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Pharmaceutical Biology Volume 52, 2014 - Issue 10
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Research Article

Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice

Kamal Razavi-AzarkhiaviDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences MashhadIran
,
Mehdi Ali-OmraniDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran
,
Reza SolgiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran
,
Pezhman BagheriDepartment of Epidemiology, School of Medical Sciences, Jiroft University of Medical Sciences JiroftIran
,
Mehdi Haji-NoormohammadiDepartment of Microbiology, Pharmaceutical Sciences Branch, Islamic Azad University TehranIran
,
Nahid AmaniDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran
&
Mohammad-Reza SepandDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIranCorrespondence[email protected]
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Pages 1267-1271 | Received 28 Oct 2013, Accepted 14 Jan 2014, Published online: 15 Jul 2014

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Sanaz Gharighnia, Ameneh Omidi, Iraj Ragerdi Kashani, Mohammad Reza Sepand & Shahram Pour Beiranvand. (2022) Ameliorative effects of acetyl-L-carnitine on corpus callosum and functional recovery in demyelinated mouse model. International Journal of Neuroscience 0:0, pages 1-11.
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Saeed Mehrzadi, Pooyan Hosseini, Mehrnaz Mehrabani, Amir Siahpoosh, Mehdi Goudarzi, Hamidreza Khalili & Alireza Malayeri. (2021) Attenuation of Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats by Combination Treatment of Two Natural Phenolic Compounds: Quercetin and Gallic Acid. Nutrition and Cancer 73:10, pages 2039-2049.
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Adem Kose, Hakan Parlakpinar, Onural Ozhan, Necip Ermis, Azibe Yildiz, Nigar Vardi & Yilmaz Cigremis. (2020) Therapeutic effects of dexpanthenol on the cardiovascular and respiratory systems following cecal ligation and puncture-induced sepsis in rats. Biotechnic & Histochemistry 95:6, pages 428-437.
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Amani Sakineh, Mohammad Foad Noorbakhsh, Nasrollah Ahmadi, Nazifi Saeed & Barzan Behdokht. (2023) Evaluation of the Protective Effect of Citral, Silymarin, and Thymoquinone on Methotrexate-Induced Lung Injury in Rats. Journal of Pharmacopuncture 26:2, pages 184-191.
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Mahsa Ghodousi, Hedyieh Karbasforooshan, Leila Arabi & Sepideh Elyasi. (2022) Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. European Journal of Clinical Pharmacology 79:1, pages 15-38.
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Sai Sushma Dudala, T. C. Venkateswarulu, Sushma Chandulee Kancharla, Vidya Prabhakar Kodali & D. John Babu. (2021) A review on importance of bioactive compounds of medicinal plants in treating idiopathic pulmonary fibrosis (special emphasis on isoquinoline alkaloids). Future Journal of Pharmaceutical Sciences 7:1.
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Heba H. Mansour, Mervat M. Omran, Hesham F. Hasan & Shereen M. El kiki. (2020) Modulation of bleomycin‐induced oxidative stress and pulmonary fibrosis by N‐acetylcysteine in rats via AMPK/SIRT1/NF‐κβ. Clinical and Experimental Pharmacology and Physiology 47:12, pages 1943-1952.
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Masoumeh Aghashahi, Hamid Reza Momeni & Niloufar Darbandi. (2020) Impact of aluminium toxicity on vital human sperm parameters—Protective effects of silymarin. Andrologia 52:10.
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Xin Wang, Zhen Zhang & Shuai-Cheng Wu. (2020) Health Benefits of Silybum marianum : Phytochemistry, Pharmacology, and Applications . Journal of Agricultural and Food Chemistry 68:42, pages 11644-11664.
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Ayman Al-Hazmi. (2020) Antioxidant Activity of Silymarin in Microcystin-LR Cardiac and Pulmonary Induced Injuries on Mice. Pakistan Journal of Biological Sciences 23:11, pages 1369-1373.
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Emin KARAKURT & Serpil DAĞ. (2020) Hepatoprotective Effect Of Silymarin Against Diethylnitrosamine Induced Oxidative-Nitrosative Stress in RatsRatlarda Dietilnitrozamin Uygulanarak Oluşturulan Oksidatif ve Nitrozatif Strese Karşı Silimarin’in Karaciğer Koruyucu Etkisi. Van Veterinary Journal 31:2, pages 105-110.
