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Research Article

Withania Somnifera (Ashwagandha), a Rejuvenating Herbal Drug Which Enhances Survival During Stress (an Adaptogen)

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Pages 29-35 | Published online: 27 Sep 2008

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S. K. Graver, H. M. Divekar, Ratan Kumar, M. L. Pahwa, S. K. Bhardwaj, A. K. Gupta And & K. K. Srivastava. (1995) Experimental Evaluation of a Composite Indian Herbal Preparation II (CIHPII) as an Adaptogen and its Mechanism of Action. International Journal of Pharmacognosy 33:2, pages 148-154.
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Anupam Bishayee & Malay Chatterjee. (1994) Anti-Stress Potential of Mikania cordata Root Extract in Mice. International Journal of Pharmacognosy 32:2, pages 126-134.
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N. Singh, S. P. Singh, R. Nath, D. R. Singh, M. L. Gupta, R. P. Kohli & K. P. Bhargava. (1986) Prevention of Urethane - Induced Lung Adenomas by Withania somnifera (L.) Dunal in Albino Mice. International Journal of Crude Drug Research 24:2, pages 90-100.
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K. Anbalagan & J. Sadique. (1985) Withania somnifera (Ashwagandha), a Rejuvenating Herbal Drug Which Controls Alpha-2-Macroglobulin Synthesis During Inflammation. International Journal of Crude Drug Research 23:4, pages 177-183.
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Articles from other publishers (42)

Mahmoud Tareq Abdelwahed, Maha A. Hegazy & Ekram H. Mohamed. (2023) Major biochemical constituents of Withania somnifera (ashwagandha) extract: A review of chemical analysis . Reviews in Analytical Chemistry 42:1.
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Bentham Science Publisher Kavita, Naina Rajak, Praveen Kumar, Shikha Singh & Neha Garg. 2023. Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach. Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach 105 116 .
Sajida & Ashwini Prabhu. (2022) Withania somnifera deploys immunomodulation and exerts anticancer effects on lung adenocarcinoma cells. South African Journal of Botany 151, pages 47-65.
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Sheikh Shohag, Shomaya Akhter, Shahidul Islam, Tonmoy Sarker, Moinuddin Khan Sifat, Md. Mominur Rahman, Md. Rezaul Islam & Rohit Sharma. (2022) Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review. Oxidative Medicine and Cellular Longevity 2022, pages 1-20.
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Mary Princess Sulekha S. (2022) A Comprehensive Review on Medicinal Herb Withania somnifera (L.) Dunal in Women’s Health: a Rejuvenator From Siddha Medicine. Current Pharmacology Reports 8:1, pages 72-77.
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Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran & Arun K. Sharma. (2022) Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides. Molecules 27:3, pages 886.
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Sriram Gopal, Ashutosh Ajgaonkar, Padmaja Kanchi, Aditi Kaundinya, Vaishali Thakare, Sanjaya Chauhan & Deepak Langade. (2021) Effect of an ashwagandha ( Withania Somnifera ) root extract on climacteric symptoms in women during perimenopause: A randomized, double‐blind , placebo‐controlled study . Journal of Obstetrics and Gynaecology Research 47:12, pages 4414-4425.
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Subhabrata Paul, Shreya Chakraborty, Uttpal Anand, Swarnali Dey, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Manoj Tukaram Patil, Ramesh Kandimalla, Jarosław Proćków & Abhijit Dey. (2021) Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & Pharmacotherapy 143, pages 112175.
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Vinod Kumar Joshi & Apurva Joshi. (2021) Rational use of Ashwagandha in Ayurveda (Traditional Indian Medicine) for health and healing. Journal of Ethnopharmacology 276, pages 114101.
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Akash Saggam, Kirti Limgaokar, Swapnil Borse, Preeti Chavan-Gautam, Santosh Dixit, Girish Tillu & Bhushan Patwardhan. (2021) Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management. Frontiers in Pharmacology 12.
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Tomoharu Kuboyama, Ximeng Yang & Chihiro Tohda. (2020) Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease. International Journal of Molecular Sciences 21:13, pages 4665.
