Publication Cover
Amyloid
The Journal of Protein Folding Disorders
Volume 6, 1999 - Issue 1
164
Views
76
CrossRef citations to date
0
Altmetric
Original Article

In vitro peroxidase oxidation induces stable dimers of β-amyloid (1-42) through dityrosine bridge formation

, , &
Pages 7-13 | Published online: 06 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Zarina Arif, Mir Yasir Arfat, Km Neelofar, Shafeeque Ahmad, Asim Badar, Md Adnan Khan, Asif Zaman & Jamal Ahmad. (2017) Effect of peroxynitrite on human serum albumin: a multi technique approach. Journal of Biomolecular Structure and Dynamics 35:9, pages 2066-2076.
Read now
Hila Shoval, Dov Lichtenberg & Ehud Gazit. (2007) The molecular mechanisms of the anti-amyloid effects of phenols. Amyloid 14:1, pages 73-87.
Read now
Anthony R White, Kevin J Barnham & Ashley I Bush. (2006) Metal homeostasis in Alzheimer’s disease. Expert Review of Neurotherapeutics 6:5, pages 711-722.
Read now
Feda E. Ali, Andrew Leung, Robert A. Cherny, Christine Mavros, Kevin J. Barnham, Frances Separovic & Colin J. Barrow. (2006) Dimerisation of N-acetyl-l-tyrosine ethyl ester and Aβ peptides via formation of dityrosine. Free Radical Research 40:1, pages 1-9.
Read now
Desiree Watson, Eduardo Castaño, Tyler A. Kokjohn, Yu-Min Kuo, Yuri Lyubchenko, David Pinsky, E. Sander Connolly, Chera Esh, Dean C. Luehrs, W. Blaine Stine, Linda M. Rowse, Mark R. Emmerling & Alex E. Roher. (2005) Physicochemical characteristics of soluble oligomeric Aβ and their pathologic role in Alzheimer's disease. Neurological Research 27:8, pages 869-881.
Read now
Bernd Moosmann & Christian Behl. (2002) Antioxidants as treatment for neurodegenerative disorders. Expert Opinion on Investigational Drugs 11:10, pages 1407-1435.
Read now
Luciano Galeazzi, Elizabeth H. Corder, Roberta Galeazzi, Tiziana Casoli, M. Beatrice Valli & Sergio Giunta. (2002) In vitro apolipoprotein E protects human red blood cells against lysis induced by amyloid-beta (Aβ) fragment 25-35. Amyloid 9:2, pages 103-107.
Read now
Sergio Giunta, Paolo Ronchi, Beatrice Valli, Claudio Franceschi & Luciano Galeazzi. (2000) Transformation of beta-amyloid (Aβ) (1-42) tyrosine to L-Dopa as the result of in vitro hydroxyl radical attack. Amyloid 7:3, pages 189-193.
Read now

Articles from other publishers (68)

Mary Alice Allnutt & Kathryn Mansfield Matera. (2023) Stabilization and Reduced Cytotoxicity of Amyloid Beta Aggregates in the Presence of Catechol Neurotransmitters. Neurochemical Research.
Crossref
Qiao Xiang, Shifang Sun, Yanan Liu, Zufang Wu & Xin Zhang. (2023) Anti-aging effect of Guanshan cherry blossom extract by regulating intestinal microbiota and activating glial cells. Food Bioscience 55, pages 103051.
Crossref
Miłosz Nesterowicz, Kamil Klaudiusz Lauko, Małgorzata Żendzian-Piotrowska, Jerzy Robert Ładny, Anna Zalewska & Mateusz Maciejczyk. (2023) Agomelatine's antiglycoxidative action—In vitro and in silico research and systematic literature review. Frontiers in Psychiatry 14.
Crossref
Mahmoud B. Maina, Youssra K. Al-Hilaly & Louise C. Serpell. (2023) Dityrosine cross-linking and its potential roles in Alzheimer’s disease. Frontiers in Neuroscience 17.
Crossref
Madhuparna Roy, Arnab Kumar Nath, Ishita Pal & Somdatta Ghosh Dey. (2022) Second Sphere Interactions in Amyloidogenic Diseases. Chemical Reviews 122:14, pages 12132-12206.
Crossref
Amit Pal, Isha Rani, Anil Pawar, Mario Picozza, Mauro Rongioletti & Rosanna Squitti. (2021) Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis. Biomolecules 11:11, pages 1598.
