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Commentary

Adapting concepts from systems biology to develop systems exposure event networks for exposure science research

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Pages 99-105 | Received 01 Sep 2010, Accepted 16 Nov 2010, Published online: 08 Dec 2010

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Read on this site (8)

Joachim D. Pleil, M. Ariel Geer Wallace, Matthew A. Stiegel & William E. Funk. (2018) Human biomarker interpretation: the importance of intra-class correlation coefficients (ICC) and their calculations based on mixed models, ANOVA, and variance estimates. Journal of Toxicology and Environmental Health, Part B 21:3, pages 161-180.
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M. Ariel Geer Wallace, Tzipporah M. Kormos & Joachim D. Pleil. (2016) Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science. Journal of Toxicology and Environmental Health, Part B 19:8, pages 380-409.
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Joachim D. Pleil & Jon R. Sobus. (2016) Estimating central tendency from a single spot measure: A closed-form solution for lognormally distributed biomarker data for risk assessment at the individual level. Journal of Toxicology and Environmental Health, Part A 79:18, pages 837-847.
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M. A. Stiegel, J. D. Pleil, J. R. Sobus, M. M. Angrish & M. K. Morgan. (2015) Kidney injury biomarkers and urinary creatinine variability in nominally healthy adults. Biomarkers 20:6-7, pages 436-452.
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Matthew A. Stiegel, Joachim D. Pleil, Jon R. Sobus, Marsha K. Morgan & Michael C. Madden. (2015) Analysis of inflammatory cytokines in human blood, breath condensate, and urine using a multiplex immunoassay platform. Biomarkers 20:1, pages 35-46.
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Joachim D. Pleil, Jon R. Sobus, Matthew A. Stiegel, Di Hu, Karen D. Oliver, Cassandra Olenick, Mark Strynar, Mary Clark, Michael C. Madden & William E. Funk. (2014) Estimating Common Parameters of Lognormally Distributed Environmental and Biomonitoring Data: Harmonizing Disparate Statistics from Publications. Journal of Toxicology and Environmental Health, Part B 17:6, pages 341-368.
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Joachim D. Pleil. (2012) Categorizing Biomarkers of the Human Exposome and Developing Metrics for Assessing Environmental Sustainability. Journal of Toxicology and Environmental Health, Part B 15:4, pages 264-280.
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Daland R. Juberg, Thomas B. Knudsen, Miriam Sander, Nancy B. Beck, Elaine M. Faustman, Donna L. Mendrick, John R. FowleIIIIII, Thomas Hartung, Raymond R. Tice, Emmanuel Lemazurier, Richard A. Becker, Suzanne Compton Fitzpatrick, George P. Daston, Alison Harrill, Ronald N. Hines, Douglas A. Keller, John C. Lipscomb, David Watson, Tina Bahadori & Kevin M. Crofton. (2017) FutureTox III: Bridges for Translation. Toxicological Sciences 155:1, pages 22-31.
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Matthew A. Stiegel, Joachim D. Pleil, Jon R. Sobus & Michael C. Madden. (2016) Inflammatory Cytokines and White Blood Cell Counts Response to Environmental Levels of Diesel Exhaust and Ozone Inhalation Exposures. PLOS ONE 11:4, pages e0152458.
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Joachim D Pleil & Kristin K Isaacs. (2016) High-resolution mass spectrometry: basic principles for using exact mass and mass defect for discovery analysis of organic molecules in blood, breath, urine and environmental media. Journal of Breath Research 10:1, pages 012001.
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Mary Regina Boland, Alexandra Jacunski, Tal Lorberbaum, Joseph D. Romano, Robert Moskovitch & Nicholas P. Tatonetti. (2015) Systems biology approaches for identifying adverse drug reactions and elucidating their underlying biological mechanisms. WIREs Systems Biology and Medicine 8:2, pages 104-122.
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Joachim D Pleil, Michelle M Angrish & Michael C Madden. (2015) Immunochemistry for high-throughput screening of human exhaled breath condensate (EBC) media: implementation of automated quanterix SIMOA instrumentation. Journal of Breath Research 9:4, pages 047108.
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Michelle M. Angrish, Michael C. Madden & Joachim D. Pleil. (2015) Probe Molecule (PrM) Approach in Adverse Outcome Pathway (AOP) Based High-Throughput Screening (HTS): In Vivo Discovery for Developing in Vitro Target Methods . Chemical Research in Toxicology 28:4, pages 551-559.
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S Ghimenti, F Di Francesco, M Onor, M A Stiegel, M G Trivella, C Comite, N Catania, R Fuoco & J D Pleil. (2013) Post-operative elimination of sevoflurane anesthetic and hexafluoroisopropanol metabolite in exhaled breath: pharmacokinetic models for assessing liver function. Journal of Breath Research 7:3, pages 036001.
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Joachim D. Pleil & Jon R. Sobus. 2013. Volatile Biomarkers. Volatile Biomarkers 2 18 .
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S. Brul, J. Bassett, P. Cook, S. Kathariou, P. McClure, P.R. Jasti & R. Betts. (2012) ‘Omics’ technologies in quantitative microbial risk assessment. Trends in Food Science & Technology 27:1, pages 12-24.
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Julia Hoeng, Renée Deehan, Dexter Pratt, Florian Martin, Alain Sewer, Ty M. Thomson, David A. Drubin, Christina A. Waters, David de Graaf & Manuel C. Peitsch. (2012) A network-based approach to quantifying the impact of biologically active substances. Drug Discovery Today 17:9-10, pages 413-418.
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Joachim D Pleil, Matthew A Stiegel & Jon R Sobus. (2011) Breath biomarkers in environmental health science: exploring patterns in the human exposome. Journal of Breath Research 5:4, pages 046005.
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Jon R. Sobus, Yu-Mei Tan, Joachim D. Pleil & Linda S. Sheldon. (2011) A biomonitoring framework to support exposure and risk assessments. Science of The Total Environment 409:22, pages 4875-4884.
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Joachim D Pleil, Matthew A Stiegel, Jon R Sobus, Qian Liu & Michael C Madden. (2011) Observing the human exposome as reflected in breath biomarkers: heat map data interpretation for environmental and intelligence research. Journal of Breath Research 5:3, pages 037104.
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Joachim D. Pleil, Matthew A. Stiegel, Michael C. Madden & Jon R. Sobus. (2011) Heat map visualization of complex environmental and biomarker measurements. Chemosphere 84:5, pages 716-723.
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