1,177
Views
77
CrossRef citations to date
0
Altmetric
REVIEW

Non-hormonal topical treatment of vulvovaginal atrophy: an up-to-date overview

&
Pages 305-312 | Received 18 Jul 2012, Accepted 27 Nov 2012, Published online: 08 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

C. Massarotti, G. Asinaro, M. G. Schiaffino, C. Ronzini, I. Vacca, M. Lambertini, P. Anserini, L. Del Mastro & A. Cagnacci. (2023) Vaginal oxygen plus hyaluronic acid on genito-urinary symptoms of breast cancer survivors. Climacteric 26:2, pages 129-134.
Read now
T. L. B. Bretas, M. C. A. Issa, S. C. A. V. Fialho, E. A. G. Villar, L. G. C. Velarde & F. R. Pérez-López. (2022) Vaginal collagen I and III changes after carbon dioxide laser application in postmenopausal women with the genitourinary syndrome: a pilot study. Climacteric 25:2, pages 186-194.
Read now
R. E. Nappi, M. Kotek, A. Brešt’anský, N. Giordan & E. Tramentozzi. (2020) Effectiveness of hyaluronate-based pessaries in the treatment of vulvovaginal atrophy in postmenopausal women. Climacteric 23:5, pages 519-524.
Read now
Anna Ghizzani, Simone Bruni & Stefano Luisi. (2018) The sex life of women surviving breast cancer. Gynecological Endocrinology 34:10, pages 821-825.
Read now
R. E. Nappi, A. Cagnacci, A. M. Becorpi, C. Nappi, A. M. Paoletti, M. Busacca, S. Martella, M. Bellafronte, Z. Tredici, C. Di Carlo, V. Corda, M. Vignali, M. Bagolan & M. Sardina. (2017) Monurelle Biogel® vaginal gel in the treatment of vaginal dryness in postmenopausal women. Climacteric 20:5, pages 467-475.
Read now
Rossella E. Nappi, Nicoletta Biglia, Angelo Cagnacci, Costantino Di Carlo, Stefano Luisi & Anna Maria Paoletti. (2016) Diagnosis and management of symptoms associated with vulvovaginal atrophy: expert opinion on behalf of the Italian VVA study group. Gynecological Endocrinology 32:8, pages 602-606.
Read now
R. J. Baber, N. Panay & A. Fenton$suffix/text()$suffix/text(). (2016) 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric 19:2, pages 109-150.
Read now
S. Salvatore, R. E. Nappi, N. Zerbinati, A. Calligaro, S. Ferrero, M. Origoni, M. Candiani & U. Leone Roberti Maggiore. (2014) A 12-week treatment with fractional CO2 laser for vulvovaginal atrophy: a pilot study. Climacteric 17:4, pages 363-369.
Read now

Articles from other publishers (68)

Vaibhavi B Wasnik, Neema Acharya & Shazia Mohammad. (2023) Genitourinary Syndrome of Menopause: A Narrative Review Focusing on Its Effects on the Sexual Health and Quality of Life of Women. Cureus.
Crossref
Salvatore Caruso, Maria Teresa Bruno, Sara Boemi, Gaia Palermo, Gabriele Mazza & Giuseppe Caruso. (2023) Vaginal health and quality of sexual life of postmenopausal women on hyaluronic acid and Biosaccharide Gum-1 vaginal gel. Taiwanese Journal of Obstetrics and Gynecology 62:5, pages 702-708.
Crossref
Nada Saleh Albalawi, Maram Ati Almohammadi & Ahmad Raja Albalawi. (2023) Comparison of the Efficacy of Vaginal Hyaluronic Acid to Estrogen for the Treatment of Vaginal Atrophy in Postmenopausal Women: A Systematic Review. Cureus.
Crossref
Parvaneh Fallah, Dianna Wolfe, Brian Hutton, Mark Clemons, Risa Shorr, Lisa Vandermeer & Moira Rushton. (2023) Management of genitourinary symptoms in patients with breast cancer: an updated systematic review of available evidence from randomized trials. Supportive Care in Cancer 31:2.
Crossref
Diana M. Ampilogova, Antonina G. Solopova, Dmitry V. Blinov, Evgeny E. Achkasov, Daria A. Petrenko & Daniil I. Korabelnikov. (2022) Vulvovaginal atrophy: issues of treatment and rehabilitation: A review. Gynecology 24:4, pages 240-245.