Crossref
Simone Mancini, Simona Mattioli, Simone Paolucci, Filippo Fratini, Alessandro Dal Bosco, Tiziano Tuccinardi & Gisella Paci. (2021) Effect of Cooking Techniques on the in vitro Protein Digestibility, Fatty Acid Profile, and Oxidative Status of Mealworms (Tenebrio molitor). Frontiers in Veterinary Science 8.
Crossref
Elmira I. Yakupova, Liya G. Bobyleva, Sergey A. Shumeyko, Ivan M. Vikhlyantsev & Alexander G. Bobylev. (2021) Amyloids: The History of Toxicity and Functionality. Biology 10:5, pages 394.
Crossref
Mahmoud B. Maina, Youssra K. Al-Hilaly, Gunasekhar Burra, Janet E. Rickard, Charles R. Harrington, Claude M. Wischik & Louise C. Serpell. (2021) Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates. Cells 10:3, pages 703.
Crossref
Mahmoud B. Maina, Gunasekhar Burra, Youssra K. Al-Hilaly, Kurtis Mengham, Kate Fennell & Louise C. Serpell. (2020) Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity. iScience 23:10, pages 101537.
Crossref
Gunnar Brinkmalm, Wei Hong, Zemin Wang, Wen Liu, Tiernan T O’Malley, Xin Sun, Matthew P Frosch, Dennis J Selkoe, Erik Portelius, Henrik Zetterberg, Kaj Blennow & Dominic M Walsh. (2019) Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer’s brain. Brain 142:5, pages 1441-1457.
Crossref
Xiaolin Dong, Teodor Svantesson, Sabrina B. Sholts, Cecilia Wallin, Jüri Jarvet, Astrid Gräslund & Sebastian K.T.S. Wärmländer. (2019) Copper ions induce dityrosine-linked dimers in human but not in murine islet amyloid polypeptide (IAPP/amylin). Biochemical and Biophysical Research Communications 510:4, pages 520-524.
Crossref
Yuanxin Chen, Tianduo Wang, Kem A. Rogers, Brian K. Rutt & John A. Ronald. (2019) Close Association of Myeloperoxidase-Producing Activated Microglia with Amyloid Plaques in Hypercholesterolemic Rabbits. Journal of Alzheimer's Disease 67:4, pages 1221-1234.
Crossref
Miao Gu, David C. Bode & John H. Viles. (2018) Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer. Scientific Reports 8:1.
Crossref
Montserrat Serra-Batiste, James Tolchard, Fabrice Giusti, Manuela Zoonens & Natàlia Carulla. (2018) Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease. Frontiers in Molecular Biosciences 5.
Crossref
Aurelio Vázquez de la Torre, Marina Gay, Sílvia Vilaprinyó-Pascual, Roberta Mazzucato, Montserrat Serra-Batiste, Marta Vilaseca & Natàlia Carulla. (2018) Direct Evidence of the Presence of Cross-Linked Aβ Dimers in the Brains of Alzheimer’s Disease Patients. Analytical Chemistry 90:7, pages 4552-4560.
Crossref
Elisabeth Chiziane, Henriette Telemann, Martin Krueger, Juliane Adler, Jürgen Arnhold, A. Alia & Jörg Flemmig. (2018) Free Heme and Amyloid-β: A Fatal Liaison in Alzheimer’s Disease. Journal of Alzheimer's Disease 61:3, pages 963-984.
Crossref
Pritam Roy, Amit Kumar Dinda, Susmitnarayan Chaudhury & Swagata Dasgupta. (2017) β‐cyclodextrin encapsulated polyphenols as effective antioxidants. Biopolymers 109:1.
Crossref
Eduardo Rojas-Gutierrez, Guadalupe Muñoz-Arenas, Samuel Treviño, Blanca Espinosa, Raúl Chavez, Karla Rojas, Gonzalo Flores, Alfonso Díaz & Jorge Guevara. (2017) Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration. Synapse 71:10, pages e21990.
Crossref
Soumya Mukherjee, Eugene A. Kapp, Amber Lothian, Anne M. Roberts, Yury V. Vasil’ev, Berin A. Boughton, Kevin J. Barnham, W. Mei Kok, Craig A. Hutton, Colin L. Masters, Ashley I. Bush, Joseph S. Beckman, Somdatta Ghosh Dey & Blaine R. Roberts. (2017) Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry. Analytical Chemistry 89:11, pages 6136-6145.
