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Climacteric Volume 15, 2012 - Issue 5
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Research Article

One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome

A. SantamariaDepartment of Obstetrics and Gynecological Sciences, University of Messina
,
D. Giordano *Policlinico Hospital, Reggio Calabria
,
F. CorradoDepartment of Obstetrics and Gynecological Sciences, University of Messina
,
B. PintaudiDepartment of Internal Medicine, University of Messina, Italy
,
M. L. InterdonatoDepartment of Obstetrics and Gynecological Sciences, University of Messina
,
G. Di ViesteDepartment of Internal Medicine, University of Messina, Italy
,
A. Di BenedettoDepartment of Internal Medicine, University of Messina, Italy
&
R. D'AnnaDepartment of Obstetrics and Gynecological Sciences, University of Messina
 show all
Pages 490-495 | Received 21 Jul 2011, Accepted 25 Sep 2011, Published online: 23 Dec 2011

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Zahra Bashiri, Nadia Sheibak, Fatemehsadat Amjadi & Zahra Zandieh. (2022) The role of myo-inositol supplement in assisted reproductive techniques. Human Fertility 0:0, pages 1-17.
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Oliver C. Watkins, Hannah E. J. Yong, Neha Sharma & Shiao-Yng Chan. (2022) A review of the role of inositols in conditions of insulin dysregulation and in uncomplicated and pathological pregnancy. Critical Reviews in Food Science and Nutrition 62:6, pages 1626-1673.
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Giuseppe Derosa, Angela D’Angelo, Arianna Vanelli & Pamela Maffioli. (2020) An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia. Diabetes, Metabolic Syndrome and Obesity 13, pages 653-661.
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Rosario D’Anna, Angelo Santamaria, Grazia Giorgianni, Alberto Vaiarelli, Giuseppe Gullo, Flavia Di Bari & Salvatore Benvenga. (2017) Myo-inositol and melatonin in the menopausal transition. Gynecological Endocrinology 33:4, pages 279-282.
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Mariano Bizzarri, Andrea Fuso, Simona Dinicola, Alessandra Cucina & Arturo Bevilacqua. (2016) Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opinion on Drug Metabolism & Toxicology 12:10, pages 1181-1196.
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Cristiana Paul, Antonio Simone Laganà, Paolo Maniglio, Onofrio Triolo & David M. Brady. (2016) Inositol’s and other nutraceuticals’ synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives. Gynecological Endocrinology 32:6, pages 431-438.
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Articles from other publishers (45)

