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Research Article

2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling

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Pages 583-592 | Received 24 Oct 2011, Accepted 17 Jan 2012, Published online: 01 Mar 2012

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Majed Shtaiwi, Nayyef Aljaar, Lana Al-Najjar, Chandi C. Malakar, Amneh Shtaiwi, Mohammad Abu-Sini & Mahmoud Al-Refai. (2023) Design, Synthesis, Biological Activity, and Molecular Modeling of Novel Spiroquinazoline Derivatives as Acetylcholinesterase Inhibitors for Alzheimer Disease. Polycyclic Aromatic Compounds 43:9, pages 8082-8095.
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Mingfei Wu, Jie Ma, Lijun Ji, Min Wang, Jianfei Han & Zeng Li. (2019) Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 177, pages 198-211.
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Sri Devi Sukumaran, Fadhil Lafta Faraj, Vannajan Sanghiran Lee, Rozana Othman & Michael J. C. Buckle. (2018) 2-Aryl-3-(arylideneamino)-1,2-dihydroquinazoline-4(3 H )-ones as inhibitors of cholinesterases and self-induced β-amyloid (Aβ) aggregation: biological evaluations and mechanistic insights from molecular dynamics simulations . RSC Advances 8:14, pages 7818-7831.
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Dawid Panek, Tomasz Wichur, Justyna Godyń , Anna Pasieka & Barbara Malawska. (2017) Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors. Future Medicinal Chemistry 9:15, pages 1835-1854.
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Muhammad Sarfraz, Nargis Sultana, Umer Rashid, Muhammad Safwan Akram, Abdul Sadiq & Muhammad Ilyas Tariq. (2017) Synthesis, biological evaluation and docking studies of 2,3-dihydroquinazolin-4(1 H )-one derivatives as inhibitors of cholinesterases. Bioorganic Chemistry 70, pages 237-244.
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Tarek Mohamed & Praveen P.N. Rao. (2017) 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies. European Journal of Medicinal Chemistry 126, pages 823-843.
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Anuradha Sharma & Poonam Piplani. (2015) Understanding the quantitative structure–activity relationship of acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of Theoretical and Computational Chemistry 14:06, pages 1550040.
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Jong-Keun Son, Hyeun Chang & Yurngdong Jahng. (2015) Progress in Studies on Rutaecarpine. II.—Synthesis and Structure-Biological Activity Relationships. Molecules 20:6, pages 10800-10821.
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