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Amyloid
The Journal of Protein Folding Disorders
Volume 20, 2013 - Issue 1
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Research Article

Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model

Hyunjin Vincent KimCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology SeoulRepublic of Korea
,
Hye Yun KimCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology SeoulRepublic of Korea
,
Hanna Y. EhrlichCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology SeoulRepublic of Korea;Department of Biology, Tufts University Medford, MAUSA
,
Seon Young ChoiCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology SeoulRepublic of Korea
,
Dong Jin KimCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology SeoulRepublic of Korea
&
YoungSoo KimCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology SeoulRepublic of KoreaCorrespondence[email protected]
Pages 7-12 | Received 03 Aug 2012, Accepted 16 Nov 2012, Published online: 19 Dec 2012

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Nad’a Majerníková, Wilfred F. A. den Dunnen & Amalia M. Dolga. (2021) The Potential of Ferroptosis-Targeting Therapies for Alzheimer’s Disease: From Mechanism to Transcriptomic Analysis. Frontiers in Aging Neuroscience 13.
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Ángel Cores, Marta Piquero, Mercedes Villacampa, Rafael León & J. Carlos Menéndez. (2020) NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases. Biomolecules 10:6, pages 904.
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Levi W. Evans, Matthew S. Stratton & Bradley S. Ferguson. (2020) Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease. Natural Product Reports 37:5, pages 653-676.
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Octavio Binvignat & Jordi Olloquequi. (2020) Excitotoxicity as a Target Against Neurodegenerative Processes. Current Pharmaceutical Design 26:12, pages 1251-1262.
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Crossref
Mikah S. Brandes & Nora E. Gray. (2020) NRF2 as a Therapeutic Target in Neurodegenerative Diseases. ASN Neuro 12, pages 175909141989978.
Crossref
Rong Wang & Viviana I. Perez. 2020. Nrf2 and its Modulation in Inflammation. Nrf2 and its Modulation in Inflammation 1 21 .
Eleni Panagiotidou & Niki Chondrogianni. 2020. Proteostasis and Disease. Proteostasis and Disease 329 348 .
Diego Lastra, Raquel Fernández-Ginés, Gina Manda & Antonio Cuadrado. 2021. Reactive Oxygen Species. Reactive Oxygen Species 93 141 .
Sunghee Kim, Jisun Oh, Chan Ho Jang & Jong-Sang Kim. (2019) Improvement of cognitive function by Gochujang supplemented with tomato paste in a mouse model. Food Science and Biotechnology 28:4, pages 1225-1233.
Crossref
Natalia Robledinos-Antón, Raquel Fernández-Ginés, Gina Manda & Antonio Cuadrado. (2019) Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Oxidative Medicine and Cellular Longevity 2019, pages 1-20.
Crossref
Farzane Sivandzade, Aditya Bhalerao & Luca Cucullo. (2019) Cerebrovascular and Neurological Disorders: Protective Role of NRF2. International Journal of Molecular Sciences 20:14, pages 3433.
Crossref
Shigeru Katayama & Soichiro Nakamura. (2018) Emerging roles of bioactive peptides on brain health promotion. International Journal of Food Science & Technology 54:6, pages 1949-1955.
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Crossref
Gahee Bahn & Dong-Gyu Jo. (2019) Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2. NeuroMolecular Medicine 21:1, pages 1-11.
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Farzane Sivandzade, Shikha Prasad, Aditya Bhalerao & Luca Cucullo. (2019) NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. Redox Biology 21, pages 101059.
Crossref
EricA Klomparens & Yuchuan Ding. (2019) The neuroprotective mechanisms and effects of sulforaphane. Brain Circulation 5:2, pages 74.
Crossref
Kyoung A. Jhang, Jin-Sun Park, Hee-Sun Kim & Young Hae Chong. (2018) Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages. Journal of Neuroinflammation 15:1.
Crossref
Li Zhou, Ruoyun Ouyang, Hong Luo, Yating Peng, Ping Chen, Siying Ren & Guiqian Liu. (2018) Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome. Oxidative Medicine and Cellular Longevity 2018, pages 1-15.