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Wilfried Dimpfel, Leonie Schombert, Ingrid K. Keplinger-Dimpfel & Alexander Panossian. (2020) Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study. Pharmaceuticals 13:3, pages 45.
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Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 1933 1950 .
Karem H. Alzoubi, Arwa S. Al Hilo, Qosay A. Al-Balas, Khalid El-Salem, Tamam El-Elimat & Feras Q. Alali. (2019) Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment. Molecular Biology Reports 46:5, pages 4709-4715.
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AK Mohiuddin. (2019) Natural Foods and Indian herbs of cardiovascular interest. Pharmacy & Pharmacology International Journal 7:2.
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Geetha Suryakumar, Richa Rathor, Akanksha Agrawal, Som Nath Singh & Bhuvnesh Kumar. 2019. Nutraceuticals and Natural Product Pharmaceuticals. Nutraceuticals and Natural Product Pharmaceuticals 141 166 .
Lian-ying Liao, Yi-fan He, Li Li, Hong Meng, Yin-mao Dong, Fan Yi & Pei-gen Xiao. (2018) A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chinese Medicine 13:1.
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Niraj Tripathi, Divya Shrivastava, Bilal Ahmad Mir, Shailesh Kumar, Sumit Govil, Maryam Vahedi & Prakash S Bisen. (2018) Metabolomic and biotechnological approaches to determine therapeutic potential of Withania somnifera (L.) Dunal: A review. Phytomedicine 50, pages 127-136.
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Ranjeet Kumar, Jaswant Rai, N.C. Kajal & Pushpa Devi. (2018) Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis. Indian Journal of Tuberculosis 65:3, pages 246-251.
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Bhagwan Sharma, Pitta Srinivas, Sneha Marlewar, G Venkateswarlu, Banamali Das, Rohit Ravte & Vanmala B Wakode. (2018) Clinical Safety of Selected Ayurvedic Formulations as Rasayana in Apparently Healthy Elderly Persons: A Pharmacoepidemiological Perspective . Journal of Research in Ayurvedic Sciences 2:2, pages 122-131.
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Babli Halder, Shruti Singh & Suman S. Thakur. (2015) Withania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells. PLOS ONE 10:9, pages e0137498.
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Swati Dongre, Deepak Langade & Sauvik Bhattacharyya. (2015) Efficacy and Safety of Ashwagandha ( Withania somnifera ) Root Extract in Improving Sexual Function in Women: A Pilot Study . BioMed Research International 2015, pages 1-9.
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Pallavi Joshi, Laxminarain Misra, Amreen A. Siddique, Monica Srivastava, Shiv Kumar & Mahendra P. Darokar. (2014) Epoxide group relationship with cytotoxicity in withanolide derivatives from Withania somnifera. Steroids 79, pages 19-27.
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Debmalya BarhNeelam Sangwan, PhD Misra, PhD Tripathi & Amit Kushwaha. 2013. OMICS Applications in Crop Science. OMICS Applications in Crop Science 385 408 .
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Ramasamy Harikrishnan, Chellam Balasundaram, Sundaram Jawahar & Moon-Soo Heo. (2012) Immunomodulatory effect of Withania somnifera supplementation diet in the giant freshwater prawn Macrobrachium rosenbergii (de Man) against Aeromonas hydrophila. Fish & Shellfish Immunology 32:1, pages 94-100.
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Vivek K. Gupta, Madhvi M. Lal, Naresh K. Satti, Prabhu Dutt, Punita Sharma, Musarat Amina & Krishan A. Suri. (2011) Isolation and Crystal Structure of 6α,7α-Epoxy-5α,17α,27-trihydroxy-1-oxo-22R-witha-2,24-dienolide monohydrate-A Withasteroid from Withania somnifera Leaves. Journal of Chemical Crystallography 41:7, pages 1064-1070.