Crossref
Zoe K. Mathys & Anthony R. White. 2017. Neurotoxicity of Metals. Neurotoxicity of Metals 199 216 .
Tsuneya Ikezu. 2017. Neuroimmune Pharmacology. Neuroimmune Pharmacology 451 476 .
Tiernan T. O’Malley, William M. WitboldIIIIII, Sara Linse & Dominic M. Walsh. (2016) The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer. Biochemistry 55:44, pages 6150-6161.
Crossref
Amit Kumar Dinda, Saparya Chattaraj, Sudeshna Ghosh, Debi Ranjan Tripathy & Swagata Dasgupta. (2016) DNA melting properties of the dityrosine cross-linked dimer of Ribonuclease A. Journal of Photochemistry and Photobiology B: Biology 162, pages 535-543.
Crossref
Meder Kamalov, Harveen Kaur & Margaret A. Brimble. (2016) Intermolecular Peptide Cross‐Linking by Using Diaminodicarboxylic Acids. Chemistry – A European Journal 22:11, pages 3622-3631.
Crossref
B. Muthuraj, Sourav Layek, S. N. Balaji, Vishal Trivedi & Parameswar Krishnan Iyer. (2015) Multiple Function Fluorescein Probe Performs Metal Chelation, Disaggregation, and Modulation of Aggregated Aβ and Aβ-Cu Complex. ACS Chemical Neuroscience 6:11, pages 1880-1891.
Crossref
Patrick Gamez & Ana B. Caballero. (2015) Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity. AIP Advances 5:9.
Crossref
Merlin Friedemann, Eneken Helk, Ann Tiiman, Kairit Zovo, Peep Palumaa & Vello Tõugu. (2015) Effect of methionine-35 oxidation on the aggregation of amyloid-β peptide. Biochemistry and Biophysics Reports 3, pages 94-99.
Crossref
Gyu Hwan Park & Jung-Hee Jang. 2015. Aging Mechanisms. Aging Mechanisms 357 393 .
Tiernan T. O’Malley, Nur Alia Oktaviani, Dainan Zhang, Aleksey LomakinBrian O’NuallainSara Linse, George B. BenedekMichael J. Rowan, Frans A. A. Mulder & Dominic M. Walsh. (2014) Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies. Biochemical Journal 461:3, pages 413-426.
Crossref
Alfred T. Welzel, John E. Maggio, Ganesh M. Shankar, Donald E. Walker, Beth L. Ostaszewski, Shaomin Li, Igor Klyubin, Michael J. Rowan, Peter Seubert, Dominic M. Walsh & Dennis J. Selkoe. (2014) Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity. Biochemistry 53:24, pages 3908-3921.
Crossref
Ewa Sitkiewicz, Jacek Olędzki, Jarosław Poznański & Michał Dadlez. (2014) Di-Tyrosine Cross-Link Decreases the Collisional Cross-Section of Aβ Peptide Dimers and Trimers in the Gas Phase: An Ion Mobility Study. PLoS ONE 9:6, pages e100200.
Crossref
Amit Kumar Dinda, Debi Ranjan Tripathy, Anushree Das & Swagata Dasgupta. (2014) Comparison of the ribonucleolytic activity of the dityrosine cross-linked Ribonuclease A dimer with its monomer in the presence of inhibitors. International Journal of Biological Macromolecules 63, pages 107-113.
Crossref
Henrik Zetterberg & Kaj Blennow. (2012) Biomarker evidence for uncoupling of amyloid build‐up and toxicity in Alzheimer's disease. Alzheimer's & Dementia 9:4, pages 459-462.
Crossref
W. Mei Kok, Jade M. Cottam, Giuseppe D. Ciccotosto, Luke A. Miles, John A. Karas, Denis B. Scanlon, Blaine R. Roberts, Michael W. Parker, Roberto Cappai, Kevin J. Barnham & Craig A. Hutton. (2013) Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers. Chemical Science 4:12, pages 4449.
Crossref
Gözde Eskici & Paul H. Axelsen. (2012) Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease. Biochemistry 51:32, pages 6289-6311.
Crossref
Iryna Benilova, Eric Karran & Bart De Strooper. (2012) The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nature Neuroscience 15:3, pages 349-357.
