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Pharmaceutical Biology Volume 48, 2010 - Issue 5
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Original Article

Tanshinone IIA protects rat primary hepatocytes against carbon tetrachloride toxicity via inhibiting mitochondria permeability transition

Bin Zhu;Department of Pharmacy, Fudan University Cancer Hospital, Shanghai, China
,
Qing Zhai;Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
&
Bo Yu;Department of Pharmacy, Fudan University Cancer Hospital, Shanghai, ChinaCorrespondence[email protected]
Pages 484-487 | Received 04 Dec 2008, Accepted 20 Feb 2009, Published online: 19 Apr 2010

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Binhao Chen, Yali Zhao, Dingyi Yu, Feifei Lin, Zhengyuan Xu, Jingmei Song & Xiaohong Li. (2023) Optimizing the extraction of active components from Salvia miltiorrhiza by combination of machine learning models and intelligent optimization algorithms and its correlation analysis of antioxidant activity. Preparative Biochemistry & Biotechnology 0:0, pages 1-16.
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Asmaa A Ashour, Amal H El-Kamel, Doaa A Abdelmonsif, Hoda M Khalifa & Alyaa A Ramadan. (2021) Modified Lipid Nanocapsules for Targeted Tanshinone IIA Delivery in Liver Fibrosis. International Journal of Nanomedicine 16, pages 8013-8033.
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Suowen Xu & Peiqing Liu. (2013) Tanshinone II-A: new perspectives for old remedies. Expert Opinion on Therapeutic Patents 23:2, pages 149-153.
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Articles from other publishers (18)

He Tai, Xiao-Zheng Cui, Jia He, Zhi-Ming Lan, Shun-Min Li, Ling-Bing Li, Si-Cheng Yao, Xiao-Lin Jiang, Xian-Sheng Meng & Jin-Song Kuang. (2022) Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats. Aging.
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Haomiao Yu, Mingzhi Zhong, Kexin Li, Yuanyuan Jiang, Jinqiu Liao, Ruiwu Yang, Long Wang, Li Lin, Jiajian Yin, Jian Zeng, Songyue Chai, Yonghong Zhou & Li Zhang. (2022) Tanshinone IIA alleviates the mitochondrial toxicity of Salvia miltiorrhiza Bunge seedlings by regulating the transport capacity of ATP-binding cassette transporter to doxycycline. Environmental and Experimental Botany, pages 105091.
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Olajumoke Olufunlayo Nwaechefu, Tomilola Debby Olaolu, Ifeoluwa Racheal Akinwunmi, Omotunde Oluwaseyi Ojezele & Olufunso Olabode Olorunsogo. (2022) Cajanus cajan ameliorated CCl4-induced oxidative stress in Wistar rats via the combined mechanisms of anti-inflammation and mitochondrial-membrane transition pore inhibition. Journal of Ethnopharmacology 289, pages 114920.
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Linhao Xu, Yizhou Xu, Zhoujing Zhu, Huiquan Gu, Chaofeng Chen & Jian Chen. (2021) Tanshinone IIA attenuates renal injury during hypothermic preservation via the MEK/ERK1/2/GSK-3β pathway. BMC Complementary Medicine and Therapies 21:1.
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He Tai, Xiao-lin Jiang, Nan Song, Hong-he Xiao, Yue Li, Mei-jia Cheng, Xiao-mei Yin, Yi-ran Chen, Guan-lin Yang, Xiao-yu Jiang, Jin-song Kuang, Zhi-ming Lan & Lian-qun Jia. (2021) Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats. Frontiers in Medicine 8.
Crossref
Shuhong Qian, Yujin Qian, Dongxia Huo, Shijin Wang & Qingwen Qian. (2019) Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1. European Journal of Pharmacology 857, pages 172419.
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Miao-Juan Shi, Ben-Sheng Dong, Wen-Na Yang, Shi-Bing Su & Hui Zhang. (2019) Preventive and therapeutic role of Tanshinone ⅡA in hepatology. Biomedicine & Pharmacotherapy 112, pages 108676.
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Milad Iranshahy, Mehrdad Iranshahi, Seyed Reza Abtahi & Gholamreza Karimi. (2018) The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review. Food and Chemical Toxicology 120, pages 261-276.
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Wenwen Wang, Cuiwen Guan, Xiaozhe Sun, Zhongxiang Zhao, Jia Li, Xinlu Fu, Yuwen Qiu, Min Huang, Jing Jin & Zhiying Huang. (2016) Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway. Phytomedicine 23:6, pages 589-596.
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Xue Yang, Jun Yan & Juan Feng. (2016) Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis. European Journal of Pharmacology 771, pages 18-28.
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Yu Jin Jeon, Joong Sun Kim, Geun Hye Hwang, Zhexue Wu, Ho Jae Han, Soo Hyun Park, Woochul Chang, Lark Kyun Kim, You-Mie Lee, Kwang-Hyeon Liu & Min Young Lee. (2015) Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells. European Journal of Pharmacology 764, pages 480-488.
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Zihan Xu, Lijun Wu, Yaowen Sun, Yadong Guo, Gaoping Qin, Shengzhi Mu, Ronghui Fan, Benfeng Wang, Wenjie Gao & Zhenxin Zhang. (2014) Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells. BMC Complementary and Alternative Medicine 14:1.
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Zihan Xu, Zhenxin Zhang, Lijun Wu, Yaowen Sun, Yadong Guo, Gaoping Qin, Shengzhi Mu, Ronghui Fan, Benfeng Wang & Wenjie Gao. (2014) Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers. International Journal of Molecular Sciences 15:10, pages 18117-18130.
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Florent Duval, Jorge E. Moreno-Cuevas, Maria Teresa González-Garza, Carlos Rodríguez-Montalvo & Delia Elva Cruz-Vega. (2014) Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells. Advances in Pharmacological Sciences 2014, pages 1-11.
Crossref
SHASHA DU, QIWEI YAO, PEIXIN TAN, GUOZHU XIE, CHEN REN, QUANQUAN SUN, XIAO ZHANG, RONG ZHENG, KAIJUN YANG, YAWEI YUAN & QUAN YUAN. (2013) Protective effect of tanshinone IIA against radiation-induced ototoxicity in HEI-OC1 cells. Oncology Letters 6:4, pages 901-906.
Crossref
John H. K. Yeung. 2013. Evidence and Rational Based Research on Chinese Drugs. Evidence and Rational Based Research on Chinese Drugs 237 282 .
Shu-Jing Wu, Shu-Jung Lee, Chun-Han Su, Doung-Liang Lin, Shyh-Shyan Wang & Lean-Teik Ng. (2012) Bioactive constituents and anti-proliferative properties of supercritical carbon dioxide Salvia miltiorrhiza extract in 3T3-L1 adipocytes. Process Biochemistry 47:2, pages 216-224.
Crossref
Zhi-Kai Dai, Jiang-Ke Qin, Jiao-E Huang, Yong Luo, Qing Xu & Hai-Lu Zhao. (2011) Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells. Journal of Natural Medicines 66:1, pages 192-201.
Crossref

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