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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 27, 2012 - Issue 6
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Research Article

Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents

Tomás HerraizSpanish National Research Council, (CSIC). Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Madrid, SpainCorrespondence[email protected]
Pages 810-817 | Received 11 Jul 2011, Accepted 20 Aug 2011, Published online: 12 Oct 2011

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Cristian Follmer. (2014) Monoamine oxidase and α-synuclein as targets in Parkinson’s disease therapy. Expert Review of Neurotherapeutics 14:6, pages 703-716.
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Haixiao Fang, Panpan Li, Congzhen Shen, Fang Tang, Aixiang Ding, Hua Bai, Bo Peng, Xuekang Yang, Zhengqiu Li, Kai Huang, Sijun Pan, Lin Li & Wei Huang. (2023) A fluorogenic-inhibitor-based probe for profiling and imaging of monoamine oxidase A in live human glioma cells and clinical tissues. Science China Chemistry 66:7, pages 2053-2061.
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Tomás Herraiz. 2023. Monoamine Oxidase. Monoamine Oxidase 97 114 .
Shazia Iqbal, Maria A. Khan, Almas Jabeen, Sammer Yousuf, Fatima Zafar, Farhana Batool, Muhammad Uzair Ganatra & Fatima Z. Basha. (2022) Synthesis, crystal structure, and reactive oxygen species (ROS) inhibition of N– and O–linked triazole analogues of harmine. Journal of Molecular Structure 1261, pages 132796.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Silvia Piccirillo, Simona Magi, Alessandra Preziuso, Tiziano Serfilippi, Giorgia Cerqueni, Monia Orciani, Salvatore Amoroso & Vincenzo Lariccia. (2022) The Hidden Notes of Redox Balance in Neurodegenerative Diseases. Antioxidants 11:8, pages 1456.
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Márcio W. Paixão, Rafaely N. Lima, Camila M. Kisukuri & Priscilla M. Matos. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 92 149 .
Pedro Besada, Dolores Viña, Tamara Costas, María Carmen Costas-Lago, Noemí Vila, Iria Torres-Terán, Mattia Sturlese, Stefano Moro & Carmen Terán. (2021) Pyridazinones containing dithiocarbamoyl moieties as a new class of selective MAO-B inhibitors. Bioorganic Chemistry 115, pages 105203.
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Haixiao Fang, Hang Zhang, Lin Li, Yun Ni, Riri Shi, Zheng Li, Xuekang Yang, Bo Ma, Chengwu Zhang, Qiong Wu, Changmin Yu, Naidi Yang, Shao Q. Yao & Wei Huang. (2020) Rational Design of a Two‐Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angewandte Chemie International Edition 59:19, pages 7536-7541.
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Haixiao Fang, Hang Zhang, Lin Li, Yun Ni, Riri Shi, Zheng Li, Xuekang Yang, Bo Ma, Chengwu Zhang, Qiong Wu, Changmin Yu, Naidi Yang, Shao Q. Yao & Wei Huang. (2020) Rational Design of a Two‐Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angewandte Chemie 132:19, pages 7606-7611.
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Rati Kailash Prasad Tripathi & Senthil Raja Ayyannan. (2019) Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: An overview and update. Medicinal Research Reviews 39:5, pages 1603-1706.
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Tomás Herraiz, Andrea Flores & Lidia Fernández. (2018) Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants. Journal of Chromatography B 1073, pages 136-144.
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Abdelrahman Ibrahim Abushouk, Ahmed Negida, Hussien Ahmed & Mohamed M. Abdel-Daim. (2017) Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: Future applications in Parkinson’s disease. Biomedicine & Pharmacotherapy 85, pages 635-645.
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Kandatege Wimalasena. 2017. 81 122 .
Tomás Herraiz. (2016) N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids. Food and Chemical Toxicology 97, pages 23-39.
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T. Bohnert, A. Patel, I. Templeton, Y. Chen, C. Lu, G. Lai, L. Leung, S. Tse, H. J. Einolf, Y.-H. Wang, M. Sinz, R. Stearns, R. Walsky, W. Geng, S. Sudsakorn, D. Moore, L. He, J. Wahlstrom, J. Keirns, R. Narayanan, D. Lang & X. Yang. (2016) Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions--an Industry Perspective. Drug Metabolism and Disposition 44:8, pages 1399-1423.
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Tomás Herraiz, Hugo Guillén & Juan Galisteo. (2013) Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro- β -carboline by Oxidative Enzymes . BioMed Research International 2013, pages 1-10.
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