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Original Article

Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson’s disease

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Pages 1516-1524 | Received 26 Jul 2014, Accepted 21 Nov 2014, Published online: 10 Apr 2015

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Ruolin Li, Yongquan Lu, Qidi Zhang, Weijin Liu, Runing Yang, Jie Jiao, Jia Liu, Ge Gao & Hui Yang. (2022) Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model. Autophagy 18:3, pages 559-575.
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Tianjing Ren & Zhong Zuo. (2019) Role of piperine in CNS diseases: pharmacodynamics, pharmacokinetics and drug interactions. Expert Opinion on Drug Metabolism & Toxicology 15:10, pages 849-867.
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Jia Liu, Weijin Liu, Yongquan Lu, Hao Tian, Chunli Duan, Lingling Lu, Ge Gao, Xia Wu, Xiaomin Wang & Hui Yang. (2018) Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy 14:5, pages 845-861.
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Xiaolu Hu, Lan Yu, Yatong Li, Xiaoxi Li, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Qijun Chen, Xing Wang, Xiaoqing Chen, Yinying Ba, Yaonan Wang & Xia Wu. (2023) Piperine improves levodopa availability in the 6‐OHDA ‐lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase . CNS Neuroscience & Therapeutics.
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Kumud Kaul & Pravir Kumar. (2023) Fate of Jeratinine E as a potential compound to target NNMT protein in countering Parkinson’s disease. Fate of Jeratinine E as a potential compound to target NNMT protein in countering Parkinson’s disease.
Protha Biswas, Mimosa Ghorai, Tulika Mishra, Abilash Valsala Gopalakrishnan, Debleena Roy, Abhijit Bhagwan Mane, Avinash Mundhra, Neela Das, Vikas Moreshwar Mohture, Manoj Tukaram Patil, Md. Habibur Rahman, Niraj Kumar Jha, Gaber El‐Saber Batiha, Suchismita Chatterjee Saha, Mahipal S Shekhawat, Radha, Manoj Kumar, Devendra Kumar Pandey & Abhijit Dey. (2022) Piper longum L.: A comprehensive review on traditional uses, phytochemistry, pharmacology, and health‐promoting activities . Phytotherapy Research 36:12, pages 4425-4476.
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Ankumoni Dutta, Banashree Chetia Phukan, Rubina Roy, Muhammed Khairujjaman Mazumder, Rajib Paul, Amarendranath Choudhury, Diwakar Kumar, Pallab Bhattacharya, Joyobrato Nath, Sanjeev Kumar & Anupom Borah. (2022) Garcinia morella extract confers dopaminergic neuroprotection by mitigating mitochondrial dysfunctions and inflammation in mouse model of Parkinson’s disease. Metabolic Brain Disease 37:6, pages 1887-1900.
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Milad Iranshahy, Behjat Javadi & Amirhossein Sahebkar. (2022) Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms. Phytotherapy Research 36:5, pages 1952-1989.
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Pulok K Mukherjee, Thomas Efferth, Bhaskar Das, Amit Kar, Suparna Ghosh, Seha Singha, Pradip Debnath, Nanaocha Sharma, Pardeep Kumar Bhardwaj & Pallab Kanti Haldar. (2022) Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications. Phytomedicine 98, pages 153930.
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Xiaoli Li, Lei Wu, Ruixia Wu, Ming Sun, Ke Fu, Tingting Kuang & Zhang Wang. (2022) Comparison of medicinal preparations of Ayurveda in India and five traditional medicines in China. Journal of Ethnopharmacology 284, pages 114775.
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Lan Yu, Xiaolu Hu, Rongrong Xu, Yinying Ba, Xiaoqing Chen, Xing Wang, Bing Cao & Xia Wu. (2022) Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: A comparative study with fruits, pericarp, stalks and leaves. Food Chemistry 368, pages 130832.
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Reza Nasrnezhad, Sohrab Halalkhor, Farzin Sadeghi & Fereshteh Pourabdolhossein. (2021) Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects. Molecular Neurobiology 58:11, pages 5473-5493.
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Christian Rafael Quijia, Victor Hugo Araujo & Marlus Chorilli. (2021) Piperine: Chemical, biological and nanotechnological applications. Acta Pharmaceutica 71:2, pages 185-213.
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Ai-Ling Sun, Wen-Wen Mu, Yan-Mo Li, Ya-Lei Sun, Peng-Xiao Li, Ren-Min Liu, Jie Yang & Guo-Yun Liu. (2021) Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation. Molecules 26:11, pages 3243.
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Apoorva M. Kulkarni, Shailima Rampogu & Keun Woo Lee. (2021) Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson’s Disease Associated Protein, Prolyl Oligopeptidase. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-10.
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Sylvester I. Omoruyi, Joshua Delport, Tusekile S. Kangwa, Abobaker S. Ibrakaw, Christopher N. Cupido, Okobi E. Ekpo & Ahmed A. Hussein. (2021) In vitro neuroprotective potential of Clivia miniata and Nerine humilis (Amaryllidaceae) in MPP+-induced neuronal toxicity in SH-SY5Y neuroblastoma cells. South African Journal of Botany 136, pages 110-117.
