613
Views
69
CrossRef citations to date
0
Altmetric
REVIEWS

DHEA and intracrinology at menopause, a positive choice for evolution of the human species

&
Pages 205-213 | Received 02 Aug 2012, Accepted 22 Sep 2012, Published online: 05 Nov 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Elena Rosato, Francesca Sciarra, Eleni Anastasiadou, Andrea Lenzi & Mary Anna Venneri. (2022) Revisiting the physiological role of androgens in women. Expert Review of Endocrinology & Metabolism 17:6, pages 547-561.
Read now
P. Stute, S. Bertschy, M. Birkhaeuser, J. Bitzer, A. Ging, A. Raggi, S. Steimann & V. Stute. (2022) Swiss consensus on the role of DHEA in the management of genitourinary syndrome of menopause. Climacteric 25:3, pages 246-256.
Read now
Andrea R. Genazzani, Patrizia Monteleone, Andrea Giannini & Tommaso Simoncini. (2021) Pharmacotherapeutic options for the treatment of menopausal symptoms. Expert Opinion on Pharmacotherapy 22:13, pages 1773-1791.
Read now
P. J. Ruiz-Montero, N. Marín-Jiménez, M. Borges-Cosic & V. A. Aparicio. (2021) Association of objectively measured physical fitness with health-related quality of life of mid-life women: the FLAMENCO project. Climacteric 24:3, pages 282-288.
Read now
Fernand Labrie. (2015) Each tissue becomes master of its sex steroid environment at menopause. Climacteric 18:5, pages 764-765.
Read now
C. Bouchard, F. Labrie, D. F. Archer, D. J. Portman, W. Koltun, É. Elfassi, D. A. Grainger, N. Ayotte, T. A. Cooper, M. Martens, A. S. Waldbaum, C. Labrie, I. Côté, L. Lavoie, C. Martel & J. Balser. (2015) Decreased efficacy of twice-weekly intravaginal dehydroepiandrosterone on vulvovaginal atrophy. Climacteric 18:4, pages 590-607.
Read now
Piera Versura, Giuseppe Giannaccare & Emilio C. Campos. (2015) Sex-Steroid Imbalance in Females and Dry Eye. Current Eye Research 40:2, pages 162-175.
Read now
Amos Pines. (2015) Climacteric Commentaries. Climacteric 18:1, pages 101-106.
Read now
Anna Fenton & Nick Panay. (2013) DHEA – finding a role for this enigmatic hormone. Climacteric 16:3, pages 303-304.
Read now

Articles from other publishers (60)

Debra Holloway. (2022) Vaginal atrophy: what is it and how can it be treated?. Practice Nursing 33:11, pages 446-451.
Crossref
Paula Briggs. (2022) Consensus statement – Urogenital atrophy. Post Reproductive Health 28:1, pages 47-50.
Crossref
Nadia Bellofiore, Jarrod McKenna, Stacey Ellery & Peter Temple-Smith. (2021) The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside. Frontiers in Reproductive Health 3.
Crossref
Nadia Bellofiore, Evgenia George, Beverley Vollenhoven & Peter Temple-Smith. (2021) Reproductive aging and menopause-like transition in the menstruating spiny mouse ( Acomys cahirinus ) . Human Reproduction 36:12, pages 3083-3094.
Crossref
Xun Jin, Jie Cheng, Jie Shen, Xing Lv, Qian Li, Yanyun Mu, Hua Bai, Yan Liu & Youbing Xia. (2021) Moxibustion improves ovarian function based on the regulation of the androgen balance. Experimental and Therapeutic Medicine 22:5.
Crossref
Typhanie Dumontet & Antoine Martinez. (2021) Adrenal androgens, adrenarche, and zona reticularis: A human affair?. Molecular and Cellular Endocrinology 528, pages 111239.
Crossref
Russell Himmelstein, Ada Spahija & H. Bobby Fokidis. (2021) Evidence for fasting induced extra-adrenal steroidogenesis in the male brown anole, Anolis sagrei. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 253, pages 110544.