Sayeree Joardar, Prangan Duarah & Mihir Kumar Purkait. (2023) Recent advances in myo-inositol recovery and purification from agricultural sources as potential dietary supplements: A review. Sustainable Chemistry and Pharmacy 36, pages 101331.
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S. V. Orlova & E. A. Nikitina. (2023) The role of lipotropic factors in the correction of metabolic disorders in women during the perimenopausal period. Medical alphabet:19, pages 7-15.
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Mariana del Carmen Fernández-Fígares Jiménez. (2023) Plant foods, healthy plant-based diets, and type 2 diabetes: a review of the evidence. Nutrition Reviews.
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Ali Jawad, Dongjin Oh, Hyerin Choi, Mirae Kim, Lian Cai, Joohyeong Lee & Sang-Hwan Hyun. (2023) Myo-inositol improves the viability of boar sperm during liquid storage. Frontiers in Veterinary Science 10.
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Murugesan Karthikeyan, Marimuthu Dhinesh Kumar, Ganesan Kaniraja, Periyasamy Ananthappan, Vairathevar Sivasamy Vasantha & Chandran Karunakaran. (2023) Gold nanoparticles enhanced molecularly imprinted poly(3-aminophenylboronic acid) sensor for myo-inositol detection. Microchemical Journal 189, pages 108536.
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Sepideh Mashayekh-Amiri, Sakineh Mohammad-Alizadeh-Charandabi, Somaiyeh Abdolalipour & Mojgan Mirghafourvand. (2022) Myo-inositol supplementation for prevention of gestational diabetes mellitus in overweight and obese pregnant women: a systematic review and meta-analysis. Diabetology & Metabolic Syndrome 14:1.
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Meysam Zarezadeh, Azadeh Dehghani, Amir Hossein Faghfouri, Nima Radkhah, Mohammad Naemi Kermanshahi, Fatemeh Hamedi Kalajahi, Niyaz Mohammadzadeh Honarvar, Zohreh Ghoreishi, Alireza Ostadrahimi & Mehrangiz Ebrahimi Mamaghani. (2021) Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials. Obesity Science & Practice 8:3, pages 387-397.
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L.E. Tumanova & O.V. Kolomiets. (2022) Therapeutic options for pre-gravidary training in women with a history of combined infertility. Reproductive health of woman:2, pages 53-58.
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James J DiNicolantonio & James H O'Keefe. (2022) Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes. Open Heart 9:1, pages e001989.
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O.A. Nochvinа & E.V. Slyvka. (2021) Role of inositol and its isomers in glucose metabolism. REPRODUCTIVE ENDOCRINOLOGY:62, pages 104-109.
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Sogol Hashemi Tari, Mohammad Hassan Sohouli, Abolfazl Lari, Somaye Fatahi & Seyedeh Tayebeh Rahideh. (2021) The effect of inositol supplementation on blood pressure: A systematic review and meta-analysis of randomized-controlled trials. Clinical Nutrition ESPEN 44, pages 78-84.
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Maria Magdalena Montt-Guevara, Michele Finiguerra, Ilaria Marzi, Tiziana Fidecicchi, Amerigo Ferrari, Alessandro D. Genazzani & Tommaso Simoncini. (2021) D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes. Frontiers in Endocrinology 12.
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Yueting Deng, Chen Huang, Jingyue Su, Chen-Wei Pan & Chaofu Ke. (2021) Identification of biomarkers for essential hypertension based on metabolomics. Nutrition, Metabolism and Cardiovascular Diseases 31:2, pages 382-395.
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George Asimakopoulos, Vasilios Pergialiotis, Eleni Anastasiou, Panagiotis Antsaklis, Mariana Theodora, Evangelia Vogiatzi, Aggela Kallergi, Michael Sindos, Dimitrios Loutradis & George Daskalakis. (2020) Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: study protocol for a randomized controlled trial. Trials 21:1.
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Arianna Pani, Riccardo Giossi, Danilo Menichelli, Veronica Andrea Fittipaldo, Francesca Agnelli, Elvira Inglese, Alessandra Romandini, Rossana Roncato, Basilio Pintaudi, Francesco Del Sole & Francesco Scaglione. (2020) Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation. Nutrients 12:11, pages 3379.
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Dawei Shi, Xian Xia, Aoyuan Cui, Zhongxiang Xiong, Yizhen Yan, Jing Luo, Guoyu Chen, Yingying Zeng, Donghong Cai, Lei Hou, Joseph McDermott, Yu Li, Hong Zhang & Jing-Dong J. Han. (2020) The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16. Nature Communications 11:1.
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Ahmad Yar Qamar, Xung Fang, Min Jung Kim & Jongki Cho. (2019) Myoinositol Supplementation of Freezing Medium Improves the Quality-Related Parameters of Dog Sperm. Animals 9:12, pages 1038.
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Inka Miñambres, Gemma Cuixart, Anna Gonçalves & Rosa Corcoy. (2019) Effects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition 38:3, pages 1146-1152.
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F. Mohammadi, N. Varanloo, M. Heydari Nasrabadi, A. Vatannejad, F. S. Amjadi, M. Javedani Masroor, L. Bajelan, M. Mehdizadeh, R. Aflatoonian & Z. Zandieh. (2019) Supplementation of sperm freezing medium with myoinositol improve human sperm parameters and protects it against DNA fragmentation and apoptosis. Cell and Tissue Banking 20:1, pages 77-86.
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Christian Egarter. (2018) Myo-InositolMyo-inositol. Gynäkologische Endokrinologie 17:1, pages 11-15.
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Reza Tabrizi, Vahidreza Ostadmohammadi, Kamran B. Lankarani, Payam Peymani, Maryam Akbari, Fariba Kolahdooz & Zatollah Asemi. (2018) The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Lipids in Health and Disease 17:1.
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Arturo Bevilacqua & Mariano Bizzarri. (2018) Inositols in Insulin Signaling and Glucose Metabolism. International Journal of Endocrinology 2018, pages 1-8.
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Robert H. Michell. (2018) Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function?. British Journal of Nutrition 120:3, pages 301-316.