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Bahareh Sadat Yousefsani, George E. Barreto & Amirhossein Sahebkar. 2021. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health 283 290 .
Md. Josim Uddin & Christian Zidorn. (2020) Traditional Herbal Medicines Against CNS Disorders from Bangladesh. Natural Products and Bioprospecting 10:6, pages 377-410.
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Amir Hossein Jamshidi, Fatemeh Eghbalian, Somaye Mahroozade, Hoorieh Mohammadi kenari, Ali Ghobadi & Bahare Sadat Yousefsani. (2020) Recommended natural products in Alzheimer's disease based on traditional Persian medicine. Journal of Medicinal Plants 19:75, pages 17-29.
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Hannaneh Roshanbakhsh, Mahmoud Elahdadi Salmani, Samaneh Dehghan, Atena Nazari, Mohammad Javan & Fereshteh Pourabdolhossein. (2020) Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination. Life Sciences 253, pages 117671.
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Jia Li, Xinchang Qi, Yajuan Sun, Yingyu Zhang & Jiajun Chen. (2020) Network Pharmacology Analysis on Zhichan Powder in the Treatment of Parkinson's Disease. Combinatorial Chemistry & High Throughput Screening 23:1, pages 28-40.
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Vaishali Yadav, Anuja Krishnan & Divya Vohora. (2020) A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. Journal of Ethnopharmacology 247, pages 112255.
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Daniel Chavarria, Carlos Fernandes, Vera Silva, Catia Silva, Eva Gil-Martins, Pedro Soares, Tiago Silva, Renata Silva, Fernando Remião, Paulo J. Oliveira & Fernanda Borges. (2020) Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies. European Journal of Medicinal Chemistry 185, pages 111770.
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Rongrong Xu, Wenwen Zhao, Lan Yu, Qijun Chen, Xiaolu Hu, Yinying Ba, Xiaoqing Chen, Xing Wang & Xia Wu. (2019) A selective and sensitive UFLC-MS/MS method for the simultaneous determination of five alkaloids from Piper longum L. and its application in the pharmacokinetic study of 6-OHDA-induced Parkinson's disease rats . RSC Advances 9:63, pages 37082-37091.
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Rongrong Xu, Xiaoqing Chen, Xing Wang, Lan Yu, Wenwen Zhao, Yinying Ba & Xia Wu. (2019) Development and validation of an ultra-high performance supercritical fluid chromatography-photodiode array detection-mass spectrometry method for the simultaneous determination of 12 compounds in Piper longum L.. Food Chemistry 298, pages 125067.
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Arun Kumar Verma, Eshan Khan, Subodh Kumar Mishra, Neha Jain & Amit Kumar. (2019) Piperine Modulates Protein Mediated Toxicity in Fragile X-Associated Tremor/Ataxia Syndrome through Interacting Expanded CGG Repeat (r(CGG) exp ) RNA . ACS Chemical Neuroscience 10:8, pages 3778-3788.
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Neha Choudhary & Vikram Singh. (2018) A census of P. longum’s phytochemicals and their network pharmacological evaluation for identifying novel drug-like molecules against various diseases, with a special focus on neurological disorders. PLOS ONE 13:1, pages e0191006.
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Shin-Young Park, Govindarajan Karthivashan, Hyun Myung Ko, Duk-Yeon Cho, Joonsoo Kim, Dae Jun Cho, Palanivel Ganesan, In Su-Kim & Dong-Kug Choi. (2018) Aqueous Extract of Dendropanax morbiferus Leaves Effectively Alleviated Neuroinflammation and Behavioral Impediments in MPTP-Induced Parkinson’s Mouse Model . Oxidative Medicine and Cellular Longevity 2018, pages 1-14.
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Abhijit Dey & Anuradha Mukherjee. 2018. Discovery and Development of Neuroprotective Agents from Natural Products. Discovery and Development of Neuroprotective Agents from Natural Products 237 320 .
Abdelrahman Ibrahim Abushouk, Ahmed Negida, Hussien Ahmed & Mohamed M. Abdel-Daim. (2017) Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: Future applications in Parkinson’s disease. Biomedicine & Pharmacotherapy 85, pages 635-645.
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Huan He, Wei-Wei Guo, Rong-Rong Xu, Xiao-Qing Chen, Nan Zhang, Xia Wu & Xiao-Min Wang. (2016) Alkaloids from piper longum protect dopaminergic neurons against inflammation-mediated damage induced by intranigral injection of lipopolysaccharide. BMC Complementary and Alternative Medicine 16:1.
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Jia Liu, Min Chen, Xue Wang, Yi Wang, Chunli Duan, Ge Gao, Lingling Lu, Xia Wu, Xiaomin Wang & Hui Yang. (2016) Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model. Oncotarget 7:38, pages 60823-60843.
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Chenrui Li, Qian Wang, Tianjing Ren, Yufeng Zhang, Christopher Wai Kei Lam, Moses S.S. Chow & Zhong Zuo. (2016) Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. Journal of Pharmaceutical and Biomedical Analysis 128, pages 286-293.
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