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Review Article

What about strontium ranelate in osteoarthritis? Doubts and securities

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Pages 881-884 | Received 02 Dec 2013, Accepted 24 Jan 2014, Published online: 19 Mar 2014

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Read on this site (3)

Peihua Cao, Yamin Li, Yujin Tang, Changhai Ding & David J. Hunter. (2020) Pharmacotherapy for knee osteoarthritis: current and emerging therapies. Expert Opinion on Pharmacotherapy 21:7, pages 797-809.
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Zhaohua Zhu, Jia Li, Guangfeng Ruan, Guoliang Wang, Cibo Huang & Changhai Ding. (2018) Investigational drugs for the treatment of osteoarthritis, an update on recent developments. Expert Opinion on Investigational Drugs 27:11, pages 881-900.
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Weiyu Han, Shicai Fan, Xiaochun Bai & Changhai Ding. (2017) Strontium ranelate, a promising disease modifying osteoarthritis drug. Expert Opinion on Investigational Drugs 26:3, pages 375-380.
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Articles from other publishers (20)

Luca M. Sihn, Erick L. Bastos, Marcelo Nakamura, Mayara K. Uchiyama & Henrique E. Toma. (2023) Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye. Colorants 2:3, pages 578-590.
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Elisa Boanini, Stefania Pagani, Matilde Tschon, Katia Rubini, Milena Fini & Adriana Bigi. (2022) Monetite vs. Brushite: Different Influences on Bone Cell Response Modulated by Strontium Functionalization. Journal of Functional Biomaterials 13:2, pages 65.
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Hao Yu, Yan Liu, Xiangwen Yang, Jiajing He, Qun Zhong & Xiaojing Guo. (2022) The anti‑inflammation effect of strontium ranelate on rat chondrocytes with or without IL‑1β in vitro . Experimental and Therapeutic Medicine 23:3.
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Hao Yu, Yan Liu, Xiangwen Yang, Jiajing He, Fan Zhang, Qun Zhong & Xiaojing Guo. (2021) Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway. Stem Cell Research & Therapy 12:1.
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Elisa Boanini, Massimo Gazzano, Katia Rubini, Paolo P. Mazzeo & Adriana Bigi. (2021) Structural interplay between strontium and calcium in α-CaHPO4 and β-SrHPO4. Ceramics International 47:17, pages 24412-24420.
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Xiexing Wu, Ziniu Tang, Kang Wu, Yanjie Bai, Xiao Lin, Huilin Yang, Qiang Yang, Zheng Wang, Xinye Ni, Huiling Liu & Lei Yang. (2021) Strontium–calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration. Journal of Materials Chemistry B 9:30, pages 5982-5997.
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Nafiseh Baheiraei, Hossein Eyni, Bita Bakhshi, Raziyeh Najafloo & Navid Rabiee. (2021) Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration. Scientific Reports 11:1.
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Zhe Wang, Xinyuan Wang, Jia Pei, Yuan Tian, Jian Zhang, Chang Jiang, Junming Huang, Zhiying Pang, Yuanwu Cao, Xiuhui Wang, Senbo An, Xiao Wang, Hua Huang, Guangyin Yuan & Zuoqin Yan. (2020) Degradation and osteogenic induction of a SrHPO4-coated Mg–Nd–Zn–Zr alloy intramedullary nail in a rat femoral shaft fracture model. Biomaterials 247, pages 119962.
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Caicai Ge, Fangping Chen, Lijie Mao, Qing Liang, Yan Su & Changsheng Liu. (2020) Strontium ranelate-loaded POFC/β-TCP porous scaffolds for osteoporotic bone repair. RSC Advances 10:15, pages 9016-9025.
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Peilin Hu, Jie Du, Shuai Zhang, Ting Wang, Jun Li, Gang Chen & Guangqian Zhou. (2019) Oral Administration of Strontium Gluconate Effectively Reduces Articular Cartilage Degeneration Through Enhanced Anabolic Activity of Chondrocytes and Chondrogenetic Differentiation of Mesenchymal Stromal Cells. Biological Trace Element Research 193:2, pages 422-433.
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Yi Pei, Ke Zheng, GuanNing Shang, YuMing Wang, Wei Wang, EnDuo Qiu, ShenLong Li & XiaoJing Zhang. (2018) Therapeutic Effect of Strontium Ranelate on Bone in Chemotherapy-Induced Osteopenic Rats via Increased Bone Volume and Reduced Bone Loss. Biological Trace Element Research 187:2, pages 472-481.
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Thiago A. Rodrigues, Abner de Oliveira Freire, Heetor C. O. Carvalho, Gyl E. B. Silva, José W. Vasconcelos, Rosane N. M. Guerra, Maria do Socorro de Sousa Cartágenes & João B. S. Garcia. (2018) Prophylactic and Therapeutic Use of Strontium Ranelate Reduces the Progression of Experimental Osteoarthritis. Frontiers in Pharmacology 9.
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Fujian Zhao, Bo Lei, Xian Li, Yunfei Mo, Renxian Wang, Dafu Chen & Xiaofeng Chen. (2018) Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes. Biomaterials 178, pages 36-47.
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Alamuddin Bakhit, Nobuyuki Kawashima, Kentaro Hashimoto, Sonoko Noda, Keisuke Nara, Masashi Kuramoto, Kento Tazawa & Takashi Okiji. (2018) Strontium ranelate promotes odonto-/osteogenic differentiation/mineralization of dental papillae cells in vitro and mineralized tissue formation of the dental pulp in vivo. Scientific Reports 8:1.
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T.A. Rodrigues, A.O. Freire, B.F. Bonfim, M.S.S. Cartágenes & J.B.S. Garcia. (2018) Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review. Brazilian Journal of Medical and Biological Research 51:8.
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Kathleen O'Connell, Caitlin Pierlot, Helen O'Shea, Diane Beaudry, Madeleine Chagnon, Michel Assad & Daniel Boyd. (2017) Host responses to a strontium releasing high boron glass using a rabbit bilateral femoral defect model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 105:7, pages 1818-1827.
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M. Pilmane, K. Salma-Ancane, D. Loca, J. Locs & L. Berzina-Cimdina. (2017) Strontium and strontium ranelate: Historical review of some of their functions. Materials Science and Engineering: C 78, pages 1222-1230.
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William Querido, Andre L. Rossi & Marcos Farina. (2016) The effects of strontium on bone mineral: A review on current knowledge and microanalytical approaches. Micron 80, pages 122-134.
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Blaine A. Christiansen, Simrit Bhatti, Ramin Goudarzi & Shahin Emami. (2014) Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. CARTILAGE 6:1, pages 30-44.
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Lynne J Hocking & Fernando Rivadeneira. (2014) Stratified medicine approaches for the treatment of musculoskeletal disorders. Current Opinion in Pharmacology 16, pages 127-132.
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