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Pharmaceutical Biology Volume 48, 2010 - Issue 12
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Research Article

Optimization of podophyllotoxin extraction method from Linum album cell cultures

Morteza YousefzadiDepartment of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran
,
Mozafar SharifiDepartment of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, TehranCorrespondence[email protected]
,
Najmeh Ahmadian ChashmiDepartment of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran
,
Mehrdad BehmaneshDepartment of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran
&
Alireza GhasempourDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
Pages 1421-1425 | Received 27 Dec 2009, Accepted 26 Apr 2010, Published online: 07 Sep 2010

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Najmeh Ahmadian Chashmi, Mohsen Sharifi & Mehrdad Behmanesh. (2016) Lignan enhancement in hairy root cultures of Linum album using coniferaldehyde and methylenedioxycinnamic acid. Preparative Biochemistry & Biotechnology 46:5, pages 454-460.
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Articles from other publishers (25)

Zahra Danaeipour, Ghasemali Garoosi, Masoud Tohidfar, Mohammad Reza Bakhtiarizadeh & Mohammad Hossein Mirjalili. (2023) Comprehensive RNA-Seq-based study and metabolite profiling to identify genes involved in podophyllotoxin biosynthesis in Linum album Kotschy ex Boiss. (Linaceae). Scientific Reports 13:1.
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Mostafa Sagharyan, Mohsen Sharifi & Elaheh Samari. (2023) Methyl jasmonate redirects the dynamics of carbohydrates and amino acids toward the lignans accumulation in Linum album cells. Plant Physiology and Biochemistry 198, pages 107677.
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Mona Soltani, Elaheh Samari, Saeide Vazirifar, Najmeh Ahmadian Chashmi, Mohsen Sharifi & Reza Fotovat. (2023) Putrescine induces lignans biosynthesis through changing the oxidative status and reprogramming amino acids and carbohydrates levels in Linum album hairy roots. Plant Cell, Tissue and Organ Culture (PCTOC) 153:2, pages 387-402.
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M. P. Kitaeva, A. A. Aksenov, T. A. Fedotcheva, A. V. Semeikin & N. L. Shimanovsky. (2022) Cytotoxic Activity of Extracts from the Intact Plant and Cell Cultures of Podophyllum peltatum Against Cervical Cancer Cells. Pharmaceutical Chemistry Journal 56:3, pages 361-365.
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Neda Javadian, Ghasem Karimzadeh, Mohsen Sharifi & Ahmad Moieni. (2022) Effect of ploidy level on podophyllotoxin content and expression of genes related to its biosynthesis in callus cultures of Linum album. Biologia 77:9, pages 2449-2458.
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Hannaneh Tashackori, Mohsen Sharifi, Najmeh Ahmadian Chashmi, Mehrdad Behmanesh, Naser Safaie & Mostafa Sagharyan. (2021) Physiological, biochemical, and molecular responses of Linum album to digested cell wall of Piriformospora indica. Physiology and Molecular Biology of Plants 27:12, pages 2695-2708.
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Abbas Khojasteh, Mohammad Hossein Mirjalili, Miguel Angel Alcalde, Rosa M. Cusido, Regine Eibl & Javier Palazon. (2020) Powerful Plant Antioxidants: A New Biosustainable Approach to the Production of Rosmarinic Acid. Antioxidants 9:12, pages 1273.
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Bharat Singh & Ram Avtar Sharma. 2020. Secondary Metabolites of Medicinal Plants. Secondary Metabolites of Medicinal Plants 604 614 .
Hannaneh Tashackori, Mohsen Sharifi, Najmeh Ahmadian Chashmi, Elisabeth Fuss, Mehrdad Behmanesh & Naser Safaie. (2019) RNAi-mediated silencing of pinoresinol lariciresinol reductase in Linum album hairy roots alters the phenolic accumulation in response to fungal elicitor. Journal of Plant Physiology 232, pages 115-126.
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Abdur Rauf, Seema Patel, Muhammad Imran, Aneela Maalik, Muhammad Umair Arshad, Farhan Saeed, Yahia N. Mabkhot, Salim S. Al-Showiman, Nazir Ahmad & Eman Elsharkawy. (2018) Honokiol: An anticancer lignan. Biomedicine & Pharmacotherapy 107, pages 555-562.
