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Original Article

Vaginal estriol to overcome side-effects of aromatase inhibitors in breast cancer patients

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Pages 339-344 | Received 29 Jun 2010, Accepted 29 Sep 2010, Published online: 13 Jan 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

C. Castelo-Branco, E. Mension, I. Torras, I. Cebrecos & S. Anglès-Acedo. (2023) Treating genitourinary syndrome of menopause in breast cancer survivors: main challenges and promising strategies. Climacteric 26:4, pages 296-301.
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Rosaria Condorelli & Ines Vaz-Luis. (2018) Managing side effects in adjuvant endocrine therapy for breast cancer. Expert Review of Anticancer Therapy 18:11, pages 1101-1112.
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A. J. Vincent. (2015) Management of menopause in women with breast cancer. Climacteric 18:5, pages 690-701.
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Ana Carolina M. Comini, Bruno M. Carvalho, Matheus José Barbosa Moreira, Pedro C. Abrahão Reis, Luisa Colapietro, Jane Northern & Felipe Batalini. (2023) Safety and Serum Estradiol Levels in Hormonal Treatments for Vulvovaginal Atrophy in Breast Cancer Survivors: A Systematic Review and Meta-Analysis. Clinical Breast Cancer 23:8, pages 835-846.
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Riccardo Vizza, Elisabetta Maria Capomolla, Livia Tosetto, Giacomo Corrado, Valentina Bruno, Benito Chiofalo, Francesca Sofia Di Lisa, Lorena Filomeno, Laura Pizzuti, Eriseld Krasniqi, Giuseppe Sanguineti, Alice Villa, Andrea Giannini, Ramy Kayal, Vincenzo Stranges, Silverio Tomao, Claudio Botti, Federica Tomao, Maddalena Barba, Enrico Vizza, Gennaro Ciliberto & Patrizia Vici. (2023) Sexual dysfunctions in breast cancer patients: evidence in context. Sexual Medicine Reviews 11:3, pages 179-195.
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Maria Sund, Hans Garmo, Anne Andersson, Sara Margolin, Johan Ahlgren & Antonis Valachis. (2023) Estrogen therapy after breast cancer diagnosis and breast cancer mortality risk. Breast Cancer Research and Treatment 198:2, pages 361-368.
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Fatemeh Sodeifian, Aida Mokhlesi & Farzad Allameh. (2022) Chemotherapy and Related Female Sexual Dysfunction: A Review of Literature. International Journal of Cancer Management 15:4.
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Daniel María Lubián López. (2022) Management of genitourinary syndrome of menopause in breast cancer survivors: An update. World Journal of Clinical Oncology 13:2, pages 71-100.
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. (2021) Treatment of Urogenital Symptoms in Individuals With a History of Estrogen-dependent Breast Cancer. Obstetrics & Gynecology 138:6, pages 950-960.
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C. Hocké, M. Diaz, V. Bernard, S. Frantz, M. Lambert, C. Mathieu & M. Grellety-Cherbero. (2021) Syndrome génito-urinaire de la ménopause (SGUM). RPC les femmes ménopausées du CNGOF et du GEMVi. Gynécologie Obstétrique Fertilité & Sénologie  49:5, pages 394-413.
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Eduard Mension, Inmaculada Alonso & Camil Castelo-Branco. (2021) Genitourinary Syndrome of Menopause: Current Treatment Options in Breast Cancer Survivors – Systematic Review. Maturitas 143, pages 47-58.
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Alyssa Streff, Michele Chu-Pilli, Alison Stopeck & Pavani Chalasani. (2020) Changes in serum estradiol levels with Estring in postmenopausal women with breast cancer treated with aromatase inhibitors. Supportive Care in Cancer 29:1, pages 187-191.
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Pedro Sánchez-Rovira, Angelica Lindén Hirschberg, Miguel Gil-Gil, Begoña Bermejo-De Las Heras & Concepción Nieto-Magro. (2020) A Phase II Prospective, Randomized, Double-Blind, Placebo-Controlled and Multicenter Clinical Trial to Assess the Safety of 0.005% Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women with Early Stage Breast Cancer in Treatment with Aromatase Inhibitor in the Adjuvant Setting. The Oncologist 25:12, pages e1846-e1854.