Crossref
Ganna Zaychenko, Olena Stryga, Oksana Sinitsyna, Anna Doroshenko, Oksana Sulaieva, Tetyana Falalyeyeva & Nazarii Kobyliak. (2022) Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms. Molecules 27:15, pages 4916.
Crossref
Atefeh Khosravi, Hedyeh Riazi, Masoumeh Simbar & Ali Montazeri. (2022) Effectiveness of Kegel exercise and lubricant gel for improving sexual function in menopausal women: A randomized trial. European Journal of Obstetrics & Gynecology and Reproductive Biology 274, pages 106-112.
Crossref
Daniel María Lubián López. (2022) Management of genitourinary syndrome of menopause in breast cancer survivors: An update. World Journal of Clinical Oncology 13:2, pages 71-100.
Crossref
Jill Krapf, Ann Nwabuebo & Lucia Miller. 2022. Each Woman’s Menopause: An Evidence Based Resource. Each Woman’s Menopause: An Evidence Based Resource 257 282 .
Ekaterina Nikolaevna Zhumanova, Dagmara Isaevna Kolgaeva & Tatyana Vladimirovna Shapovalenko. (2021) Possibilities of using neodymium laser to improve the condition of vaginal mucosa in women of various ages with initial stages of genital prolapse. Fizioterapevt (Physiotherapist):6, pages 61-69.
Crossref
. (2021) Treatment of Urogenital Symptoms in Individuals With a History of Estrogen-dependent Breast Cancer. Obstetrics & Gynecology 138:6, pages 950-960.
Crossref
Paula Briggs & Dharani K Hapangama. (2021) Urogenital atrophy: The ‘unknown factors’ challenging current practice. Post Reproductive Health 27:2, pages 109-120.
Crossref
Arie Knuistingh Neven. 2021. Kleine Kwalen en alledaagse klachten bij ouderen. Kleine Kwalen en alledaagse klachten bij ouderen 265 268 .
Adam B. SmithNeil FawkesNancy KhammoSarah Hood. (2020) The Humanistic and Economic Impact of Vaginal Dryness in Premenopausal, Perimenopausal, and Postmenopausal Women. Journal of Women's Health 29:11, pages 1457-1463.
Crossref
M. V. Koval & T. A. Oboskalova. (2020) Individualized correction of sex steroid deficiency in early postmenopausal women with uterine leiomyoma. Obstetrics, Gynecology and Reproduction 14:4, pages 457-468.
Crossref
Cristina L. Benetti-Pinto, Helena P. Giraldo, Andrea E. Giraldo, Ticiana A. Mira & Daniela A. Yela. (2020) Interferential current: a new option for the treatment of sexual complaints in women with premature ovarian insufficiency using systemic hormone therapy: a randomized clinical trial. Menopause 27:5, pages 519-525.
Crossref
Santiago Palacios, Josep Combalia, Carine Emsellem, Yann Gaslain & Danial Khorsandi. (2019) Therapies for the management of genitourinary syndrome of menopause. Post Reproductive Health 26:1, pages 32-42.
Crossref
Fakhriyeh Mazalzadeh, Khadijeh Hekmat, Foroogh Namjouyan & Amal Saki. (2020) Effect of Trigonella foenum (fenugreek) vaginal cream on vaginal atrophy in postmenopausal women. Journal of Family Medicine and Primary Care 9:6, pages 2714.
Crossref
T.Yu. Pestrikova, E.A. Yurasova, M.A. Shveeva & T.D. Kovaleva. (2020) Personificated approach to management tactics for patients with atrophic vulvovaginitis in postmenopause. Rossiiskii vestnik akushera-ginekologa 20:3, pages 62.
Crossref
Michelle N. Ferreira, Julie Y. Ramseier & Jonathan S. Leventhal. (2019) Dermatologic conditions in women receiving systemic cancer therapy. International Journal of Women's Dermatology 5:5, pages 285-307.
Crossref
E. I. Ermakova. (2019) Genitourinary menopausal syndrome: diagnosis and treatment principles. Medical Council:13, pages 106-111.
Crossref
Irene Scavello, Elisa Maseroli, Vincenza Di Stasi & Linda Vignozzi. (2019) Sexual Health in Menopause. Medicina 55:9, pages 559.