Crossref
Blaine R. Roberts, Timothy M. Ryan, Ashley I. Bush, Colin L. Masters & James A. Duce. (2011) The role of metallobiology and amyloid‐β peptides in Alzheimer’s disease. Journal of Neurochemistry 120:s1, pages 149-166.
Crossref
Dominika Bystranowska, Zbigniew Szewczuk, Marek Lisowski, Ewa Sitkiewicz, Piotr Dobryszycki, Andrzej Ożyhar & Marian Kochman. (2012) Intramolecular cross-linking in the native JHBP molecule. Archives of Biochemistry and Biophysics 517:1, pages 12-19.
Crossref
Youssef El Khoury, Pierre Dorlet, Peter Faller & Petra Hellwig. (2011) New Insights into the Coordination of Cu(II) by the Amyloid-B 16 Peptide from Fourier Transform IR Spectroscopy and Isotopic Labeling. The Journal of Physical Chemistry B 115:49, pages 14812-14821.
Crossref
Sharad P. Adekar, Igor Klyubin, Sally Macy, Michael J. Rowan, Alan Solomon, Scott K. Dessain & Brian O'Nuallain. (2010) Inherent Anti-amyloidogenic Activity of Human Immunoglobulin γ Heavy Chains. Journal of Biological Chemistry 285:2, pages 1066-1074.
Crossref
Laura Bica, Peter J. Crouch, Roberto Cappai & Anthony R. White. (2009) Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer’s disease. Mol. BioSyst. 5:2, pages 134-142.
Crossref
Anthony R. White & Ashley I. Bush. 2008. Alzheimer's Disease. Alzheimer's Disease 107 136 .
Denise V. Dear, Duncan S. Young, Jurate Kazlauskaite, Filip Meersman, David Oxley, Judith Webster, Teresa J.T. Pinheiro, Andrew C. Gill, Igor Bronstein & Christopher R. Lowe. (2007) Effects of post-translational modifications on prion protein aggregation and the propagation of scrapie-like characteristics in vitro. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1774:7, pages 792-802.
Crossref
David P. Smith, Giuseppe D. Ciccotosto, Deborah J. Tew, Michelle T. Fodero-Tavoletti, Timothy Johanssen, Colin L. Masters, Kevin J. Barnham & Roberto Cappai. (2007) Concentration Dependent Cu 2+ Induced Aggregation and Dityrosine Formation of the Alzheimer's Disease Amyloid-β Peptide . Biochemistry 46:10, pages 2881-2891.
Crossref
C.J. Carter. (2007) Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis. Neurochemistry International 50:1, pages 12-38.
Crossref
Laszlo OtvosJr.Jr.. 2007. Abeta Peptide and Alzheimer’s Disease. Abeta Peptide and Alzheimer’s Disease 102 124 .
S. Giunta, M.B. Valli, R. Galeazzi, P. Fattoretti, E.H. Corder & L. Galeazzi. (2005) Transthyretin inhibition of amyloid beta aggregation and toxicity. Clinical Biochemistry 38:12, pages 1112-1119.
Crossref
Christa J. Maynard, Ashley I. Bush, Colin L. Masters, Roberto Cappai & Qiao-Xin Li. (2005) Metals and amyloid-β in Alzheimer's disease. International Journal of Experimental Pathology 86:3, pages 147-159.
Crossref
Robert D. Moir, Katya A. Tseitlin, Stephanie Soscia, Bradley T. Hyman, Michael C. Irizarry & Rudolph E Tanzi. (2005) Autoantibodies to Redox-modified Oligomeric Aβ Are Attenuated in the Plasma of Alzheimer's Disease Patients. Journal of Biological Chemistry 280:17, pages 17458-17463.
Crossref
P. J. Crouch. (2005) Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid- 1-42. Journal of Neuroscience 25:3, pages 672-679.
Crossref
Christian Behl. 2005. Alzheimer’s Disease. Alzheimer’s Disease 65 78 .
Seiichi Nagano, Xudong Huang, Robert D. Moir, Sandra M. Payton, Rudolph E. Tanzi & Ashley I. Bush. (2004) Peroxidase Activity of Cyclooxygenase-2 (COX-2) Cross-links β-Amyloid (Aβ) and Generates Aβ-COX-2 Hetero-oligomers That Are Increased in Alzheimer's Disease. Journal of Biological Chemistry 279:15, pages 14673-14678.
