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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 119, 2013 - Issue 5
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Research Article

Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic rats

Kais MnafguiLaboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax P.O. Box 95, Sfax 3052Tunisia;Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax B.P. 1171, 3000 SfaxTunisiaCorrespondence[email protected]
,
Fatima KaanichLaboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax B.P. 1171, 3000 SfaxTunisia
,
Amal DerbaliLaboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax P.O. Box 95, Sfax 3052Tunisia
,
Khaled HamdenLaboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax P.O. Box 95, Sfax 3052Tunisia
,
Fatma DerbaliService of Internal Medicine, Hospital of Sidi BouzidTunisia
,
Sadok SlamaHematological and Clinical Biochemistry Laboratory
,
Noureddine AlloucheLaboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax B.P. 1171, 3000 SfaxTunisia
&
Abdelfattah ElfekiLaboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax P.O. Box 95, Sfax 3052Tunisia
 show all
Pages 225-233 | Received 21 Apr 2013, Accepted 01 Jul 2013, Published online: 25 Jul 2013

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Dalila Junqueira Alvarenga, Laira Maria Faria Matias, Cleydson Finotti Cordeiro, Thiago Belarmino de Souza, Stefânia Neiva Lavorato, Marília Gabriella Alves Goulart Pereira, Danielle Ferreira Dias & Diogo Teixeira Carvalho. (2022) Synthesis of eugenol-derived glucosides and evaluation of their ability in inhibiting the angiotensin converting enzyme. Natural Product Research 36:9, pages 2246-2253.
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Yosra Tahri, Imed Koubaa, Doniyez Frikha, Sami Maalej & Noureddine Allouche. (2020) Chemical Investigation and Biological Valorization of Two Essential Oils Newly Extracted from Different Parts of Drimia maritima. Journal of Essential Oil Bearing Plants 23:5, pages 1022-1034.
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Kais Mnafgui, Mouna Kchaou, Hichem Ben Salah, Raouf Hajji, Gaddour Khabbabi, Abdelfattah Elfeki, Noureddine Allouche & Neji Gharsallah. (2016) Essential oil of Zygophyllum album inhibits key-digestive enzymes related to diabetes and hypertension and attenuates symptoms of diarrhea in alloxan-induced diabetic rats. Pharmaceutical Biology 54:8, pages 1326-1333.
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Articles from other publishers (43)

Sri R. Chilukoti, Chittaranjan Sahu & Gopabandhu Jena. (2023) Protective role of eugenol against diabetes‐induced oxidative stress, DNA damage, and apoptosis in rat testes. Journal of Biochemical and Molecular Toxicology.
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Jihane Touhtouh, Mustapha Laghmari, Taoufiq Benali, Tarik Aanniz, Ahmed Lemhadri, Mohamed Akhazzane, Khaoula Habbadi, Abdelhakim Bouyahya, Gokhan Zengin & Khalil Hammani. (2023) Determination of the antioxidant and enzyme-inhibiting activities and evaluation of selected terpenes' ADMET properties: in vitro and in silico approaches. Biochemical Systematics and Ecology 111, pages 104733.
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Renner Philipe Rodrigues Carvalho, Isadora Ribeiro de Carvalho, Rosiany Vieira da Costa, Luiz Otávio Guimarães-Ervilha & Mariana Machado-Neves. (2023) The effects of eugenol on histological, enzymatic, and oxidative parameters in the major salivary glands and pancreas of healthy male Wistar rats. Archives of Oral Biology 154, pages 105764.
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Heba A. Hashem, Zohour I. Nabil & Heba N. Gad EL-Hak. (2023) Ashwagandha root extract’s phenolic compound counteracts alloxan’s effects on oxidative stress, inflammatory cytokines, and peripheral neuropathy in rats. Comparative Clinical Pathology.
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Yosra Ibn ElAchaouia, Jawhar Fakhfakh, Mariem Adhar, Marwa Affes, Slim Tounsi & Noureddine Allouche. (2023) Determination of Chemical Composition, Antioxidant, Antibacterial and Antidiabetic Activities During Maturation of Ficus-carica Stems Barks Essential Oils. Chemistry Africa 6:3, pages 1163-1173.
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Siwar Soltani, Imed Koubaa, Ines Dhouib, Bassem Khemakhem, Pascal Marchand & Noureddine Allouche. (2023) New Specific α‐Glucosidase Inhibitor Flavonoid from Thymelaea tartonraira Leaves: Structure Elucidation, Biological and Molecular Docking Studies . Chemistry & Biodiversity 20:3.
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Renner Philipe Rodrigues Carvalho, Graziela Domingues de Almeida Lima, Fernanda Carolina Dias Ribeiro, Luiz Otávio Guimarães Ervilha, Elizabeth Lopes Oliveira, Arabela Guedes Azevedo Viana & Mariana Machado-Neves. (2022) Eugenol reduces serum testosterone levels and sperm viability in adult Wistar rats. Reproductive Toxicology 113, pages 110-119.