Crossref
Carlos A. Politano, Lucia Costa-Paiva, Luiza B. Aguiar, Helymar C. Machado & Luiz F. Baccaro. (2019) Fractional CO2 laser versus promestriene and lubricant in genitourinary syndrome of menopause: a randomized clinical trial. Menopause 26:8, pages 833-840.
Crossref
Jairam Krishnamurthy & Pavan Kumar Tandra. (2019) Genitourinary Syndrome of Menopause in Breast Cancer Survivors: A Common Complication With Effective Treatment Strategies. Journal of Oncology Practice 15:7, pages 373-374.
Crossref
Maryam Najjarzadeh, Sakineh Mohammad Alizadeh Charandabi, Marzyeh Mohammadi & Mojgan Mirghafourvand. (2019) Comparison of the effect of hyaluronic acid and estrogen on atrophic vaginitis in menopausal women: A systematic review. Post Reproductive Health 25:2, pages 100-108.
Crossref
Violante Di Donato, Michele Carlo Schiavi, Valentina Iacobelli, Ottavia D’oria, Evangelos Kontopantelis, Tommaso Simoncini, Ludovico Muzii & Pierluigi Benedetti Panici. (2019) Ospemifene for the treatment of vulvar and vaginal atrophy: A meta-analysis of randomized trials. Part II: Evaluation of tolerability and safety. Maturitas 121, pages 93-100.
Crossref
Andrew M. Kaunitz, JoAnn V. Pinkerton & JoAnn E Manson. (2019) Vaginal estrogen: Underprescribed treatment for an underdiagnosed condition of menopausal women. Maturitas 121, pages 83-85.
Crossref
Dimitrios Chatsiproios, Iris M. Schmidts-Winkler, Lisa König, Clarissa Masur & Christoph Abels. (2019) Topical treatment of vaginal dryness with a non-hormonal cream in women undergoing breast cancer treatment - An open prospective multicenter study. PLOS ONE 14:1, pages e0210967.
Crossref
Shirin Khanjani & Nick Panay. (2019) Vaginal estrogen deficiency. The Obstetrician & Gynaecologist 21:1, pages 37-42.
Crossref
E. N. Zhumanova, K. V. Lyadov & K. V. Kotenko. (2018) Application of modern non-medicine technologies to improve the state of the mucous vagina in patients of different age groups after plastic surgery for the rectocele. Russian Journal of Physiotherapy, Balneology and Rehabilitation 17:6, pages 317-323.
Crossref
Robin J. Bell, Farwa Rizvi, Rakabul M. Islam & Susan R. Davis. (2018) A systematic review of intravaginal testosterone for the treatment of vulvovaginal atrophy. Menopause 25:6, pages 704-709.
Crossref
Carly S. Sears, John W. Robinson & Lauren M. Walker. (2018) A comprehensive review of sexual health concerns after cancer treatment and the biopsychosocial treatment options available to female patients. European Journal of Cancer Care 27:2, pages e12738.
Crossref
David F. ArcherThomas D. KimbleF.D. Yuhua LinSimona BattucciVilma SniukieneJames H. Liu. (2018) A Randomized, Multicenter, Double-Blind, Study to Evaluate the Safety and Efficacy of Estradiol Vaginal Cream 0.003% in Postmenopausal Women with Vaginal Dryness as the Most Bothersome Symptom. Journal of Women's Health 27:3, pages 231-237.
Crossref
Yu.E. Dobrokhotova, I.Yu. Ilyina, M.G. Venediktova, K.V. Morozova & V.A. Suvorova. (2018) Local nonhormonal therapy in patients with genitourinary menopausal syndrome. Rossiiskii vestnik akushera-ginekologa 18:3, pages 88.
Crossref
Yu. E. Dobrokhotova, I. Yu. Ilyina, M. G. Venediktova, K. V. Morozova & V. A. Suvorova. (2018) Local nonhormonal therapy in patients with genitourinary menopausal syndrome. Rossiiskii vestnik akushera-ginekologa 18:3, pages 88.
Crossref
James A. SimonCorrado AltomareSusannah CortWei JiangJoAnn V. Pinkerton. (2018) Overall Safety of Ospemifene in Postmenopausal Women from Placebo-Controlled Phase 2 and 3 Trials. Journal of Women's Health 27:1, pages 14-23.