Crossref
Eman Y. Gohar, Malgorzata Kasztan, Shali Zhang, Edward W. Inscho & David M. Pollock. (2020) Role for ovarian hormones in purinoceptor-dependent natriuresis. Biology of Sex Differences 11:1.
Crossref
L. Marina, A. S. Sojat, E. Maseroli, G. Spaggiari, S. Pandurevic & D. Santi. (2020) Hormonal profile of menopausal women receiving androgen replacement therapy: a meta-analysis. Journal of Endocrinological Investigation 43:6, pages 717-735.
Crossref
Caio Jordão Teixeira, Katherine Veras & Carla Roberta de Oliveira Carvalho. (2019) Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period. Journal of Molecular Medicine 98:1, pages 39-57.
Crossref
Nadia Bellofiore & Jemma Evans. (2019) Monkeys, mice and menses: the bloody anomaly of the spiny mouse. Journal of Assisted Reproduction and Genetics 36:5, pages 811-817.
Crossref
Fernand Labrie. (2019) Intracrinology and menopause: the science describing the cell-specific intracellular formation of estrogens and androgens from DHEA and their strictly local action and inactivation in peripheral tissues. Menopause 26:2, pages 220-224.
Crossref
Kamyar M. Hedayat & Jean-Claude Lapraz. 2019. The Theory of Endobiogeny. The Theory of Endobiogeny 165 183 .
Kamyar M. Hedayat & Jean-Claude Lapraz. 2019. The Theory of Endobiogeny. The Theory of Endobiogeny 135 164 .
Kamyar M. Hedayat & Jean-Claude Lapraz. 2019. The Theory of Endobiogeny. The Theory of Endobiogeny 55 67 .
Kamyar M. Hedayat & Jean-Claude Lapraz. 2019. The Theory of Endobiogeny. The Theory of Endobiogeny 89 104 .
Kamyar M. Hedayat & Jean-Claude Lapraz. 2019. The Theory of Endobiogeny. The Theory of Endobiogeny 61 88 .
Fernand Labrie, David F. Archer, William Koltun, Andrée Vachon, Douglas Young, Louise Frenette, David Portman, Marlene Montesino, Isabelle Côté, Julie Parent, Lyne Lavoie, Adam Beauregard BSc, Céline Martel, Mario Vaillancourt, John Balser & Érick Moyneur. (2018) Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. Menopause 25:11, pages 1339-1353.
Crossref
Gonda Konings, Linda Brentjens, Bert Delvoux, Tero Linnanen, Karlijn Cornel, Pasi Koskimies, Marlies Bongers, Roy Kruitwagen, Sofia Xanthoulea & Andrea Romano. (2018) Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery. Frontiers in Pharmacology 9.
Crossref
Fernand Labrie. 2018. Pre-Menopause, Menopause and Beyond. Pre-Menopause, Menopause and Beyond 269 284 .
Fernand Labrie. 2018. Pre-Menopause, Menopause and Beyond. Pre-Menopause, Menopause and Beyond 3 15 .
Emma J Gibson, Fiona Stapleton, James S Wolffsohn & Blanka Golebiowski. (2017) Local synthesis of sex hormones: are there consequences for the ocular surface and dry eye?. British Journal of Ophthalmology 101:12, pages 1596-1603.
Crossref
Fernand Labrie, David F. Archer, Céline Martel, Mario Vaillancourt & Marlene Montesino. (2017) Combined data of intravaginal prasterone against vulvovaginal atrophy of menopause. Menopause 24:11, pages 1246-1256.
Crossref
David F. Archer, Fernand Labrie, Marlene Montesino & Céline Martel. (2017) Comparison of intravaginal 6.5 mg (0.50%) prasterone, 0.3 mg conjugated estrogens and 10 μg estradiol on symptoms of vulvovaginal atrophy. The Journal of Steroid Biochemistry and Molecular Biology 174, pages 1-8.
