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Original Article

Pharmacokinetics and preliminary efficacy of two vaginal gel formulations of ultra-low-dose estriol in postmenopausal women

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Pages 172-180 | Received 21 Jul 2015, Accepted 17 Sep 2015, Published online: 19 Nov 2015

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Read on this site (7)

R. E. Nappi, L. Tiranini, E. Martini, D. Bosoni, C. Cassani & L. Cucinella. (2023) Different local estrogen therapies for a tailored approach to GSM. Climacteric 26:4, pages 361-366.
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Marcos J. Cuerva, Silvia P. González, Jesús Lazaro-Carrasco De La Fuente, Francisco J. Lopez & Concepción Nieto. (2022) Effect of oestriol gel on dyspareunia in postmenopausal women in 2 weeks of treatment: a pilot study. Journal of Obstetrics and Gynaecology 42:7, pages 3397-3399.
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Andrea R. Genazzani, Patrizia Monteleone, Andrea Giannini & Tommaso Simoncini. (2021) Pharmacotherapeutic options for the treatment of menopausal symptoms. Expert Opinion on Pharmacotherapy 22:13, pages 1773-1791.
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Natalícia de Jesus Antunes, Raimundo Vieira de Oliveira Filho, Jaime de Oliveira Ilha, Ronilson A. Moreno, André Felipe Nahoum, Ralph-Steven Wedemeyer, André Warnke & Gilberto De Nucci. (2021) Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential. The European Journal of Contraception & Reproductive Health Care 26:3, pages 184-194.
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Federica Palma, Anjeza Xholli & Angelo Cagnacci. (2017) Management of vaginal atrophy: a real mess. Results from the AGATA study. Gynecological Endocrinology 33:9, pages 702-707.
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G. P. Siliquini, V. Tuninetti, V. E. Bounous, F. Bert & N. Biglia. (2017) Fractional CO2 laser therapy: a new challenge for vulvovaginal atrophy in postmenopausal women. Climacteric 20:4, pages 379-384.
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Articles from other publishers (13)

Abbie Laing & Tim Hillard. (2023) Oestrogen-based therapies for menopausal symptoms. Best Practice & Research Clinical Endocrinology & Metabolism, pages 101789.
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Rossella E. Nappi, Laura Cucinella, Ellis Martini & Chiara Cassani. (2021) The role of hormone therapy in urogenital health after menopause. Best Practice & Research Clinical Endocrinology & Metabolism 35:6, pages 101595.
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Nèvine West, Richard Day, Garry Graham, Michael Wright, Christopher White, Gordana Popovic & Kate Hilda Moore. (2020) Serum concentrations of estriol vary widely after application of vaginal oestriol cream. British Journal of Clinical Pharmacology 87:5, pages 2354-2360.
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Pedro Sánchez-Rovira, Angelica Lindén Hirschberg, Miguel Gil-Gil, Begoña Bermejo-De Las Heras & Concepción Nieto-Magro. (2020) A Phase II Prospective, Randomized, Double-Blind, Placebo-Controlled and Multicenter Clinical Trial to Assess the Safety of 0.005% Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women with Early Stage Breast Cancer in Treatment with Aromatase Inhibitor in the Adjuvant Setting. The Oncologist 25:12, pages e1846-e1854.
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Zhenxing Si, Shifeng Zhou, Zilong Shen & Feiyu Luan. (2020) High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis. Frontiers in Pharmacology 11.
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Angelica Lindén Hirschberg, Pedro Sánchez-Rovira, Jesús Presa-Lorite, Miriam Campos-Delgado, Miguel Gil-Gil, Elisabet Lidbrink, Javier Suárez-AlmarzaConcepción Nieto-Magro. (2020) Efficacy and safety of ultra-low dose 0.005% estriol vaginal gel for the treatment of vulvovaginal atrophy in postmenopausal women with early breast cancer treated with nonsteroidal aromatase inhibitors: a phase II, randomized, double-blind, placebo-controlled trial. Menopause 27:5, pages 526-534.
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Sônia M.R.R. Lima & Juliana V. Honorato. (2019) Critical analysis of methods for assessing genitourinary syndrome of menopause used in clinical trials. Menopause 26:12, pages 1436-1442.
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Angelo Cagnacci, Mario Gallo, Marco Gambacciani & Stefano Lello. (2019) Joint recommendations for the diagnosis and treatment of vulvo-vaginal atrophy in women in the peri- and post-menopausal phases from the Società Italiana per la Menopausa (SIM) and the Società Italiana della Terza Età (SIGiTE). Minerva Ginecologica 71:5.
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Raimundo Vieira de Oliveira Filho, Natalícia de Jesus Antunes, Jaime de Oliveira Ilha, Ronilson Agnaldo Moreno, Ralph‐Steven Wedemeyer, André Warnke & Gilberto De Nucci. (2018) Pharmacokinetics and pharmacodynamics of three dosages of oestriol after continuous vaginal ring administration for 21 days in healthy, postmenopausal women. British Journal of Clinical Pharmacology 85:3, pages 551-562.
Crossref
Vincenzina Bruni & Francesca Pampaloni. 2019. Menstrual Cycle Related Disorders. Menstrual Cycle Related Disorders 111 142 .
Meghan S Vermillion, Rebecca L Ursin, Sarah E Attreed & Sabra L Klein. (2018) Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza. Endocrinology 159:9, pages 3306-3320.
Crossref
María-Dolores Veiga, Roberto Ruiz-Caro, Araceli Martín-Illana, Fernando Notario-Pérez & Raúl Cazorla-Luna. 2018. Polymer Gels. Polymer Gels 197 246 .
Anne Lethaby, Reuben Olugbenga Ayeleke & Helen Roberts. (2016) Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database of Systematic Reviews 2016:11.
Crossref

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