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Xiulai Chen, Cong Gao, Liang Guo, Guipeng Hu, Qiuling Luo, Jia Liu, Jens Nielsen, Jian Chen & Liming Liu. (2017) DCEO Biotechnology: Tools To Design, Construct, Evaluate, and Optimize the Metabolic Pathway for Biosynthesis of Chemicals. Chemical Reviews 118:1, pages 4-72.
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Wu Ning, Haijing Li, Fanqiang Meng, Jianhua Cheng, Xin Song, Guochao Zhang, Wenyue Wang, Shengming Wu, Junjian Fang, Kunpeng Ma, Jie Yang, Dongpo Pei & Fangting Dong. (2017) Identification of differential metabolic characteristics between tumor and normal tissue from colorectal cancer patients by gas chromatography-mass spectrometry. Biomedical Chromatography 31:11, pages e3999.
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Simona Dinicola, Mirko Minini, Vittorio Unfer, Roberto Verna, Alessandra Cucina & Mariano Bizzarri. (2017) Nutritional and Acquired Deficiencies in Inositol Bioavailability. Correlations with Metabolic Disorders. International Journal of Molecular Sciences 18:10, pages 2187.
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Stefano Tassinari, Andrés Azuero, Dan Arreaza, María C. Rueda-Rodríguez, Camilo Castañeda-Cardona & Diego Rosselli. (2017) Suplementos nutricionales como modificadores del riesgo cardiovascular en componentes del síndrome metabólico en adultos. Revista Colombiana de Cardiología 24:3, pages 277-285.
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Qiaoya Ma, Ying Yang, Yuyan Na, Tianbo Jin, Yidong Xue, Yuting Shi, Chen Li & Wanggang Zhang. (2016) IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population . Oncotarget 7:46, pages 75273-75278.
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Francesca Ferrari, Fabio Facchinetti, Alejandra E. Ontiveros, Robyn P. Roberts, Mia M. Saade, Sean C. Blackwell, Baha M. Sibai, Jerrie S. Refuerzo & Monica Longo. (2016) The effect of combined inositol supplementation on maternal metabolic profile in pregnancies complicated by metabolic syndrome and obesity. American Journal of Obstetrics and Gynecology 215:4, pages 503.e1-503.e8.
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Min Fu, Yang Song, Zhaoxia Wen, Xingyi Lu & Lianhua Cui. (2016) Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice. Nutrients 8:5, pages 286.
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Claudio Celentano, Barbara Matarrelli, Peter A. Mattei, Giulia Pavone, Ester Vitacolonna & Marco Liberati. (2016) Myo-Inositol Supplementation to Prevent Gestational Diabetes Mellitus. Current Diabetes Reports 16:3.
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Basilio Pintaudi, Giacoma Di Vieste & Matteo Bonomo. (2016) The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes. International Journal of Endocrinology 2016, pages 1-5.
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Saghar Salehpour, Leila Nazari, Sedighe Hoseini, Nasrin Saharkhiz, Fatemeh Ghazi & Mohammad Reza Sohrabi. (2016) A Potential Therapeutic Role of Myoinositol in the Metabolic and Cardiovascular Profile of PCOS Iranian Women Aged between 30 and 40 Years. International Journal of Endocrinology 2016, pages 1-5.
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Mariano Bizzarri, Simona Dinicola, Arturo Bevilacqua & Alessandra Cucina. (2016) Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. International Journal of Endocrinology 2016, pages 1-14.
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Giovanna Muscogiuri, Stefano Palomba, Antonio Simone Laganà & Francesco Orio. (2016) Inositols in the Treatment of Insulin-Mediated Diseases. International Journal of Endocrinology 2016, pages 1-6.
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Mario Montanino Oliva, Elisa Minutolo, Assunta Lippa, Paola Iaconianni & Alberto Vaiarelli. (2016) Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome. International Journal of Endocrinology 2016, pages 1-5.
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Fabio Facchinetti, Mariano Bizzarri, Salvatore Benvenga, Rosario D’Anna, Antonio Lanzone, Christophe Soulage, Gian Carlo Di Renzo, Moshe Hod, Pietro Cavalli, Tony T. Chiu, Zdravko A. Kamenov, Arturo Bevilacqua, Gianfranco Carlomagno, Sandro Gerli, Mario Montanino Oliva & Paul Devroey. (2015) Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS. European Journal of Obstetrics & Gynecology and Reproductive Biology 195, pages 72-76.
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Marine L. Croze, Alain Géloën & Christophe O. Soulage. (2015) Abnormalities in myo -inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo -inositol supplementation . British Journal of Nutrition 113:12, pages 1862-1875.
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Maxim D. Seferovic, Danielle M. Goodspeed, Derrick M. Chu, Laura A. Krannich, Pablo J. Gonzalez‐Rodriguez, James E. Cox & Kjersti M. Aagaard. (2015) Heritable IUGR and adult metabolic syndrome are reversible and associated with alterations in the metabolome following dietary supplementation of 1‐carbon intermediates. The FASEB Journal 29:6, pages 2640-2652.
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Rosario D’Anna, Angelo Santamaria, Maria Letizia Cannata, Maria Lieta Interdonato, Grazia Maria Giorgianni, Roberta Granese, Francesco Corrado & Alessandra Bitto. (2014) Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial. International Journal of Endocrinology 2014, pages 1-7.
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Marine L. Croze & Christophe O. Soulage. (2013) Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 95:10, pages 1811-1827.
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Donald R. Coustan. (2013) Can a Dietary Supplement Prevent Gestational Diabetes Mellitus?. Diabetes Care 36:4, pages 777-779.
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Rosario D’Anna, Angela Scilipoti, Domenico Giordano, Carmela Caruso, Maria Letizia Cannata, Maria Lieta Interdonato, Francesco Corrado & Antonino Di Benedetto. (2013) myo -Inositol Supplementation and Onset of Gestational Diabetes Mellitus in Pregnant Women With a Family History of Type 2 Diabetes . Diabetes Care 36:4, pages 854-857.
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Rosario D’Anna & Maria Lieta InterdonatoDr.Dr.. 2013. Nutrition and Diet in Menopause. Nutrition and Diet in Menopause 241 254 .

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