Crossref
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F. Archer & Wulf H. Utian. (2017) Science of intracrinology in postmenopausal women. Menopause 24:6, pages 702-712.
Crossref
Fernand LabrieCéline MartelGeorges Pelletier. (2017) Is vulvovaginal atrophy due to a lack of both estrogens and androgens?. Menopause 24:4, pages 452-461.
Crossref
Fernand Labrie, Céline Martel, Alain Bélanger & Georges Pelletier. (2017) Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology. The Journal of Steroid Biochemistry and Molecular Biology 168, pages 9-18.
Crossref
G.F.J. Konings, N.L. Reynaert, B. Delvoux, F.M. Verhamme, K.R. Bracke, G.G. Brusselle, A. Romano & J.H.J. Vernooy. (2017) Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease. Molecular and Cellular Endocrinology 443, pages 23-31.
Crossref
Fernand Labrie & Céline Martel. (2017) A low dose (6.5 mg) of intravaginal DHEA permits a strictly local action while maintaining all serum estrogens or androgens as well as their metabolites within normal values. Hormone Molecular Biology and Clinical Investigation 29:2, pages 39-60.
Crossref
Alain Y. Dury, Yuyong Ke & Fernand Labrie. (2016) Precise and accurate assay of pregnenolone and five other neurosteroids in monkey brain tissue by LC–MS/MS. Steroids 113, pages 64-70.
Crossref
Dan Xu & Sheng-Xiang Lin. (2016) Mimicking postmenopausal steroid metabolism in breast cancer cell culture: Differences in response to DHEA or other steroids as hormone sources. The Journal of Steroid Biochemistry and Molecular Biology 161, pages 92-100.
Crossref
Yuyong Ke, Renaud Gonthier & Fernand Labrie. (2016) The conversion of 16β hydroxyldehydroepiandrosterone in human serum. Steroids 109, pages 50-55.
Crossref
Céline Martel, Fernand Labrie, David F. Archer, Yuyong Ke, Renaud Gonthier, Jean-Nicolas Simard, Lyne Lavoie, Mario Vaillancourt, Marlene Montesino, John Balser & Érick Moyneur. (2016) Serum steroid concentrations remain within normal postmenopausal values in women receiving daily 6.5 mg intravaginal prasterone for 12 weeks. The Journal of Steroid Biochemistry and Molecular Biology 159, pages 142-153.
Crossref
Bartosz Adam FryczDawid MurawaMaciej Borejsza-WysockiMateusz WichtowskiArkadiusz SpychałaRyszard MarciniakPaweł MurawaMichał DrewsPaweł Piotr Jagodziński. (2016) Transcript level of AKR1C3 is down-regulated in gastric cancer . Biochemistry and Cell Biology 94:2, pages 138-146.
Crossref
David J. Portman, David F. Archer, Céline Martel & Fernand Labrie. (2016) To the Editor. Menopause 23:4, pages 471-472.
Crossref
Céline Bouchard, Fernand Labrie, Leonard Derogatis, Ginette Girard, Normand Ayotte, John Gallagher, Leonello Cusan, David F. Archer, David Portman, Lyne Lavoie, Adam Beauregard, Isabelle Côté, Céline Martel, Mario Vaillancourt, John Balser, Erick Moyneur & other participating Members of the VVA Prasterone Group. (2016) Effect of intravaginal dehydroepiandrosterone (DHEA) on the female sexual function in postmenopausal women: ERC-230 open-label study. Hormone Molecular Biology and Clinical Investigation 25:3, pages 181-190.
Crossref
Fernand Labrie, David F. Archer, William Koltun, Andrée Vachon, Douglas Young, Louise Frenette, David Portman, Marlene Montesino, Isabelle Côté, Julie Parent, Lyne Lavoie, Adam Beauregard, Céline Martel, Mario Vaillancourt, John Balser & Érick Moyneur. (2016) Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. Menopause 23:3, pages 243-256.