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Renner Philipe Rodrigues Carvalho, Fernanda Carolina Dias Ribeiro, Thainá Iasbik Lima, Luiz Otávio Guimarães Ervilha, Elizabeth Lopes de Oliveira, Alessandra de Oliveira Faustino, Graziela Domingues de Almeida Lima & Mariana Machado-Neves. (2022) High doses of eugenol cause structural and functional damage to the rat liver. Life Sciences 304, pages 120696.
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Kherraz Khaled, Ghemam Amara Djilani, Laoudj Hacen, Mahdid Mohmed & Chefrour Azedinne. (2022) The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats. Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale.
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Nicole Stevens & Kathryn Allred. (2022) Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations. Molecules 27:3, pages 853.
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Alok K. Paul, Md K. Hossain, Tooba Mahboob, Veeranoot Nissapatorn, Polrat Wilairatana, Rownak Jahan, Khoshnur Jannat, Tohmina A. Bondhon, Anamul Hasan, Maria de Lourdes Pereira & Mohammed Rahmatullah. (2022) Does Oxidative Stress Management Help Alleviation of COVID-19 Symptoms in Patients Experiencing Diabetes?. Nutrients 14:2, pages 321.
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Biswanath Dinda, Subhajit Dinda & Mithun Chakraborty. 2022. Natural Products in Obesity and Diabetes. Natural Products in Obesity and Diabetes 277 467 .
Priyanka Rathod & Raman P. Yadav. (2021) Anti-diabesity potential of various multifunctional natural molecules. Journal of Herbal Medicine 27, pages 100430.
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Mariam H Fawzy, Noha M Saeed, Doaa A El-Sherbiny & Ebtehal El-Demerdash. (2021) Eugenol modulates insulin sensitivity by upregulating insulin receptor substrate-2 in non-alcoholic fatty liver disease in rats. Journal of Pharmacy and Pharmacology 73:6, pages 846-854.
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Renner Philipe Rodrigues Carvalho, Graziela Domingues de Almeida Lima & Mariana Machado-Neves. (2021) Effect of eugenol treatment in hyperglycemic murine models: A meta-analysis. Pharmacological Research 165, pages 105315.
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Suchitra K. Panigrahy, Renu Bhatt & Awanish Kumar. (2020) Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics. Biologia 76:1, pages 241-254.
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Ali Akbar Oroojan, Narges Chenani & Marzieh An’aam. (2020) Antioxidant Effects of Eugenol on Oxidative Stress Induced by Hydrogen Peroxide in Islets of Langerhans Isolated from Male Mouse. International Journal of Hepatology 2020, pages 1-5.
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Rasha Hussein, Marwa Khalaf & Wafaa Mohamed. (2020) Hesperidin and eugenol attenuate cadmium-induced nephrotoxicity via regulation of oxidative stress, Bax/Bcl2 and cleaved caspase 3 expression. Turkish Journal of Biochemistry 45:6, pages 767-775.
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Abdelmaoujoud Taia, Mohamed Essaber, Abdeljalil Aatif, Karim Chkirate, Tuncer Hökelek, Joel T. Mague & Nada Kheira Sebbar. (2020) Crystal structure, Hirshfeld surface analysis, interaction energy and DFT studies of 4-[(4-allyl-2-methoxyphenoxy)methyl]-1-(4-methoxyphenyl)-1 H -1,2,3-triazole . Acta Crystallographica Section E Crystallographic Communications 76:6, pages 962-966.
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Sang-Kyun Kim, Seungho Lee, Myung-Ku Lee & Sanghun Lee. (2019) A systems pharmacology approach to investigate the mechanism of Oryeong-san formula for the treatment of hypertension. Journal of Ethnopharmacology 244, pages 112129.
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Farheen Naz, Haider Anis, Ziaul Hasan, Asimul Islam & Luqman A. Khan. (2019) Exploration of Fungal Lipase as Direct Target of Eugenol through Spectroscopic Techniques. Protein & Peptide Letters 26:12, pages 919-929.
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Rajeev Kumar Singla & Ashok Kumar Dubey. (2019) Phytochemical Profiling, GC-MS Analysis and α-Amylase Inhibitory Potential of Ethanolic Extract of Cocos nucifera Linn. Endocarp . Endocrine, Metabolic & Immune Disorders - Drug Targets 19:4, pages 419-442.
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Jubril Olayinka Akolade, Asiat Na’Allah, Abdulhakeem Olarewaju Sulyman, Azeemat Titilola Abdulazeez, Asiata Opeyemi Atoti & Mardiya Bawa Isiaku. (2018) Antidiabetic Screening of Phenolic-rich Extracts of Selected Medicinal Spices. Iranian Journal of Science and Technology, Transactions A: Science 43:2, pages 357-367.
