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Original Article

Antianxiety activity of Gelsemium sempervirens

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Pages 1091-1096 | Received 14 Mar 2009, Accepted 15 Nov 2009, Published online: 22 Sep 2010

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Read on this site (2)

Ashutosh Sharma, Alexandre Cardoso-Taketa, Griselda García & María Luisa Villarreal. (2012) A systematic updated review of scientifically tested selected plants used for anxiety disorders. Botanics: Targets and Therapy 2, pages 21-39.
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Salvatore Chirumbolo. (2012) Plant-Derived Extracts in the Neuroscience of Anxietyon Animal Models: Biases and Comments. International Journal of Neuroscience 122:4, pages 177-188.
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Articles from other publishers (35)

Jiangyu Long, Mohuan Tang, Mengting Zuo, Wenbo Xu, Siyu Meng & Zhaoying Liu. (2023) The antianxiety effects of koumine and gelsemine, two main active components in the traditional Chinese herbal medicine Gelsemium : A comprehensive review . Brain‐X 1:4.
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Jyoti & Vandana Garg. (2023) Acacia catechu Willd. and Acacia arabica Willd. decrease the extent of anxiety behavior by reducing oxidative stress and moderating neurochemicals. Journal of Ethnopharmacology 312, pages 116496.
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Meng-Ting Zuo, Si-Juan Huang, Yong Wu, Mo-Huan Tang, Hui Yu, Xue-Jia Qi & Zhao-Ying Liu. (2022) A Proteomics Study of the Subacute Toxicity of Rat Brain after Long- Term Exposure of Gelsemium elegans . Current Molecular Pharmacology 15:5, pages 794-801.
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Meng‐Die Gong, Jiao‐Yan Qin, Meng‐Ting Zuo, Xue‐Jia Qi, Yong Wu, Xiao‐Feng Zheng & Zhao‐Ying Liu. (2022) A high‐resolution mass spectrometric approach to a qualitative and quantitative comparative metabolism of the humantenine‐type alkaloid rankinidine. Rapid Communications in Mass Spectrometry 36:12.
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Hui Yu, Mo-Huan Tang, Zi-Yue Zeng, Si-Juan Huang, Xiao-Feng Zheng & Zhao-Ying Liu. (2022) Suppressive Effects of Gelsemine on Anxiety-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice. Brain Sciences 12:2, pages 191.
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Yu-Juan Li, Kun Yang, Xue-Ming Long, Gang Xiao, Si-Juan Huang, Zi-Yue Zeng, Zhao-Ying Liu & Zhi-Liang Sun. (2022) Toxicity assessment of gelsenicine and the search for effective antidotes. Human & Experimental Toxicology 41, pages 096032712110628.
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Meng-Ting Zuo, Yong Wu, Zi-Yuan Wang, Na Wang, Si-Juan Huang, Hui Yu, Xue-Jiao Zhao, Chong-Yin Huang & Zhao-Ying Liu. (2021) A comprehensive toxicity evaluation in rats after long-term oral Gelsemium elegans exposure. Biomedicine & Pharmacotherapy 137, pages 111284.
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Divneet Kaur, Richa Shri & Anjoo Kamboj. (2021) Bioactivity‐directed isolation, characterization, and quantification of an anxiolytic flavonoid from Brassica oleracea L. . Journal of Food Biochemistry 45:4.
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Reuben S. Maghembe. 2021. Phytochemistry, the Military and Health. Phytochemistry, the Military and Health 313 351 .
Hongqiang Qiu, Changxi Yu, Yu Cheng, Wancai Que, Xiaofang Zeng, Hui Wang & Maobai Liu. (2019) Simultaneous Determination of Koumine and Gelsemine in Human Plasma Using HPLC-UV Assay and Its Clinical Application. Current Pharmaceutical Analysis 15:6, pages 640-649.
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Sha-Sha Liu, Kun Yang, Zhi-Liang Sun, Xiaofeng Zheng, Xia Bai & Zhao-Ying Liu. (2019) A novel two-dimensional liquid chromatography system for the simultaneous determination of three monoterpene indole alkaloids in biological matrices. Analytical and Bioanalytical Chemistry 411:17, pages 3857-3870.
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Kun Yang, Xue-Ming Long, Yan-Chun Liu, Fu-Hua Chen, Xiao-Feng Liu, Zhi-Liang Sun & Zhao-Ying Liu. (2018) Development and in-house validation of a sensitive LC–MS/MS method for simultaneous quantification of gelsemine, koumine and humantenmine in porcine plasma. Journal of Chromatography B 1076, pages 54-60.
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Paolo Bellavite, Clara Bonafini & Marta Marzotto. (2018) Experimental neuropharmacology of Gelsemium sempervirens : Recent advances and debated issues. Journal of Ayurveda and Integrative Medicine 9:1, pages 69-74.
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Luis Hortal Muñoz, Gualberto Díaz Saez, Camino Díaz Díez, M. Nieves Domínguez Agüero, Paloma Verdú Sotomayor & José Ignacio Torres Jiménez. (2017) Control de la belonefobia con homeopatía: alta repercusión en un caso de hepatitis A. Revista Médica de Homeopatía 10:3, pages 95-98.
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Chao-Jie Chen, Zhi-Feng Zhong, Zhi-Ming Xin, Long-Hui Hong, Yan-Ping Su & Chang-Xi Yu. (2017) Koumine exhibits anxiolytic properties without inducing adverse neurological effects on functional observation battery, open-field and Vogel conflict tests in rodents. Journal of Natural Medicines 71:2, pages 397-408.
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Angel Josabad Alonso-Castro, Fabiola Domínguez, Alan Joel Ruiz-Padilla, Nimsi Campos-Xolalpa, Juan Ramón Zapata-Morales, Candy Carranza-Alvarez & Juan Jose Maldonado-Miranda. (2017) Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-28.