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Vivek K. Gupta, Shaveta Mahajan, Naresh K. Satti, Krishan A. Suri & G. N. Qazi. (2008) (20R,22R)-6α,7α-Epoxy-5α,27-dihydroxy-1-oxowitha-2,24-dienolide in Leaves of Withania somnifera: Isolation and its Crystal Structure. Journal of Chemical Crystallography 38:10, pages 769-773.
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S. Saggu & R. Kumar. (2008) Effect of seabuckthorn ( Hippophae rhamnoides ) leaf aqueous and ethanol extracts on avoidance learning during stressful endurance performance of rats: a dose dependent study . Phytotherapy Research 22:9, pages 1183-1187.
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Hari SharmaH.M. ChandolaGurdip SinghGopal Basisht. (2007) Utilization of Ayurveda in Health Care: An Approach for Prevention, Health Promotion, and Treatment of Disease. Part 2—Ayurveda in Primary Health Care. The Journal of Alternative and Complementary Medicine 13:10, pages 1135-1150.
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Pankaj Bandhoria, Vivek K. Gupta, Musarat Amina, Naresh K. Satti, Prabhu Dutt & Krishan A. Suri. (2006) 6α,7α-epoxy-5α,17α,dihydroxy-1-oxo-22R-witha-2,24-dienolide in leaves of Withania somnifera: Isolation and its crystal structure. Journal of Chemical Crystallography 36:2, pages 153-159.
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Ravi K. Khajuria, Krishan A. Suri, Rajinder K. Gupta, Naresh K. Satti, Musarat Amina, Om P. Suri & Ghulam N. Qazi. (2004) Separation, identification, and quantification of selected withanolides in plant extracts ofWithania somnifera by HPLC-UV(DAD) - Positive ion electrospray ionisation-mass spectrometry. Journal of Separation Science 27:7-8, pages 541-546.
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Parvinder Kaur, Meenakshi Sharma, Sheenu Mathur, Manisha Tiwari, Harish M. Divekar, Ratan Kumar, Kaushal K. Srivastava & Ramesh Chandra. (2003) Effect of 1-Oxo-5 β , 6 β -Epoxy-Witha-2-Ene-27-Ethoxy-Olide Isolated from the Roots of Withania somnifera on Stress Indices in Wistar Rats . The Journal of Alternative and Complementary Medicine 9:6, pages 897-907.
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Deepak Rai, Gitika Bhatia, Gautam Palit, Raghwendra Pal, Satyawan Singh & Hemant K. Singh. (2003) Adaptogenic effect of Bacopa monniera (Brahmi). Pharmacology Biochemistry and Behavior 75:4, pages 823-830.
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E.M. Abdel-Magied, H.A. Abdel-Rahman & F.M. Harraz. (2001) The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. Journal of Ethnopharmacology 75:1, pages 1-4.
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A. A. Al-Qarawi, H. A. Abdel-Rahman, A. A. El-Badry, F. Harraz, N. A. Razig & E. M. Abdel-Magied. (2000) The effect of extracts of Cynomorium coccineum and Withania somnifera on gonadotrophins and ovarian follicles of immature Wistar rats. Phytotherapy Research 14:4, pages 288-290.
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Nirmala N. Rege, Urmila M. Thatte & Sharadini A. Dahanukar. (1999) Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytotherapy Research 13:4, pages 275-291.
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Ratan Kumar, S. K. Grover, H. M. Divekar, A. K. Gupta, Radhey Shyam & K. K. Srivastava. (1996) Enhanced thermogenesis in rats byPanax ginseng, multivitamins and minerals. International Journal of Biometeorology 39:4, pages 187-191.
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H. Wagner, H. Nörr & H. Winterhoff. (1994) Plant adaptogens. Phytomedicine 1:1, pages 63-76.
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F. Ahumada, F. Aspee, G. Wikman & J. Hancke. (1991) Withania somnifera extract. Its effect on arterial blood pressure in anaesthetized dogs. Phytotherapy Research 5:3, pages 111-114.
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Uma Ramachandran, H.M. Divekar, S.K. Grover & K.K. Srivastava. (1990) New experimental model for the evaluation of adaptogenic products. Journal of Ethnopharmacology 29:3, pages 275-281.
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