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Angelica Lindén Hirschberg, Pedro Sánchez-Rovira, Jesús Presa-Lorite, Miriam Campos-Delgado, Miguel Gil-Gil, Elisabet Lidbrink, Javier Suárez-AlmarzaConcepción Nieto-Magro. (2020) Efficacy and safety of ultra-low dose 0.005% estriol vaginal gel for the treatment of vulvovaginal atrophy in postmenopausal women with early breast cancer treated with nonsteroidal aromatase inhibitors: a phase II, randomized, double-blind, placebo-controlled trial. Menopause 27:5, pages 526-534.
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Nicolás Mendoza, Rosalía Carrión, Loreto Mendoza-Huertas & Ana Rosa Jurado. (2020) Efficacy and Safety of Treatments to Improve Dyspareunia in Breast Cancer Survivors: A Systematic Review. Breast Care 15:6, pages 599-607.
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Benjamin S. Harris, Katherine C. Bishop, Jeffrey A. Kuller, Anne C. Ford, Lisa C. Muasher, Sarah E. Cantrell & Thomas M. Price. (2020) Hormonal management of menopausal symptoms in women with a history of gynecologic malignancy. Menopause 27:2, pages 243-248.
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R.T. Pavlović, S.M. Janković, J.R. Milovanović, S.M. Stefanović, M.M. Folić, O.Z. Milovanović, C. Mamillapalli & M.N. Milosavljević. (2019) The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-positive Breast Cancer Who Are on Adjuvant Aromatase Inhibitor Therapy: Meta-analysis. Clinical Breast Cancer 19:6, pages e731-e740.
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No Author. (2019) Chapitre 8 : Sexualité et ménopause. Journal of Obstetrics and Gynaecology Canada 41, pages S103-S121.
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Sheryl A. Kingsberg, Lisa Larkin, Michael Krychman, Sharon J. Parish, Brian Bernick & Sebastian Mirkin. (2019) WISDOM survey: attitudes and behaviors of physicians toward vulvar and vaginal atrophy (VVA) treatment in women including those with breast cancer history. Menopause 26:2, pages 124-131.
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Ines Vaz-Luis & Ann H. Partridge. (2018) Exogenous reproductive hormone use in breast cancer survivors and previvors. Nature Reviews Clinical Oncology 15:4, pages 249-261.
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Myrtle Wilhite. 2018. Integrative Medicine. Integrative Medicine 592 599.e2 .
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Mariana S. SousaMichelle Peate, Sherin Jarvis, Martha Hickey & Michael Friedlander. (2017) A clinical guide to the management of genitourinary symptoms in breast cancer survivors on endocrine therapy. Therapeutic Advances in Medical Oncology 9:4, pages 269-285.
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Elisabeth Sulaica, Tiffany Han, Weiqun Wang, Raksha Bhat, Meghana V. Trivedi & Polly Niravath. (2016) Vaginal estrogen products in hormone receptor-positive breast cancer patients on aromatase inhibitor therapy. Breast Cancer Research and Treatment 157:2, pages 203-210.
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Susan M. Seav, Sally A. Dominick, Boris Stepanyuk, Jessica R. Gorman, Diana T. Chingos, Jennifer L. Ehren, Michael L. Krychman & H. Irene Su. (2015) Management of sexual dysfunction in breast cancer survivors: a systematic review. Women's Midlife Health 1:1.
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Nicoletta Biglia, Valentina E. Bounous, Luca G. Sgro, Marta D'Alonzo, Silvia Pecchio & Rossella E. Nappi. (2015) Genitourinary Syndrome of Menopause in Breast Cancer Survivors: Are We Facing New and Safe Hopes?. Clinical Breast Cancer 15:6, pages 413-420.
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L. Guédra, A. Fèvre & O. Graesslin. (2015) Alternativas al tratamiento hormonal sustitutivo de la menopausia. EMC - Ginecología-Obstetricia 51:4, pages 1-12.
