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Amyloid
The Journal of Protein Folding Disorders
Volume 19, 2012 - Issue 4
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Original Article

Overexpression of human amyloidogenic light chains causes heart failure in embryonic zebrafish: a preliminary report

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Pages 191-196 | Received 17 Jun 2012, Accepted 01 Sep 2012, Published online: 05 Nov 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Taxiarchis V Kourelis & Morie A Gertz. (2015) Improving strategies for the diagnosis of cardiac amyloidosis. Expert Review of Cardiovascular Therapy 13:8, pages 945-961.
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Luisa Diomede, Paola Rognoni, Francesca Lavatelli, Margherita Romeo, Andrea di Fonzo, Claudia Foray, Fabio Fiordaliso, Giovanni Palladini, Veronica Valentini, Vittorio Perfetti, Mario Salmona & Giampaolo Merlini. (2014) Investigating heart-specific toxicity of amyloidogenic immunoglobulin light chains: A lesson from C. elegans. Worm 3:3.
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Giampaolo Merlini, Raymond L Comenzo, David C Seldin, Ashutosh Wechalekar & Morie A Gertz. (2014) Immunoglobulin light chain amyloidosis. Expert Review of Hematology 7:1, pages 143-156.
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Articles from other publishers (13)

Luca Broggini, Maria Monica Barzago, Valentina Speranzini, Tim Schulte, Federica Sonzini, Matteo Giono, Margherita Romeo, Paolo Milani, Serena Caminito, Giulia Mazzini, Paola Rognoni, Giampaolo Merlini, Carlo Pappone, Luigi Anastasia, Mario Nuvolone, Giovanni Palladini, Luisa Diomede & Stefano Ricagno. (2023) Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation. Journal of Molecular Biology 435:24, pages 168320.
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Gemma Martinez-Rivas, Sébastien Bender & Christophe Sirac. (2022) Understanding AL amyloidosis with a little help from in vivo models. Frontiers in Immunology 13.
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Kevin M. Alexander, Isabel Morgado & Ronglih Liao. 2022. Biochemistry of Apoptosis and Autophagy. Biochemistry of Apoptosis and Autophagy 219 237 .
Christophe Sirac, Guillermo A. Herrera, Paul W. Sanders, Vecihi Batuman, Sebastien Bender, Maria V. Ayala, Vincent Javaugue, Jiamin Teng, Elba A. Turbat-Herrera, Michel Cogné, Guy Touchard, Nelson Leung & Frank Bridoux. (2018) Animal models of monoclonal immunoglobulin-related renal diseases. Nature Reviews Nephrology 14:4, pages 246-264.
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Chunlan Zhang, Xufei Huang & Jian Li. (2017) Light chain amyloidosis: Where are the light chains from and how they play their pathogenic role?. Blood Reviews 31:4, pages 261-270.
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Sohsuke Meshitsuka, Sumito Shingaki, Masatoshi Hotta, Miku Goto, Makoto Kobayashi, Yuuichi Ukawa, Yuko M. Sagesaka, Yasuyo Wada, Masanori Nojima & Kenshi Suzuki. (2016) Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis. International Journal of Hematology 105:3, pages 295-308.
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Marie E. Oskarsson, Kailash Singh, Jian Wang, Israel Vlodavsky, Jin-ping Li & Gunilla T. Westermark. (2015) Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis. Journal of Biological Chemistry 290:24, pages 15121-15132.
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Jian Guan, Shikha Mishra, Yiling Qiu, Jianru Shi, Kyle Trudeau, Guy Las, Marc Liesa, Orian S Shirihai, Lawreen H Connors, David C Seldin, Rodney H Falk, Calum A MacRae & Ronglih Liao. (2014) Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain‐mediated cardiotoxicity. EMBO Molecular Medicine 6:11, pages 1493-1507.
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Luisa DiomedePaola RognoniFrancesca LavatelliMargherita RomeoElena del FaveroLaura CantùElena GhibaudiAndrea di FonzoAlessandro CorbelliFabio FiordalisoGiovanni Palladini, Veronica ValentiniVittorio Perfetti, Mario SalmonaGiampaolo Merlini. (2014) A Caenorhabditis elegans–based assay recognizes immunoglobulin light chains causing heart amyloidosis. Blood 123:23, pages 3543-3552.
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Marten Beeg, Luisa Diomede, Matteo Stravalaci, Mario Salmona & Marco Gobbi. (2013) Novel approaches for studying amyloidogenic peptides/proteins. Current Opinion in Pharmacology 13:5, pages 797-801.
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Yau‐Hung Chen, Chiung‐Wen Pai, Shu‐Wei Huang, Sheng‐Nan Chang, Lian‐Yu Lin, Fu‐Tien Chiang, Jiunn‐Lee Lin, Juey‐Jen Hwang & Chia‐Ti Tsai. (2013) Inactivation of Myosin Binding Protein C Homolog in Zebrafish as a Model for Human Cardiac Hypertrophy and Diastolic Dysfunction. Journal of the American Heart Association 2:5.
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Inken G. Huttner, Gunjan Trivedi, Arie Jacoby, Stefan A. Mann, Jamie I. Vandenberg & Diane Fatkin. (2013) A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death. Journal of Molecular and Cellular Cardiology 61, pages 123-132.
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Shikha MishraJian GuanEva PlovieDavid C. SeldinLawreen H. ConnorsGiampaolo Merlini, Rodney H. Falk, Calum A. MacRaeRonglih Liao. (2013) Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish. American Journal of Physiology-Heart and Circulatory Physiology 305:1, pages H95-H103.
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