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Review Article

Effects of Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: review of recently completed randomised, controlled trials

Pages 8-14 | Received 10 Jun 2013, Accepted 10 Jun 2013, Published online: 27 Aug 2013

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Walter E. Müller, Anne Eckert, Gunter P. Eckert, Heidrun Fink, Kristina Friedland, Serge Gauthier, Robert Hoerr, Ralf Ihl, Siegfried Kasper & Hans-Jürgen Möller. (2019) Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease. The World Journal of Biological Psychiatry 20:3, pages 173-189.
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Tavga Ahmed Aziz, Saad Abdulrahman Hussain, Taha Othman Mahwi & Zheen Aorahman Ahmed. (2018) Efficacy and safety of Ginkgo biloba extract as an “add-on” treatment to metformin for patients with metabolic syndrome: a pilot clinical study. Therapeutics and Clinical Risk Management 14, pages 1219-1226.
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Vida Demarin, Vanja Bašić Kes, Zlatko Trkanjec, Mislav Budišić, Marija Bošnjak Pašić, Petra Črnac & Hrvoje Budinčević. (2017) Efficacy and safety of Ginkgo biloba standardized extract in the treatment of vascular cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial. Neuropsychiatric Disease and Treatment 13, pages 483-490.
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Min Liu, Yulin Peng, Yilin Che, Meirong Zhou, Ying Bai, Wei Tang, Shanshan Huang, Baojing Zhang, Sa Deng, Chao Wang & Zhenlong Yu. (2022) MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation. Frontiers in Pharmacology 13.
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Liming Xie, Qi Zhu & Jiahong Lu. (2022) Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies. Cells 11:3, pages 479.
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Seo-Hee KIM & Soon-Ho YIM. (2022) Effects of Bilobol from the Fruit Pulp of Ginkgo biloba on Cell Viability. Food Science and Technology 42.
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Ovidiu Băjenaru, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any A. Docu, Valérie Perrot, Madalina Avram & Cristina Tiu. (2021) Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment. CNS & Neurological Disorders - Drug Targets 20:4, pages 378-384.
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Xiaoyue WANG, Xiaoyan GONG, Huina ZHANG, Wanshan ZHU, Zewu JIANG, Yujing SHI & Li LI. (2020) In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents. Food Science and Technology 40:2, pages 476-482.
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Le Chen, Chenghong Zhang, Ying Han, Xianyi Meng, Ying Zhang, Haiying Chu & Haiying Ma. (2019) Gingko biloba Extract (EGb) Inhibits Oxidative Stress in Neuro 2A Cells Overexpressing APPsw . BioMed Research International 2019, pages 1-9.
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Roman Jirák. (2018) Ginkgo biloba EGb761 extract and its use in psychiatry. Neurologie pro praxi 19:Demence - strašák 21. století, pages 15-18.
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Arrigo F.G. Cicero, Federica Fogacci & Maciej Banach. (2018) Botanicals and phytochemicals active on cognitive decline: The clinical evidence. Pharmacological Research 130, pages 204-212.
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Zhongping Huang, Yueting Xu, Yilei Huang, Charles Liu, Kezhi Jiang & Lili Wang. (2017) Rapid determination of ginkgolic acids in Ginkgo biloba kernels and leaves by direct analysis in real time-mass spectrometry . Journal of Separation Science 40:24, pages 4857-4864.
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Wenbin Wan, Chunyan Zhang, Mark Danielsen, Qianlei Li, Wenjing Chen, Yuanjin CHAN & Yaming Li. (2016) EGb761 improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse. Experimental Gerontology 81, pages 92-100.
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Jing Yang, An-Qi Wang, Xue-jing Li, Xue Fan, Shan-Shan Yin & Ke Lan. (2016) A chemical profiling strategy for semi-quantitative analysis of flavonoids in Ginkgo extracts. Journal of Pharmaceutical and Biomedical Analysis 123, pages 147-154.
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Izaskun Buendia, Patrycja Michalska, Elisa Navarro, Isabel Gameiro, Javier Egea & Rafael León. (2016) Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacology & Therapeutics 157, pages 84-104.
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Yong Joo Park, Hui Yeon Ahn, Ha Ryong Kim, Kyu Hyuck Chung & Seung Min Oh. (2016) Ginkgo biloba extract EGb 761-mediated inhibition of aromatase for the treatment of hormone-dependent breast cancer. Food and Chemical Toxicology 87, pages 157-165.
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Zhuhong Zhang, Nan Mei, Si Chen, Lei Guo & Xiaoqing Guo. 2016. Nutraceuticals. Nutraceuticals 883 892 .
Nicole J. Brandt & Daniel Z. Mansour. 2016. Dementia Care. Dementia Care 73 95 .
Xin-Guang Liu, Si-Qi Wu, Ping Li & Hua Yang. (2015) Advancement in the chemical analysis and quality control of flavonoid in Ginkgo biloba. Journal of Pharmaceutical and Biomedical Analysis 113, pages 212-225.
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Jennifer DoleyMBAMBA. 2015. Integrative Nutrition Therapy. Integrative Nutrition Therapy 49 88 .
Siegfried Kasper. (2015) Phytopharmaceutical treatment of anxiety, depression, and dementia in the elderly: evidence from randomized, controlled clinical trialsPhytopharmaka bei der Behandlung von Angststörungen, Depressionen und Demenz bei älteren Patienten – Evidenz aus randomisierten, klinischenStudien. Wiener Medizinische Wochenschrift 165:11-12, pages 217-228.
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F. Jessen. (2014) Therapie von DemenzerkrankungenTherapy for patients with dementia. Der Internist 55:7, pages 769-774.
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Shuifen Ye, Yong Gu, Yihui Xu, Wen Fan, Xiaoting Wang, Shuting Chen, Siyi Cai, Shirong Lv, Yao Tong & Jing Cai. (2014) Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion. Molecular Medicine Reports.
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Jonathan M. Ford & Nicole J. Brandt. (2014) Role of Nutraceuticals in Dementia Care. Journal of Gerontological Nursing 40:4, pages 12-17.
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