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Hannaneh Tashackori, Mohsen Sharifi, Najmeh Ahmadian Chashmi, Mehrdad Behmanesh & Naser Safaie. (2018) Piriformospora indica cell wall modulates gene expression and metabolite profile in Linum album hairy roots. Planta 248:5, pages 1289-1306.
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Liliana Lalaleo, Rubén Alcazar, Javier Palazon, Elisabeth Moyano, Rosa M. Cusido & Mercedes Bonfill. (2018) Comparing aryltetralin lignan accumulation patterns in four biotechnological systems of Linum album. Journal of Plant Physiology 228, pages 197-207.
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Mina Esfandiari, Mohsen Sharifi, Farzaneh Mohamadyar-Toupkanlou, Hana Hanaee-Ahwaz, Morteza Yousefzadi, Azizollah Jafari, Simzar Hosseinzadeh & Masoud Soleimani. (2017) Optimization of cell/tissue culture of Linum persicum for production of lignans derivatives including Podophyllotoxin. Plant Cell, Tissue and Organ Culture (PCTOC) 133:1, pages 51-61.
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Hélio Nitta Matsuura, Sonia Malik, Fernanda de Costa, Morteza Yousefzadi, Mohammad Hossein Mirjalili, Randolph Arroo, Avninder S. Bhambra, Miroslav Strnad, Mercedes Bonfill & Arthur Germano Fett-Neto. (2017) Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production. Molecular Biotechnology 60:2, pages 169-183.
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Neda Javadian, Ghasem Karimzadeh, Mohsen Sharifi, Ahmad Moieni & Mehrdad Behmanesh. (2017) In vitro polyploidy induction: changes in morphology, podophyllotoxin biosynthesis, and expression of the related genes in Linum album (Linaceae). Planta 245:6, pages 1165-1178.
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Xiang Yu, Zhiping Che & Hui Xu. (2017) Recent Advances in the Chemistry and Biology of Podophyllotoxins. Chemistry - A European Journal 23:19, pages 4467-4526.
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Isabella Zanella, Giorgio Biasiotto, Finn Holm & Diego di Lorenzo. (2017) Cereal Lignans, Natural Compounds of Interest for Human Health?. Natural Product Communications 12:1, pages 1934578X1701200.
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Pavlina Sasheva & Iliana Ionkova. 2017. Biotechnology and Production of Anti-Cancer Compounds. Biotechnology and Production of Anti-Cancer Compounds 177 199 .
Hannaneh Tashackori, Mohsen Sharifi, Najmeh Ahmadian Chashmi, Naser Safaie & Mehrdad Behmanesh. (2016) Induced-differential changes on lignan and phenolic acid compounds in Linum album hairy roots by fungal extract of Piriformospora indica. Plant Cell, Tissue and Organ Culture (PCTOC) 127:1, pages 187-194.
Crossref
Tingting Liu, Lei Yang, Xiaoyu Sui, Jie Zhang, Li Li, Shuang Fu, Wenjing Li & Xin Liang. (2015) Vacuum-powered bubble-assisted solvent extraction followed by macroporous resin enrichment for isolation of podophyllotoxin from Sinopodophyllum emodi. Journal of Chromatography B 1002, pages 364-371.
Crossref
S. Malik, O. Bíba, J. Grúz, R. R. J. Arroo & M. Strnad. (2014) Biotechnological approaches for producing aryltetralin lignans from Linum species. Phytochemistry Reviews 13:4, pages 893-913.
Crossref
Najmeh Ahmadian Chashmi, Mozafar Sharifi, Morteza Yousefzadi, Mehrdad Behmanesh, Hassan Rezadoost, Alejandra Cardillo & Javier Palazon. (2012) Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss. Medicinal Chemistry Research 22:2, pages 745-752.
Crossref
Morteza Yousefzadi, Mozafar Sharifi, Mehrdad Behmanesh, Alireza Ghasempour, Elisabeth Moyano & Javier Palazon. (2012) The effect of light on gene expression and podophyllotoxin biosynthesis in Linum album cell culture. Plant Physiology and Biochemistry 56, pages 41-46.
Crossref
Morteza Yousefzadi, Mozafar Sharifi, Mehrdad Behmanesh, Alireza Ghasempour, Elisabeth Moyano & Javier Palazon. (2010) Salicylic acid improves podophyllotoxin production in cell cultures of Linum album by increasing the expression of genes related with its biosynthesis. Biotechnology Letters 32:11, pages 1739-1743.
Crossref
Morteza Yousefzadi, Mozafar Sharifi, Mehrdad Behmanesh, Elisabeth Moyano, Mercedis Bonfill, Rosa M. Cusido & Javier Palazon. (2010) Podophyllotoxin: Current approaches to its biotechnological production and future challenges. Engineering in Life Sciences 10:4, pages 281-292.
Crossref

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