Crossref
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Crossref
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Crossref
Siyoung Lee, Bo‐Ryoung Choi, Jisung Kim, Frank M. LaFerla, Jung Han Yoon Park, Jung‐Soo Han, Ki Won Lee & Jiyoung Kim. (2018) Sulforaphane Upregulates the Heat Shock Protein Co‐Chaperone CHIP and Clears Amyloid‐β and Tau in a Mouse Model of Alzheimer's Disease. Molecular Nutrition & Food Research 62:12, pages 1800240.
Crossref
Mohammed Jaafaru, Nurul Abd Karim, Mohamad Enas, Patrick Rollin, Emanuela Mazzon & Ahmad Abdull Razis. (2018) Protective Effect of Glucosinolates Hydrolytic Products in Neurodegenerative Diseases (NDDs). Nutrients 10:5, pages 580.
Crossref
Chao Chen, Bin Li, Guangqing Cheng, Xiaoni Yang, Ningning Zhao & Ran Shi. (2018) Amentoflavone Ameliorates Aβ1–42-Induced Memory Deficits and Oxidative Stress in Cellular and Rat Model. Neurochemical Research 43:4, pages 857-868.
Crossref
Ji Seo, Bo Kim, Jisun Oh & Jong-Sang Kim. (2018) Soybean-Derived Phytoalexins Improve Cognitive Function through Activation of Nrf2/HO-1 Signaling Pathway. International Journal of Molecular Sciences 19:1, pages 268.
Crossref
Rongrong Zhang, Mengxue Xu, Yu Wang, Fei Xie, Gang Zhang & Xinyue Qin. (2016) Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke. Molecular Neurobiology 54:8, pages 6006-6017.
Crossref
Jeffrey Liddell. (2017) Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?. Antioxidants 6:3, pages 65.
Crossref
G J McBean, M G López & F K Wallner. (2017) Redox-based therapeutics in neurodegenerative disease. British Journal of Pharmacology 174:12, pages 1750-1770.
Crossref
Eva Ramos, Javier Egea, Cristóbal de los Ríos, José Marco-Contelles & Alejandro Romero. (2017) Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration. Future Medicinal Chemistry 9:8, pages 765-780.
Crossref
Ji Yeon Seo, Soon Sung Lim, Jiyoung Kim, Ki Won Lee & Jong-Sang Kim. (2017) Alantolactone and Isoalantolactone Prevent Amyloid β 25-35 -induced Toxicity in Mouse Cortical Neurons and Scopolamine-induced Cognitive Impairment in Mice . Phytotherapy Research 31:5, pages 801-811.
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Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K. Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C. Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M. Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton & Linda Partridge. (2017) Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLOS Genetics 13:3, pages e1006593.
Crossref
Aditya Sunkaria, Aarti Yadav, Sunil Kumar Sharma & Rajat Sandhir. 2017. Neuroprotective Effects of Phytochemicals in Neurological Disorders. Neuroprotective Effects of Phytochemicals in Neurological Disorders 515 559 .
Jisung Kim, Siyoung Lee, Bo-Ryoung Choi, Hee Yang, Youjin Hwang, Jung Han Yoon Park, Frank M. LaFerla, Jung-Soo Han, Ki Won Lee & Jiyoung Kim. (2017) Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways. Molecular Nutrition & Food Research 61:2, pages 1600194.
Crossref
Seung‐Hoon Yang, Dongkeun Kenneth Lee, Jisu Shin, Sejin Lee, Seungyeop Baek, Jiyoon Kim, Hoyong Jung, Jung‐Mi Hah & YoungSoo Kim. (2016) Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP / PS 1 mice . EMBO Molecular Medicine 9:1, pages 61-77.
Crossref
Lhassane Ismaili, Alejandro Romero, María do Carmo Carreiras & José Marco-Contelles. 2017. Design of Hybrid Molecules for Drug Development. Design of Hybrid Molecules for Drug Development 5 46 .
Hye Yun Kim, Seung-Hoon Yang, Jin Yoon, HoChung Jang, Seungyeop Baek, Jisu Shin, Sung Hoon Kim & YoungSoo Kim. 2017. Taurine 10. Taurine 10 225 232 .