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Cesar O Lara, Pablo Murath, Braulio Muñoz, Ana M Marileo, Loreto San Martín, Victoria P San Martín, Carlos F Burgos, Trinidad A Mariqueo, Luis G Aguayo, Jorge Fuentealba, Patricio Godoy, Leonardo Guzman & Gonzalo E Yévenes. (2016) Functional modulation of glycine receptors by the alkaloid gelsemine. British Journal of Pharmacology 173:14, pages 2263-2277.
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Yu-er Wu, Ya-dong Li, Yan-jia Luo, Tian-xiao Wang, Hui-jing Wang, Shuo-nan Chen, Wei-min Qu & Zhi-li Huang. (2015) Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice. Acta Pharmacologica Sinica 36:11, pages 1308-1317.
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Hong-Qiang Qiu, Ying Xu, Gui-Lin Jin, Jian Yang, Ming Liu, Su-Ping Li & Chang-Xi Yu. (2015) Koumine Enhances Spinal Cord 3α-Hydroxysteroid Oxidoreductase Expression and Activity in a Rat Model of Neuropathic Pain. Molecular Pain 11, pages s12990-015-0050.
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Salvatore Chirumbolo. (2014) On Gelsemium and Complementary and Alternative Medicine (CAM) in Anxiety and Experimental Neurology. Neurology and Therapy 4:1, pages 1-10.
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Wilfried Dimpfel & Andreas Biller. (2015) Mechanism of Action of Low Dose Preparations from <i>Coffea arabica</i>, <i>Gelsemium</i> and <i>Veratrum</i> Based on <i>in Vivo</i> and <i>in Vitro</i> Neurophysiological Findings. Journal of Behavioral and Brain Science 05:09, pages 368-380.
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Partha Palit, Dhrubojyoti Mukherjee & Subhash C Mandal. (2015) Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model. Journal of Ethnopharmacology 159, pages 274-284.
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Jing-Yang Zhang & Yong-Xiang Wang. (2015) Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. Fitoterapia 100, pages 35-43.
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Marta Marzotto, Debora Olioso, Maurizio Brizzi, Paola Tononi, Mirco Cristofoletti & Paolo Bellavite. (2014) Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens. BMC Complementary and Alternative Medicine 14:1.
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Debora Olioso, Marta Marzotto, Elisabetta Moratti, Maurizio Brizzi & Paolo Bellavite. (2014) Effects of Gelsemium sempervirens L. on pathway-focused gene expression profiling in neuronal cells. Journal of Ethnopharmacology 153:2, pages 535-539.
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P. Bellavite, M. Marzotto & A. Conforti. (2014) Scientific criticism in homoeopathy: need to test more than disputes. International Journal of Clinical Practice 68:3, pages 403-404.
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Gui-Lin Jin, Yan-Ping Su, Ming Liu, Ying Xu, Jian Yang, Kai-Jun Liao & Chang-Xi Yu. (2014) Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)—A review of their phytochemistry, pharmacology, toxicology and traditional use. Journal of Ethnopharmacology 152:1, pages 33-52.
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Juan Francisco Rodríguez-Landa, Julio Vicente-Serna, Luis Alfredo Rodríguez-Blanco, María de Jesús Rovirosa-Hernández, Francisco García-Orduña & Miguel Carro-Juárez. (2014) Montanoa frutescens and Montanoa grandiflora Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats . BioMed Research International 2014, pages 1-9.
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Paolo Bellavite, Marta Marzotto, Debora Olioso, Elisabetta Moratti & Anita Conforti. (2014) High-dilution effects revisited. 2. Pharmacodynamic mechanisms. Homeopathy 103:1, pages 22-43.
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Jing-Yang Zhang, Nian Gong, Jin-Lu Huang, Ling-Chen Guo & Yong-Xiang Wang. (2013) Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors. Pain 154:11, pages 2452-2462.
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Salvatore Chirumbolo. (2013) Homeopathy: bias, mis-interpretation and other. Journal of Medicine and the Person 11:1, pages 37-44.
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Ming Liu, Hui-Hui Huang, Jian Yang, Yan-Ping Su, Hong-Wei Lin, Li-Qing Lin, Wei-Jian Liao & Chang-Xi Yu. (2012) The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics. Psychopharmacology 225:4, pages 839-851.
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Long Cheng, Guo-feng Pan, Xiao-bo Sun, Yun-xiang Huang, You-shun Peng & Lin-yan Zhou. (2013) Evaluation of Anxiolytic-Like Effect of Aqueous Extract of Asparagus Stem in Mice . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-10.
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Miguel Carro-Juárez, Juan Francisco Rodríguez-Landa, María de Lourdes Rodríguez-Peña, María de Jesús Rovirosa-Hernández & Francisco García-Orduña. (2012) The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: Involvement of GABAA receptor. Journal of Ethnopharmacology 143:2, pages 592-598.
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Paolo Bellavite, Anita Conforti, Marta Marzotto, Paolo Magnani, Mirko Cristofoletti, Debora Olioso & Maria Elisabetta Zanolin. (2012) Testing Homeopathy in Mouse Emotional Response Models: Pooled Data Analysis of Two Series of Studies. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-9.
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