Crossref
Santiago Palacios, Fernando Losa, Damián Dexeus & Javier Cortés. (2017) Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women. BMC Women's Health 17:1.
Crossref
Rita Monteiro Machado, Ana Palmeira-de-Oliveira, José Martinez-de-Oliveira & Rita Palmeira-de-Oliveira. (2017) Vaginal semisolid products: Technological performance considering physiologic parameters. European Journal of Pharmaceutical Sciences 109, pages 556-568.
Crossref
Ludwig Kiesel & Annemarie Kohl. (2017) Klinische Relevanz des urogenitalen Syndroms der MenopauseThe clinical relevance of genitourinary syndrome of menopause. Gynäkologische Endokrinologie 15:4, pages 319-327.
Crossref
Željka Vanić & Nataša Škalko-Basnet. 2017. Functional Hydrogels in Drug Delivery. Functional Hydrogels in Drug Delivery 259 302 .
Hans-Heinrich Henneicke-von Zepelin, Ragna Williams, Wiebke Havemeister, Walter Wigger-Alberti & Klaus-Ulrich Nolte. (2017) Clinical trial shows lasting function of a new moisturizing cream against vaginal drynessKlinische Studie zeigt anhaltende Wirkung einer neuen Feuchtigkeitscreme gegen Scheidentrockenheit. Wiener Medizinische Wochenschrift 167:7-8, pages 189-195.
Crossref
Mariana S. SousaMichelle Peate, Sherin Jarvis, Martha Hickey & Michael Friedlander. (2017) A clinical guide to the management of genitourinary symptoms in breast cancer survivors on endocrine therapy. Therapeutic Advances in Medical Oncology 9:4, pages 269-285.
Crossref
Petra M. CaseyKathy L. MacLaughlinStephanie S. Faubion. (2017) Impact of Contraception on Female Sexual Function. Journal of Women's Health 26:3, pages 207-213.
Crossref
E. I. Ermakova, V. E. Balan, E. V. Tikhomirova, I. N. Lazareva, A. V. Lapina & E. M. Panina. (2017) Genitourinary syndrome of menopause: diagnosis and principles of treatment (brief clinical recommendations). Rossiiskii vestnik akushera-ginekologa 17:6, pages 89.
Crossref
Rinaldo Florencio‐Silva, Ricardo Santos Simões, João Henrique Rodrigues Castello Girão, Adriana Aparecida Ferraz Carbonel, Cristiane de Paula Teixeira & Gisela Rodrigues da Silva Sasso. (2017) Tratamento da atrofia vaginal da mulher na pós‐menopausa. Reprodução & Climatério 32:1, pages 43-47.
Crossref
Rossella E. Nappi, Chiara Benedetto, Federica Campolo, Silvia Martella, Claudia Tosti, Antonio Cianci, Salvatore Caruso, Secondo Guaschino, Eva Grimaldi, Massimo Bagolan & Marco Sardina. (2016) Efficacy, tolerability and safety of a new medical device, Monurelle Biogel ® vaginal gel, in the treatment of vaginal dryness: a randomized clinical trial in women of reproductive age. European Journal of Obstetrics & Gynecology and Reproductive Biology 203, pages 82-88.
Crossref
Sandy J. Falk & Sharon Bober. (2016) Vaginal Health During Breast Cancer Treatment. Current Oncology Reports 18:5.
Crossref
John Eden. (2016) ENDOCRINE DILEMMA: Managing menopausal symptoms after breast cancer. European Journal of Endocrinology 174:3, pages R71-R77.
Crossref
Selma Jonkers, Arie Knuistingh Neven & Just Eekhof. (2016) Dyspareunie bij oudere vrouwen. Huisarts en wetenschap 59:1, pages 28-29.
Crossref
Just Eekhof, Arie Knuistingh Neven, Sjoerd Bruggink & Marissa Scherptong-EngbersSelma Jonkers. 2016. Kleine kwalen en alledaagse klachten bij ouderen. Kleine kwalen en alledaagse klachten bij ouderen 228 231 .
Kandace P. McGuire. 2016. Breast Disease. Breast Disease 375 387 .
Andrea Giannini, Andrea R. Genazzani & Tommaso Simoncini. 2016. Frontiers in Gynecological Endocrinology. Frontiers in Gynecological Endocrinology 161 168 .
