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Research Article

Anticonvulsant activity of solasodine isolated from Solanum sisymbriifolium fruits in rodents

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Pages 194-199 | Received 23 May 2010, Accepted 12 Jul 2010, Published online: 09 Nov 2010

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Vivek Jain, Saurabh K. Sinha, Kajol Rustage, Ashutosh Pareek, Manish Srivastava, Mukesh K. Meena, Anshul Shakya, Madan Mohan Gupta, Nitish Rai, Aaushi Pareek, Yashumati Ratan, Min Hua Chen, Satyendra Kumar Prasad & Ghulam Md Ashraf. (2023) Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition. Molecular Neurobiology 60:9, pages 5378-5394.
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Diptesh Biswas, Sk. Moquammel Haque & Biswajit Ghosh. (2023) Solanum sisymbriifolium Lam.: an underutilised plant with future prospects in nutrition and medicine. Proceedings of the Indian National Science Academy.
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Laura Soraia Perpétuo, Maria José M. da Cunha, Maria Teresa Batista & Isabel Luci Conceição. (2023) Evaluation of Solanum linnaeanum and S. sisymbriifolium extracts for the management of Meloidogyne chitwoodi. Heliyon 9:6, pages e16298.
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Lee Hsien Siang, Alina Arulsamy, Yeong Keng Yoon & Mohd. Farooq Shaikh. (2022) Fruits for Seizures? A Systematic Review on the Potential Anti-Convulsant Effects of Fruits and their Phytochemicals. Current Neuropharmacology 20:10, pages 1925-1940.
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Poonam Arora, Lalit Mohan Nainwal, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Brian G. Oliver & Kamal Dua. (2022) Orally administered solasodine, a steroidal glycoalkaloid, suppresses ovalbumin-induced exaggerated Th2-immune response in rat model of bronchial asthma. Chemico-Biological Interactions 366, pages 110138.
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Ana Raquel Pereira da Silva, Maria do Socorro Costa, Nara Juliana Santos Araújo, Thiago Sampaio de Freitas, Ray Silva de Almeida, José Maria Barbosa Filho, Josean Fechine Tavares, Erlânio Oliveira de Souza, Pablo Antonio Maia de Farias, Jacqueline Cosmo Andrade Pinheiro & Henrique Douglas Melo Coutinho. (2022) Potentiation of Antibiotic Action and Efflux Pump Inhibitory Effect on Staphylococcus aureus Strains by Solasodine. Antibiotics 11:10, pages 1309.
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Tiantian Lu, Xiaohong Wang, Qi Zhang, Kun Liu, Tongxin Xu, Quande Wang, Pengfei Zhao & Zhongzhe Cheng. (2022) Validated LC-MS/MS method for quantitation of solasodine in rat urine and feces: Blocking nonspecific adsorption. Acta Chromatographica.
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Mei Qu, Peng Xue, Qi Zhang, Tiantian Lu, Kun Liu, Bingying Hu, Jingjing Pang, Qianqian Xiao, Tongxin Xu, Quande Wang & Zhongzhe Cheng. (2022) Pharmacokinetics, oral bioavailability and metabolic analysis of solasodine in mice by dried blood spot LC-MS/MS and UHPLC-Q-Exactive MS. Journal of Pharmaceutical and Biomedical Analysis 210, pages 114542.
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Syamkumar Sivasankara Pillai & Louise-Marie Dandurand. (2021) Effect of Steroidal Glycoalkaloids on Hatch and Reproduction of the Potato Cyst Nematode Globodera pallida . Plant Disease 105:10, pages 2975-2980.
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Lucía Soledad Di Ciaccio, Julián Guariniello, Jésica Ianicelli & Alejandro Escandón. 2021. Medicinal and Aromatic Plants of South America Vol. 2. Medicinal and Aromatic Plants of South America Vol. 2 517 524 .
Sonia Verma, Anurag Kuhad, Ranjana Bhandari, Satyendra K. Prasad, Anshul Shakya, Rupali S. Prasad & Saurabh K. Sinha. (2020) Effect of ethanolic extract of Solanum virginianum Linn. on neuropathic pain using chronic constriction injury rat model and molecular docking studies. Naunyn-Schmiedeberg's Archives of Pharmacology 393:9, pages 1715-1728.
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Urszula Kiełczewska, Jacek W. Morzycki, Lucie Rárová & Agnieszka Wojtkielewicz. (2019) The synthesis of solasodine F-homo-analogues. Organic & Biomolecular Chemistry 17:40, pages 9050-9058.
