Search in:

Journal of Enzyme Inhibition and Medicinal Chemistry Volume 25, 2010 - Issue 4

Submit an article Journal homepage

Free access

618

Views

CrossRef citations to date

Altmetric

Original Article

A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice

Jiri KassaDepartment of Toxicology, Hradec Kralove, Czech RepublicCorrespondence[email protected]

Jana Zdarova KarasovaDepartment of Toxicology, Hradec Kralove, Czech Republic

Filip CaisbergerDepartment of Anatomy, Faculty of Medicine, Charles University, Hradec Kralove, Czech Republic

Kamil MusilekDepartment of Toxicology, Hradec Kralove, Czech Republic

Kamil KucaCenter of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic

Young-Sik JungMedicinal Science Division, Korea Research Institute of Chemical Technology, Yusong, Daejeon, Korea

Pages 480-484 | Received 11 Jun 2009, Accepted 12 Aug 2009, Published online: 16 Mar 2010

Cite this article
https://doi.org/10.3109/14756360903257918

Full Article
Figures & data
References
Citations
Metrics
Reprints & Permissions
View PDF PDF

Citations (11)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (11)

Eliska Prchalova, Zuzana Kohoutova, Karolina Knittelova, David Malinak & Kamil Musilek. (2023) Strategies for enhanced bioavailability of oxime reactivators in the central nervous system. Archives of Toxicology 97:11, pages 2839-2860.
Crossref

Tereza Kobrlova, Jan Korabecny & Ondrej Soukup. (2019) Current approaches to enhancing oxime reactivator delivery into the brain. Toxicology 423, pages 75-83.
Crossref

Lukas Gorecki, Ondrej Soukup, Tomas Kucera, David Malinak, Daniel Jun, Kamil Kuca, Kamil Musilek & Jan Korabecny. (2018) Oxime K203: a drug candidate for the treatment of tabun intoxication. Archives of Toxicology 93:3, pages 673-691.
Crossref

Tamara Zorbaz, David Malinak, Nikola Maraković, Nikolina Maček Hrvat, Antonio Zandona, Michal Novotny, Adam Skarka, Rudolf Andrys, Marketa Benkova, Ondrej Soukup, Maja Katalinić, Kamil Kuca, Zrinka Kovarik & Kamil Musilek. (2018) Pyridinium Oximes with Ortho -Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents . Journal of Medicinal Chemistry 61:23, pages 10753-10766.
Crossref

Lukas Gorecki, Jan Korabecny, Kamil Musilek, David Malinak, Eugenie Nepovimova, Rafael Dolezal, Daniel Jun, Ondrej Soukup & Kamil Kuca. (2016) SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. Archives of Toxicology 90:12, pages 2831-2859.
Crossref

Evica Antonijevic, Kamil Musilek, Kamil Kuca, Danijela Djukic-Cosic, Slavica Vucinic & Biljana Antonijevic. (2016) Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor. NeuroToxicology 55, pages 33-39.
Crossref

H. Kalász, S. M. Nurulain, G. Veress, S. Antus, F. Darvas, E. Adeghate, A. Adem, F. Hashemi & K. Tekes. (2015) Mini review on blood-brain barrier penetration of pyridinium aldoximes. Journal of Applied Toxicology 35:2, pages 116-123.
Crossref

Jiří Kassa, Jana Žďárová Karasová, Kamil Kuča, Kamil Musílek & Young-Sik Jung. (2014) Comparison of the neuroprotective effects of a novel bispyridinium oxime KR-22934 with the oxime K203 and obidoxime in tabun-poisoned male rats. Journal of Applied Biomedicine 12:2, pages 111-117.
Crossref

Jana Zdarova Karasova, Filip Zemek, Kamil Musilek & Kamil Kuca. (2012) Time-Dependent Changes of Oxime K027 Concentrations in Different Parts of Rat Central Nervous System. Neurotoxicity Research 23:1, pages 63-68.
Crossref

Christopher M. Timperley, R. Eric Banks, Ian M. Young & Robert N. Haszeldine. (2011) Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning. Journal of Fluorine Chemistry 132:8, pages 541-547.
Crossref

Jiri Kassa, Jana Zdarova Karasova, Sandra Tesarova, Kamil Musilek, Kamil Kuca & Young‐Sik Jung. (2010) A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR‐22836) with Obidoxime in Tabun‐Poisoned Rats. Basic & Clinical Pharmacology & Toxicology 107:5, pages 861-867.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice

Articles from other publishers (11)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice

Citations (11)

Articles from other publishers (11)

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date