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Original Article

Efficacy of the clinical use of iguratimod therapy in patients with rheumatoid arthritis

, , , &
Pages 235-240 | Received 22 Apr 2014, Accepted 19 Jun 2014, Published online: 28 Jul 2014

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Takahito Suto, Yukio Yonemoto, Koichi Okamura, Hideo Sakane, Kimihiko Takeuchi, Yasuyuki Tamura, Tetsuya Kaneko, Keio Ayabe & Hirotaka Chikuda. (2019) The three-year efficacy of iguratimod in clinical daily practice in patients with rheumatoid arthritis. Modern Rheumatology 29:5, pages 775-781.
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Ayaka Yoshikawa, Shuzo Yoshida, Yuko Kimura, Nao Tokai, Yohei Fujiki, Takuya Kotani, Yoko Matsumura, Tohru Takeuchi & Shigeki Makino. (2018) Add-on iguratimod as a therapeutic strategy to achieve remission in patients with rheumatoid arthritis inadequately responding to biological DMARDs: A retrospective study. Modern Rheumatology 28:2, pages 227-234.
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Karen J. Wedekind, Kevin J. Ruff, Cindy A. Atwell, Joseph L. Evans & Alison M. Bendele. (2017) Beneficial effects of natural eggshell membrane (NEM) on multiple indices of arthritis in collagen-induced arthritic rats. Modern Rheumatology 27:5, pages 838-848.
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Yutaka Yoshioka, Nobunori Takahashi, Atsushi Kaneko, Yuji Hirano, Yasuhide Kanayama, Hiroyasu Kanda, Hideki Takagi, Takayasu Ito, Takefumi Kato, Kiwamu Saito, Koji Funahashi, Shuji Asai, Toki Takemoto, Kenya Terabe, Nobuyuki Asai, Naoki Ishiguro & Toshihisa Kojima. (2016) Disease activity early in treatment as a predictor of future low disease activity in RA patients treated with iguratimod. Modern Rheumatology 26:2, pages 169-174.
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Keiichi Tanaka, Tomonobu Yamaguchi & Masako Hara. (2015) Iguratimod for the treatment of rheumatoid arthritis in Japan. Expert Review of Clinical Immunology 11:5, pages 565-573.
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Articles from other publishers (16)

Sajan Shrestha, Jing Zhao, Changqing Yang & Jinping Zhang. (2021) Iguratimod combination therapy compared with methotrexate monotherapy for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Clinical Rheumatology 40:10, pages 4007-4017.
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Rong Mu, Chun Li, Xiaomei Li, Yao Ke, Ling Zhao, Lin Chen, Rui Wu, Zhenbiao Wu, Xiaoxia Zuo, Yanli Xie, Jinwei Chen, Wei Wei, Yi Liu, Zhijun Li, Lie Dai, Lingyun Sun, Xiangyuan Liu & Zhanguo Li. (2021) Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study. The Lancet Regional Health - Western Pacific 10, pages 100128.
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Sha Liu, Li-Ping Song, Rong-Bin Li, Le-Heng Feng & Hui Zhu. (2021) Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nuclear factor-κB pathway. World Journal of Clinical Cases 9:10, pages 2181-2191.
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Huihui Jiang, Hongyan Gao, Qin Wang, Miao Wang & Bin Wu. (2020) Molecular mechanisms and clinical application of Iguratimod: A review. Biomedicine & Pharmacotherapy 122, pages 109704.
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Muhammad Younis, Wang Faming, Zhao Hongyan, Tan Mengmeng, Song Hang & Yuan Liudi. (2019) Iguratimod encapsulated PLGA-NPs improves therapeutic outcome in glioma, glioma stem-like cells and temozolomide resistant glioma cells. Nanomedicine: Nanotechnology, Biology and Medicine 22, pages 102101.
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Jie Li, Jun Bao, Jian Zeng, Aizhu Yan, Chunqiu Zhao & Qiang Shu. (2019) Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology. Bone Research 7:1.
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Ying Xia, Shunbo Zhao, Meng Gong & Li Ding. (2018) A rapid and sensitive LC-MS/MS method for analysis of iguratimod in human plasma: Application to a pharmacokinetic study in Chinese healthy volunteers. Biomedical Chromatography 32:9, pages e4277.
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Wenjing Xiao, Jian-Ping Guo, Chun Li, Hua Ye, Wei Wei, Yaohong Zou, Lie Dai, Zhijun Li, Miaojia Zhang, Xiangpei Li, Xiaoyan Cai, Jianhong Zhao, Youlian Wang, Yi Tao, Dongzhou Liu, Yasong Li, Min Wu, Erwei Sun, Lijun Wu, Li Luo, Rong Mu & Zhanguo Li. (2018) Genetic predictors of efficacy and toxicity of iguratimod in patients with rheumatoid arthritis. Pharmacogenomics 19:5, pages 383-392.
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Jinglue Song, Hongli Liu, Qi Zhu, Yutong Miao, Feiyan Wang, Fan Yang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He & Guangjie Chen. (2018) T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF- κ B . BioMed Research International 2018, pages 1-8.
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Feng Xiao, Feng Zhang, Ling-ling Zhang & Wei Wei. (2017) A randomized phase I study to evaluate the safety, tolerability, pharmacokinetics and food-effect of Iguratimod in healthy adult volunteers. European Journal of Clinical Pharmacology 74:1, pages 69-77.
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K. Morimoto, A. Miura & Keiichi Tanaka. (2017) Anti-allodynic action of the disease-modifying anti-rheumatic drug iguratimod in a rat model of neuropathic pain. Inflammation Research 66:10, pages 855-862.
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Yue Sun, Ying-Xing Wu, Peng Zhang, Guang Peng & Shi-Ying Yu. (2017) Anti-rheumatic drug iguratimod protects against cancer-induced bone pain and bone destruction in a rat model. Oncology Letters 13:6, pages 4849-4856.
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Yukio Yonemoto, Koichi Okamura, Tetsuya Kaneko, Chisa Okura, Tsutomu Kobayashi, Takahito Suto, Yoshito Tsushima & Kenji Takagishi. (2017) Effect of total knee arthroplasty on other joints in patients with rheumatoid arthritis evaluated by 18-FDG-PET. International Journal of Rheumatic Diseases 20:6, pages 702-707.
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Yue Sun, Da-wei Ye, Peng Zhang, Ying-xing Wu, Bang-yan Wang, Guang Peng & Shi-ying Yu. (2016) Anti-rheumatic drug iguratimod (T-614) alleviates cancer-induced bone destruction via down-regulating interleukin-6 production in a nuclear factor-κB-dependent manner. Journal of Huazhong University of Science and Technology [Medical Sciences] 36:5, pages 691-699.
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Jun Shiota, Hidetoshi Murao, Akihiko Miura, Masaaki Mikami & Keiichi Tanaka. (2016) Iguratimod, a Disease-Modifying Anti-Rheumatic Drug, Inhibits Osteoclastogenesis and Bone Resorption through Suppression of the Nuclear Factor of Activated T Cells Signaling Pathway. Open Journal of Rheumatology and Autoimmune Diseases 06:04, pages 106-119.
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Yunzhi Xu, Qi Zhu, Jinglve Song, Hongli Liu, Yutong Miao, Fan Yang, Feiyan Wang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He & Guangjie Chen. (2015) Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators of Inflammation 2015, pages 1-13.
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