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Joseph Sakah Kaunda & Ying-Jun Zhang. (2019) The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review. Natural Products and Bioprospecting 9:2, pages 77-137.
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Garland K. More. (2017) A review of the ethnopharmacology, phytochemistry and pharmacological relevance of the South African weed Solanum sisymbriifolium Lam. (Solanaceae). Environment, Development and Sustainability 21:1, pages 37-50.
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Ling-Li Hou, Yong Shi, Zhi-Dan Zhang, Jing-Jing Wu, Qing-Xiong Yang & Wei-Sheng Tian. (2017) Divergent Synthesis of Solanidine and 22- epi -Solanidine . The Journal of Organic Chemistry 82:14, pages 7463-7469.
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Laura García-Pupo, Armando Zaldo-Castro, Vassiliki Exarchou, Juan Tacoronte-Morales, Luc Pieters, Wim Vanden Berghe, Yanier Nuñez-Figueredo & René Delgado-Hernández. (2016) In Vitro Neuroprotective and Anti-Inflammatory Activities of Natural and Semi-Synthetic Spirosteroid Analogues. Molecules 21:8, pages 992.
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Zhi-Dan Zhang, Yong Shi, Jing-Jing Wu, Jing-Rong Lin & Wei-Sheng Tian. (2016) Synthesis of Demissidine and Solanidine. Organic Letters 18:12, pages 3038-3040.
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Jing-Jing Wu, Yong Shi & Wei-Sheng Tian. (2015) Facile synthesis of solasodine based on a mild halogenation-ring opening reaction of spiroketals in steroidal sapogenins. Tetrahedron Letters 56:10, pages 1215-1217.
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Soura Challal, Olivia E. M. Buenafe, Emerson F. Queiroz, Snezana Maljevic, Laurence Marcourt, Merle Bock, Werner Kloeti, Fabian M. Dayrit, Alan L. Harvey, Holger Lerche, Camila V. Esguerra, Peter A. M. de Witte, Jean-Luc Wolfender & Alexander D. Crawford. (2014) Zebrafish Bioassay-Guided Microfractionation Identifies Anticonvulsant Steroid Glycosides from the Philippine Medicinal Plant Solanum torvum . ACS Chemical Neuroscience 5:10, pages 993-1004.
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Jianshe Ma, Xitao Ding, Chengxiang Sun, Chongliang Lin, Xinxin An, Guanyang Lin, Xuezhi Yang & Xianqin Wang. (2014) Development and validation a liquid chromatography mass spectrometry for determination of solasodine in rat plasma and its application to a pharmacokinetic study. Journal of Chromatography B 963, pages 24-28.
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Tejas Sharma, Vishal Airao, Nimesh Panara, Devendra Vaishnav, Vishavas Ranpariya, Navin Sheth & Sachin Parmar. (2014) Solasodine protects rat brain against ischemia/reperfusion injury through its antioxidant activity. European Journal of Pharmacology 725, pages 40-46.
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Maria Conceição M. Torres, Roberta Jeane B. Jorge, Rafael M. Ximenes, Natacha Teresa Q. Alves, João Victor de A. Santos, Aline D. Marinho, Helena S.A. Monteiro, Marcos H. Toyama, Raimundo Braz-Filho, Edilberto R. Silveira & Otília Deusdênia L. Pessoa. (2013) Solanidane and iminosolanidane alkaloids from Solanum campaniforme. Phytochemistry 96, pages 457-464.
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Yi Kou & Seongmin Lee. (2013) Unexpected opening of steroidal E-ring during hypoiodite-mediated oxidation. Tetrahedron Letters 54:31, pages 4106-4109.
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Apurba Sarker Apu, Maima Matin, Shakhawat Hossan Bhuyan, Md. Faruq Hossain & Kazi Ireen. (2013) Study of Analgesic, Neuropharmacological and Anti-diarrheal Activities of Ethanol Extract of Solanum sisymbriifolium Fruits. Pharmacologia 4:3, pages 164-169.
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Kanika Patel, Ravi B. Singh & Dinesh K. Patel. (2013) Medicinal significance, pharmacological activities, and analytical aspects of solasodine: A concise report of current scientific literature. Journal of Acute Disease 2:2, pages 92-98.
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Yi Kou, Myong Chul Koag, Young Cheun, Aram Shin & Seongmin Lee. (2012) Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate. Steroids 77:11, pages 1069-1074.
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