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Pharmaceutical Biology Volume 49, 2011 - Issue 5
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Original Article

Isolation and structure determination of a sesquiterpene lactone (vernodalinol) from Vernonia amygdalina extracts

Xuan LuoDepartment of Chemistry and Biochemistry,
,
Yan JiangJackson State University, Jackson, MS, USA, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, China,
,
Frank R. FronczekDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, USA,
,
Cuiwu LinJackson State University, Jackson, MS, USA, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, China,
,
Ernest B. Izevbigie
&
Ken S. LeeDepartment of Chemistry and Biochemistry,Correspondence[email protected]
Pages 464-470 | Received 07 Jul 2010, Accepted 09 Sep 2010, Published online: 01 Feb 2011

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Bhavana Joshi, Aakriti Bhandari & G.S. Panwar. (2020) An efficient micropropagation protocol for Vernonia amygdalina Delile – An economically valuable shrub. Journal of Herbs, Spices & Medicinal Plants 26:3, pages 267-274.
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Ablajan Turak & Haji Akber Aisa. (2018) Three new elemanolides from the seeds of Vernonia anthelmintica. Journal of Asian Natural Products Research 20:4, pages 313-320.
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E. Lulekal, J. Rondevaldova, E. Bernaskova, J. Cepkova, Z. Asfaw, E. Kelbessa, L. Kokoska & P. Van Damme. (2014) Antimicrobial activity of traditional medicinal plants from Ankober District, North Shewa Zone, Amhara Region, Ethiopia. Pharmaceutical Biology 52:5, pages 614-620.
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Articles from other publishers (32)

