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Research Article

Silymarin selectively protects human renal cells from cisplatin-induced cell death

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Pages 1082-1090 | Received 19 Nov 2010, Accepted 01 Mar 2011, Published online: 18 May 2011

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Masoumeh Asgharpour & Amirhesam Alirezaei. (2021) Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications. Renal Failure 43:1, pages 351-361.
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Sahar Fanoudi, Mohaddeseh Sadat Alavi, Gholamreza Karimi & Hossein Hosseinzadeh. (2020) Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug and Chemical Toxicology 43:3, pages 240-254.
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Durrin Ozlem Dabak & Nevin Kocaman. (2015) Effects of silymarin on methotrexate-induced nephrotoxicity in rats. Renal Failure 37:4, pages 734-739.
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Articles from other publishers (17)

Ricardo Aparecido Baptista Nucci, Victor Abou Nehmi-Filho, Marta Ferreira Bastos, Jéssica Alves de Freitas, José Pinhata Otoch, Ana Flávia Marçal Pessoa & Wilson Jacob-Filho. (2023) Modulation of Small-Intestine Morphology in Mice by a Novel Supplement Containing Silybum marianum, Yeast β-Glucan, Prebiotics, and Minerals. Journal of Health and Allied Sciences NU.
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Yin Wang, Ai-Jun Yuan, Yue-Jin Wu, Li-Mei Wu & Ling Zhang. (2023) Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations. Journal of Functional Foods 100, pages 105384.
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Mahsa Ghodousi, Hedyieh Karbasforooshan, Leila Arabi & Sepideh Elyasi. (2022) Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. European Journal of Clinical Pharmacology 79:1, pages 15-38.
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Pía Loren, Yuliannis Lugones, Nicolás Saavedra, Kathleen Saavedra, Isis Páez, Nelia Rodriguez, Patricia Moriel & Luis A. Salazar. (2022) MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis. Biomolecules 12:9, pages 1206.
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Chun-yan Fang, Da-yong Lou, Li-qin Zhou, Jin-cheng Wang, Bo Yang, Qiao-jun He, Jia-jia Wang & Qin-jie Weng. (2021) Natural products: potential treatments for cisplatin-induced nephrotoxicity. Acta Pharmacologica Sinica 42:12, pages 1951-1969.
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Mohammad Mehdi Ommati, Omid Farshad, Negar Azarpira, Elmira Ghazanfari, Hossein Niknahad & Reza Heidari. (2021) Silymarin mitigates bile duct obstruction-induced cholemic nephropathy. Naunyn-Schmiedeberg's Archives of Pharmacology 394:6, pages 1301-1314.
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Xin Wang, Zhen Zhang & Shuai-Cheng Wu. (2020) Health Benefits of Silybum marianum : Phytochemistry, Pharmacology, and Applications . Journal of Agricultural and Food Chemistry 68:42, pages 11644-11664.
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Verônica de Souza Santos, Beatriz Peters, Larissa Zambom Côco, Gisele Maziero Alves, Arícia Leone Evangelista Monteiro de Assis, Breno Valentim Nogueira, Silvana Santos Meyrelles, Marcella Leite Porto, Elisardo Corral Vasquez, Bianca Prandi Campagnaro & Thiago Melo Costa Pereira. (2019) Silymarin protects against radiocontrast-induced nephropathy in mice. Life Sciences 228, pages 305-315.
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Vassilios Liakopoulos, Stefanos Roumeliotis, Andreas Bozikas, Theodoros Eleftheriadis & Evangelia Dounousi. (2019) Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?. Oxidative Medicine and Cellular Longevity 2019, pages 1-23.
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Rosanne Pruitt, Ashley Lemanski & Adam Carroll. (2018) Herbal supplements. The Nurse Practitioner 43:5, pages 32-37.
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Nizar TliliAnouar FerianiMohamed Salah AllaguiEzzeddine SaadouiAbdelhamid KhaldiNizar Nasri. (2016) Effects of Rhus tripartitum fruit extract on CCl 4 -induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats . Canadian Journal of Physiology and Pharmacology 94:8, pages 801-807.
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Xiao Pan, Liping Jiang, Laifu Zhong, Chengyan Geng, Li Jia, Shuang Liu, Huai Guan, Guang Yang, Xiaofeng Yao, Fengyuan Piao & Xiance Sun. (2016) Arsenic induces apoptosis by the lysosomal-mitochondrial pathway in INS-1 cells. Environmental Toxicology 31:2, pages 133-141.
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Hadi Darvishi Khezri, Ebrahim Salehifar, Mehrnoush Kosaryan, Aily Aliasgharian, Hossein Jalali & Arash Hadian Amree. (2016) Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β -Thalassemia Major: A Comprehensive Review in 2015 . Advances in Pharmacological Sciences 2016, pages 1-8.
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Peter Surai. (2015) Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 4:1, pages 204-247.
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Seema PatelSeema Patel. 2015. Emerging Bioresources with Nutraceutical and Pharmaceutical Prospects. Emerging Bioresources with Nutraceutical and Pharmaceutical Prospects 101 114 .
Robert Domitrović, Iva Potočnjak, Željka Crnčević-Orlić & Marko Škoda. (2014) Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice. Food and Chemical Toxicology 66, pages 321-328.
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So-Jung Sohn, Sun Young Kim, Hyung Sik Kim, Young-Jin Chun, Soon Young Han, Seung Hee Kim & Aree Moon. (2013) In vitro evaluation of biomarkers for cisplatin-induced nephrotoxicity using HK-2 human kidney epithelial cells. Toxicology Letters 217:3, pages 235-242.
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