Crossref
Yuyong Ke, Renaud Gonthier, Jean-Nicolas Simard, David Archer, Lyne Lavoie, Céline Martel, Mario Vaillancourt & Fernand Labrie. (2015) Serum steroids remain within the same normal postmenopausal values during 12-month intravaginal 0.50% DHEA. Hormone Molecular Biology and Clinical Investigation 24:3, pages 117-129.
Crossref
Fernand Labrie, Leonard Derogatis, David F. Archer, William Koltun, Andrée Vachon, Douglas Young, Louise Frenette, David Portman, Marlene Montesino, Isabelle Côté, Julie Parent, Lyne Lavoie, Adam Beauregard, Céline Martel, Mario Vaillancourt, John Balser & Érick Moyneur. (2015) Effect of Intravaginal Prasterone on Sexual Dysfunction in Postmenopausal Women with Vulvovaginal Atrophy. The Journal of Sexual Medicine 12:12, pages 2401-2412.
Crossref
David J. Portman, Fernand Labrie, David F. Archer, Céline Bouchard, Leonello Cusan, Ginette Girard, Normand Ayotte, William Koltun, François Blouin, Douglas Young, Anthony Wade, Céline Martel & Robert Dubé. (2015) Lack of effect of intravaginal dehydroepiandrosterone (DHEA, prasterone) on the endometrium in postmenopausal women. Menopause 22:12, pages 1289-1295.
Crossref
Yuyong Ke, Fernand Labrie, Renaud Gonthier, Jean-Nicolas Simard, Danielle Bergeron, Céline Martel, Mario Vaillancourt, Marlene Montesino, Lyne Lavoie, David F. Archer, John Balser & Erick Moyneur. (2015) Serum levels of sex steroids and metabolites following 12 weeks of intravaginal 0.50% DHEA administration. The Journal of Steroid Biochemistry and Molecular Biology 154, pages 186-196.
Crossref
David F. Archer, Fernand Labrie, Céline Bouchard, David J. Portman, William Koltun, Leonello Cusan, Claude Labrie, Isabelle Côté, Lyne Lavoie, Céline Martel & John Balser. (2015) Treatment of pain at sexual activity (dyspareunia) with intravaginal dehydroepiandrosterone (prasterone). Menopause 22:9, pages 950-963.
Crossref
Fernand Labrie, Yuyong Ke, Renaud Gonthier & Alain Bélanger. (2015) Reprint of “Why both LC–MS/MS and FDA-compliant validation are essential for accurate estrogen assays?”. The Journal of Steroid Biochemistry and Molecular Biology 153, pages 54-56.
Crossref
Jens Krøll. (2015) Dehydroepiandrosterone, Molecular Chaperones, and the Epigenetics of Primate Longevity. Rejuvenation Research 18:4, pages 341-346.
Crossref
Jonathan Bertin, Alain Y. Dury, Yuyong Ke, Johanne Ouellet & Fernand Labrie. (2015) Accurate and sensitive liquid chromatography/tandem mass spectrometry simultaneous assay of seven steroids in monkey brain. Steroids 98, pages 37-48.
Crossref
Fernand Labrie, David F. Archer, Céline Bouchard, Ginette Girard, Normand Ayotte, John C. Gallagher, Leonello Cusan, Mira Baron, François Blouin, Arthur S. Waldbaum, William Koltun, David J. Portman, Isabelle Côté, Lyne Lavoie, Adam Beauregard, Claude Labrie, Céline Martel, John Balser & Érick Moyneur. (2015) Prasterone has parallel beneficial effects on the main symptoms of vulvovaginal atrophy: 52-week open-label study. Maturitas 81:1, pages 46-56.
Crossref
Fernand Labrie, Yuyong Ke, Renaud Gonthier & Alain Bélanger. (2015) Why both LC–MS/MS and FDA-compliant validation are essential for accurate estrogen assays?. The Journal of Steroid Biochemistry and Molecular Biology 149, pages 89-91.
