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Original Article

Pharmacokinetic studies of solubilized estradiol given vaginally in a novel softgel capsule

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Pages 181-187 | Received 04 Dec 2015, Accepted 25 Dec 2015, Published online: 09 Feb 2016

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G. Stabile, G. A. Topouzova & F. De Seta. (2023) The role of microbiota in the management of genitourinary syndrome of menopause. Climacteric 26:4, pages 353-360.
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R. E. Nappi, L. Tiranini, E. Martini, D. Bosoni, C. Cassani & L. Cucinella. (2023) Different local estrogen therapies for a tailored approach to GSM. Climacteric 26:4, pages 361-366.
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James H. Liu, Brian Bernick & Sebastian Mirkin. (2020) Estradiol softgel inserts for the treatment of VVA symptoms: an expert opinion. Expert Opinion on Drug Delivery 17:11, pages 1573-1581.
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J. A. Simon, R. Kagan, D. F. Archer, G. D. Constantine, B. Bernick, S. Graham & S. Mirkin. (2019) TX-004HR clinically improves symptoms of vulvar and vaginal atrophy in postmenopausal women. Climacteric 22:4, pages 412-418.
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D. J. Portman, S. R. Goldstein & R. Kagan. (2019) Treatment of moderate to severe dyspareunia with intravaginal prasterone therapy: a review. Climacteric 22:1, pages 65-72.
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Iuliia Naumova & Camil Castelo-Branco. (2018) Current treatment options for postmenopausal vaginal atrophy. International Journal of Women's Health 10, pages 387-395.
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Articles from other publishers (20)

Mark S. Newman, Doreen Saltiel, Jaclyn Smeaton & Frank Z. Stanczyk. (2023) Comparative estrogen exposure from compounded transdermal estradiol creams and Food and Drug Administration-approved transdermal estradiol gels and patches. Menopause.
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Ahmed Abdelgader, Mershen Govender, Pradeep Kumar & Yahya E. Choonara. (2023) Intravaginal Drug Delivery Systems to Treat the Genitourinary Syndrome of Menopause: Towards the Design of Safe and Efficacious Estrogen-loaded Prototypes. Journal of Pharmaceutical Sciences 112:6, pages 1566-1585.
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Ritu Thapa, Shila Gurung, Marie-Odile Parat, Harendra S. Parekh & Preeti Pandey. (2022) Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery. Gels 8:2, pages 99.
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Sebastian Mirkin, James A. Simon, James H. Liu, David F. Archer, Patricia D. Castro, Shelli Graham, Brian Bernick & Barry Komm. (2021) Evaluation of endometrial progesterone receptor expression after 12 weeks of exposure to a low-dose vaginal estradiol insert. Menopause 28:9, pages 998-1003.
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. (2020) The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society. Menopause 27:9, pages 976-992.
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Carolyn J. Crandall, Allison Diamant & Nanette Santoro. (2020) Safety of vaginal estrogens: a systematic review. Menopause 27:3, pages 339-360.
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Richard J. Santen, Sebastian Mirkin, Brian Bernick & Ginger D. Constantine. (2020) Systemic estradiol levels with low-dose vaginal estrogens. Menopause 27:3, pages 361-370.
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James A. Simon, James H. Pickar, Annette M. Shadiack, Bharat Warrier, Shelli Graham, Brian Bernick & Sebastian Mirkin. (2020) Physical characteristics and properties of estradiol softgel vaginal inserts. Menopause 27:2, pages 150-155.
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Sheryl A. Kingsberg, Lisa Larkin, Michael Krychman, Sharon J. Parish, Brian Bernick & Sebastian Mirkin. (2019) WISDOM survey: attitudes and behaviors of physicians toward vulvar and vaginal atrophy (VVA) treatment in women including those with breast cancer history. Menopause 26:2, pages 124-131.
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Claude Hocké. 2019. La Ménopause en Pratique. La Ménopause en Pratique 109 116 .
Yuyong Ke, Jean-Nicolas Simard, Renaud Gonthier, Céline Martel, Mario Vaillancourt, David Portman, Alain Bélanger & Fernand Labrie. (2018) In Reply:. Menopause 25:8, pages 953-954.
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David F. Archer, James H. Pickar, Ginger D. Constantine, Annette M. Shadiack, Brian Bernick & Sebastian Mirkin. (2018) To the Editor:. Menopause 25:8, pages 952-953.
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Yuyong Ke, Alain BélangerJean-Nicolas Simard, Renaud Gonthier, Céline Martel, Mario Vaillancourt & Fernand Labrie. (2018) Concentration range of serum sex steroids in normal postmenopausal women and those with diagnosis of vulvovaginal atrophy. Menopause 25:3, pages 293-300.
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Fernand Labrie. 2018. Pre-Menopause, Menopause and Beyond. Pre-Menopause, Menopause and Beyond 3 15 .
Stephanie S. Faubion, Richa Sood & Ekta Kapoor. (2017) Genitourinary Syndrome of Menopause: Management Strategies for the Clinician. Mayo Clinic Proceedings 92:12, pages 1842-1849.
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Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F. Archer & Wulf H. Utian. (2017) Science of intracrinology in postmenopausal women. Menopause 24:6, pages 702-712.
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Ginger D. ConstantineCeline BouchardJames H. PickarDavid F. ArcherShelli GrahamBrian BernickSebastian Mirkin. (2017) Consistency of Effect with a Low-Dose, Estradiol Vaginal Capsule (TX-004HR): Evaluating Improvement in Vaginal Physiology and Moderate-to-Severe Dyspareunia in Subgroups of Postmenopausal Women. Journal of Women's Health 26:6, pages 616-623.
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David F. Archer, Ginger D. Constantine, James A. Simon, Harvey Kushner, Philip Mayer, Brian BernickShelli GrahamSebastian Mirkin. (2017) TX-004HR vaginal estradiol has negligible to very low systemic absorption of estradiol. Menopause 24:5, pages 510-516.
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James A. Simon, David F. Archer, Ginger D. Constantine, James H. Pickar, Julia M. Amadio, Brian Bernick, Shelli Graham & Sebastian Mirkin. (2017) A vaginal estradiol softgel capsule, TX-004HR, has negligible to very low systemic absorption of estradiol: Efficacy and pharmacokinetic data review. Maturitas 99, pages 51-58.
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Fernand Labrie & Céline Martel. (2017) A low dose (6.5 mg) of intravaginal DHEA permits a strictly local action while maintaining all serum estrogens or androgens as well as their metabolites within normal values. Hormone Molecular Biology and Clinical Investigation 29:2, pages 39-60.
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