Neha Mishra, Ena Gupta, Priyanka Singh, Shashi Soni & Uroosa Noor. (2023) Insight on Vernonia Plant for its Pharmacological Properties: A Review. Recent Advances in Food, Nutrition & Agriculture 14:2, pages 84-93.
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Arlette Nguemfo Tchankugni, Mpoame Mbida, Jürgen Hescheler & Filomain Nguemo. (2023) Effect of Ethanolic Extract of Vernonia amygdalina on the Proliferation, Viability and Function of Mouse Induced Pluripotent Stem Cells and Cardiomyocytes. Plants 12:5, pages 1108.
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Nneka Nkechi Uchegbu, Temitope Omolayo Fasuan & Kunle Oni. (2022) Biocompounds and amino acid in Vernonia amygdalina: impact of post-harvest treatments. Journal of Food Measurement and Characterization 17:1, pages 385-407.
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Ablajan Turak & Haji Akber Aisa. (2022) Oxygen heterocyclic Diels-Alder-Type sesquiterpenoid dimers from Vernonia anthelmintica. Phytochemistry 203, pages 113386.
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Eziuche A. Ugbogu, Okezie Emmanuel, Emmanuel D. Dike, Grace O. Agi, Ositadimma C. Ugbogu, Chibuike Ibe & Emeka J. Iweala. (2021) The Phytochemistry, Ethnobotanical, and Pharmacological Potentials of the Medicinal Plant-Vernonia amygdalina L. (bitter Leaf). Clinical Complementary Medicine and Pharmacology 1:1, pages 100006.
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R.A. Syahputra, U. Harahap, A. Dalimunthe, M. Pandapotan & D. Satria. (2021) Protective effect of Vernonia amygdalina Delile against doxorubicin-induced cardiotoxicity. Heliyon 7:7, pages e07434.
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O. Ajayi Clement, A. Elujoba Anthony, M. Kasali Félicien, G. Tenywa Mercy, Okella Hedmon, Weisheit Anke, U. Tolo Casim & E. Ogwang Patrick. (2020) A review for selecting medicinal plants commonly used for malaria in Uganda. African Journal of Pharmacy and Pharmacology 14:9, pages 347-361.
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Magalie El Hajj & Lone Holst. (2020) Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa. Frontiers in Pharmacology 11.
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Bhavana Joshi, Giriraj Panwar & S. Singh. (2019) Vernonia amygdalina Delile - a promising anti-cancerous and Ethnomedicinal shrub. Journal of Non Timber Forest Products 26:4, pages 225-228.
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Winnie Mozirandi, Dexter Tagwireyi & Stanley Mukanganyama. (2019) Evaluation of antimicrobial activity of chondrillasterol isolated from Vernonia adoensis (Asteraceae). BMC Complementary and Alternative Medicine 19:1.
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Trong Q. Luu, Phat T. Le, Khoa C. M. Le, An H. T. Phan, Kim Zitzmann, Kim T. Nguyen, Nam V. H. Phan & Khoi T. Nguyen. (2019) Improving the quality of Vernonia amygdalina extract by ultrasound‐assisted extraction coupled with gas bubble flotation . Journal of Food Process Engineering 42:8.
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Sanit Thongnest, Pornsuda Chawengrum, Siriporn Keeratichamroen, Kriengsak Lirdprapamongkol, Chatchakorn Eurtivong, Jutatip Boonsombat, Prasat Kittakoop, Jisnuson Svasti & Somsak Ruchirawat. (2019) Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells. Bioorganic Chemistry 92, pages 103197.
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O.R. Alara, N.H. Abdurahman, S.K. Abdul Mudalip & O.A. Olalere. (2019) Effect of drying methods on the free radicals scavenging activity of Vernonia amygdalina growing in Malaysia. Journal of King Saud University - Science 31:4, pages 495-499.
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S. Dagnon, Z. Novkova, D. Bojilov, P. Nedialkov & Ch. Kouassi. (2019) Development of surrogate standards approach for the determination of polyphenols in Vernonia amygdalina Del.. Journal of Food Composition and Analysis 82, pages 103231.
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Xiangzhong Liu, Wenjing Tian, Guanghui Wang, Qiannan Xu, Mi Zhou, Shuo Gao, Daren Qiu, Xin Jiang, Cuiling Sun, Rong Ding, Ting Lin & Haifeng Chen. (2019) Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina. Phytochemistry 158, pages 67-76.
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Ketharin Tunasamy, Nagaraja Suryadevara & Thevanayagy Athimoolam. (2019) Screening of Vernonia amygdalina leaf extracts for antioxidant and antimicrobial activity. Materials Today: Proceedings 16, pages 1809-1818.
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O.R. Alara, N.H. Abdurahman, S.K. Abdul Mudalip & O.A. Olalere. (2018) Microwave-assisted extraction of Vernonia amygdalina leaf for optimal recovery of total phenolic content. Journal of Applied Research on Medicinal and Aromatic Plants 10, pages 16-24.
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Ifeoluwa T. Oyeyemi, Akinbiyi A. Akinlabi, Aderiike Adewumi, Abimbola O. Aleshinloye & Oyetunde T. Oyeyemi. (2018) Vernonia amygdalina : A folkloric herb with anthelminthic properties. Beni-Suef University Journal of Basic and Applied Sciences 7:1, pages 43-49.
Crossref
Oluwaseun Ruth Alara, Nour Hamid Abdurahman, Siti Kholijah Abdul Mudalip & Olusegun Abayomi Olalere. (2017) Characterization and effect of extraction solvents on the yield and total phenolic content from Vernonia amygdalina leaves. Journal of Food Measurement and Characterization 12:1, pages 311-316.
Crossref
Nlandu Roger Ngatu. 2018. Occupational and Environmental Skin Disorders. Occupational and Environmental Skin Disorders 93 103 .
Racquel Wright, Ken Lee, Hyacinth Hyacinth, Jacqueline Hibbert, Marvin Reid, Andrew Wheatley & Helen Asemota. (2017) An Investigation of the Antioxidant Capacity in Extracts from Moringa oleifera Plants Grown in Jamaica. Plants 6:4, pages 48.
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Ablajan Turak, Zulipiya Maimaiti, HaiRong Ma & Haji Akber Aisa. (2017) Pseudo-disesquiterpenoids from seeds of Vernonia anthelmintica and their biological activities. Phytochemistry Letters 21, pages 163-168.
Crossref
Solomon M Abay, Leonardo Lucantoni, Nisha Dahiya, Geme Dori, Edson G Dembo, Fulvio Esposito, Guilio Lupidi, Sonny Ogboi, Robert K Ouédraogo, Annamaria Sinisi, Orazio Taglialatela-Scafati, R Serge Yerbanga, Massimo Bramucci, Luana Quassinti, Jean Bosco Ouédraogo, George Christophides & Annette Habluetzel. (2015) Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds. Malaria Journal 14:1.
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Annamaria Sinisi, Estrella Millán, Solomon M. Abay, Annette Habluetzel, Giovanni Appendino, Eduardo Muñoz & Orazio Taglialatela-Scafati. (2015) Poly-Electrophilic Sesquiterpene Lactones from Vernonia amygdalina : New Members and Differences in Their Mechanism of Thiol Trapping and in Bioactivity . Journal of Natural Products 78:7, pages 1618-1623.
Crossref
Ablajan Turak, Yongqiang Liu & Haji Akber Aisa. (2015) Elemanolide dimers from seeds of Vernonia anthelmintica. Fitoterapia 104, pages 23-30.
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Abubakar Babando Aliyu, Brenda Moodley, Hafizah Chenia & Neil A. Koorbanally. (2015) Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria. Phytochemistry 111, pages 163-168.
Crossref
Eirini Kouloura, Job Tchoumtchoua, Maria Halabalaki & Alexios‐Leandros Skaltsounis. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry 1 53 .
Márcia do Rocio Duarte & Ariane Gonçalves Silva. (2013) Anatomical characters of the medicinal leaf and stem of Gymnanthemum amygdalinum (Delile) Sch.Bip. ex Walp. (Asteraceae). Brazilian Journal of Pharmaceutical Sciences 49:4, pages 719-727.
Crossref
M. A. Ibrahim, A. B. Aliyu, H. Abdullahi, T. Solomon, E. Toko, A. Garba, M. Bashir & N. Habila. (2013) Lactone-rich fraction from Vernonia blumeoides: antitrypanosomal activity and alleviation of the parasite-induced anemia and organ damage. Journal of Natural Medicines 67:4, pages 750-757.
Crossref
Ngeh J. Toyang & Rob Verpoorte. (2013) A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). Journal of Ethnopharmacology 146:3, pages 681-723.
Crossref
Maurice D. Awouafack, Pierre Tane, Victor Kuete & Jacobus N. Eloff. 2013. Medicinal Plant Research in Africa. Medicinal Plant Research in Africa 33 103 .
Braulio M. Fraga. (2012) Natural sesquiterpenoids. Natural Product Reports 29:11, pages 1334.
Crossref

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