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Research Article

Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol compared with one containing levonorgestrel and ethinylestradiol on haemostasis, lipids and carbohydrate metabolism

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Pages 444-457 | Published online: 08 Nov 2011

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Suzanne Reed, Carol Koro, Julia DiBello, Kerstin Becker, Anja Bauerfeind, Christian Franke & Klaas Heinemann. (2021) Prospective controlled cohort study on the safety of a monophasic oral contraceptive containing nomegestrol acetate (2.5mg) and 17β-oestradiol (1.5mg) (PRO-E2 study): risk of venous and arterial thromboembolism. The European Journal of Contraception & Reproductive Health Care 26:6, pages 439-446.
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Santiago Palacios, Enrico Colli & Pedro A. Regidor. (2021) Metabolic and laboratory effects of a progestin-only pill containing drospirenone 4 mg in comparison to desogestrel 75 µg: a double-blind, double-dummy, prospective, randomised study. The European Journal of Contraception & Reproductive Health Care 26:6, pages 454-461.
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Luca Liban Mariani, Lorenzo Novara, Matteo Mancarella, Luca Fuso, Elisa Casula & Nicoletta Biglia. (2021) Estradiol/nomegestrol acetate as a first-line and rescue therapy for the treatment of ovarian and deep infiltrating endometriosis. Gynecological Endocrinology 37:7, pages 646-649.
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Kristine Kollerøs Panton, Gustav Mikkelsen, Wenche Øiestad Irgens, Ann Kristin Hovde, Marte Wien Killingmo, Monja Airin Øien, Per Medbøe Thorsby & Arne Åsberg. (2019) New reference intervals for cortisol, cortisol binding globulin and free cortisol index in women using ethinyl estradiol. Scandinavian Journal of Clinical and Laboratory Investigation 79:5, pages 314-319.
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Franca Fruzzetti & Angelo Cagnacci. (2018) Venous thrombosis and hormonal contraception: what’s new with estradiol-based hormonal contraceptives?. Open Access Journal of Contraception 9, pages 75-79.
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Ingrid Duijkers, Christine Klipping, Doris Heger-Mahn, Ghassan N. Fayad, Tara L. Frenkl, Sandra M. Cruz & Tjeerd Korver. (2018) Phase II dose-finding study on ovulation inhibition and cycle control associated with the use of contraceptive vaginal rings containing 17β-estradiol and the progestagens etonogestrel or nomegestrol acetate compared to NuvaRing. The European Journal of Contraception & Reproductive Health Care 23:4, pages 245-254.
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Michelle Yagnatovsky, Amos Z Dai, Michael Zacchilli & Laith M Jazrawi. (2018) Acute pulmonary embolism after arthroscopic glenoid labral repair and subacromial decompression: case report and review of the literature. The Physician and Sportsmedicine 46:1, pages 135-138.
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Manuela Neri, Maria Elena Malune, Valentina Corda, Bruno Piras, Pierina Zedda, Monica Pilloni, Maria Paola Orani, Valerio Vallerino, Gian Benedetto Melis & Anna Maria Paoletti. (2017) Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC). Gynecological Endocrinology 33:12, pages 958-962.
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Manuela Farris, Carlo Bastianelli, Elena Rosato, Ivo Brosens & Giuseppe Benagiano. (2017) Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. effects on hemostasis. Expert Review of Clinical Pharmacology 10:10, pages 1129-1144.
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Giovanni Grandi, Fabio Facchinetti & Johannes Bitzer. (2017) Estradiol in hormonal contraception: real evolution or just same old wine in a new bottle?. The European Journal of Contraception & Reproductive Health Care 22:4, pages 245-246.
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Angelo Cagnacci. (2017) Hormonal contraception: venous and arterial disease. The European Journal of Contraception & Reproductive Health Care 22:3, pages 191-199.
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Carlo Bastianelli, Manuela Farris, Elena Rosato, Ivo Brosens & Giuseppe Benagiano. (2017) Pharmacodynamics of combined estrogen-progestin oral contraceptives: 1. Effects on metabolism. Expert Review of Clinical Pharmacology 10:3, pages 315-326.