Crossref
Elena Pomari, Luisa Dalla Valle, Paolo Pertile, Lorenzo Colombo & M. Julie Thornton. (2014) Intracrine sex steroid synthesis and signaling in human epidermal keratinocytes and dermal fibroblasts. The FASEB Journal 29:2, pages 508-524.
Crossref
Carola S Scheffers, Sarah Armstrong, Astrid EP Cantineau, Cindy Farquhar & Vanessa Jordan. (2015) Dehydroepiandrosterone for women in the peri- or postmenopausal phase. Cochrane Database of Systematic Reviews 2015:1.
Crossref
Fernand Labrie. (2015) All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause. The Journal of Steroid Biochemistry and Molecular Biology 145, pages 133-138.
Crossref
Jonathan Bertin, Johanne Ouellet, Alain Yves Dury, Georges Pelletier & Fernand Labrie. (2014) Expression of the estrogen receptors and steroidogenic enzymes involved in estradiol formation in the monkey vagina. American Journal of Obstetrics and Gynecology 211:5, pages 499.e1-499.e9.
Crossref
Carmen Moreno-Frías, Nicté Figueroa-Vega & Juan Manuel Malacara. (2014) Relationship of sleep alterations with perimenopausal and postmenopausal symptoms. Menopause 21:9, pages 1017-1022.
Crossref
Fernand Labrie. (2014) GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer. Endocrine-Related Cancer 21:4, pages R301-R317.
Crossref
Jonathan Bertin, Alain Y. Dury, Johanne Ouellet, Georges Pelletier & Fernand Labrie. (2014) Localization of the Androgen‐Synthesizing Enzymes, Androgen Receptor, and Sex Steroids in the Vagina: Possible Implications for the Treatment of Postmenopausal Sexual Dysfunction. The Journal of Sexual Medicine 11:8, pages 1949-1961.
Crossref
Fernand Labrie, David Archer, Céline Bouchard, Michel Fortier, Leonello Cusan, José‐Luis Gomez, Ginette Girard, Mira Baron, Normand Ayotte, Michèle Moreau, Robert Dubé, Isabelle Côté, Claude Labrie, Lyne Lavoie, Lucy Gilbert, Céline Martel & John Balser. (2014) Lack of Influence of Dyspareunia on the Beneficial Effect of Intravaginal Prasterone (Dehydroepiandrosterone, DHEA) on Sexual Dysfunction in Postmenopausal Women. The Journal of Sexual Medicine 11:7, pages 1766-1785.
Crossref
Susanne Strauss, Tine Greve, Erik Ernst, Matthiaos Fraidakis, Jurgis Gedis Grudzinskas & Claus Yding Andersen. (2014) Administration of DHEA augments progesterone production in a woman with low ovarian reserve being transplanted with cryopreserved ovarian tissue. Journal of Assisted Reproduction and Genetics 31:6, pages 645-649.
Crossref
Lúcia Alves da Silva Lara, Alfredo Ribeiro da Silva, Julio Cesar Rosa-e-Silva, Marcos Felipe Silva-de-Sá & Ana Carolina Japur de Sá Rosa-e-Silva. (2014) Estrogen receptor expression and vessel density in the vagina wall in postmenopausal women with prolapse. Tissue and Cell 46:2, pages 159-164.
Crossref
Tea Lanišnik Rižner. (2013) Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer. Molecular and Cellular Endocrinology 381:1-2, pages 124-139.
Crossref
Georges Pelletier, Johanne Ouellet, Céline Martel & Fernand Labrie. (2013) Androgenic Action of Dehydroepiandrosterone (DHEA) on Nerve Density in the Ovariectomized Rat Vagina. The Journal of Sexual Medicine 10:8, pages 1908-1914.
Crossref
Eduardo Melani Rocha, Flavio Mantelli, Luis Fernando Nominato & Stefano Bonini. (2013) Hormones and dry eye syndrome. Current Opinion in Ophthalmology 24:4, pages 348-355.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.