Crossref
Craig S. AtwoodGeorge PerryHong ZengYoji KatoWalton D. JonesKe-Qing LingXudong HuangRobert D. MoirDandan WangLawrence M. SayreMark A. SmithShu G. ChenAshley I. Bush. (2003) Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β. Biochemistry 43:2, pages 560-568.
Crossref
Stéphanie Blanchin, Valérie Estienne, Josée-Martine Durand-Gorde, Pierre Carayon & Jean Ruf. (2003) Complement Activation by Direct C4 Binding to Thyroperoxidase in Hashimoto’s Thyroiditis. Endocrinology 144:12, pages 5422-5429.
Crossref
Feda E. Ali, Kevin J. Barnham, Colin J. Barrow & Frances Separovic. (2003) Copper catalysed oxidation of amino acids and Alzheimer's disease. International Journal of Peptide Research and Therapeutics 10:5-6, pages 405-412.
Crossref
Joshua C. Yoburn, Wenqiang Tian, Justin O. Brower, James S. Nowick, Charles G. Glabe & David L. Van Vranken. (2003) Dityrosine Cross-Linked Aβ Peptides:  Fibrillar β-Structure in Aβ(1-40) Is Conducive to Formation of Dityrosine Cross-Links but a Dityrosine Cross-Link in Aβ(8-14) Does Not Induce β-Structure. Chemical Research in Toxicology 16:4, pages 531-535.
Crossref
W F Reynolds, K Patel, S Pianko, L M Blatt, J J Nicholas & J G McHutchison. (2002) A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection. Genes & Immunity 3:6, pages 345-349.
Crossref
Sonia S. Jung & William E. Van Nostrand. (2002) A?? does not induce oxidative stress in human cerebrovascular smooth muscle cells. Neuroreport 13:10, pages 1309-1312.
Crossref
Craig S Atwood, Ralph N Martins, Mark A Smith & George Perry. (2002) Senile plaque composition and posttranslational modification of amyloid-β peptide and associated proteins. Peptides 23:7, pages 1343-1350.
Crossref
Jarrod Bailey, Robert J. Phillips, Alison J. Pollard, Kate Gilmore, Stephen C. Robson & G. Nicholas Europe-Finner. (2002) Characterization and Functional Analysis of cAMP Response Element Modulator Protein and Activating Transcription Factor 2 (ATF2) Isoforms in the Human Myometrium during Pregnancy and Labor: Identification of a Novel ATF2 Species with Potent Transactivation Properties. The Journal of Clinical Endocrinology & Metabolism 87:4, pages 1717-1728.
Crossref
Dorairajan Balasubramanian & Ritu Kanwar. 2002. Oxygen/Nitrogen Radicals: Cell Injury and Disease. Oxygen/Nitrogen Radicals: Cell Injury and Disease 27 38 .
Elizabeth Head, William Garzon-Rodriguez, Julene K. Johnson, Ira T. Lott, Carl W. Cotman & Charles Glabe. (2001) Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome. Neurobiology of Disease 8:5, pages 792-806.
Crossref
Maria Brzyska, Andrzej Bacia & Danek Elbaum. (2001) Oxidative and hydrolytic properties of β‐amyloid. European Journal of Biochemistry 268:12, pages 3443-3454.
Crossref
Igor L. Shamovsky, Richard J. Riopelle & Gregory M. Ross. (2001) Ab Initio Studies on the Mechanism of Tyrosine Coupling. The Journal of Physical Chemistry A 105:6, pages 1061-1070.
Crossref
Ritu Kanwar & Dorairajan Balasubramanian. (2000) Structural Studies on Some Dityrosine-Cross-Linked Globular Proteins:  Stability Is Weakened, but Activity Is Not Abolished. Biochemistry 39:48, pages 14976-14983.
Crossref
Soledad Miranda, Carlos Opazo, Luis F Larrondo, Francisco J Muñoz, Francisca Ruiz, Federico Leighton & Nibaldo C Inestrosa. (2000) The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease. Progress in Neurobiology 62:6, pages 633-648.
Crossref
LUCIANO GALEAZZI, TIZIANA CASOLI, SERGIO GIUNTA, PATRIZIA FATTORETTI, NATASCIA GRACCIOTTI, UGO CASELLI & CARLO BERTONI-FREDDARI. (2000) beta-Amyloid Fragment 25-35 Induces Changes in Cytosolic Free Calcium in Human Platelets. Annals of the New York Academy of Sciences 903:1 VASCULAR FACT, pages 451-456.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.