Cristina Angeloni, Silvana Hrelia & Marco Malaguti. 2017. Glucosinolates. Glucosinolates 275 299 .
Jeffrey R. Liddell, Sarka Lehtonen, Clare Duncan, Velta Keksa-Goldsteine, Anna-Liisa Levonen, Gundars Goldsteins, Tarja Malm, Anthony R. White, Jari Koistinaho & Katja M. Kanninen. (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. Journal of Neuroinflammation 13:1.
Crossref
Kira M. Holmström, Rumen V. Kostov & Albena T. Dinkova-Kostova. (2016) The multifaceted role of Nrf2 in mitochondrial function. Current Opinion in Toxicology 1, pages 80-91.
Crossref
Dahee Jung, Yu J. Hwang, Hoon Ryu, Masanobu Kano, Kenji Sakimura & Jeiwon Cho. (2016) Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. Frontiers in Behavioral Neuroscience 10.
Crossref
Venugopalan Rajesh & Sakthivel Ilanthalir. (2016) Cognition Enhancing Activity of Sulforaphane Against Scopolamine Induced Cognitive Impairment in Zebra Fish (Danio rerio). Neurochemical Research 41:10, pages 2538-2548.
Crossref
Jiseon Lee, Huijeong Ahn, Eui-Ju Hong, Beum-Soo An, Eui-Bae Jeung & Geun-Shik Lee. (2016) Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome. Cellular Immunology 306-307, pages 53-60.
Crossref
Ye Won An, Kyoung A. Jhang, So-Youn Woo, Jihee Lee Kang & Young Hae Chong. (2016) Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages. Neurobiology of Aging 38, pages 1-10.
Crossref
Izaskun Buendia, Patrycja Michalska, Elisa Navarro, Isabel Gameiro, Javier Egea & Rafael León. (2016) Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacology & Therapeutics 157, pages 84-104.
Crossref
Sergio Davinelli, Giovanni Scapagnini, Guido Koverech, Maria Luca, Carmela Calandra & Vittorio Calabrese. 2016. Molecular Basis of Nutrition and Aging. Molecular Basis of Nutrition and Aging 251 261 .
Cristina Angeloni, Silvana Hrelia & Marco Malaguti. 2016. Glucosinolates. Glucosinolates 1 25 .
Hye Yun Kim, Hyunjin Vincent Kim, Seonmi Jo, C. Justin Lee, Seon Young Choi, Dong Jin Kim & YoungSoo Kim. (2015) EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nature Communications 6:1.
Crossref
Othman Al-Sawaf, Tim Clarner, Athanassios Fragoulis, Yuet Wai KanThomas Pufe, Konrad Streetz & Christoph Jan Wruck. (2015) Nrf2 in health and disease: current and future clinical implications. Clinical Science 129:12, pages 989-999.
Crossref
Delinda A. Johnson & Jeffrey A. Johnson. (2015) Nrf2—a therapeutic target for the treatment of neurodegenerative diseases. Free Radical Biology and Medicine 88, pages 253-267.
Crossref
Katja M. Kanninen, Yuriy Pomeshchik, Hanna Leinonen, Tarja Malm, Jari Koistinaho & Anna-Liisa Levonen. (2015) Applications of the Keap1–Nrf2 system for gene and cell therapy. Free Radical Biology and Medicine 88, pages 350-361.
Crossref
Sabrina Giacoppo, Maria Galuppo, Sabine Montaut, Renato Iori, Patrick Rollin, Placido Bramanti & Emanuela Mazzon. (2015) An overview on neuroprotective effects of isothiocyanates for the treatment of neurodegenerative diseases. Fitoterapia 106, pages 12-21.
Crossref
Xu Jing, Huanying Shi, Xiuying Zhu, Xinbing Wei, Manru Ren, Minxing Han, Dongmei Ren & Haiyan Lou. (2015) Eriodictyol Attenuates ?-Amyloid 25?35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2. Neurochemical Research 40:7, pages 1463-1471.
Crossref
Cristina Angeloni, Marco Malaguti, Benedetta Rizzo, Maria Cristina Barbalace, Daniele Fabbri & Silvana Hrelia. (2015) Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity. Chemical Research in Toxicology 28:6, pages 1234-1245.
