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Research Article

Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal

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Pages 947-954 | Received 24 Aug 2010, Accepted 24 Jan 2011, Published online: 19 May 2011

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Tareq Abu-Izneid, Abdur Rauf, Anees Ahmed Khalil, Ahmed Olatunde, Ahood Khalid, Fahad A. Alhumaydhi, Abdullah S. M. Aljohani, Md. Sahab Uddin, Mojtaba Heydari, Mars Khayrullin, Mohammad Ali Shariati, Adeyemi Oladapo Aremu, Ahmed Alafnan & Kannan R. R. Rengasamy. (2022) Nutritional and health beneficial properties of saffron (Crocus sativus L): a comprehensive review. Critical Reviews in Food Science and Nutrition 62:10, pages 2683-2706.
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Shirin Amini, Houra Mohseni, Behnaz Abiri & Sima Jafarirad. (2023) The role of saffron ( Crocus sativus L) on testosterone and depression in andropause middle-aged and elderly men: a systematic review . Nutrition & Food Science 53:8, pages 1419-1436.
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Camille Pouchieu, Line Pourtau, Julie Brossaud, David Gaudout, Jean-Benoit Corcuff, Lucile Capuron, Nathalie Castanon & Pierre Philip. (2023) Acute Effect of a Saffron Extract (Safr’InsideTM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study. Nutrients 15:13, pages 2921.
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Morvarid Irani, Adeleh Rahmanian & Narges Soltani. (2023) Efficacy of Saffron (Crocus sativus L.) in Premenstrual Syndrome, Labor, Childbirth, and Menopause: A Systematic Review of Clinical Trials. Modern Care Journal 20:3.
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Renata Matraszek-Gawron, Mirosława Chwil, Karol Terlecki & Michał Marian Skoczylas. (2022) Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.. Pharmaceuticals 16:1, pages 58.
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Vali Musazadeh, Meysam Zarezadeh, Amir Hossein Faghfouri, Majid Keramati, Zohreh Ghoreishi & Alireza Farnam. (2022) Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis. Pharmacological Research 175, pages 105963.
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Camille Monchaux De Oliveira, Véronique De Smedt-Peyrusse, Jennifer Morael, Sylvie Vancassel, Lucile Capuron, David Gaudout, Line Pourtau & Nathalie Castanon. (2021) Prevention of Stress-Induced Depressive-like Behavior by Saffron Extract Is Associated with Modulation of Kynurenine Pathway and Monoamine Neurotransmission. Pharmaceutics 13:12, pages 2155.
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Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Frank Thies, Sophia Tsabouri, Marco Vinceti, Jean‐Louis Bresson & Alfonso Siani. (2021) Affron® and increase in positive mood: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal 19:7.
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Ahmad Fotoohi, Mohammad Raman Moloudi, Saed Hosseini, Kambiz Hassanzadeh, Marco Feligioni & Esmael Izadpanah. (2021) A Novel Pharmacological Protective Role for Safranal in an Animal Model of Huntington’s Disease. Neurochemical Research 46:6, pages 1372-1379.
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Camille Monchaux De Oliveira, Line Pourtau, Sylvie Vancassel, Camille Pouchieu, Lucile Capuron, David Gaudout & Nathalie Castanon. (2021) Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission. Nutrients 13:3, pages 904.
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Philippa A. Jackson, Joanne Forster, Julie Khan, Camille Pouchieu, Séverine Dubreuil, David Gaudout, Benjamin Moras, Line Pourtau, Florent Joffre, Carole Vaysse, Karène Bertrand, Hélène Abrous, David Vauzour, Julie Brossaud, Jean Benoit Corcuff, Lucile Capuron & David O. Kennedy. (2021) Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial. Frontiers in Nutrition 7.
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Mohammad Saeedi & Ali Rashidy-Pour. (2021) Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron. Biomedicine & Pharmacotherapy 133, pages 110995.
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Laura Orio, Francisco Alen, Antonio Ballesta, Raquel Martin & Raquel Gomez de Heras. (2020) Antianhedonic and Antidepressant Effects of Affron®, a Standardized Saffron (Crocus Sativus L.) Extract. Molecules 25:14, pages 3207.
