Mia Choi, William S Dukes, Timothy Nesper & Michael K Mesisca. (2022) Incidence of Dissociation With Low-Dose Pre-hospital Ketamine in Geriatric Patients With Trauma-Related Pain. Cureus.
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Joseph C. Watso, Luke N. Belval, Frank A. Cimino3rd3rd, Bonnie D. Orth, Joseph M. Hendrix, Mu Huang, Elias Johnson, Josh Foster, Carmen Hinojosa-Laborde & Craig G. Crandall. (2022) Low-dose morphine reduces pain perception and blood pressure, but not muscle sympathetic outflow, responses during the cold pressor test. American Journal of Physiology-Heart and Circulatory Physiology 323:1, pages H223-H234.
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Joseph C. Watso, Luke N. Belval, Frank A. Cimino3rd3rd, Bonnie D. Orth, Joseph M. Hendrix, Mu Huang, Elias Johnson, Josh Foster, Carmen Hinojosa-Laborde & Craig G. Crandall. (2022) Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow. American Journal of Physiology-Heart and Circulatory Physiology 323:1, pages H89-H99.
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Caroline A. Browne, Hildegard A. Wulf, Moriah L. Jacobson, Mario G. Oyola, T. John Wu & Irwin Lucki. (2022) Long-term increase in sensitivity to ketamine's behavioral effects in mice exposed to mild blast induced traumatic brain injury. Experimental Neurology 350, pages 113963.
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Kristian Dahl Friesgaard, Gunn Elisabeth Vist, Per Kristian Hyldmo, Lasse Raatiniemi, Jouni Kurola, Robert Larsen, Poul Kongstad, Vidar Magnusson, Mårten Sandberg, Marius Rehn & Leif Rognås. (2022) Opioids for Treatment of Pre-hospital Acute Pain: A Systematic Review. Pain and Therapy 11:1, pages 17-36.
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Anya Critchley. (2022) Intravenous ketamine as an analgesia in prehospital adult trauma patients. Journal of Paramedic Practice 14:1, pages 26-36.
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Antonio R. Fernandez, Scott S. Bourn, Remle P. Crowe, E. Stein Bronsky, Kenneth A. Scheppke, Peter Antevy & J. Brent Myers. (2021) Out-of-Hospital Ketamine: Indications for Use, Patient Outcomes, and Associated Mortality. Annals of Emergency Medicine 78:1, pages 123-131.
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Seung Lee, Azuka Onye & Asad Latif. (2020) Emergency Anesthesia in Resource-Limited Areas. Advances in Anesthesia 38, pages 209-227.
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Mårten Sandberg, Per Kristian Hyldmo, Poul Kongstad, Kristian Dahl Friesgaard, Lasse Raatiniemi, Robert Larsen, Vidar Magnusson, Leif Rognås, Jouni Kurola, Marius Rehn & Gunn Elisabeth Vist. (2020) Ketamine for the treatment of prehospital acute pain: a systematic review of benefit and harm. BMJ Open 10:11, pages e038134.
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Nicklaus Brandehoff, Jordan Max Benjamin, Cellou Balde & Jean-Philippe Chippaux. (2020) Ketamine for pain control of snake envenomation in Guinea: A case series. Toxicon 187, pages 82-85.
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Megan Cook & Matthew Hawks. (2020) Should ketamine be used for analgesia in an austere environment?. Evidence-Based Practice 23:9, pages 33-34.
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Nualnong Wongtongkam & Margaret E. Adams. (2020) Triple Therapeutic Effects of Ketamine in Prehospital Settings: Systematic Review. Current Emergency and Hospital Medicine Reports 8:3, pages 122-132.
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Alex Jabourian, Fanglong Dong, Kevin Mackey, Reza Vaezazizi, Troy W Pennington & Michael Neeki. (2020) Evaluation of Safety and Efficacy of Prehospital Paramedic Administration of Sub-Dissociative Dose of Ketamine in the Treatment of Trauma-Related Pain in Adult Civilian Population. Cureus.
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Kimberly P. Hurth, Anthony Jaworski, Kristen B. Thomas, William B. Kirsch, Michael A. Rudoni & Kevin M. Wohlfarth. (2020) The Reemergence of Ketamine for Treatment in Critically Ill Adults. Critical Care Medicine 48:6, pages 899-911.
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Akhil Bansal, Matthew Miller, Ian Ferguson & Brian Burns. (2020) Ketamine as a Prehospital Analgesic: A Systematic Review. Prehospital and Disaster Medicine 35:3, pages 314-321.
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Seung Lee, Azuka Onye & Asad Latif. (2020) Emergency Anesthesia in Resource-Limited Areas. Anesthesiology Clinics 38:1, pages 213-230.
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Gaël de Rocquigny, Christophe Dubecq, Thibault Martinez, John Peffer, Amandine Cauet, Stéphane Travers & Pierre Pasquier. (2020) Use of ketamine for prehospital pain control on the battlefield: A systematic review. Journal of Trauma and Acute Care Surgery 88:1, pages 180-185.