Crossref
Guoguo Shang, Xinjun Tang, Pan Gao, Fanli Guo, Hongpeng Liu, Zhonghua Zhao, Qi Chen, Tao Jiang, Nong Zhang & Hui Li. (2015) Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway. The Journal of Nutritional Biochemistry 26:6, pages 596-606.
Crossref
Javier Egea, Izaskun Buendia, Esther Parada, Elisa Navarro, Patricia Rada, Antonio Cuadrado, Manuela G López, Antonio G García & Rafael León. (2015) Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a ‘drug-prodrug’ mechanism of action. British Journal of Pharmacology 172:7, pages 1807-1821.
Crossref
Rui Zhang, Qian-Wei Miao, Chun-Xiao Zhu, Yue Zhao, Li Liu, Jun Yang & Li An. (2014) Sulforaphane Ameliorates Neurobehavioral Deficits and Protects the Brain From Amyloid β Deposits and Peroxidation in Mice With Alzheimer-Like Lesions. American Journal of Alzheimer's Disease & Other Dementiasr 30:2, pages 183-191.
Crossref
Yang Yang, Shuai Jiang, Juanjuan Yan, Yue Li, Zhenlong Xin, Yan Lin & Yan Qu. (2015) An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders. Cytokine & Growth Factor Reviews 26:1, pages 47-57.
Crossref
Linjie Yu, Sulei Wang, Xiang Chen, Hui Yang, Xiaoxi Li, Yun Xu & Xiaolei Zhu. (2015) Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease. Life Sciences 121, pages 104-109.
Crossref
Chulman Jo, Sunhyo Kim, Sun-Jung Cho, Ki Ju Choi, Sang-Moon Yun, Young Ho Koh, Gail V.W. Johnson & Sang Ick Park. (2014) Sulforaphane induces autophagy through ERK activation in neuronal cells. FEBS Letters 588:17, pages 3081-3088.
Crossref
Rui Zhang, Jingzhu Zhang, Lingduo Fang, Xi Li, Yue Zhao, Wanying Shi & Li An. (2014) Neuroprotective Effects of Sulforaphane on Cholinergic Neurons in Mice with Alzheimer’s Disease-Like Lesions. International Journal of Molecular Sciences 15:8, pages 14396-14410.
Crossref
Li Gan & Jeffrey A. Johnson. (2014) Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:8, pages 1208-1218.
Crossref
Jaewon Lee, Dong-Gyu Jo, Daeui Park, Hae Young Chung & Mark P. Mattson. (2014) Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System. Pharmacological Reviews 66:3, pages 815-868.
Crossref
Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee & Jiyoung Kim. (2014) Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological Research 85, pages 23-32.
Crossref
Yanying Liu, Casey L. Hettinger, Dong Zhang, Khosrow Rezvani, Xuejun Wang & Hongmin Wang. (2014) Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease. Journal of Neurochemistry 129:3, pages 539-547.
Crossref
Kristina Friedland-Leuner, Carola Stockburger, Isabel Denzer, Gunter P. Eckert & Walter E. Müller. 2014. The Mitochondrion in Aging and Disease. The Mitochondrion in Aging and Disease 183 210 .
Min-Young Noh, Kwangwoo Chun, Byung Yong Kang, Heejaung Kim, Ji-Seon Park, Han-Chang Lee, Young-Ha Kim, Saekwang Ku & Seung Hyun Kim. (2013) Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer’s disease. Biochemical and Biophysical Research Communications 435:2, pages 274-281.
Crossref
Andrea Tarozzi, Cristina Angeloni, Marco Malaguti, Fabiana Morroni, Silvana Hrelia & Patrizia Hrelia. (2013) Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity 2013, pages 1-10.
Crossref
Chan Lee, Gyu Hwan Park, Seong-Ryong Lee & Jung-Hee Jang. (2013) Attenuation of -Amyloid-Induced Oxidative Cell Death by Sulforaphane via Activation of NF-E2-Related Factor 2 . Oxidative Medicine and Cellular Longevity 2013, pages 1-12.
Crossref

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