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David G. Litvin, Scott J. Denstaedt, Lauren F. Borkowski, Nicole L. Nichols, Thomas E. Dick, Corey B. Smith & Frank J. Jacono. (2020) Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats. Brain, Behavior, and Immunity 87, pages 610-633.
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Meng-Yue Tian, Jing-Hui Fan, Zhi-Wei Zhuang, Fei Dai, Cheng-Yu Wang, Hai-Ting Hou & Yu-Zhong Ma. (2019) Effects of silymarin on p65 NF-κB, p38 MAPK and CYP450 in LPS-induced hoof dermal inflammatory cells of dairy cows. BMC Veterinary Research 15:1.
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Reihaneh Ebrahimi, Mohammad Reza Sepand, Seyed Afshin Seyednejad, Ameneh Omidi, Mostafa Akbariani, Maryam Gholami & Omid Sabzevari. (2019) Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats. DARU Journal of Pharmaceutical Sciences 27:2, pages 721-733.
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Ayed Allawzi, Hanan Elajaili, Elizabeth F. Redente & Eva Nozik-Grayck. (2019) Oxidative toxicology of bleomycin: Role of the extracellular redox environment. Current Opinion in Toxicology 13, pages 68-73.
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Sarasadat Hosseini, Mohsen Imenshahidi, Hossein Hosseinzadeh & Gholamreza Karimi. (2018) Effects of plant extracts and bioactive compounds on attenuation of bleomycin-induced pulmonary fibrosis. Biomedicine & Pharmacotherapy 107, pages 1454-1465.
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Mustafa CENGİZ. (2018) The Protective Effects of Silymarin on D-Galactosamine/Tumor Necrosis FactorAlpha-Induced Oxidative Stress and Lung Injury in Mice. Adıyaman University Journal of Science 8:1, pages 42-52.
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David G. Litvin, Thomas E. Dick, Corey B. Smith & Frank J. Jacono. (2018) Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats. Brain, Behavior, and Immunity 70, pages 398-422.
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Vida Bodaghi-Namileh, Mohammad Reza Sepand, Ameneh Omidi, Mehdi Aghsami, Seyed Afshin Seyednejad, Sara Kasirzadeh & Omid Sabzevari. (2018) Acetyl- l -carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats. Environmental Toxicology and Pharmacology 58, pages 11-20.
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Ehab Tousson, Mohamed F. Bayomy & Alaa A. Ahmed. (2018) Rosemary extract modulates fertility potential, DNA fragmentation, injury, KI67 and P53 alterations induced by etoposide in rat testes. Biomedicine & Pharmacotherapy 98, pages 769-774.
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Yi-Hsuan Tsai, Yu-Ning Yang, Yi-Cheng Ho, Min-Lang Tsai & Fwu-Long Mi. (2018) Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films. Carbohydrate Polymers 180, pages 286-296.
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Mehdi Aliomrani, Mohammad Reza Sepand, Hamid Reza Mirzaei, Ali Reza kazemi, Saeid Nekonam & Omid Sabzevari. (2016) Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis. DARU Journal of Pharmaceutical Sciences 24:1.
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Mohammad Reza Sepand, Mohammad Hossein Ghahremani, Kamal Razavi-Azarkhiavi, Mehdi Aghsami, Jalil Rajabi, Hedieh Keshavarz-Bahaghighat & Maliheh Soodi. (2016) Ellagic acid confers protection against gentamicin-induced oxidative damage, mitochondrial dysfunction and apoptosis-related nephrotoxicity. Journal of Pharmacy and Pharmacology 68:9, pages 1222-1232.
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Mohammad Reza Sepand, Kamal Razavi-Azarkhiavi, Ameneh Omidi, Mohammad Reza Zirak, Samin Sabzevari, Ali Reza Kazemi & Omid Sabzevari. (2015) Effect of Acetyl-l-Carnitine on Antioxidant Status, Lipid Peroxidation, and Oxidative Damage of Arsenic in Rat. Biological Trace Element Research 171:1, pages 107-115.
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Feng Zhao, Danyang Shi, Tiegang Li, Lizhuo Li & Min Zhao. (2015) Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro . Clinical and Experimental Pharmacology and Physiology 42:9, pages 988-998.
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Peter Surai. (2015) Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 4:1, pages 204-247.
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