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Kristian D. Friesgaard, Hans Kirkegaard, Claus-Henrik Rasmussen, Matthias Giebner, Erika F. Christensen & Lone Nikolajsen. (2019) Prehospital intravenous fentanyl administered by ambulance personnel: a cluster-randomised comparison of two treatment protocols. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 27:1.
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Ayman A. Metry, Neven G. Fahmy, George M. Nakhla, Rami M. Wahba, Milad Z. Ragaei & Fady A. Abdelmalek. (2019) Lornoxicam with Low-Dose Ketamine versus Pethidine to Control Pain of Acute Renal Colic. Pain Research and Treatment 2019, pages 1-7.
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Theresa M. Frey, Todd A. Florin, Michelle Caruso, Nanhua Zhang, Yin Zhang & Matthew R. Mittiga. (2019) Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children. JAMA Pediatrics 173:2, pages 140.
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Clément Le Cornec, Said Lariby, Vivien Brenckmann, Jean Benoit Hardouin, Claude Ecoffey, Marion Le Pottier, Philippe Fradin, Hélène Broch, Amine Kabbaj, Yannick Auffret, Florence Deciron, Céline Longo, François Javaudin, Quentin Le Bastard, Joël Jenvrin & Emmanuel Montassier. (2018) Is intravenously administered, subdissociative-dose KETAmine non-inferior to MORPHine for prehospital analgesia (the KETAMORPH study): study protocol for a randomized controlled trial. Trials 19:1.
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Michael Zhang, Timothy Cowan, John‐Paul Smiles, Mary Morgan, Jessica Armstrong, Chinky Goswami & Claire Sewell. (2017) Prehospital analgesic choice in injured patients does not impact on rates of vomiting: Experience from a New South Wales primary retrieval service. Emergency Medicine Australasia 30:3, pages 406-411.
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David Häske, Bernd W. Böttiger, Bertil Bouillon, Matthias Fischer, Gernot Gaier, Bernhard Gliwitzky, Matthias Helm, Peter Hilbert-Carius, Björn Hossfeld, Christoph Meisner, Benjamin Schempf, Arasch Wafaisade & Michael Bernhard. (2017) Analgesia in Patients with Trauma in Emergency Medicine. Deutsches Ärzteblatt international.
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Milan Kirit Sheth, Asher Brand & Julia Halterman. (2017) Ketamine-induced Changes in Blood Pressure and Heart Rate in Pre-hospital Intubated Patients. Advanced Journal of Graduate Research 3:1, pages 20-33.
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Ramin Parvizrad, Abdolghader Pakniyat, Bita Malekianzadeh & Amir Almasi-Hashiani. (2017) Comparing the analgesic effect of intranasal with intravenous ketamine in isolated orthopedic trauma: A randomized clinical trial. Turkish Journal of Emergency Medicine 17:3, pages 99-103.
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Richard J. Bodnar. (2017) Endogenous Opiates and Behavior: 2015. Peptides 88, pages 126-188.
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Travis D. Olives, Paul C. Nystrom, Jon B. Cole, Kenneth W. Dodd & Jeffrey D. Ho. (2016) Intubation of Profoundly Agitated Patients Treated with Prehospital Ketamine. Prehospital and Disaster Medicine 31:6, pages 593-602.
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Denise Sullivan, Mary Lyons, Robert Montgomery & Ann Quinlan-Colwell. (2016) Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective. Journal of Trauma Nursing 23:6, pages 361-375.
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Eun Nam Lee & Jae Hoon Lee. (2016) The Effects of Low-Dose Ketamine on Acute Pain in an Emergency Setting: A Systematic Review and Meta-Analysis. PLOS ONE 11:10, pages e0165461.
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Rajesh M. C & Sheeja Rajan T. M. (2016) PAIN RELIEF IN POLYTRAUMA PATIENTS. Journal of Evidence Based Medicine and Healthcare 3:78, pages 4249-4252.
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Tanya L Zakrison, Nicholas Namias, Marc M Grossman, David V Shatz, Fahim Habib, Louis Pizano, Antonio Marttos & Gabriel Ruiz. (2016) The Rare Requirement of On-scene Extremity Amputations in the Entrapped Trauma Patient. Panamerican Journal of Trauma, Critical Care & Emergency Surgery 5:2, pages 93-100.
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D. Eidenbenz, P. Taffé, O. Hugli, E. Albrecht & M. Pasquier. (2016) A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury. Anaesthesia 71:7, pages 779-787.
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Ole Kristian Losvik, Mudhafar Kareem Murad, Eystein Skjerve & Hans Husum. (2015) Ketamine for prehospital trauma analgesia in a low-resource rural trauma system: a retrospective comparative study of ketamine and opioid analgesia in a ten-year cohort in Iraq. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 23:1.
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