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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 3
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Research Article

Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine

Manuela CervelliDepartment of Biology, University Roma Tre, Rome, ItalyCorrespondence[email protected]
,
Fabio Polticelli
,
Laura FiorucciDepartment of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
,
Emanuela AngelucciDepartment of Biology, University Roma Tre, Rome, Italy
,
Rodolfo FedericoDepartment of Biology, University Roma Tre, Rome, Italy
&
Paolo MariottiniDepartment of Biology, University Roma Tre, Rome, Italy
Pages 463-467 | Received 09 Nov 2011, Accepted 13 Dec 2011, Published online: 03 Feb 2012

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Maria Luisa Di Paolo, Manuela Cervelli, Paolo Mariottini, Alessia Leonetti, Fabio Polticelli, Michela Rosini, Andrea Milelli, Filippo Basagni, Rina Venerando, Enzo Agostinelli & Anna Minarini. (2019) Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 740-752.
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Articles from other publishers (11)

Guangtian Wang, Zhihui Li, Peng Lin, Huishu Zhang, Yanyan Wang, Tongshuai Zhang, Hui Wang, Heming Li, Lexun Lin, Yuehui Zhao, Lina Jia, Yang Chen, Hong Ji, Wenran Zhao, Zhongqiu Fu & Zhaohua Zhong. (2024) Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke. International Immunopharmacology 126, pages 111183.
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Amelia B. Furbish, Ahmed S. Alford, Pieter Burger, Yuri K. Peterson, Tracy Murray-Stewart, Robert A. CaseroJr.Jr. & Patrick M. Woster. (2022) Identification and Characterization of Novel Small-Molecule SMOX Inhibitors. Medical Sciences 10:3, pages 47.
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Manuela Cervelli, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Cristian Fiorucci, Marianna Nicoletta Rossi, Guido Maura, Paolo Mariottini, Chiara Cervetto & Manuela Marcoli. (2022) The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration. Biomedicines 10:7, pages 1756.
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Sergey P. Syatkin, Ekaterina V. Neborak, Andrei I. Khlebnikov, Marina V. Komarova, Natalia A. Shevkun, Eduard G. Kravtsov, Mikhail L. Blagonravov & Enzo Agostinelli. (2019) The investigation of structure–activity relationship of polyamine-targeted synthetic compounds from different chemical groups. Amino Acids 52:2, pages 199-211.
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Fang Liu, Alan B. Saul, Prahalathan Pichavaram, Zhimin Xu, Madhuri Rudraraju, Payaningal R. Somanath, Sylvia B. Smith, Ruth B. Caldwell & S. Priya Narayanan. (2020) Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice. Journal of Clinical Medicine 9:2, pages 340.
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Steven Holshouser, Matthew Dunworth, Tracy Murray-Stewart, Yuri K. Peterson, Pieter Burger, Joy Kirkpatrick, Huan-Huan Chen, Robert A. Casero & Patrick M. Woster. (2019) Dual inhibitors of LSD1 and spermine oxidase. MedChemComm 10:5, pages 778-790.
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Prahalathan Pichavaram, Chithra Devi Palani, Chintan Patel, Zhimin Xu, Esraa Shosha, Abdelrahman Y. Fouda, Ruth B. Caldwell & Subhadra Priya Narayanan. (2019) Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration. Frontiers in Neuroscience 12.
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Takashi Masuko, Koichi Takao, Keijiro Samejima, Akira Shirahata, Kazuei Igarashi, Robert A. CaseroJr.Jr., Yasuo Kizawa & Yoshiaki Sugita. (2018) N1-Nonyl-1,4-diaminobutane ameliorates brain infarction size in photochemically induced thrombosis model mice. Neuroscience Letters 672, pages 118-122.
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Roberta Mastrantonio, Manuela Cervelli, Stefano Pietropaoli, Paolo Mariottini, Marco Colasanti & Tiziana Persichini. (2016) HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells. PLOS ONE 11:2, pages e0149802.
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Manuela Cervelli, Emanuela Angelucci, Pasquale Stano, Loris Leboffe, Rodolfo Federico, Giovanni Antonini, Paolo Mariottini & Fabio Polticelli. (2014) The Glu216/Ser218 pocket is a major determinant of spermine oxidase substrate specificity. Biochemical Journal 461:3, pages 453-459.
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Caterina Capone, Manuela Cervelli, Emanuela Angelucci, Marco Colasanti, Alberto Macone, Paolo Mariottini & Tiziana Persichini. (2013) A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity. Free Radical Biology and Medicine 63, pages 99-107.
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