Susan R. Davis, Irene Lambrinoudaki, Maryann Lumsden, Gita D. Mishra, Lubna Pal, Margaret Rees, Nanette Santoro & Tommaso Simoncini. (2015) Menopause. Nature Reviews Disease Primers 1:1.
Crossref
Nicoletta Biglia, Valentina E. Bounous, Luca G. Sgro, Marta D'Alonzo, Silvia Pecchio & Rossella E. Nappi. (2015) Genitourinary Syndrome of Menopause in Breast Cancer Survivors: Are We Facing New and Safe Hopes?. Clinical Breast Cancer 15:6, pages 413-420.
Crossref
AHINOAM LEV-SAGIE. (2015) Vulvar and Vaginal Atrophy. Clinical Obstetrics & Gynecology 58:3, pages 476-491.
Crossref
Sasha Mazzarello, Brian Hutton, Mohammed F. K. Ibrahim, Carmel Jacobs, Risa Shorr, Stephanie Smith, Terry Ng & Mark Clemons. (2015) Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials. Breast Cancer Research and Treatment 152:1, pages 1-8.
Crossref
Jennifer J. Wright & Kim M. O’Connor. (2015) Female Sexual Dysfunction. Medical Clinics of North America 99:3, pages 607-628.
Crossref
Manuel Neves-e-Castro, Martin Birkhauser, Goran Samsioe, Irene Lambrinoudaki, Santiago Palacios, Rafael Sanchez Borrego, Placido Llaneza, Iuliana Ceausu, Herman Depypere, C. Tamer Erel, Faustino R. Pérez-López, Karin Schenck-Gustafsson, Yvonne T. van der Schouw, Tommaso Simoncini, Florence Tremollieres & Margaret Rees. (2015) EMAS position statement: The ten point guide to the integral management of menopausal health. Maturitas 81:1, pages 88-92.
Crossref
Hyun-Kyung KimSo-Yeon KangYoun-Jee ChungJang-Heub KimMee-Ran Kim. (2015) The Recent Review of the Genitourinary Syndrome of Menopause. Journal of Menopausal Medicine 21:2, pages 65.
Crossref
Andrea Salonia, Giulia Castagna & Francesco Montorsi. 2015. Clinical Uro-Andrology. Clinical Uro-Andrology 147 168 .
Jill M. Krapf, Zoe Belkin, Frank Dreher & Andrew T. Goldstein. 2015. Skin, Mucosa and Menopause. Skin, Mucosa and Menopause 229 235 .
Ana Cunha, Rita Machado, Ana Palmeira-de-Oliveira, José Martinez-de-Oliveira, José das Neves & Rita Palmeira-de-Oliveira. (2014) Characterization of Commercially Available Vaginal Lubricants: A Safety Perspective. Pharmaceutics 6:3, pages 530-542.
Crossref
Jane Woyka & Nuttan Tanna. (2014) Consensus statement for non-estrogen-based treatments for menopausal symptoms. Post Reproductive Health 20:2, pages 76-79.
Crossref
Kylie N. Barnes, Erica F. Pearce, Abigail M. Yancey & Alicia B. Forinash. (2014) Ospemifene in the Treatment of Vulvovaginal Atrophy. Annals of Pharmacotherapy 48:6, pages 752-757.
Crossref
Rafael Sánchez-Borrego, Montserrat Manubens, Maria Concepción Navarro, Mª Jesús Cancelo, Estanislao Beltrán, Magda Duran, Teresa Orte, Laura Baquedano, Santiago Palacios & Nicolás Mendoza. (2014) Position of the Spanish Menopause Society regarding vaginal health care in postmenopausal women. Maturitas 78:2, pages 146-150.
Crossref
Petra M Casey. (2014) Caring for the breast cancer survivor’s health and well-being. World Journal of Clinical Oncology 5:4, pages 693.
Crossref
K. Schiessl. (2013) Urogenitaler Östrogenmangel im SeniumUrogenital estrogen deficiency in elderly women. Gynäkologische Endokrinologie 11:4, pages 243-247.
Crossref
Selma Jonkers & Arie Knuistingh Neven. (2013) Behandeling van vaginale atrofie. Huisarts en wetenschap 56:8, pages 426-426.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.