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Pharmaceutical Biology Volume 52, 2014 - Issue 4
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Research Article

Long-term systemic toxicity of shikonin derivatives in Wistar rats

Long SuDepartment of Hematology and Oncology
,
LiHua LiuDepartment of Laboratory Medicine, The First Hospital, Jilin University ChangchunChinaCorrespondence[email protected]
,
YingLi WangProvincial Cancer Institute, Jilin Provincial Hospital for Cancer ChangchunChina
,
GuangZhi YanProvincial Cancer Institute, Jilin Provincial Hospital for Cancer ChangchunChina
&
Yang ZhangProvincial Cancer Institute, Jilin Provincial Hospital for Cancer ChangchunChina
Pages 486-490 | Received 12 May 2013, Accepted 28 Aug 2013, Published online: 05 Nov 2013

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Yuzhen Zhu, Yu Zhong, Xun Long, Zhu Zhu, Yu Zhou, Hua Ye, Xiaobin Zeng & Xuebao Zheng. (2019) Deoxyshikonin isolated from Arnebia euchroma inhibits colorectal cancer by down-regulating the PI3K/Akt/mTOR pathway. Pharmaceutical Biology 57:1, pages 412-423.
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Articles from other publishers (16)

Olagoke Zacchaeus Olatunde, Jianping Yong, Canzhong Lu & Yanlin Ming. (2024) A Review on Shikonin and its Derivatives as Potent Anticancer Agents Targeted against Topoisomerases. Current Medicinal Chemistry 31:8, pages 920-937.
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Oleg Shuvalov, Yulia Kirdeeva, Alexandra Daks, Olga Fedorova, Sergey Parfenyev, Hans-Uwe Simon & Nickolai A. Barlev. (2023) Phytochemicals Target Multiple Metabolic Pathways in Cancer. Antioxidants 12:11, pages 2012.
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Han Dong, Chun-Di Chang, Fei Gao, Na Zhang, Xing-Jian Yan, Xue Wu & Yue-Hui Wang. (2023) The anti-leukemia activity and mechanisms of shikonin: a mini review. Frontiers in Pharmacology 14.
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Mohd Rihan & Shyam Sunder Sharma. (2023) Inhibition of Pyruvate kinase M2 (PKM2) by shikonin attenuates isoproterenol-induced acute myocardial infarction via reduction in inflammation, hypoxia, apoptosis, and fibrosis. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Mark D. Minden, Julie A. Reisz, Angelo D'Alessandro, Jakub Rohlena & Paul A. Spagnuolo. (2022) Shikonin impairs mitochondrial activity to selectively target leukemia cells. Phytomedicine Plus 2:3, pages 100300.
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Hongkang Zhu, Chang Liu & He Qian. (2022) Pharmaceutical Potential of High-Altitude Plants for Fatigue-Related Disorders: A Review. Plants 11:15, pages 2004.
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Snehlata Yadav, Ajay Sharma, Gulzar Ahmad Nayik, Raymond Cooper, Garima Bhardwaj, Harvinder Singh Sohal, Vishal Mutreja, Ramandeep Kaur, Franklin Ore Areche, Mohannad AlOudat, Ayaz Mukarram Shaikh, Béla Kovács & Abdelhakam Esmaeil Mohamed Ahmed. (2022) Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology. Frontiers in Pharmacology 13.
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Hadi Almasi, Samira Forghani & Mehran Moradi. (2022) Recent advances on intelligent food freshness indicators; an update on natural colorants and methods of preparation. Food Packaging and Shelf Life 32, pages 100839.
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Md. Rezaul Islam, Fahadul Islam, Mohamed H. Nafady, Muniya Akter, Saikat Mitra, Rajib Das, Humaira Urmee, Sheikh Shohag, Aklima Akter, Kumarappan Chidambaram, Fahad A. Alhumaydhi, Talha Bin Emran & Simona Cavalu. (2022) Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint. Molecules 27:7, pages 2165.
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Yangli Wan, Xiaowen Wang, Pengfei Zhang, Meng Zhang, Mingying Kou, Chao Shi, Xiaoli Peng & Xin Wang. (2021) Control of Foodborne Staphylococcus aureus by Shikonin, a Natural Extract. Foods 10:12, pages 2954.
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Orawin Prangsaengtong, Phatcharida Jantaree, Kriengsak Lirdprapamongkol, Jisnuson Svasti & Keiichi Koizumi. (2018) Shikonin Suppresses Lymphangiogenesis <i>via</i> NF-κB/HIF-1α Axis Inhibition. Biological and Pharmaceutical Bulletin 41:11, pages 1659-1666.
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Qisen Li, Jiacheng Zeng, Meiling Su, Yu He & Banghao Zhu. (2018) Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. Brain Research Bulletin 137, pages 311-318.
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Sarmistha Mitra & Raju Dash. (2018) Natural Products for the Management and Prevention of Breast Cancer. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-23.
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Po-Lin Liao, Cheng-Hui Lin, Ching-Hao Li, Chi-Hao Tsai, Jau-Der Ho, George C. Y. Chiou, Jaw-Jou Kang & Yu-Wen Cheng. (2017) Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy. Scientific Reports 7:1.
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M. Mehta, O. A. Branford & K. J. Rolfe. (2016) The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring. Burns & Trauma 4.
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. (2015) Scientific Opinion on the safety of refined Buglossoides oil as a novel food ingredient. EFSA Journal 13:2.
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