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Tahereh-Sadat Javadifar, Mehdi Amirikia, Nahid Sarahian, Mohammad-Ali Ketabi, Hedayat Sahraei, Mohammad Nasehi & Mohammad-Reza Zarrindast. (2020) SHELL Part of Nucleus Accumbens and Its Laterality Has Important Role in Response to Chronic Stress in Female Rats. Brazilian Archives of Biology and Technology 63.
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Bhupesh Sharma, Hariom Kumar, Prachi Kaushik, Roohi Mirza, Rajendra Awasthi & G.T. Kulkarni. 2020. Saffron. Saffron 117 130 .
Adrian L Lopresti, Stephen J Smith, Sean D Hood & Peter D Drummond. (2019) Efficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled study. Journal of Psychopharmacology 33:11, pages 1415-1427.
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Wolfgang Marx, Melissa Lane, Tetyana Rocks, Anu Ruusunen, Amy Loughman, Adrian Lopresti, Skye Marshall, Michael Berk, Felice Jacka & Olivia M Dean. (2019) Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. Nutrition Reviews 77:8, pages 557-571.
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Hadi Fathimoghadam, Yaghoub Farbod, Ataallah Ghadiri & Rouholah Fatemi. (2019) Moderating effects of crocin on some stress oxidative markers in rat brain following demyelination with ethidium bromide. Heliyon 5:2, pages e01213.
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Bashir Ahmad, Vinoy K. Shrivastava, Ramadan Saleh, Ralf Henkel & Ashok Agarwal. (2018) Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus). Clinical and Experimental Reproductive Medicine 45:4, pages 163-169.
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Sara Asalgoo, Gila Pirzad Jahromi, Boshra Hatef & Hedayat Sahraei. (2018) The Effect of Saffron Aqueous Extract and Crocin on PTSD Rat Models: The Focus on Learning and Spatial Memory. Journal of Advances in Medical and Biomedical Research 26:119, pages 34-42.
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Adrian L. Lopresti, Peter D. Drummond, Antonio M. Inarejos-García & Marin Prodanov. (2018) affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders 232, pages 349-357.
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Mojtaba Shafiee, Soheil Arekhi, Alireza Omranzadeh & Amirhossein Sahebkar. (2018) Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. Journal of Affective Disorders 227, pages 330-337.
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Sara Asalgoo, Mahdi Tat, Hedayat Sahraei & Gila Pirzad Jahromi. (2017) The Psychoactive Agent Crocin Can Regulate Hypothalamic-Pituitary-Adrenal Axis Activity. Frontiers in Neuroscience 11.
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Jamshid Tabeshpour, Farzaneh Sobhani, Seyed Alireza Sadjadi, Hossein Hosseinzadeh, Seyed Ahmad Mohajeri, Omid Rajabi, Zhila Taherzadeh & Saeid Eslami. (2017) A double-blind, randomized, placebo-controlled trial of saffron stigma ( Crocus sativus L . ) in mothers suffering from mild-to-moderate postpartum depression. Phytomedicine 36, pages 145-152.
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Oussama Ahrazem, Angela Rubio-Moraga, Sergio G. Nebauer, Rosa Victoria Molina & Lourdes Gómez-Gómez. (2015) Saffron: Its Phytochemistry, Developmental Processes, and Biotechnological Prospects. Journal of Agricultural and Food Chemistry 63:40, pages 8751-8764.
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Adrian L. Lopresti & Peter D. Drummond. (2014) Saffron ( Crocus sativus ) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action . Human Psychopharmacology: Clinical and Experimental 29:6, pages 517-527.
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T. K. LimT. K. Lim. 2014. Edible Medicinal and Non Medicinal Plants. Edible Medicinal and Non Medicinal Plants 77 136 .
Denys J. CharlesDenys J. Charles. 2013. Antioxidant Properties of Spices, Herbs and Other Sources. Antioxidant Properties of Spices, Herbs and Other Sources 509 520 .
Sara Asalgoo, Gila Pirzad Jahromi, Boshra Hatef & Hedayat Sahraei. (2018) The Effect of Saffron Aqueous Extract and Crocin on PTSD Rat Models: The Focus on Learning and Spatial Memory. SSRN Electronic Journal.
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