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Perino Antonino & Calagna Gloria. (2015) A new approach to treatment of vulvo-vaginal atrophy. Maturitas 81:4, pages 499.
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Joanne Lester, Gaurav Pahouja, Barbara Andersen & Maryam Lustberg. (2015) Atrophic Vaginitis in Breast Cancer Survivors: A Difficult Survivorship Issue. Journal of Personalized Medicine 5:2, pages 50-66.
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Antonino Perino, Alberto Calligaro, Francesco Forlani, Corrado Tiberio, Gaspare Cucinella, Alessandro Svelato, Salvatore Saitta & Gloria Calagna. (2015) Vulvo-vaginal atrophy: A new treatment modality using thermo-ablative fractional CO2 laser. Maturitas 80:3, pages 296-301.
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. (2014) RETIRED: Managing Menopause Chapter 8 Sexuality and Menopause. Journal of Obstetrics and Gynaecology Canada 36:9, pages S59-S73.
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Dudley Robinson, Linda Cardozo, Ian Milsom, Montserrat Espuna Pons, Michael Kirby, Heinz Koelbl & Mark Vierhout. (2014) Oestrogens and overactive bladder. Neurourology and Urodynamics 33:7, pages 1086-1091.
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Magnus Diller, Susanne Schüler, Stefan Buchholz, Claus Lattrich, Oliver Treeck & Olaf Ortmann. (2014) Effects of estriol on growth, gene expression and estrogen response element activation in human breast cancer cell lines. Maturitas 77:4, pages 336-343.
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Lesley Fallowfield & Valerie Jenkins. 2014. Breast Surgery. Breast Surgery 258 267 .
Sandy J. Falk & Don S. Dizon. (2013) Sexual dysfunction in women with cancer. Fertility and Sterility 100:4, pages 916-921.
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S. Buchholz & O. Ortmann. (2013) Behandlung von klimakterischen Symptomen bei Frauen mit gyn?kologischen Malignomen und MammakarzinomTreatment of climacteric symptoms in women with gynecological malignancies and breast cancer. Der Gyn?kologe 46:3, pages 160-164.
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Juliane Baumgart, Kerstin Nilsson, Anneli Stavreus Evers, Theodora Kunovac Kallak & Inger Sundström Poromaa. (2013) Sexual dysfunction in women on adjuvant endocrine therapy after breast cancer. Menopause 20:2, pages 162-168.
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Juan López-Belmonte, Concepción Nieto, José Estevez, Juan L. Delgado & Jaime Moscoso del Prado. (2012) Comparative uterine effects on ovariectomized rats after repeated treatment with different vaginal estrogen formulations. Maturitas 72:4, pages 353-358.
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C. Lattrich, S. Schüler, M. Mögele & O. Ortmann. (2012) Hormonsubstitution bei gynäkologischen MalignomenHormone substitution in gynecologic malignancies. Der Gynäkologe 45:8, pages 618-622.
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Ritu Salani & Barbara L. Andersen. (2012) Gynecologic care for breast cancer survivors: assisting in the transition to wellness. American Journal of Obstetrics and Gynecology 206:5, pages 390-397.
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M. Moegele, S. Buchholz, S. Seitz & Olaf Ortmann. (2012) Vaginal estrogen therapy in postmenopausal breast cancer patients treated with aromatase inhibitors. Archives of Gynecology and Obstetrics 285:5, pages 1397-1402.
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M. Moegele, S. Buchholz, S. Seitz, C. Lattrich & O. Ortmann. (2012) Vaginale Östrogentherapie bei MammakarzinompatientinnenVaginal estrogen therapy in breast cancer patients. Gynäkologische Endokrinologie 10:1, pages 57-60.
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Myrtle Wilhite. 2012. Integrative Medicine. Integrative Medicine 529 536.e1 .
Mary Panjari & Susan R. Davis. (2011) Vaginal DHEA to treat menopause related atrophy: A review of the evidence. Maturitas 70:1, pages 22-25.
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