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Irushika T. Fernando, Kumudu I. Perera, Senarath B. P. Athauda, Ramiah Sivakanesan, Nimal Savitri Kumar & Lalith Jayasinghe. (2019) Heat stability of the in vitro inhibitory effect of spices on lipase, amylase, and glucosidase enzymes. Food Science & Nutrition 7:2, pages 425-432.
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Bahaa Al-Trad, Hakam Alkhateeb, Wesam Alsmadi & Mazhar Al-Zoubi. (2019) Eugenol ameliorates insulin resistance, oxidative stress and inflammation in high fat-diet/streptozotocin-induced diabetic rat. Life Sciences 216, pages 183-188.
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Solomon Habtemariam. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases 551 578 .
Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti & Bharat B. Aggarwal. (2018) Chronic diseases, inflammation, and spices: how are they linked?. Journal of Translational Medicine 16:1.
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Ning Ma, Xi-Wang Liu, Xiao-Jun Kong, Shi-Hong Li, Zeng-Hua Jiao, Zhe Qin, Ya-Jun Yang & Jian-Yong Li. (2018) Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia. BMC Veterinary Research 14:1.
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Sahla Belhadj, Olfa Hentati, Majdi Hammami, Aida Ben Hadj, Tahia Boudawara, Mohamed Dammak, Sami Zouari & AbdelFattah El Feki. (2018) Metabolic impairments and tissue disorders in alloxan-induced diabetic rats are alleviated by Salvia officinalis L. essential oil. Biomedicine & Pharmacotherapy 108, pages 985-995.
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Aminu Mohammed & Md. Shahidul Islam. (2018) Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus. Frontiers in Pharmacology 9.
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Wei Fen, Longyu Jin, Qianyi Xie, Lihua Huang, Zhibin Jiang, Ying Ji, Chunyun Li, Linfei Yang & Dianjun Wang. (2018) Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis. Experimental and Therapeutic Medicine.
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Rania Mhiri, Mona Kchaou, Sahla Belhadj, Abdelfattah El Feki & Noureddine Allouche. (2017) Characterization of aromatic compounds and biological activities of essential oils from Tunisian aromatic plants. Journal of Food Measurement and Characterization 12:2, pages 839-847.
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Ning Ma, Yajun Yang, Xiwang Liu, Xiaojun Kong, Shihong Li, Zhe Qin, Zenghua Jiao & Jianyong Li. (2017) UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters. Scientific Reports 7:1.
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Relja Suručić, Tatjana Kundaković, Branislava Lakušić, Dragana Drakul, Slobodan R. Milovanović & Nada Kovačević. (2017) Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae) . Chemistry & Biodiversity 14:5, pages e1600407.
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Sita Sharan Patel & Malairaman Udayabanu. (2017) Effect of natural products on diabetes associated neurological disorders. Reviews in the Neurosciences 28:3, pages 271-293.
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І. V. GerushО. G. CherniukhМ. V. Dikal. (2017) PECULIARITIES OF TRANSFERASE ENZYMATIC ACTIVITY CHANGES IN SIMULATING ALLOXAN-INDUCED DIABETES MELLITUS IN RATS. World of Medicine and Biology 13:62, pages 123.
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Kais Mnafgui, Raouf Hajji, Fatma Derbali, Anis Gammoudi, Gaddour Khabbabi, Hedi Ellefi, Noureddine Allouche, Adel Kadri & Neji Gharsallah. (2015) Anti-inflammatory, Antithrombotic and Cardiac Remodeling Preventive Effects of Eugenol in Isoproterenol-Induced Myocardial Infarction in Wistar Rat. Cardiovascular Toxicology 16:4, pages 336-344.
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Sathya N. Prasad, M.M. Srinivas Bharath & Muralidhara. (2016) Neurorestorative effects of eugenol, a spice bioactive: Evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat. Neurochemistry International 95, pages 24-36.
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Ramachandran Vinayagam, Muthukumaran Jayachandran & Baojun Xu. (2016) Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review. Phytotherapy Research 30:2, pages 184-199.
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N. Satheeshkumar, R. S. K. Vijayan, A. Lingesh, S. Santhikumar & Ch. Vishnuvardhan. 2016. The Benefits of Natural Products for Neurodegenerative Diseases. The Benefits of Natural Products for Neurodegenerative Diseases 57 78 .
Isam Karam, Ning Ma, Xi-Wang Liu, Shi-Hong Li, Xiao-Jun Kong, Jian-Yong Li & Ya-Jun Yang. (2015) Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia. BMC Veterinary Research 11:1.
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Nelli Giribabu, Kilari Eswar Kumar, Somesula Swapna Rekha, Sekaran Muniandy & Naguib Salleh. (2015) Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-8.
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Kyong Ju Jeong, Do Yeon Kim, Hai-Yan Quan, Hee Kyung Jo, Go Woon Kim & Sung Hyun Chung. (2014) Effects of eugenol on hepatic glucose production and AMPK signaling pathway in hepatocytes and C57BL/6J mice. Fitoterapia 93, pages 150-162.
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