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Giovanni Grandi, Antonella Napolitano & Angelo Cagnacci. (2016) Metabolic impact of combined hormonal contraceptives containing estradiol. Expert Opinion on Drug Metabolism & Toxicology 12:7, pages 779-787.
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Hannat Akintomide & Sabeena Panicker. (2015) Nomegestrol acetate/17-beta estradiol: a review of efficacy, safety, and patient acceptability. Open Access Journal of Contraception 6, pages 77-86.
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Anita L Nelson. (2015) An update on new orally administered contraceptives for women. Expert Opinion on Pharmacotherapy 16:18, pages 2759-2772.
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Marie Mawet, Catherine Maillard, Christine Klipping, Yvette Zimmerman, Jean-Michel Foidart & Herjan J.T. Coelingh Bennink. (2015) Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives. The European Journal of Contraception & Reproductive Health Care 20:6, pages 463-475.
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Manuel Luque-Ramírez & Héctor Francisco Escobar-Morreale. (2015) Targets to treat androgen excess in polycystic ovary syndrome. Expert Opinion on Therapeutic Targets 19:11, pages 1545-1560.
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Giovanni Grandi, Antonella Napolitano, Anjeza Xholli, Alessandra Tirelli, Costantino Di Carlo & Angelo Cagnacci. (2015) Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea. Gynecological Endocrinology 31:10, pages 774-778.
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Iñaki Lete, Nathalie Chabbert-Buffet, Christian Jamin, Stefano Lello, Paloma Lobo, Rossella E. Nappi & Axelle Pintiaux. (2015) Haemostatic and metabolic impact of estradiol pills and drospirenone-containing ethinylestradiol pills vs. levonorgestrel-containing ethinylestradiol pills: A literature review. The European Journal of Contraception & Reproductive Health Care 20:5, pages 329-343.
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Regine Sitruk-Ware & Anita Nath. (2015) Applying emerging science to contraception research: implications for the clinic. Expert Review of Endocrinology & Metabolism 10:1, pages 115-126.
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Kai J. Buhling, Lisa Klovekorn, Benita Daniels, Friederike S. G. Studnitz, Christine Eulenburg & Alfred O. Mueck. (2014) Contraceptive counselling and self-prescription of contraceptives of German gynaecologists: Results of a nationwide survey. The European Journal of Contraception & Reproductive Health Care 19:6, pages 448-456.
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Anne Burke. (2013) Nomegestrol acetate-17b-estradiol for oral contraception. Patient Preference and Adherence 7, pages 607-619.
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Jeffrey T Jensen, Johannes Bitzer & Marco Serrani. (2013) Comparison of the pharmacologic and clinical profiles of new combined oral contraceptives containing estradiol. Open Access Journal of Contraception 4, pages 39-50.
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Nathalie Chabbert-Buffet, Jan Gerris, Christian Jamin, Stefano Lello, Inaki Lete, Paloma Lobo, Rossella E. Nappi & Axelle Pintiaux. (2013) Toward a new concept of “natural balance” in oral estroprogestin contraception. Gynecological Endocrinology 29:10, pages 891-896.
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Yvette Zimmerman, Wout Wouters & Herjan J. T. Coelingh Bennink. (2013) The bioequivalence of the contraceptive steroids ethinylestradiol and drospirenone is not affected by co-administration of dehydroepiandrosterone. The European Journal of Contraception & Reproductive Health Care 18:3, pages 206-214.
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Ulla M. Ågren, Marjatta Anttila, Kristiina Mäenpää-Liukko, Maija-Liisa Rantala, Hilkka Rautiainen, Werner F. Sommer & Ellen Mommers. (2011) Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function. The European Journal of Contraception & Reproductive Health Care 16:6, pages 458-467.
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Diana Mansour, Carole Verhoeven, Werner Sommer, Edith Weisberg, Surasak Taneepanichskul, Gian Benedetto Melis, Inger Sundström-Poromaa & Tjeerd Korver. (2011) Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen. The European Journal of Contraception & Reproductive Health Care 16:6, pages 430-443.
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